Aliases for PLAC8L1 Gene

Aliases for PLAC8L1 Gene

  • PLAC8 Like 1 2 3 5
  • PLAC8-Like Protein 1 3 4
  • PLAC8L1 5

External Ids for PLAC8L1 Gene

Previous GeneCards Identifiers for PLAC8L1 Gene

  • GC05M145444
  • GC05M140610
  • GC05M145463

Summaries for PLAC8L1 Gene

GeneCards Summary for PLAC8L1 Gene

PLAC8L1 (PLAC8 Like 1) is a Protein Coding gene. Diseases associated with PLAC8L1 include Christianson Syndrome. An important paralog of this gene is CNFN.

Additional gene information for PLAC8L1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLAC8L1 Gene

Genomics for PLAC8L1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLAC8L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J146104 Promoter 0.3 EPDnew 600.7 +1.2 1161 0.1 PLAC8L1 ENSG00000251556 RF00017-4985 GRXCR2
GH05J145934 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.5 +164.4 164384 13.6 HNRNPL GATAD2A PRDM10 REST ZNF629 LEF1 ZNF692 RCOR2 ZNF7 JUND SH3RF2 PLAC8L1 GRXCR2 piR-31210-036 LOC107986458
GH05J146075 Enhancer 0.9 FANTOM5 Ensembl ENCODE 12.4 +29.1 29076 1.8 KDM1A HDAC1 SOX6 CTBP1 OSR2 SPI1 SIN3A FEZF1 CEBPG SMARCA4 LARS1 PLAC8L1 GRXCR2 LOC107986458 ENSG00000251556 RF00017-4985 SH3RF2
GH05J146137 Enhancer 1 Ensembl ENCODE 11.4 -32.7 -32683 1.4 GATAD2A ATF7 PRDM10 RCOR2 RXRB ZNF600 CEBPA FOXK2 SCRT2 SOX13 ENSG00000239602 RPL35AP16 RPL35AP17 lnc-SH3RF2-4 lnc-SH3RF2-5 LARS1 PLAC8L1 RF00017-4985
GH05J146024 Enhancer 1 Ensembl ENCODE 10.4 +78.2 78182 4.8 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 KDM1A ZHX2 FOXA1 ATF7 LARS1 PLAC8L1 RF00017-4985 lnc-RBM27-3 ENSG00000248493 LOC107986458 GRXCR2 SH3RF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLAC8L1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLAC8L1

Top Transcription factor binding sites by QIAGEN in the PLAC8L1 gene promoter:
  • C/EBPalpha
  • E47
  • FOXO1
  • FOXO1a
  • LCR-F1
  • MRF-2
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • TGIF

Genomic Locations for PLAC8L1 Gene

Genomic Locations for PLAC8L1 Gene
chr5:146,084,149-146,105,577
(GRCh38/hg38)
Size:
21,429 bases
Orientation:
Minus strand
chr5:145,463,876-145,483,946
(GRCh37/hg19)
Size:
20,071 bases
Orientation:
Minus strand

Genomic View for PLAC8L1 Gene

Genes around PLAC8L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAC8L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAC8L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAC8L1 Gene

Proteins for PLAC8L1 Gene

  • Protein details for PLAC8L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L4L8-PL8L1_HUMAN
    Recommended name:
    PLAC8-like protein 1
    Protein Accession:
    A1L4L8

    Protein attributes for PLAC8L1 Gene

    Size:
    177 amino acids
    Molecular mass:
    19885 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLAC8L1 Gene

Post-translational modifications for PLAC8L1 Gene

No Post-translational modifications

Other Protein References for PLAC8L1 Gene

No data available for DME Specific Peptides for PLAC8L1 Gene

Domains & Families for PLAC8L1 Gene

Gene Families for PLAC8L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PLAC8L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLAC8L1 Gene

GenScript: Design optimal peptide antigens:
  • PLAC8-like protein 1 (PL8L1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A1L4L8

UniProtKB/Swiss-Prot:

PL8L1_HUMAN :
  • Belongs to the cornifelin family.
Family:
  • Belongs to the cornifelin family.
genes like me logo Genes that share domains with PLAC8L1: view

Function for PLAC8L1 Gene

Phenotypes From GWAS Catalog for PLAC8L1 Gene

genes like me logo Genes that share phenotypes with PLAC8L1: view

Animal Model Products

CRISPR Products

miRNA for PLAC8L1 Gene

miRTarBase miRNAs that target PLAC8L1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAC8L1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLAC8L1 Gene

Localization for PLAC8L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAC8L1 gene
Compartment Confidence
peroxisome 2
extracellular 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLAC8L1 Gene

Pathways & Interactions for PLAC8L1 Gene

PathCards logo

SuperPathways for PLAC8L1 Gene

No Data Available

Interacting Proteins for PLAC8L1 Gene

Selected Interacting proteins: A1L4L8-PL8L1_HUMAN for PLAC8L1 Gene via IID

Symbol External ID(s) Details
DLG1

Gene Ontology (GO) - Biological Process for PLAC8L1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PLAC8L1 Gene

Drugs & Compounds for PLAC8L1 Gene

No Compound Related Data Available

Transcripts for PLAC8L1 Gene

mRNA/cDNA for PLAC8L1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAC8L1

Alternative Splicing Database (ASD) splice patterns (SP) for PLAC8L1 Gene

No ASD Table

Relevant External Links for PLAC8L1 Gene

GeneLoc Exon Structure for
PLAC8L1

Expression for PLAC8L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLAC8L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAC8L1 Gene

This gene is overexpressed in Testis (x14.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLAC8L1

SOURCE GeneReport for Unigene cluster for PLAC8L1 Gene:

Hs.162369
genes like me logo Genes that share expression patterns with PLAC8L1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAC8L1 Gene

Orthologs for PLAC8L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAC8L1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLAC8L1 30 31
  • 98.68 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PLAC8L1 30 31
  • 86.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Plac8l1 30
  • 82.86 (n)
Dog
(Canis familiaris)
Mammalia PLAC8L1 30 31
  • 81.17 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Plac8l1 30 17 31
  • 80.23 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PLAC8L1 31
  • 60 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PLAC8L1 31
  • 49 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PLAC8L1 31
  • 53 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii plac8l1 30 31
  • 59.89 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
OneToMany
Species where no ortholog for PLAC8L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PLAC8L1 Gene

ENSEMBL:
Gene Tree for PLAC8L1 (if available)
TreeFam:
Gene Tree for PLAC8L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLAC8L1: view image

Paralogs for PLAC8L1 Gene

Paralogs for PLAC8L1 Gene

(2) SIMAP similar genes for PLAC8L1 Gene using alignment to 2 proteins:

  • PL8L1_HUMAN
  • D6RBV4_HUMAN
genes like me logo Genes that share paralogs with PLAC8L1: view

Variants for PLAC8L1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLAC8L1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs12187913 - p.Cys11Ser

Additional dbSNP identifiers (rs#s) for PLAC8L1 Gene

Variation tolerance for PLAC8L1 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAC8L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAC8L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLAC8L1 Gene

Disorders for PLAC8L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLAC8L1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
christianson syndrome
  • mental retardation, x-linked, syndromic, christianson type
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with PLAC8L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAC8L1 Gene

Publications for PLAC8L1 Gene

  1. Common functions or only phylogenetically related? The large family of PLAC8 motif-containing/PCR genes. (PMID: 21347707) Song WY … Martinoia E (Molecules and cells 2011) 3
  2. Evolution of FW2.2-like (FWL) and PLAC8 genes in eukaryotes. (PMID: 20855956) Libault M … Stacey G (Plant signaling & behavior 2010) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
  5. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington JJ … Ducar M (Nature biotechnology 2001) 3

Products for PLAC8L1 Gene

Sources for PLAC8L1 Gene