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Aliases for PLAC4 Gene

Subcategory (RNA class) for PLAC4 Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for PLAC4 Gene

  • Placenta Specific 4 2 3 5
  • C21orf115 3 4
  • Chromosome 21 Open Reading Frame 115 2
  • D21S418E 4
  • PRED78 3

External Ids for PLAC4 Gene

Previous HGNC Symbols for PLAC4 Gene

  • C21orf115

Previous GeneCards Identifiers for PLAC4 Gene

  • GC21U990111
  • GC21M041469
  • GC21M041470
  • GC21M042547

Summaries for PLAC4 Gene

GeneCards Summary for PLAC4 Gene

PLAC4 (Placenta Specific 4) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for PLAC4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAC4 Gene

Genomics for PLAC4 Gene

GeneHancer (GH) Regulatory Elements for PLAC4 Gene

Promoters and enhancers for PLAC4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I041186 Enhancer 0.5 ENCODE 550.8 -1.7 -1700 0.2 PKNOX1 RFX1 POLR2A KLF9 MNT BMI1 ENSG00000225745 PLAC4 GC21P041172 BACE2 GC21P041210
GH21I041183 Enhancer 0.2 ENCODE 550.8 +1.4 1351 0.9 PLAC4 BACE2-IT1 ENSG00000225745 GC21P041172 BACE2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLAC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLAC4 gene promoter:

Genomic Locations for PLAC4 Gene

Genomic Locations for PLAC4 Gene
10,009 bases
Minus strand

Genomic View for PLAC4 Gene

Genes around PLAC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAC4 Gene

Proteins for PLAC4 Gene

  • Protein details for PLAC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Placenta-specific protein 4
    Protein Accession:

    Protein attributes for PLAC4 Gene

    150 amino acids
    Molecular mass:
    16680 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLAC4 Gene

Post-translational modifications for PLAC4 Gene

No Post-translational modifications

Other Protein References for PLAC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLAC4 Gene

Domains & Families for PLAC4 Gene

Protein Domains for PLAC4 Gene


Suggested Antigen Peptide Sequences for PLAC4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLAC4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PLAC4 Gene

Function for PLAC4 Gene

Phenotypes for PLAC4 Gene

GenomeRNAi human phenotypes for PLAC4:
genes like me logo Genes that share phenotypes with PLAC4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLAC4 Gene

Localization for PLAC4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PLAC4 Gene

Pathways & Interactions for PLAC4 Gene

SuperPathways for PLAC4 Gene

No Data Available

Interacting Proteins for PLAC4 Gene

Gene Ontology (GO) - Biological Process for PLAC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for PLAC4 Gene

Drugs & Compounds for PLAC4 Gene

No Compound Related Data Available

Transcripts for PLAC4 Gene

mRNA/cDNA for PLAC4 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(363) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLAC4 Gene

Placenta-specific 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAC4 Gene

No ASD Table

Relevant External Links for PLAC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLAC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLAC4 Gene

mRNA differential expression in normal tissues according to GTEx for PLAC4 Gene

This gene is overexpressed in Esophagus - Mucosa (x7.1) and Minor Salivary Gland (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of PLAC4 Gene:


SOURCE GeneReport for Unigene cluster for PLAC4 Gene:


mRNA Expression by UniProt/SwissProt for PLAC4 Gene:

Tissue specificity: Expressed in placental syncytiotrophoblast and choriocarcinoma cells.
genes like me logo Genes that share expression patterns with PLAC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAC4 Gene

Orthologs for PLAC4 Gene

Evolution for PLAC4 Gene

Gene Tree for PLAC4 (if available)
Gene Tree for PLAC4 (if available)

No data available for Orthologs for PLAC4 Gene

Paralogs for PLAC4 Gene

(1) SIMAP similar genes for PLAC4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLAC4: view

No data available for Paralogs for PLAC4 Gene

Variants for PLAC4 Gene

Sequence variations from dbSNP and Humsavar for PLAC4 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000019718 -- 41,174,752(-) T/C downstream_transcript_variant
rs1000340323 -- 41,184,954(-) C/T 5_prime_UTR_variant
rs1000436243 -- 41,186,387(-) G/A upstream_transcript_variant
rs1000474970 -- 41,179,849(-) G/A 5_prime_UTR_variant
rs1000619519 -- 41,186,576(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PLAC4 Gene

Variant ID Type Subtype PubMed ID
nsv587492 CNV loss 21841781
nsv7347 OTHER inversion 18451855

Additional Variant Information for PLAC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PLAC4 Gene

Disorders for PLAC4 Gene

Additional Disease Information for PLAC4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLAC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLAC4 Gene

Publications for PLAC4 Gene

  1. Synergy of total PLAC4 RNA concentration and measurement of the RNA single-nucleotide polymorphism allelic ratio for the noninvasive prenatal detection of trisomy 21. (PMID: 19892844) Tsui NB … Lo YM (Clinical chemistry 2010) 3 22 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma cells. (PMID: 8406465) Kido S … Strauss JF (Genomics 1993) 3 4 58
  4. Explore the dynamic alternation of gene PLAC4 mRNA expression levels in maternal plasma in second trimester for nonivasive detection of trisomy 21. (PMID: 26217595) Yang L … Xiao JP (Obstetrics & gynecology science 2015) 3 58
  5. Application of multiplex SNaPshot assay in measurement of PLAC4 RNA-SNP allelic ratio for noninvasive prenatal detection of trisomy 21. (PMID: 24214739) Yang L … Xiao J (Prenatal diagnosis 2014) 3 58

Products for PLAC4 Gene

Sources for PLAC4 Gene

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