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Aliases for PLAUR Gene

Aliases for PLAUR Gene

  • Plasminogen Activator, Urokinase Receptor 2 3 5
  • UPAR 3 4 4
  • Urokinase-Type Plasminogen Activator (UPA) Receptor 2 3
  • Urokinase Plasminogen Activator Surface Receptor 2 3
  • Monocyte Activation Antigen Mo3 3 4
  • U-PAR 3 4
  • U-Plasminogen Activator Receptor Form 2 3
  • CD87 Antigen 4
  • CD87 3
  • URKR 3
  • MO3 4

External Ids for PLAUR Gene

Previous GeneCards Identifiers for PLAUR Gene

  • GC19M044796
  • GC19M044542
  • GC19M048826
  • GC19M048844
  • GC19M048842
  • GC19M044150
  • GC19M040580

Summaries for PLAUR Gene

Entrez Gene Summary for PLAUR Gene

  • This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLAUR Gene

PLAUR (Plasminogen Activator, Urokinase Receptor) is a Protein Coding gene. Diseases associated with PLAUR include Ureter, Cancer Of and Perforated Corneal Ulcer. Among its related pathways are Cell adhesion_ECM remodeling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.

UniProtKB/Swiss-Prot for PLAUR Gene

  • Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

Gene Wiki entry for PLAUR Gene

Additional gene information for PLAUR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAUR Gene

Genomics for PLAUR Gene

GeneHancer (GH) Regulatory Elements for PLAUR Gene

Promoters and enhancers for PLAUR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J043667 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.3 1277 4.2 HDGF PKNOX1 SMAD1 ARNT SIN3A FEZF1 ZNF2 POLR2B ZNF213 E2F8 PLAUR ZNF45 ZNF180 ZNF225 ZNF224 ZNF155 ZNF284 ZNF234 ZNF227 ZNF283
GH19J043672 Enhancer 1 ENCODE dbSUPER 650.7 -1.7 -1717 0.2 HDAC1 ZBTB21 TAL1 MZF1 ZIC2 MTA3 ZBTB48 PATZ1 PRDM10 ZNF600 PLAUR GC19P043667 LOC105372412
GH19J043673 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 50.5 -4.3 -4303 3 PKNOX1 ATF1 ZNF133 SIN3A YBX1 ZNF2 ZBTB7B ZNF48 ZNF121 ZNF143 ZNF225 ZNF283 ZNF45 PLAUR ZNF180 ZNF226 ZNF112 ZNF234 ZNF223 ZNF224
GH19J043762 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 40.2 -95.4 -95431 6.6 HDGF PKNOX1 SMAD1 SIN3A ZNF2 IRF4 ZNF766 ZNF207 ZNF143 FOS ZNF180 ZNF45 XRCC1 ZNF155 ZNF234 ZNF225 PLAUR ZNF224 SMG9 ZNF284
GH19J043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.7 -109.4 -109355 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF284 ZNF224 ZNF227 ZNF223 ZNF235 ZNF283
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLAUR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLAUR gene promoter:
  • STAT3
  • STAT1
  • Sp1

Genomic Locations for PLAUR Gene

Genomic Locations for PLAUR Gene
chr19:43,646,095-43,670,547
(GRCh38/hg38)
Size:
24,453 bases
Orientation:
Minus strand
chr19:44,150,247-44,174,699
(GRCh37/hg19)
Size:
24,453 bases
Orientation:
Minus strand

Genomic View for PLAUR Gene

Genes around PLAUR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAUR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAUR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAUR Gene

Proteins for PLAUR Gene

  • Protein details for PLAUR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03405-UPAR_HUMAN
    Recommended name:
    Urokinase plasminogen activator surface receptor
    Protein Accession:
    Q03405
    Secondary Accessions:
    • A8K409
    • Q12876
    • Q15845
    • Q16887
    • Q6IB52
    • Q9BWT0
    • Q9NYC8
    • Q9UD69
    • Q9UEA6
    • Q9UM92
    • Q9UMV0

    Protein attributes for PLAUR Gene

    Size:
    335 amino acids
    Molecular mass:
    36978 Da
    Quaternary structure:
    • Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with SORL1. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane.

    Three dimensional structures from OCA and Proteopedia for PLAUR Gene

    Alternative splice isoforms for PLAUR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLAUR Gene

Post-translational modifications for PLAUR Gene

  • Glycosylation at Asn255, isoforms=2, 3222, Asn194, Asn184, and Asn74
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PLAUR Gene

Domains & Families for PLAUR Gene

Gene Families for PLAUR Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLAUR: view

No data available for UniProtKB/Swiss-Prot for PLAUR Gene

Function for PLAUR Gene

Molecular function for PLAUR Gene

UniProtKB/Swiss-Prot Function:
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
GENATLAS Biochemistry:
plasminogen activator urokinase receptor,significantly diminished in diffuse type gastric carcinoma

Phenotypes From GWAS Catalog for PLAUR Gene

Gene Ontology (GO) - Molecular Function for PLAUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 12665524
GO:0005515 protein binding IPI 11290596
GO:0019899 enzyme binding IPI 14688365
GO:0019904 protein domain specific binding IPI 12665524
GO:0030377 urokinase plasminogen activator receptor activity NAS,IEA 1689240
genes like me logo Genes that share ontologies with PLAUR: view
genes like me logo Genes that share phenotypes with PLAUR: view

Animal Models for PLAUR Gene

MGI Knock Outs for PLAUR:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLAUR Gene

Localization for PLAUR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAUR Gene

Cell membrane. Cell projection, invadopodium membrane. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. {ECO:0000269 PubMed:12376466}.
Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAUR gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 4
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLAUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with PLAUR: view

Pathways & Interactions for PLAUR Gene

genes like me logo Genes that share pathways with PLAUR: view

SIGNOR curated interactions for PLAUR Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLAUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 22984561
GO:0006935 chemotaxis TAS 10749881
GO:0007165 signal transduction TAS 10749881
GO:0007596 blood coagulation NAS,TAS 8392005
GO:0016255 attachment of GPI anchor to protein TAS --
genes like me logo Genes that share ontologies with PLAUR: view

Drugs & Compounds for PLAUR Gene

(63) Drugs for PLAUR Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urokinase Approved, Investigational, Withdrawn Pharma activator, Target 0
Alteplase Approved Pharma Target 0
Anistreplase Approved Pharma Target 0
Reteplase Approved, Investigational Pharma Target 6
Tenecteplase Approved Pharma Target 42

(47) Additional Compounds for PLAUR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PLAUR: view

Transcripts for PLAUR Gene

mRNA/cDNA for PLAUR Gene

Unigene Clusters for PLAUR Gene

Plasminogen activator, urokinase receptor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAUR Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - -
SP7: - -
SP8: - - -
SP9: - - - - -
SP10:
SP11:

Relevant External Links for PLAUR Gene

GeneLoc Exon Structure for
PLAUR
ECgene alternative splicing isoforms for
PLAUR

Expression for PLAUR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLAUR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAUR Gene

This gene is overexpressed in Whole Blood (x22.6).

Protein differential expression in normal tissues from HIPED for PLAUR Gene

This gene is overexpressed in Cervix (35.7), Peripheral blood mononuclear cells (11.5), and Breast (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLAUR Gene



NURSA nuclear receptor signaling pathways regulating expression of PLAUR Gene:

PLAUR

SOURCE GeneReport for Unigene cluster for PLAUR Gene:

Hs.466871

mRNA Expression by UniProt/SwissProt for PLAUR Gene:

Q03405-UPAR_HUMAN
Tissue specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Evidence on tissue expression from TISSUES for PLAUR Gene

  • Skin(4.5)
  • Lung(4.1)
  • Bone marrow(3.1)
  • Blood(2.9)
  • Intestine(2.7)
  • Heart(2.5)
  • Nervous system(2.5)
  • Liver(2.2)
  • Lymph node(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with PLAUR: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAUR Gene

Orthologs for PLAUR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAUR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLAUR 34 33
  • 99.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PLAUR 34 33
  • 80.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PLAUR 34 33
  • 75.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plaur 33
  • 70.97 (n)
mouse
(Mus musculus)
Mammalia Plaur 16 34 33
  • 69.78 (n)
oppossum
(Monodelphis domestica)
Mammalia PLAUR 34
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLAUR 34
  • 31 (a)
OneToOne
Species where no ortholog for PLAUR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLAUR Gene

ENSEMBL:
Gene Tree for PLAUR (if available)
TreeFam:
Gene Tree for PLAUR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLAUR: view image

Paralogs for PLAUR Gene

No data available for Paralogs for PLAUR Gene

Variants for PLAUR Gene

Sequence variations from dbSNP and Humsavar for PLAUR Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000165827 -- 43,663,971(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000416994 -- 43,669,998(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000480779 -- 43,652,482(-) A/G intron_variant
rs1000802063 -- 43,657,254(-) A/C intron_variant
rs1001095928 -- 43,661,324(-) T/TT 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLAUR Gene

Variant ID Type Subtype PubMed ID
esv2445332 CNV insertion 19546169
esv3893220 CNV gain 25118596
nsv833839 CNV loss 17160897

Variation tolerance for PLAUR Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.73; 86.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAUR Gene

Human Gene Mutation Database (HGMD)
PLAUR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAUR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAUR Gene

Disorders for PLAUR Gene

MalaCards: The human disease database

(21) MalaCards diseases for PLAUR Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ureter, cancer of
  • ureter cancer
perforated corneal ulcer
paroxysmal nocturnal hemoglobinuria
  • marchiafava-micheli disease
lipodermatosclerosis
  • acute lipodermatosclerosis
mal de meleda
  • mdm
- elite association - COSMIC cancer census association via MalaCards
Search PLAUR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLAUR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PLAUR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAUR Gene

Publications for PLAUR Gene

  1. PLAUR polymorphisms and lung function in UK smokers. (PMID: 19878584) Stewart CE … Sayers I (BMC medical genetics 2009) 3 22 44 58
  2. PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline. (PMID: 19443020) Barton SJ … Sayers I (The Journal of allergy and clinical immunology 2009) 3 22 44 58
  3. Cell-surface acceleration of urokinase-catalyzed receptor cleavage. (PMID: 9030717) Høyer-Hansen G … Danø K (European journal of biochemistry 1997) 3 4 22 58
  4. The structure of the urokinase-type plasminogen activator receptor gene. (PMID: 8049431) Casey JR … Rosse WF (Blood 1994) 3 4 22 58
  5. An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator. (PMID: 8392005) Pyke C … Danø K (FEBS letters 1993) 3 4 22 58

Products for PLAUR Gene

Sources for PLAUR Gene

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