Aliases for PLAUR Gene
External Ids for PLAUR Gene
Previous GeneCards Identifiers for PLAUR Gene
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
GeneCards Summary for PLAUR Gene
PLAUR (Plasminogen Activator, Urokinase Receptor) is a Protein Coding gene. Diseases associated with PLAUR include Ureter, Cancer Of and Paroxysmal Nocturnal Hemoglobinuria. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and amb2 Integrin signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is LYPD3.
UniProtKB/Swiss-Prot Summary for PLAUR Gene
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.