Aliases for PLAAT5 Gene

Aliases for PLAAT5 Gene

  • Phospholipase A And Acyltransferase 5 2 3 4 5
  • Ca(2+)-Independent N-Acyltransferase 2 3 4
  • H-Rev107-Like Protein 5 2 3 4
  • HRAS Like Suppressor Family Member 5 2 3
  • HRAS-Like Suppressor 5 3 4
  • HRASLS5 3 4
  • HRLP5 3 4
  • HRSL5 3 4
  • INAT 3 4
  • Calcium-Independent Phosphatidylethanolamine N-Acyltransferase 3
  • Lecithin-Retinol Acyltransferase (LRAT)-Like Protein-1 3
  • HRAS-Like Suppressor Family, Member 5 2
  • Phospholipase A/Acyltransferase-5 3
  • Phospholipase A/Acyltransferase‐5 2
  • Testicular Tissue Protein Li 90 3
  • EC 3.1.1.32 4
  • EC 2.3.1.- 4
  • EC 3.1.1.4 4
  • PLAAT-5 3
  • RLP1 3

External Ids for PLAAT5 Gene

Previous HGNC Symbols for PLAAT5 Gene

  • HRASLS5

Summaries for PLAAT5 Gene

GeneCards Summary for PLAAT5 Gene

PLAAT5 (Phospholipase A And Acyltransferase 5) is a Protein Coding gene. Diseases associated with PLAAT5 include Poland Syndrome and Myasthenic Syndrome, Congenital, 5. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. An important paralog of this gene is PLAAT3.

UniProtKB/Swiss-Prot Summary for PLAAT5 Gene

  • Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:22825852). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19000777, PubMed:22825852).

Additional gene information for PLAAT5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLAAT5 Gene

Genomics for PLAAT5 Gene

GeneHancer (GH) Regulatory Elements for PLAAT5 Gene

Promoters and enhancers for PLAAT5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J063489 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +0.4 358 3.7 RBPJ SMARCE1 NR2F6 CREB1 MYC HLF MAX TEAD4 RERE MLLT1 PLAAT5 RF00005-039 ENSG00000203520 PLAAT3 ENSG00000256789 BSCL2 ATL3
GH11J063608 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -118.6 -118583 3.2 CTCF FOXA1 RAD21 ELF3 SP1 SP7 PPARG EGR1 GLIS2 ZIC2 LGALS12 PLAAT3 PLAAT5 ENSG00000203520 lnc-PLA2G16-1 LOC105369335
GH11J063478 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +12.2 12207 0.8 CTCF CC2D1A ELF1 L3MBTL2 RBM39 RAD21 TEAD4 PRDM1 IKZF1 ARID2 NXF1 CSKMT GANAB SNHG1 EML3 INTS5 STX5 MTA2 ENSG00000256789 TUT1
GH11J063495 Enhancer 0.3 Ensembl dbSUPER 0.6 -3.0 -2993 0.4 ENSG00000287412 lnc-LGALS12-2 ENSG00000256789 ATL3 PLAAT5
GH11J063461 Enhancer 0.2 Ensembl 0.3 +28.9 28907 0.6 ENSG00000203520 PLAAT3 ENSG00000256789 ENSG00000275598 LOC100533643 piR-37656-039 PLAAT5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLAAT5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PLAAT5 Gene

Genomic Locations for PLAAT5 Gene
chr11:63,461,404-63,491,208
(GRCh38/hg38)
Size:
29,805 bases
Orientation:
Minus strand
chr11:63,228,876-63,258,680
(GRCh37/hg19)
Size:
29,805 bases
Orientation:
Minus strand

Genomic View for PLAAT5 Gene

Genes around PLAAT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAAT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAAT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAAT5 Gene

Proteins for PLAAT5 Gene

  • Protein details for PLAAT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KN8-PLAT5_HUMAN
    Recommended name:
    Phospholipase A and acyltransferase 5
    Protein Accession:
    Q96KN8
    Secondary Accessions:
    • B7X6T1
    • F5GZ87
    • F5H4Y9

    Protein attributes for PLAAT5 Gene

    Size:
    279 amino acids
    Molecular mass:
    30312 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLAAT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLAAT5 Gene

Post-translational modifications for PLAAT5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PLAAT5 Gene

Domains & Families for PLAAT5 Gene

Gene Families for PLAAT5 Gene

Protein Domains for PLAAT5 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLAAT5 Gene

GenScript: Design optimal peptide antigens:
  • HRAS-like suppressor family, member 5, isoform CRA_b (B7X6T1_HUMAN)
  • H-rev107-like protein 5 (HRSL5_HUMAN)
  • HRASLS5 protein (Q8NE88_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96KN8

UniProtKB/Swiss-Prot:

PLAT5_HUMAN :
  • Belongs to the H-rev107 family.
Family:
  • Belongs to the H-rev107 family.
genes like me logo Genes that share domains with PLAAT5: view

Function for PLAAT5 Gene

Molecular function for PLAAT5 Gene

UniProtKB/Swiss-Prot Function:
Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:22825852). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19000777, PubMed:22825852).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269 PubMed:19000777, ECO:0000269 PubMed:22825852};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence={ECO:0000269 PubMed:19000777, ECO:0000269 PubMed:22825852};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45476, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003, ChEBI:CHEBI:74986, ChEBI:CHEBI:85277; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45477; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45176, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:78097; Evidence={ECO:0000269 PubMed:19000777, ECO:0000269 PubMed:22825852}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45177; Evidence={ECO:0000269 PubMed:19000777, ECO:0000269 PubMed:22825852};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45172, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:76078, ChEBI:CHEBI:78097; Evidence={ECO:0000269 PubMed:19000777, ECO:0000269 PubMed:22825852}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45173; Evidence={ECO:0000269 PubMed:19000777, ECO:0000269 PubMed:22825852};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45192, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:62537, ChEBI:CHEBI:64612; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45193; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45188, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875, ChEBI:CHEBI:62537, ChEBI:CHEBI:64612; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45189; Evidence=. ;.

Enzyme Numbers (IUBMB) for PLAAT5 Gene

Phenotypes From GWAS Catalog for PLAAT5 Gene

Gene Ontology (GO) - Molecular Function for PLAAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IDA 22825852
GO:0008970 phospholipase A1 activity IDA,IEA 22825852
GO:0016410 N-acyltransferase activity IDA,IEA 19000777
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with PLAAT5: view
genes like me logo Genes that share phenotypes with PLAAT5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAAT5

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLAAT5 Gene

Localization for PLAAT5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAAT5 gene
Compartment Confidence
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PLAAT5 Gene

Pathways & Interactions for PLAAT5 Gene

genes like me logo Genes that share pathways with PLAAT5: view

Pathways by source for PLAAT5 Gene

Gene Ontology (GO) - Biological Process for PLAAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070292 N-acylphosphatidylethanolamine metabolic process IDA,IEA 19000777
genes like me logo Genes that share ontologies with PLAAT5: view

No data available for SIGNOR curated interactions for PLAAT5 Gene

Drugs & Compounds for PLAAT5 Gene

No Compound Related Data Available

Transcripts for PLAAT5 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAAT5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAAT5 Gene

No ASD Table

Relevant External Links for PLAAT5 Gene

GeneLoc Exon Structure for
PLAAT5
ECgene alternative splicing isoforms for
PLAAT5

Expression for PLAAT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PLAAT5 Gene:

PLAAT5

SOURCE GeneReport for Unigene cluster for PLAAT5 Gene:

Hs.410316

mRNA Expression by UniProt/SwissProt for PLAAT5 Gene:

Q96KN8-PLAT5_HUMAN
Tissue specificity: Highest expression level in testis and pancreas.
genes like me logo Genes that share expression patterns with PLAAT5: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAAT5 Gene

Orthologs for PLAAT5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAAT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRASLS5 33 32
  • 98.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HRASLS5 33 32
  • 86.21 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HRASLS5 33 32
  • 84.27 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hrasls5 33 32
  • 76.99 (n)
OneToOne
Plaat5 17
rat
(Rattus norvegicus)
Mammalia Hrasls5 32
  • 75.42 (n)
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 32 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR383676.3 33
  • 40 (a)
ManyToMany
zgc:92249 33
  • 36 (a)
ManyToMany
CU138503.3 33
  • 36 (a)
ManyToMany
zgc:154040 33
  • 34 (a)
ManyToMany
Species where no ortholog for PLAAT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLAAT5 Gene

ENSEMBL:
Gene Tree for PLAAT5 (if available)
TreeFam:
Gene Tree for PLAAT5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLAAT5: view image

Paralogs for PLAAT5 Gene

Paralogs for PLAAT5 Gene

genes like me logo Genes that share paralogs with PLAAT5: view

Variants for PLAAT5 Gene

Sequence variations from dbSNP and Humsavar for PLAAT5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000062038 -- 63,465,647(-) G/C intron_variant
rs1000142795 -- 63,473,578(-) C/G intron_variant
rs1000263319 -- 63,492,187(-) AGTTAG/AG upstream_transcript_variant
rs1000371253 -- 63,467,451(-) G/T intron_variant
rs1000413915 -- 63,461,261(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PLAAT5 Gene

Variant ID Type Subtype PubMed ID
nsv468588 CNV loss 19166990
nsv509417 CNV insertion 20534489
nsv555179 CNV loss 21841781

Variation tolerance for PLAAT5 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAAT5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAAT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAAT5 Gene

Disorders for PLAAT5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PLAAT5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
poland syndrome
  • poland syndactyly
myasthenic syndrome, congenital, 5
  • cms5
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with PLAAT5: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for PLAAT5 Gene

Publications for PLAAT5 Gene

  1. cDNA cloning and characterization of human and mouse Ca(2+)-independent phosphatidylethanolamine N-acyltransferases. (PMID: 19000777) Jin XH … Ueda N (Biochimica et biophysica acta 2009) 2 3 4 56
  2. Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family. (PMID: 22825852) Uyama T … Ueda N (The Journal of biological chemistry 2012) 3 4 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp JJ … Guthrie C (Nature structural & molecular biology 2015) 3 56

Products for PLAAT5 Gene

Sources for PLAAT5 Gene