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Aliases for PLAC1 Gene

Aliases for PLAC1 Gene

  • Placenta Specific 1 2 3 5
  • Cancer/Testis Antigen 92 2 3
  • Placenta-Specific Protein 1 3
  • OOSP2L 3
  • CT92 3

External Ids for PLAC1 Gene

Previous GeneCards Identifiers for PLAC1 Gene

  • GC0XM128345
  • GC0XM130545
  • GC0XM131644
  • GC0XM132405
  • GC0XM133425
  • GC0XM133527
  • GC0XM133699
  • GC0XM123098

Summaries for PLAC1 Gene

GeneCards Summary for PLAC1 Gene

PLAC1 (Placenta Specific 1) is a Protein Coding gene. Diseases associated with PLAC1 include Pre-Eclampsia. An important paralog of this gene is OOSP2.

UniProtKB/Swiss-Prot for PLAC1 Gene

  • May play a role in placental development.

Gene Wiki entry for PLAC1 Gene

Additional gene information for PLAC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAC1 Gene

Genomics for PLAC1 Gene

GeneHancer (GH) Regulatory Elements for PLAC1 Gene

Promoters and enhancers for PLAC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI134659 Promoter 0.8 EPDnew 550.1 +105.8 105834 0.1 ZNF217 CTBP1 ATF4 PKNOX1 GATA3 CEBPB EP300 PLAC1 GC0XP134651 GC0XM134761 RNU4-44P
GH0XI134745 Enhancer 0.7 Ensembl ENCODE 0.4 +18.0 18032 1.3 MEIS2 JUND TEAD4 SPI1 GC0XM134761 RNU4-44P PLAC1 GC0XP134651
GH0XI134751 Enhancer 0.6 ENCODE 0.4 +11.4 11389 2.5 CTCF ZNF654 REST RAD21 GATA3 SCRT2 HMBOX1 SMC3 PRDM10 ZBTB17 LINC00629 MIR503 MIR503HG MIR450A1 MIR450A2 MIR450B MIR542 GC0XM134761 RNU4-44P PLAC1
GH0XI134732 Enhancer 0.8 Ensembl ENCODE 0.3 +30.1 30112 3.2 ZNF398 ZIC2 OSR2 ZFHX2 JUND VEZF1 ZNF341 GLIS1 EGR2 CHD2 RNU4-44P GC0XM134761 PLAC1 GC0XP134651
GH0XI134714 Enhancer 1.2 Ensembl ENCODE 0.2 +47.2 47188 4.9 CLOCK FOXA2 ARNT SIN3A FEZF1 ZNF2 ZNF766 GLIS2 GATA2 KLF7 GC0XM134761 RNU4-44P PLAC1 GC0XP134651
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLAC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLAC1 gene promoter:

Genomic Locations for PLAC1 Gene

Genomic Locations for PLAC1 Gene
chrX:134,565,838-134,764,322
(GRCh38/hg38)
Size:
198,485 bases
Orientation:
Minus strand
chrX:133,699,868-133,898,352
(GRCh37/hg19)

Genomic View for PLAC1 Gene

Genes around PLAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAC1 Gene

Proteins for PLAC1 Gene

  • Protein details for PLAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBJ0-PLAC1_HUMAN
    Recommended name:
    Placenta-specific protein 1
    Protein Accession:
    Q9HBJ0

    Protein attributes for PLAC1 Gene

    Size:
    212 amino acids
    Molecular mass:
    23616 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLAC1 Gene

Post-translational modifications for PLAC1 Gene

  • Ubiquitination at Lys108
  • Modification sites at PhosphoSitePlus

Other Protein References for PLAC1 Gene

No data available for DME Specific Peptides for PLAC1 Gene

Domains & Families for PLAC1 Gene

Gene Families for PLAC1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PLAC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBJ0

UniProtKB/Swiss-Prot:

PLAC1_HUMAN :
  • Belongs to the PLAC1 family.
Family:
  • Belongs to the PLAC1 family.
genes like me logo Genes that share domains with PLAC1: view

Function for PLAC1 Gene

Molecular function for PLAC1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in placental development.
UniProtKB/Swiss-Prot Induction:
Up-regulated during trophoblast differentiation and by FGF7 in trophoblast cells.

Phenotypes From GWAS Catalog for PLAC1 Gene

Gene Ontology (GO) - Molecular Function for PLAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with PLAC1: view
genes like me logo Genes that share phenotypes with PLAC1: view

Animal Models for PLAC1 Gene

MGI Knock Outs for PLAC1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLAC1 Gene

Localization for PLAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAC1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PLAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLAC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLAC1 Gene

Pathways & Interactions for PLAC1 Gene

SuperPathways for PLAC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001890 placenta development IEP 10995572
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with PLAC1: view

No data available for Pathways by source and SIGNOR curated interactions for PLAC1 Gene

Drugs & Compounds for PLAC1 Gene

No Compound Related Data Available

Transcripts for PLAC1 Gene

Unigene Clusters for PLAC1 Gene

Placenta-specific 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for PLAC1 Gene

GeneLoc Exon Structure for
PLAC1
ECgene alternative splicing isoforms for
PLAC1

Expression for PLAC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAC1 Gene

This gene is overexpressed in Testis (x14.4).

Protein differential expression in normal tissues from HIPED for PLAC1 Gene

This gene is overexpressed in Ovary (36.0), Testis (22.0), and Esophagus (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLAC1 Gene



Protein tissue co-expression partners for PLAC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLAC1 Gene:

PLAC1

SOURCE GeneReport for Unigene cluster for PLAC1 Gene:

Hs.496811

mRNA Expression by UniProt/SwissProt for PLAC1 Gene:

Q9HBJ0-PLAC1_HUMAN
Tissue specificity: Expressed in placenta. Localizes primarily to differentiated syncytiotrophoblast throughout gestation as well as to a small population of villous cytotrophoblasts. Also detected in maternal blood and rapidly disappears following delivery, but is not detected in other adult or fetal tissues examined.
genes like me logo Genes that share expression patterns with PLAC1: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAC1 Gene

Orthologs for PLAC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PLAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLAC1 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLAC1 33 34
  • 81.94 (n)
dog
(Canis familiaris)
Mammalia PLAC1 33 34
  • 81.29 (n)
rat
(Rattus norvegicus)
Mammalia LOC102550080 33
  • 72.9 (n)
mouse
(Mus musculus)
Mammalia Plac1 16 34 33
  • 71.35 (n)
Species where no ortholog for PLAC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLAC1 Gene

ENSEMBL:
Gene Tree for PLAC1 (if available)
TreeFam:
Gene Tree for PLAC1 (if available)

Paralogs for PLAC1 Gene

Paralogs for PLAC1 Gene

genes like me logo Genes that share paralogs with PLAC1: view

Variants for PLAC1 Gene

Sequence variations from dbSNP and Humsavar for PLAC1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000002593 -- 134,573,673(-) G/A intron_variant
rs1000071479 -- 134,672,344(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000082839 -- 134,745,196(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000084419 -- 134,660,352(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000086268 -- 134,678,702(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLAC1 Gene

Variant ID Type Subtype PubMed ID
esv3405054 CNV insertion 20981092
nsv517076 CNV gain 19592680
nsv521365 CNV gain 19592680
nsv521470 CNV gain 19592680
nsv525660 CNV gain 19592680
nsv7102 CNV insertion 18451855

Variation tolerance for PLAC1 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAC1 Gene

Disorders for PLAC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLAC1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pre-eclampsia
  • toxemia of pregnancy
- elite association - COSMIC cancer census association via MalaCards
Search PLAC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLAC1

genes like me logo Genes that share disorders with PLAC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAC1 Gene

Publications for PLAC1 Gene

  1. PLAC1, an Xq26 gene with placenta-specific expression. (PMID: 10995572) Cocchia M … Schlessinger D (Genomics 2000) 2 3 4 22 58
  2. Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery. (PMID: 15608456) Concu M … Carinci P (Fetal diagnosis and therapy 2005) 3 4 22 58
  3. PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis. (PMID: 15803460) Massabbal E … Fant M (Molecular reproduction and development 2005) 3 4 22 58
  4. PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor. (PMID: 12412044) Fant M … Schlessinger D (Molecular reproduction and development 2002) 3 4 22 58
  5. Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2. (PMID: 19652226) Koslowski M … Sahin U (The Journal of biological chemistry 2009) 3 22 58

Products for PLAC1 Gene

Sources for PLAC1 Gene

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