This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and pe... See more...

Aliases for PLAUR Gene

Aliases for PLAUR Gene

  • Plasminogen Activator, Urokinase Receptor 2 3 5
  • UPAR 2 3 4 4
  • Urokinase Plasminogen Activator Surface Receptor 2 3 4
  • Urokinase-Type Plasminogen Activator (UPA) Receptor 2 3
  • Monocyte Activation Antigen Mo3 3 4
  • U-PAR 3 4
  • CD87 2 3
  • URKR 2 3
  • U-Plasminogen Activator Receptor Form 2 3
  • CD87 Antigen 4
  • PLAUR 5
  • MO3 4

External Ids for PLAUR Gene

Previous GeneCards Identifiers for PLAUR Gene

  • GC19M044796
  • GC19M044542
  • GC19M048826
  • GC19M048844
  • GC19M048842
  • GC19M044150
  • GC19M040580

Summaries for PLAUR Gene

Entrez Gene Summary for PLAUR Gene

  • This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLAUR Gene

PLAUR (Plasminogen Activator, Urokinase Receptor) is a Protein Coding gene. Diseases associated with PLAUR include Ureter, Cancer Of and Paroxysmal Nocturnal Hemoglobinuria. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and amb2 Integrin signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is LYPD3.

UniProtKB/Swiss-Prot Summary for PLAUR Gene

  • Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

Gene Wiki entry for PLAUR Gene

Additional gene information for PLAUR Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLAUR Gene

Genomics for PLAUR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLAUR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J043667 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.4 350 6 CTCF PRDM10 ZNF629 REST IKZF1 KDM1A ZNF692 POLR2A JUND LARP7 MN297594 PLAUR ZNF45 ZNF180 ZNF225 ZNF224 ZNF155 ZNF284 ZNF234 ZNF223
GH19J043673 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 50.4 -4.3 -4303 3 CREB1 PRDM10 ZNF629 ZNF512 IKZF1 JUND ZNF300 ZNF143 PRDM1 MTA2 ZNF225 ZNF283 ZNF45 PLAUR ZNF180 ZNF226 ZNF112 ZNF234 ZNF223 ZNF224
GH19J043762 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 40.2 -95.4 -95431 6.6 SP1 CTCF PRDM10 ZNF629 IKZF1 POLR2A BACH1 JUND LARP7 STAT3 ZNF180 ZNF45 PLAUR XRCC1 ZNF155 ZNF234 ZNF225 SMG9 ZNF224 ZNF230
GH19J043773 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 21.7 -109.4 -109421 12.3 ARHGAP35 CREB1 CTCF HNRNPL PRDM10 ZNF629 TFE3 ZNF512 RFX1 LEF1 KCNN4 ZNF45 ZNF180 ZNF225 ZNF284 ZNF224 ZNF227 ZNF223 ZNF283 ZNF234
GH19J043683 Enhancer 0.9 FANTOM5 dbSUPER 49.8 -12.9 -12915 0.1 CREB1 FOXJ2 ZNF766 NFE2 ZNF316 NR2C2 FOSL1 MAFG CEBPG MAFK lnc-PLAUR-1 lnc-IRGC-3 PLAUR SMG9 KCNN4 IRGQ ZNF222 TEX101 LOC105372412 lnc-IRGC-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLAUR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLAUR

Top Transcription factor binding sites by QIAGEN in the PLAUR gene promoter:
  • Sp1
  • STAT1
  • STAT3

Genomic Locations for PLAUR Gene

Genomic Locations for PLAUR Gene
chr19:43,646,095-43,670,547
(GRCh38/hg38)
Size:
24,453 bases
Orientation:
Minus strand
chr19:44,150,247-44,174,699
(GRCh37/hg19)
Size:
24,453 bases
Orientation:
Minus strand

Genomic View for PLAUR Gene

Genes around PLAUR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAUR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAUR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAUR Gene

Proteins for PLAUR Gene

  • Protein details for PLAUR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03405-UPAR_HUMAN
    Recommended name:
    Urokinase plasminogen activator surface receptor
    Protein Accession:
    Q03405
    Secondary Accessions:
    • A8K409
    • Q12876
    • Q15845
    • Q16887
    • Q6IB52
    • Q9BWT0
    • Q9NYC8
    • Q9UD69
    • Q9UEA6
    • Q9UM92
    • Q9UMV0

    Protein attributes for PLAUR Gene

    Size:
    335 amino acids
    Molecular mass:
    36978 Da
    Quaternary structure:
    • Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane. Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (PubMed:14764453, PubMed:23486467). The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (PubMed:15053742).

    Three dimensional structures from OCA and Proteopedia for PLAUR Gene

    Alternative splice isoforms for PLAUR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLAUR Gene

Post-translational modifications for PLAUR Gene

  • Glycosylation at Asn74, Asn222, Asn184, Asn194, and Asn255
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PLAUR Gene

Domains & Families for PLAUR Gene

Gene Families for PLAUR Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PLAUR Gene

InterPro:
Blocks:
  • CD59 antigen
  • Urokinase plasminogen activator surface receptor
ProtoNet:

Suggested Antigen Peptide Sequences for PLAUR Gene

GenScript: Design optimal peptide antigens:
  • Urokinase plasminogen activator receptor (Q6GY32_HUMAN)
  • U-plasminogen activator receptor form 2-human [AA 1-206] (Q9UPI5_HUMAN)
  • Monocyte activation antigen Mo3 (UPAR_HUMAN)
genes like me logo Genes that share domains with PLAUR: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PLAUR Gene

Function for PLAUR Gene

Molecular function for PLAUR Gene

UniProtKB/Swiss-Prot Function:
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
GENATLAS Biochemistry:
plasminogen activator urokinase receptor,significantly diminished in diffuse type gastric carcinoma

Phenotypes From GWAS Catalog for PLAUR Gene

Gene Ontology (GO) - Molecular Function for PLAUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 12665524
GO:0005515 protein binding IPI 11290596
GO:0019899 enzyme binding IPI 14688365
GO:0019904 protein domain specific binding IPI 12665524
GO:0030377 urokinase plasminogen activator receptor activity IEA,NAS 1689240
genes like me logo Genes that share ontologies with PLAUR: view
genes like me logo Genes that share phenotypes with PLAUR: view

Animal Models for PLAUR Gene

MGI Knock Outs for PLAUR:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAUR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLAUR Gene

Localization for PLAUR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAUR Gene

Cell membrane. Cell projection, invadopodium membrane. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. {ECO:0000269 PubMed:12376466}.
[Isoform 1]: Cell membrane. Lipid-anchor, GPI-anchor.
[Isoform 2]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAUR gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 4
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLAUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with PLAUR: view

Pathways & Interactions for PLAUR Gene

genes like me logo Genes that share pathways with PLAUR: view

Pathways by source for PLAUR Gene

3 GeneGo (Thomson Reuters) pathways for PLAUR Gene
  • Cell adhesion PLAU signaling
  • Cell adhesion_ECM remodeling
  • Development VEGF signaling via VEGFR2 - generic cascades
3 Qiagen pathways for PLAUR Gene
  • Glioma Invasiveness
  • UPA-UPAR Pathway
  • WNT Signaling
1 Cell Signaling Technology pathway for PLAUR Gene

SIGNOR curated interactions for PLAUR Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PLAUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 22984561
GO:0006935 chemotaxis TAS 10749881
GO:0007165 signal transduction TAS 10749881
GO:0007596 blood coagulation TAS,NAS 8392005
GO:0030162 regulation of proteolysis IEA,NAS 1689240
genes like me logo Genes that share ontologies with PLAUR: view

Drugs & Compounds for PLAUR Gene

(61) Drugs for PLAUR Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urokinase Approved, Investigational, Withdrawn Pharma Target, inducer, modulator, activator 0
Alteplase Approved Pharma Target 0
Tenecteplase Approved Pharma Target 51
Lanoteplase Investigational Pharma Target 0
WX-UK1 Investigational Pharma Target 0

(47) Additional Compounds for PLAUR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PLAUR: view

Transcripts for PLAUR Gene

mRNA/cDNA for PLAUR Gene

4 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAUR

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAUR Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - -
SP7: - -
SP8: - - -
SP9: - - - - -
SP10:
SP11:

Relevant External Links for PLAUR Gene

GeneLoc Exon Structure for
PLAUR

Expression for PLAUR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLAUR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAUR Gene

This gene is overexpressed in Whole Blood (x22.6).

Protein differential expression in normal tissues from HIPED for PLAUR Gene

This gene is overexpressed in Cervix (35.7), Peripheral blood mononuclear cells (11.5), and Breast (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLAUR Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLAUR

SOURCE GeneReport for Unigene cluster for PLAUR Gene:

Hs.466871

mRNA Expression by UniProt/SwissProt for PLAUR Gene:

Q03405-UPAR_HUMAN
Tissue specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Evidence on tissue expression from TISSUES for PLAUR Gene

  • Skin(4.6)
  • Lung(4.2)
  • Bone marrow(3.5)
  • Blood(3.3)
  • Intestine(3.2)
  • Nervous system(3)
  • Heart(3)
  • Liver(2.9)
  • Lymph node(2.7)
  • Pancreas(2.7)
  • Kidney(2.6)
  • Spleen(2.6)
  • Muscle(2.6)
  • Stomach(2.5)
  • Gall bladder(2.1)
  • Urine(2)
genes like me logo Genes that share expression patterns with PLAUR: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAUR Gene

Orthologs for PLAUR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAUR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLAUR 30 31
  • 99.3 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PLAUR 30 31
  • 80.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PLAUR 30 31
  • 75.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Plaur 30
  • 70.97 (n)
Mouse
(Mus musculus)
Mammalia Plaur 30 17 31
  • 69.78 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PLAUR 31
  • 48 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PLAUR 31
  • 31 (a)
OneToOne
Species where no ortholog for PLAUR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PLAUR Gene

ENSEMBL:
Gene Tree for PLAUR (if available)
TreeFam:
Gene Tree for PLAUR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLAUR: view image

Paralogs for PLAUR Gene

Paralogs for PLAUR Gene

genes like me logo Genes that share paralogs with PLAUR: view

Variants for PLAUR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLAUR Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
712815 Likely Benign: not provided 43,670,060(-) C/A INTRON_VARIANT
714141 Likely Benign: not provided 43,655,570(-) C/T MISSENSE_VARIANT,INTRON_VARIANT
728077 Likely Benign: not provided 43,649,070(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
741417 Likely Benign: not provided 43,655,510(-) T/C MISSENSE_VARIANT,INTRON_VARIANT
754228 Likely Benign: not provided 43,655,518(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for PLAUR Gene

Structural Variations from Database of Genomic Variants (DGV) for PLAUR Gene

Variant ID Type Subtype PubMed ID
esv2445332 CNV insertion 19546169
esv3893220 CNV gain 25118596
nsv833839 CNV loss 17160897

Variation tolerance for PLAUR Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.73; 86.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAUR Gene

Human Gene Mutation Database (HGMD)
PLAUR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAUR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAUR Gene

Disorders for PLAUR Gene

MalaCards: The human disease database

(37) MalaCards diseases for PLAUR Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PLAUR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLAUR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PLAUR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAUR Gene

Publications for PLAUR Gene

  1. PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline. (PMID: 19443020) Barton SJ … Sayers I (The Journal of allergy and clinical immunology 2009) 3 23 41
  2. PLAUR polymorphisms and lung function in UK smokers. (PMID: 19878584) Stewart CE … Sayers I (BMC medical genetics 2009) 3 23 41
  3. Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide. (PMID: 15861141) Llinas P … Ménez A (The EMBO journal 2005) 3 4 23
  4. Cell-surface acceleration of urokinase-catalyzed receptor cleavage. (PMID: 9030717) Høyer-Hansen G … Danø K (European journal of biochemistry 1997) 3 4 23
  5. The structure of the urokinase-type plasminogen activator receptor gene. (PMID: 8049431) Casey JR … Rosse WF (Blood 1994) 3 4 23

Products for PLAUR Gene

Sources for PLAUR Gene