Aliases for PLAC4 Gene

Subcategory (RNA class) for PLAC4 Gene

lncRNA

Quality Score for this RNA gene is

14

Aliases for PLAC4 Gene

  • Placenta Enriched 4 2 3 5
  • Placenta Specific 4 2 3
  • C21orf115 3 4
  • Chromosome 21 Open Reading Frame 115 2
  • Placenta-Specific Protein 4 4
  • Lnc-TMPRSS2-83 170
  • HSALNG0133194 169
  • HSALNG0133191 169
  • D21S418E 4
  • PRED78 3
  • PLAC4 2

External Ids for PLAC4 Gene

Previous HGNC Symbols for PLAC4 Gene

  • C21orf115

Previous GeneCards Identifiers for PLAC4 Gene

  • GC21U990111
  • GC21M041469
  • GC21M041470
  • GC21M042547

Summaries for PLAC4 Gene

GeneCards Summary for PLAC4 Gene

PLAC4 (Placenta Enriched 4) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with PLAC4 include Chromosomal Disease.

Additional gene information for PLAC4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLAC4 Gene

Genomics for PLAC4 Gene

GeneHancer (GH) Regulatory Elements for PLAC4 Gene

Promoters and enhancers for PLAC4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J041186 Enhancer 0.7 Ensembl ENCODE 750.6 +0.4 387 2.4 MNT ZIC2 RFX1 POLR2A PKNOX1 BMI1 GLIS1 PLAC4 BACE2-IT1 BACE2
GH21J041188 Enhancer 0.3 ENCODE 750.6 -1.9 -1861 0.2 CEBPG PLAC4 BACE2 piR-39300-067
GH21J041189 Enhancer 0.3 Ensembl 0.6 -2.7 -2713 1 ZNF133 CEBPG BACE2 ENSG00000227698 PLAC4 piR-39300-067
GH21J041183 Enhancer 0.3 Ensembl ENCODE 0.6 +3.0 2987 1.2 BACE2-IT1 PLAC4 BACE2
GH21J041178 Enhancer 0.3 Ensembl 0.4 +7.4 7387 2.4 TARDBP HES1 BACE2-IT1 PLAC4 BACE2 LINC00323
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLAC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLAC4 gene promoter:
  • C/EBPalpha
  • C/EBPbeta
  • Evi-1
  • FOXO4
  • GATA-1
  • HSF2
  • Lmo2
  • NCX
  • Nkx2-5
  • Sox9

Genomic Locations for PLAC4 Gene

Genomic Locations for PLAC4 Gene
chr21:41,175,231-41,186,788
(GRCh38/hg38)
Size:
11,558 bases
Orientation:
Minus strand
chr21:42,547,158-42,558,715
(GRCh37/hg19)
Size:
11,558 bases
Orientation:
Minus strand

Genomic View for PLAC4 Gene

Genes around PLAC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAC4 Gene

Proteins for PLAC4 Gene

  • Protein details for PLAC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY50-PLAC4_HUMAN
    Recommended name:
    Placenta-specific protein 4
    Protein Accession:
    Q8WY50

    Protein attributes for PLAC4 Gene

    Size:
    150 amino acids
    Molecular mass:
    16680 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLAC4 Gene

Post-translational modifications for PLAC4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PLAC4 Gene

Domains & Families for PLAC4 Gene

Protein Domains for PLAC4 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PLAC4 Gene

GenScript: Design optimal peptide antigens:
  • Placenta-specific protein 4 (PLAC4_HUMAN)
  • cDNA FLJ35112 fis, clone PLACE6007239 (Q8NAM4_HUMAN)
genes like me logo Genes that share domains with PLAC4: view

No data available for Gene Families , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PLAC4 Gene

Function for PLAC4 Gene

Phenotypes From GWAS Catalog for PLAC4 Gene

genes like me logo Genes that share phenotypes with PLAC4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAC4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLAC4 Gene

Localization for PLAC4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PLAC4 Gene

Pathways & Interactions for PLAC4 Gene

PathCards logo

SuperPathways for PLAC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLAC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PLAC4 Gene

Drugs & Compounds for PLAC4 Gene

No Compound Related Data Available

Transcripts for PLAC4 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAC4

Alternative Splicing Database (ASD) splice patterns (SP) for PLAC4 Gene

No ASD Table

Relevant External Links for PLAC4 Gene

GeneLoc Exon Structure for
PLAC4
ECgene alternative splicing isoforms for
PLAC4

Expression for PLAC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLAC4 Gene

mRNA differential expression in normal tissues according to GTEx for PLAC4 Gene

This gene is overexpressed in Esophagus - Mucosa (x7.1) and Minor Salivary Gland (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of PLAC4 Gene:

PLAC4

SOURCE GeneReport for Unigene cluster for PLAC4 Gene:

Hs.472492

mRNA Expression by UniProt/SwissProt for PLAC4 Gene:

Q8WY50-PLAC4_HUMAN
Tissue specificity: Expressed in placental syncytiotrophoblast and choriocarcinoma cells.
genes like me logo Genes that share expression patterns with PLAC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAC4 Gene

Orthologs for PLAC4 Gene

Evolution for PLAC4 Gene

ENSEMBL:
Gene Tree for PLAC4 (if available)
TreeFam:
Gene Tree for PLAC4 (if available)

No data available for Orthologs for PLAC4 Gene

Paralogs for PLAC4 Gene

(1) SIMAP similar genes for PLAC4 Gene using alignment to 2 proteins:

  • PLAC4_HUMAN
  • Q8NAM4_HUMAN
genes like me logo Genes that share paralogs with PLAC4: view

No data available for Paralogs for PLAC4 Gene

Variants for PLAC4 Gene

Sequence variations from dbSNP and Humsavar for PLAC4 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000019718 -- 41,174,752(-) T/C downstream_transcript_variant
rs1000340323 -- 41,184,954(-) C/T non_coding_transcript_variant
rs1000436243 -- 41,186,387(-) G/A upstream_transcript_variant
rs1000474970 -- 41,179,849(-) G/A non_coding_transcript_variant
rs1000619519 -- 41,186,576(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PLAC4 Gene

Variant ID Type Subtype PubMed ID
nsv587492 CNV loss 21841781
nsv7347 OTHER inversion 18451855

Additional Variant Information for PLAC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAC4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PLAC4 Gene

Disorders for PLAC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLAC4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosomal disease
  • chromosomal disorders
- elite association - COSMIC cancer census association via MalaCards
Search PLAC4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLAC4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PLAC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAC4 Gene

Publications for PLAC4 Gene

  1. D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma cells. (PMID: 8406465) Kido S … Strauss JF (Genomics 1993) 2 3 4 56
  2. PLAC4 is upregulated in severe early onset preeclampsia and upregulated with syncytialisation but not hypoxia. (PMID: 23312075) Tuohey L … Kaitu'u-Lino TJ (Placenta 2013) 2 3 56
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  4. Synergy of total PLAC4 RNA concentration and measurement of the RNA single-nucleotide polymorphism allelic ratio for the noninvasive prenatal detection of trisomy 21. (PMID: 19892844) Tsui NB … Lo YM (Clinical chemistry 2010) 3 23 56
  5. Explore the dynamic alternation of gene PLAC4 mRNA expression levels in maternal plasma in second trimester for nonivasive detection of trisomy 21. (PMID: 26217595) Yang L … Xiao JP (Obstetrics & gynecology science 2015) 3 56

Products for PLAC4 Gene

Sources for PLAC4 Gene