Aliases for PLB1 Gene
External Ids for PLB1 Gene
Previous GeneCards Identifiers for PLB1 Gene
This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]
GeneCards Summary for PLB1 Gene
PLB1 (Phospholipase B1) is a Protein Coding gene. Diseases associated with PLB1 include Fungal Meningitis and Amyotrophic Lateral Sclerosis 9. Among its related pathways are Acyl chain remodelling of PE and Linoleic acid metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and lysophospholipase activity.
UniProtKB/Swiss-Prot Summary for PLB1 Gene
Membrane-associated phospholipase. Exhibits a calcium-independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity).