Aliases for PLAT Gene
External Ids for PLAT Gene
Previous GeneCards Identifiers for PLAT Gene
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
GeneCards Summary for PLAT Gene
PLAT (Plasminogen Activator, Tissue Type) is a Protein Coding gene. Diseases associated with PLAT include Lethal Hydranencephaly-Diaphragmatic Hernia Syndrome and Thrombophilia, Familial, Due To Decreased Release Of Tissue Plasminogen Activator. Among its related pathways are NOTCH1 regulation of human endothelial cell calcification and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PLG.
UniProtKB/Swiss-Prot Summary for PLAT Gene
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.