Aliases for PLB1 Gene
External Ids for PLB1 Gene
Previous GeneCards Identifiers for PLB1 Gene
This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]
GeneCards Summary for PLB1 Gene
PLB1 (Phospholipase B1) is a Protein Coding gene. Diseases associated with PLB1 include Fungal Meningitis and Cryptococcosis. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and lysophospholipase activity.
UniProtKB/Swiss-Prot Summary for PLB1 Gene
Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (By similarity). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (By similarity). May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (By similarity).