Aliases for PLAU Gene
External Ids for PLAU Gene
Previous GeneCards Identifiers for PLAU Gene
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
GeneCards Summary for PLAU Gene
PLAU (Plasminogen Activator, Urokinase) is a Protein Coding gene. Diseases associated with PLAU include Quebec Platelet Disorder and Alzheimer Disease. Among its related pathways are Proteoglycans in cancer and Cell adhesion_ECM remodeling. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS1.
UniProtKB/Swiss-Prot Summary for PLAU Gene
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.