Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008] See more...

Aliases for PLAGL2 Gene

Aliases for PLAGL2 Gene

  • PLAG1 Like Zinc Finger 2 2 3 5
  • Pleiomorphic Adenoma-Like Protein 2 3 4
  • Pleiomorphic Adenoma Gene-Like 2 2 3
  • C2H2-Type Zinc Finger Protein 2 3
  • Zinc Finger Protein PLAGL2 3 4
  • KIAA0198 4
  • ZNF900 3

External Ids for PLAGL2 Gene

Previous GeneCards Identifiers for PLAGL2 Gene

  • GC20M030568
  • GC20M031478
  • GC20M031525
  • GC20M030243
  • GC20M030780
  • GC20M027568

Summaries for PLAGL2 Gene

Entrez Gene Summary for PLAGL2 Gene

  • Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLAGL2 Gene

PLAGL2 (PLAG1 Like Zinc Finger 2) is a Protein Coding gene. Diseases associated with PLAGL2 include Pleomorphic Adenoma and Adenoma. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is PLAG1.

UniProtKB/Swiss-Prot Summary for PLAGL2 Gene

Gene Wiki entry for PLAGL2 Gene

Additional gene information for PLAGL2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLAGL2 Gene

Genomics for PLAGL2 Gene

GeneHancer (GH) Regulatory Elements for PLAGL2 Gene

Promoters and enhancers for PLAGL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLAGL2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLAGL2

Top Transcription factor binding sites by QIAGEN in the PLAGL2 gene promoter:
  • c-Myb
  • COUP
  • COUP-TF1
  • CUTL1
  • HNF-4alpha1
  • HNF-4alpha2
  • Lmo2
  • RORalpha2
  • Sp1

Genomic Locations for PLAGL2 Gene

Genomic Locations for PLAGL2 Gene
15,240 bases
Minus strand
15,289 bases
Minus strand

Genomic View for PLAGL2 Gene

Genes around PLAGL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAGL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAGL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAGL2 Gene

Proteins for PLAGL2 Gene

  • Protein details for PLAGL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein PLAGL2
    Protein Accession:
    Secondary Accessions:
    • A8K8T5
    • E1P5M3
    • Q92584

    Protein attributes for PLAGL2 Gene

    496 amino acids
    Molecular mass:
    54584 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA12113.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PLAGL2 Gene

Post-translational modifications for PLAGL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLAGL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLAGL2 Gene

Domains & Families for PLAGL2 Gene

Gene Families for PLAGL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for PLAGL2 Gene

Suggested Antigen Peptide Sequences for PLAGL2 Gene

GenScript: Design optimal peptide antigens:
  • Pleiomorphic adenoma-like protein 2 (PLAL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with PLAGL2: view

Function for PLAGL2 Gene

Molecular function for PLAGL2 Gene

UniProtKB/Swiss-Prot Function:
Shows weak transcriptional activatory activity.

Phenotypes From GWAS Catalog for PLAGL2 Gene

Gene Ontology (GO) - Molecular Function for PLAGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 15361364
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS 9722527
genes like me logo Genes that share ontologies with PLAGL2: view
genes like me logo Genes that share phenotypes with PLAGL2: view

Animal Models for PLAGL2 Gene

MGI Knock Outs for PLAGL2:

Animal Model Products

CRISPR Products

miRNA for PLAGL2 Gene

miRTarBase miRNAs that target PLAGL2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLAGL2 Gene

Localization for PLAGL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAGL2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAGL2 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLAGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PLAGL2: view

Pathways & Interactions for PLAGL2 Gene

PathCards logo

SuperPathways for PLAGL2 Gene

No Data Available

SIGNOR curated interactions for PLAGL2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PLAGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006629 lipid metabolic process IEA --
GO:0009791 post-embryonic development IEA --
GO:0034378 chylomicron assembly IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with PLAGL2: view

No data available for Pathways by source for PLAGL2 Gene

Drugs & Compounds for PLAGL2 Gene

(1) Drugs for PLAGL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PLAGL2: view

Transcripts for PLAGL2 Gene

mRNA/cDNA for PLAGL2 Gene

5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAGL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - -
SP3: - - - - -
SP4: -

Relevant External Links for PLAGL2 Gene

GeneLoc Exon Structure for

Expression for PLAGL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLAGL2 Gene

Protein differential expression in normal tissues from HIPED for PLAGL2 Gene

This gene is overexpressed in Heart (53.7) and Prostate (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLAGL2 Gene

Protein tissue co-expression partners for PLAGL2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLAGL2

SOURCE GeneReport for Unigene cluster for PLAGL2 Gene:


Evidence on tissue expression from TISSUES for PLAGL2 Gene

  • Bone marrow(4.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with PLAGL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAGL2 Gene

Orthologs for PLAGL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLAGL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLAGL2 31 30
  • 99.73 (n)
(Canis familiaris)
Mammalia PLAGL2 31 30
  • 95.77 (n)
(Bos Taurus)
Mammalia PLAGL2 31 30
  • 94.96 (n)
(Mus musculus)
Mammalia Plagl2 17 31 30
  • 92.94 (n)
(Monodelphis domestica)
Mammalia PLAGL2 31
  • 90 (a)
(Gallus gallus)
Aves PLAGL2 31
  • 84 (a)
LOC100859766 30
  • 77.78 (n)
(Anolis carolinensis)
Reptilia PLAGL2 31
  • 82 (a)
(Danio rerio)
Actinopterygii plagl2 30
  • 64.66 (n)
plagx 31
  • 46 (a)
-- 30
fruit fly
(Drosophila melanogaster)
Insecta CG42726 31
  • 18 (a)
CG2678 31
  • 15 (a)
Species where no ortholog for PLAGL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLAGL2 Gene

Gene Tree for PLAGL2 (if available)
Gene Tree for PLAGL2 (if available)
Evolutionary constrained regions (ECRs) for PLAGL2: view image

Paralogs for PLAGL2 Gene

(6) SIMAP similar genes for PLAGL2 Gene using alignment to 1 proteins:

  • PLAL2_HUMAN Pseudogenes for PLAGL2 Gene

genes like me logo Genes that share paralogs with PLAGL2: view

Variants for PLAGL2 Gene

Additional dbSNP identifiers (rs#s) for PLAGL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PLAGL2 Gene

Variant ID Type Subtype PubMed ID
nsv3349 CNV insertion 18451855
nsv833953 CNV loss 17160897
nsv833954 CNV loss 17160897

Variation tolerance for PLAGL2 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAGL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLAGL2 Gene

Disorders for PLAGL2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PLAGL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pleomorphic adenoma
  • mixed tumor of the salivary gland
  • acinar cell adenoma
cataract 30
  • ctrct30
bladder urothelial carcinoma
  • bladder transitional cell carcinoma
gastrointestinal system benign neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLAGL2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PLAGL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAGL2 Gene

Publications for PLAGL2 Gene

  1. Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. (PMID: 15585652) Landrette SF … Castilla LH (Blood 2005) 2 3 23 54
  2. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. (PMID: 9722527) Kas K … Van de Ven WJ (The Journal of biological chemistry 1998) 3 4 23 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity. (PMID: 19574421) Yang YS … Weissler JC (American journal of physiology. Lung cellular and molecular physiology 2009) 3 23 54
  5. Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation. (PMID: 18655774) Guo Y … Yang YS (Biochemical and biophysical research communications 2008) 3 23 54

Products for PLAGL2 Gene

Sources for PLAGL2 Gene