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Aliases for PLAC8 Gene

Aliases for PLAC8 Gene

  • Placenta Specific 8 2 3 5
  • Down-Regulated In Gastrointestinal Cancer Protein 3
  • Placenta-Specific Gene 8 Protein 3
  • Protein C15 4
  • PNAS-144 3
  • Onzin 3
  • DGIC 3
  • C15 3

External Ids for PLAC8 Gene

Previous GeneCards Identifiers for PLAC8 Gene

  • GC04M083935
  • GC04M084305
  • GC04M084469
  • GC04M084368
  • GC04M079752

Summaries for PLAC8 Gene

GeneCards Summary for PLAC8 Gene

PLAC8 (Placenta Specific 8) is a Protein Coding gene. Among its related pathways are Innate Immune System and Differentiation of white and brown adipocyte. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is CNFN.

Additional gene information for PLAC8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAC8 Gene

Genomics for PLAC8 Gene

GeneHancer (GH) Regulatory Elements for PLAC8 Gene

Promoters and enhancers for PLAC8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I083107 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 575.1 +25.2 25177 9.3 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A ZNF2 ZBTB7B IRF4 YY1 PLAC8 HELQ THAP9 LIN54 COQ2 HPSE GC04P083063
GH04I083197 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 41.1 -61.0 -61026 2.2 CEBPB CEBPG ZNF644 RARA TCF12 SKI POLR2A IKZF1 ETV6 BCL6 PLAC8 THAP9 HPSE COQ2 GC04M083225
GH04I083170 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 34.2 -34.3 -34342 1.4 ELF3 SOX13 EBF1 CEBPG ZNF644 RARA ZNF547 NR2F6 HOMEZ SOX5 PLAC8 THAP9 MRPS18C HPSE COQ2 GC04M083225
GH04I083215 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 28.8 -81.1 -81094 4.7 PKNOX1 SMAD1 RB1 BMI1 YBX1 BATF KLF5 IRF4 RAD21 ZNF207 PLAC8 LOC391674 THAP9 HPSE COQ2 LIN54 HELQ GC04M083225
GH04I083230 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 30.4 -94.7 -94734 2.1 CEBPG BATF IRF4 RELA POLR2A ATF7 ETV6 IKZF2 RUNX3 CBFB GC04M083232 PLAC8 LOC391674 THAP9 HPSE COQ2 GC04M083225
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLAC8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLAC8 gene promoter:

Genomic Locations for PLAC8 Gene

Genomic Locations for PLAC8 Gene
47,028 bases
Minus strand

Genomic View for PLAC8 Gene

Genes around PLAC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAC8 Gene

Proteins for PLAC8 Gene

  • Protein details for PLAC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Placenta-specific gene 8 protein
    Protein Accession:
    Secondary Accessions:
    • C1K3N2

    Protein attributes for PLAC8 Gene

    115 amino acids
    Molecular mass:
    12507 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLAC8 Gene

Post-translational modifications for PLAC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLAC8 Gene

No data available for DME Specific Peptides for PLAC8 Gene

Domains & Families for PLAC8 Gene

Gene Families for PLAC8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PLAC8 Gene


Suggested Antigen Peptide Sequences for PLAC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cornifelin family.
  • Belongs to the cornifelin family.
genes like me logo Genes that share domains with PLAC8: view

Function for PLAC8 Gene

Phenotypes From GWAS Catalog for PLAC8 Gene

Gene Ontology (GO) - Molecular Function for PLAC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with PLAC8: view
genes like me logo Genes that share phenotypes with PLAC8: view

Animal Models for PLAC8 Gene

MGI Knock Outs for PLAC8:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLAC8

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLAC8 Gene

Localization for PLAC8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAC8 gene
Compartment Confidence
extracellular 5
lysosome 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLAC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0035578 azurophil granule lumen TAS --
genes like me logo Genes that share ontologies with PLAC8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PLAC8 Gene

Pathways & Interactions for PLAC8 Gene

genes like me logo Genes that share pathways with PLAC8: view

Pathways by source for PLAC8 Gene

1 Cell Signaling Technology pathway for PLAC8 Gene

Interacting Proteins for PLAC8 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: Q9NZF1-PLAC8_HUMAN ENSP00000309509 for PLAC8 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PLAC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0009409 response to cold IEA --
GO:0040015 negative regulation of multicellular organism growth IEA --
GO:0042742 defense response to bacterium IEA --
GO:0043066 negative regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with PLAC8: view

No data available for SIGNOR curated interactions for PLAC8 Gene

Drugs & Compounds for PLAC8 Gene

No Compound Related Data Available

Transcripts for PLAC8 Gene

Unigene Clusters for PLAC8 Gene

Placenta-specific 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAC8 Gene

No ASD Table

Relevant External Links for PLAC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLAC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLAC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAC8 Gene

This gene is overexpressed in Whole Blood (x21.4) and Colon - Transverse (x5.9).

Protein differential expression in normal tissues from HIPED for PLAC8 Gene

This gene is overexpressed in Blymphocyte (36.4), NK cells (23.1), and Colon (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLAC8 Gene

Protein tissue co-expression partners for PLAC8 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLAC8 Gene:


SOURCE GeneReport for Unigene cluster for PLAC8 Gene:


mRNA Expression by UniProt/SwissProt for PLAC8 Gene:

Tissue specificity: Expressed at high levels in plasmacytoid dendritic cells. High expression in spleen, lymph nodes, peripheral blood leukocytes, and bone marrow, with lower expression in thymus, appendix, and fetal liver.

Evidence on tissue expression from TISSUES for PLAC8 Gene

  • Spleen(4.5)
  • Blood(4.4)
  • Bone marrow(4.4)
  • Lymph node(4.3)
  • Intestine(2.4)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with PLAC8: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAC8 Gene

Orthologs for PLAC8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLAC8 33 34
  • 100 (n)
(Canis familiaris)
Mammalia LOC100685470 33
  • 88.5 (n)
PLAC8 34
  • 66 (a)
(Bos Taurus)
Mammalia PLAC8 34
  • 87 (a)
(Mus musculus)
Mammalia Plac8 33 16 34
  • 81.68 (n)
(Rattus norvegicus)
Mammalia Plac8 33
  • 80.48 (n)
(Monodelphis domestica)
Mammalia PLAC8 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia PLAC8 34
  • 69 (a)
(Gallus gallus)
Aves PLAC8 33 34
  • 63.21 (n)
(Anolis carolinensis)
Reptilia PLAC8 34
  • 72 (a)
(Danio rerio)
Actinopterygii plac8.1 34
  • 48 (a)
plac8.2 34
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
Species where no ortholog for PLAC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLAC8 Gene

Gene Tree for PLAC8 (if available)
Gene Tree for PLAC8 (if available)

Paralogs for PLAC8 Gene

Paralogs for PLAC8 Gene

(2) SIMAP similar genes for PLAC8 Gene using alignment to 3 proteins: Pseudogenes for PLAC8 Gene

genes like me logo Genes that share paralogs with PLAC8: view

Variants for PLAC8 Gene

Sequence variations from dbSNP and Humsavar for PLAC8 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000126862 -- 83,107,880(-) T/A coding_sequence_variant, synonymous_variant
rs1000132028 -- 83,093,697(-) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000155333 -- 83,115,973(-) ATG/ upstream_transcript_variant
rs1000196018 -- 83,109,351(-) G/A intron_variant
rs1000457954 -- 83,098,398(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLAC8 Gene

Variant ID Type Subtype PubMed ID
dgv328e215 CNV deletion 23714750
dgv846e201 CNV deletion 23290073
esv2727897 CNV deletion 23290073
esv2727899 CNV deletion 23290073
esv3564157 CNV deletion 23714750
esv3893971 CNV gain 25118596
nsv1136883 CNV deletion 24896259
nsv522237 CNV gain 19592680
nsv829990 CNV gain 17160897
nsv829991 CNV loss 17160897
nsv950349 CNV duplication 24416366

Variation tolerance for PLAC8 Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAC8 Gene

Disorders for PLAC8 Gene

Additional Disease Information for PLAC8

No disorders were found for PLAC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLAC8 Gene

Publications for PLAC8 Gene

  1. Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. (PMID: 12384430) Rissoan MC … Bates EE (Blood 2002) 2 3 4 58
  2. Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis. (PMID: 12758124) Galaviz-Hernandez C … Nagaraja R (Gene 2003) 2 3 58
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58
  4. PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways. (PMID: 26669866) Kaistha BP … Buchholz M (Cancer research 2016) 3 58
  5. Expression of placenta-specific 8 in human oocytes, embryos, and models of in vitro implantation. (PMID: 27322877) Li M … Yao Y (Fertility and sterility 2016) 3 58

Products for PLAC8 Gene

Sources for PLAC8 Gene

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