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Aliases for PLAC9 Gene

Aliases for PLAC9 Gene

  • Placenta Specific 9 2 3 5
  • Placenta-Specific Protein 9 3

External Ids for PLAC9 Gene

Previous GeneCards Identifiers for PLAC9 Gene

  • GC10P080849
  • GC10P081114
  • GC10P082023
  • GC10P081556
  • GC10P081882
  • GC10P081891
  • GC10P075735

Summaries for PLAC9 Gene

GeneCards Summary for PLAC9 Gene

PLAC9 (Placenta Specific 9) is a Protein Coding gene.

Additional gene information for PLAC9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAC9 Gene

Genomics for PLAC9 Gene

GeneHancer (GH) Regulatory Elements for PLAC9 Gene

Promoters and enhancers for PLAC9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J080132 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 667.6 +1.3 1260 2.4 POLR2A ZNF366 ZNF512 HLF PRDM1 EZH2 ZBTB20 PLAC9 TMEM254-AS1 PIR39736
GH10J080131 Enhancer 0.4 ENCODE dbSUPER 650.7 0.0 -42 0.2 PLAC9 GC10P081678
GH10J080153 Enhancer 1.4 Ensembl ENCODE dbSUPER 15 +29.9 29850 15.4 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 FOS DEK REST SMARCB1 LINC00857 ENSG00000272489 MBL1P ANXA11 PLAC9 MAT1A SFTPD TSPAN14 GC10M080155 PIR39736
GH10J080406 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.9 +280.1 280064 10.7 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF143 FAM213A DYDC2 LOC642361 DYDC1 MBL1P PLAC9 ANXA11 PIR57963
GH10J080453 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.8 +332.7 332685 22.7 HDGF PKNOX1 ARNT SIN3A DMAP1 IRF4 YY1 POLR2B ZNF766 ZNF207 TSPAN14 FAM213A ENSG00000272489 LOC101929574 DYDC1 DYDC2 ANXA11 PLAC9 MBL1P SH2D4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLAC9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLAC9 gene promoter:
  • AML1a
  • E2F-1
  • E2F
  • HSF1short
  • HSF1 (long)
  • AREB6
  • CRE-BP1
  • ATF-2
  • Bach2
  • GR-alpha

Genomic Locations for PLAC9 Gene

Genomic Locations for PLAC9 Gene
chr10:80,131,682-80,145,359
(GRCh38/hg38)
Size:
13,678 bases
Orientation:
Plus strand
chr10:81,891,438-81,905,115
(GRCh37/hg19)
Size:
13,678 bases
Orientation:
Plus strand

Genomic View for PLAC9 Gene

Genes around PLAC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAC9 Gene

Proteins for PLAC9 Gene

  • Protein details for PLAC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JTB6-PLAC9_HUMAN
    Recommended name:
    Placenta-specific protein 9
    Protein Accession:
    Q5JTB6

    Protein attributes for PLAC9 Gene

    Size:
    97 amino acids
    Molecular mass:
    10309 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLAC9 Gene

Post-translational modifications for PLAC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLAC9 Gene

Antibody Products

  • Abcam antibodies for PLAC9
  • Santa Cruz Biotechnology (SCBT) Antibodies for PLAC9

No data available for DME Specific Peptides for PLAC9 Gene

Domains & Families for PLAC9 Gene

Gene Families for PLAC9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PLAC9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLAC9 Gene

Graphical View of Domain Structure for InterPro Entry

Q5JTB6

UniProtKB/Swiss-Prot:

PLAC9_HUMAN :
  • Belongs to the PLAC9 family.
Family:
  • Belongs to the PLAC9 family.
genes like me logo Genes that share domains with PLAC9: view

Function for PLAC9 Gene

Phenotypes From GWAS Catalog for PLAC9 Gene

Gene Ontology (GO) - Molecular Function for PLAC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PLAC9: view
genes like me logo Genes that share phenotypes with PLAC9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAC9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLAC9 Gene

Localization for PLAC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAC9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAC9 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for PLAC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLAC9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLAC9 Gene

Pathways & Interactions for PLAC9 Gene

SuperPathways for PLAC9 Gene

No Data Available

Interacting Proteins for PLAC9 Gene

Gene Ontology (GO) - Biological Process for PLAC9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PLAC9 Gene

Drugs & Compounds for PLAC9 Gene

No Compound Related Data Available

Transcripts for PLAC9 Gene

mRNA/cDNA for PLAC9 Gene

Unigene Clusters for PLAC9 Gene

Placenta-specific 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAC9

Alternative Splicing Database (ASD) splice patterns (SP) for PLAC9 Gene

No ASD Table

Relevant External Links for PLAC9 Gene

GeneLoc Exon Structure for
PLAC9
ECgene alternative splicing isoforms for
PLAC9

Expression for PLAC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLAC9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLAC9 Gene

This gene is overexpressed in Fetal ovary (27.3), Placenta (22.2), and Fetal heart (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLAC9 Gene



Protein tissue co-expression partners for PLAC9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLAC9 Gene:

PLAC9

SOURCE GeneReport for Unigene cluster for PLAC9 Gene:

Hs.204947
genes like me logo Genes that share expression patterns with PLAC9: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAC9 Gene

Orthologs for PLAC9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PLAC9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLAC9 34 33
  • 83.12 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Plac9a 34
  • 66 (a)
OneToMany
Plac9b 34
  • 66 (a)
OneToMany
Species where no ortholog for PLAC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLAC9 Gene

ENSEMBL:
Gene Tree for PLAC9 (if available)
TreeFam:
Gene Tree for PLAC9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLAC9: view image

Paralogs for PLAC9 Gene

No data available for Paralogs for PLAC9 Gene

Variants for PLAC9 Gene

Sequence variations from dbSNP and Humsavar for PLAC9 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000110268 -- 80,135,267(+) C/T intron_variant
rs1000834765 -- 80,135,086(+) C/T intron_variant
rs1001188287 -- 80,143,220(+) C/T intron_variant
rs1001343229 -- 80,140,462(+) G/A intron_variant
rs1001509352 -- 80,132,605(+) G/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PLAC9 Gene

Variant ID Type Subtype PubMed ID
esv3623946 CNV loss 21293372
esv3623947 CNV gain 21293372
esv989822 CNV loss 20482838
nsv1141879 OTHER inversion 24896259
nsv551635 CNV loss 21841781
nsv948099 CNV duplication 23825009

Variation tolerance for PLAC9 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAC9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAC9 Gene

Disorders for PLAC9 Gene

Additional Disease Information for PLAC9

No disorders were found for PLAC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLAC9 Gene

Publications for PLAC9 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58
  5. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin EJ … Vasan RS (BMC medical genetics 2007) 44 58

Products for PLAC9 Gene

Sources for PLAC9 Gene

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