Aliases for PLAAT5 Gene

Aliases for PLAAT5 Gene

  • Phospholipase A And Acyltransferase 5 2 3 4 5
  • Ca(2+)-Independent N-Acyltransferase 2 3 4
  • H-Rev107-Like Protein 5 2 3 4
  • HRLP5 2 3 4
  • INAT 2 3 4
  • HRAS Like Suppressor Family Member 5 2 3
  • HRAS-Like Suppressor 5 3 4
  • HRASLS5 3 4
  • PLAAT-5 2 3
  • HRSL5 3 4
  • Calcium-Independent Phosphatidylethanolamine N-Acyltransferase 3
  • Lecithin-Retinol Acyltransferase (LRAT)-Like Protein-1 3
  • HRAS-Like Suppressor Family, Member 5 2
  • Phospholipase A/Acyltransferase‐5 2
  • Phospholipase A/Acyltransferase-5 3
  • Testicular Tissue Protein Li 90 3
  • EC 3.1.1.32 4
  • EC 2.3.1.- 4
  • EC 3.1.1.4 4
  • PLAAT5 5
  • RLP1 3

External Ids for PLAAT5 Gene

Previous HGNC Symbols for PLAAT5 Gene

  • HRASLS5

Previous GeneCards Identifiers for PLAAT5 Gene

  • GC11M063462
  • GC11M063467

Summaries for PLAAT5 Gene

GeneCards Summary for PLAAT5 Gene

PLAAT5 (Phospholipase A And Acyltransferase 5) is a Protein Coding gene. Diseases associated with PLAAT5 include Poland Syndrome. Among its related pathways are Glycerophospholipid biosynthesis and Acyl chain remodelling of PE. An important paralog of this gene is PLAAT4.

UniProtKB/Swiss-Prot Summary for PLAAT5 Gene

  • Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:22825852). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19000777, PubMed:22825852).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLAAT5 Gene

Genomics for PLAAT5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLAAT5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLAAT5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLAAT5

Genomic Locations for PLAAT5 Gene

Latest Assembly
chr11:63,461,404-63,491,203
(GRCh38/hg38)
Size:
29,800 bases
Orientation:
Minus strand

Previous Assembly
chr11:63,228,876-63,258,639
(GRCh37/hg19 by Entrez Gene)
Size:
29,764 bases
Orientation:
Minus strand

chr11:63,228,876-63,258,666
(GRCh37/hg19 by Ensembl)
Size:
29,791 bases
Orientation:
Minus strand

Genomic View for PLAAT5 Gene

Genes around PLAAT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAAT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAAT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAAT5 Gene

Proteins for PLAAT5 Gene

  • Protein details for PLAAT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KN8-PLAT5_HUMAN
    Recommended name:
    Phospholipase A and acyltransferase 5
    Protein Accession:
    Q96KN8
    Secondary Accessions:
    • B7X6T1
    • F5GZ87
    • F5H4Y9

    Protein attributes for PLAAT5 Gene

    Size:
    279 amino acids
    Molecular mass:
    30312 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLAAT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLAAT5 Gene

Post-translational modifications for PLAAT5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PLAAT5 Gene

Domains & Families for PLAAT5 Gene

Gene Families for PLAAT5 Gene

Protein Domains for PLAAT5 Gene

InterPro:
Blocks:
  • NC
ProtoNet:

Suggested Antigen Peptide Sequences for PLAAT5 Gene

GenScript: Design optimal peptide antigens:
  • HRAS-like suppressor family, member 5, isoform CRA_b (B7X6T1_HUMAN)
  • H-rev107-like protein 5 (HRSL5_HUMAN)
  • HRASLS5 protein (Q8NE88_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96KN8

UniProtKB/Swiss-Prot:

PLAT5_HUMAN :
  • Belongs to the H-rev107 family.
Family:
  • Belongs to the H-rev107 family.
genes like me logo Genes that share domains with PLAAT5: view

Function for PLAAT5 Gene

Molecular function for PLAAT5 Gene

UniProtKB/Swiss-Prot Function:
Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:22825852). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19000777, PubMed:22825852).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269|PubMed:19000777, ECO:0000269|PubMed:22825852};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence={ECO:0000269|PubMed:19000777, ECO:0000269|PubMed:22825852};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45476, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003, ChEBI:CHEBI:74986, ChEBI:CHEBI:85277; Evidence={ECO:0000269|PubMed:19000777};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45176, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:78097; Evidence={ECO:0000269|PubMed:19000777, ECO:0000269|PubMed:22825852};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45172, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:76078, ChEBI:CHEBI:78097; Evidence={ECO:0000269|PubMed:19000777, ECO:0000269|PubMed:22825852};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45192, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:62537, ChEBI:CHEBI:64612; Evidence={ECO:0000269|PubMed:19000777};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45188, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875, ChEBI:CHEBI:62537, ChEBI:CHEBI:64612; Evidence={ECO:0000269|PubMed:19000777};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:56504, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001, ChEBI:CHEBI:74986, ChEBI:CHEBI:85291; Evidence={ECO:0000250|UniProtKB:Q4KLN5};.

Enzyme Numbers (IUBMB) for PLAAT5 Gene

Phenotypes From GWAS Catalog for PLAAT5 Gene

Gene Ontology (GO) - Molecular Function for PLAAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IBA,IDA 22825852
GO:0005515 protein binding IPI --
GO:0008970 phospholipase A1 activity IBA,IDA 22825852
GO:0016410 N-acyltransferase activity IEA,IDA 19000777
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PLAAT5: view
genes like me logo Genes that share phenotypes with PLAAT5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAAT5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLAAT5 Gene

Localization for PLAAT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAAT5 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAAT5 gene
Compartment Confidence
cytosol 4
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLAAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with PLAAT5: view

Pathways & Interactions for PLAAT5 Gene

genes like me logo Genes that share pathways with PLAAT5: view

Pathways by source for PLAAT5 Gene

1 GeneGo (Thomson Reuters) pathway for PLAAT5 Gene
  • Anandamide biosynthesis and metabolism

Gene Ontology (GO) - Biological Process for PLAAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070292 N-acylphosphatidylethanolamine metabolic process IEA,IDA 19000777
genes like me logo Genes that share ontologies with PLAAT5: view

No data available for SIGNOR curated interactions for PLAAT5 Gene

Drugs & Compounds for PLAAT5 Gene

No Compound Related Data Available

Transcripts for PLAAT5 Gene

mRNA/cDNA for PLAAT5 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAAT5

Alternative Splicing Database (ASD) splice patterns (SP) for PLAAT5 Gene

No ASD Table

Relevant External Links for PLAAT5 Gene

GeneLoc Exon Structure for
PLAAT5

Expression for PLAAT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLAAT5

SOURCE GeneReport for Unigene cluster for PLAAT5 Gene:

Hs.410316

mRNA Expression by UniProt/SwissProt for PLAAT5 Gene:

Q96KN8-PLAT5_HUMAN
Tissue specificity: Highest expression level in testis and pancreas.

Evidence on tissue expression from TISSUES for PLAAT5 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with PLAAT5: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAAT5 Gene

Orthologs for PLAAT5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAAT5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HRASLS5 30 31
  • 98.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HRASLS5 30 31
  • 86.21 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HRASLS5 30 31
  • 84.27 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Hrasls5 30 31
  • 76.99 (n)
OneToOne
Plaat5 17
Rat
(Rattus norvegicus)
Mammalia Hrasls5 30
  • 75.42 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 32 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii CR383676.3 31
  • 40 (a)
ManyToMany
zgc:92249 31
  • 36 (a)
ManyToMany
CU138503.3 31
  • 36 (a)
ManyToMany
zgc:154040 31
  • 34 (a)
ManyToMany
Species where no ortholog for PLAAT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PLAAT5 Gene

ENSEMBL:
Gene Tree for PLAAT5 (if available)
TreeFam:
Gene Tree for PLAAT5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLAAT5: view image

Paralogs for PLAAT5 Gene

Paralogs for PLAAT5 Gene

genes like me logo Genes that share paralogs with PLAAT5: view

Variants for PLAAT5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLAAT5 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10897424 - p.Ser31Gly
rs35375575 - p.Ala258Val
rs35735923 - p.Gln214Arg
rs940611 - p.Ala93Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLAAT5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLAAT5 Gene

Variant ID Type Subtype PubMed ID
nsv468588 CNV loss 19166990
nsv509417 CNV insertion 20534489
nsv555179 CNV loss 21841781

Variation tolerance for PLAAT5 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAAT5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAAT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAAT5 Gene

Disorders for PLAAT5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLAAT5 Gene - From: COP

Disorder Aliases PubMed IDs
poland syndrome
  • poland syndactyly
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLAAT5

genes like me logo Genes that share disorders with PLAAT5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAAT5 Gene

Publications for PLAAT5 Gene

  1. cDNA cloning and characterization of human and mouse Ca(2+)-independent phosphatidylethanolamine N-acyltransferases. (PMID: 19000777) Jin XH … Ueda N (Biochimica et biophysica acta 2009) 2 3 4
  2. Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family. (PMID: 22825852) Uyama T … Ueda N (The Journal of biological chemistry 2012) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The HRASLS (PLA/AT) subfamily of enzymes. (PMID: 26503625) Mardian EB … Duncan RE (Journal of biomedical science 2015) 4

Products for PLAAT5 Gene

Sources for PLAAT5 Gene