Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 ar... See more...

Aliases for PLAAT4 Gene

Aliases for PLAAT4 Gene

  • Phospholipase A And Acyltransferase 4 2 3 4 5
  • Retinoic Acid Receptor Responder (Tazarotene Induced) 3 2 3
  • Retinoic Acid Receptor Responder Protein 3 3 4
  • Retinoic Acid Receptor Responder 3 2 3
  • Retinoid-Inducible Gene 1 Protein 3 4
  • Tazarotene-Induced Gene 3 Protein 3 4
  • RAR-Responsive Protein TIG3 3 4
  • HRAS-Like Suppressor 4 3 4
  • RARRES3 3 4
  • HRSL4 3 4
  • RIG1 3 4
  • TIG3 3 4
  • Phospholipase A/Acyltransferase-4 3
  • Phospholipase A/Acyltransferase‐4 2
  • Retinoic Acid-Inducible Gene 1 3
  • Retinoid-Inducible Gene 1 2
  • EC 3.1.1.32 4
  • EC 2.3.1.- 4
  • EC 3.1.1.4 4
  • PLA1/2-3 3
  • HRASLS4 3
  • PLAAT-4 3

External Ids for PLAAT4 Gene

Previous HGNC Symbols for PLAAT4 Gene

  • RARRES3

Summaries for PLAAT4 Gene

Entrez Gene Summary for PLAAT4 Gene

  • Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLAAT4 Gene

PLAAT4 (Phospholipase A And Acyltransferase 4) is a Protein Coding gene. Diseases associated with PLAAT4 include Poland Syndrome. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. An important paralog of this gene is PLAAT3.

UniProtKB/Swiss-Prot Summary for PLAAT4 Gene

  • Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852). Promotes keratinocyte differentiation via activation of TGM1 (PubMed:17762858).

Gene Wiki entry for PLAAT4 Gene

Additional gene information for PLAAT4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLAAT4 Gene

Genomics for PLAAT4 Gene

GeneHancer (GH) Regulatory Elements for PLAAT4 Gene

Promoters and enhancers for PLAAT4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLAAT4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PLAAT4 Gene

Genomic Locations for PLAAT4 Gene
chr11:63,536,801-63,546,462
(GRCh38/hg38)
Size:
9,662 bases
Orientation:
Plus strand
chr11:63,304,273-63,313,934
(GRCh37/hg19)
Size:
9,662 bases
Orientation:
Plus strand

Genomic View for PLAAT4 Gene

Genes around PLAAT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAAT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAAT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAAT4 Gene

Proteins for PLAAT4 Gene

  • Protein details for PLAAT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL19-PLAT4_HUMAN
    Recommended name:
    Phospholipase A and acyltransferase 4
    Protein Accession:
    Q9UL19
    Secondary Accessions:
    • B2R599
    • B4DDW2
    • E7ENZ7
    • O95200

    Protein attributes for PLAAT4 Gene

    Size:
    164 amino acids
    Molecular mass:
    18179 Da
    Quaternary structure:
    • Interacts with TGM1.

    Three dimensional structures from OCA and Proteopedia for PLAAT4 Gene

    Alternative splice isoforms for PLAAT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLAAT4 Gene

Post-translational modifications for PLAAT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLAAT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLAAT4 Gene

Domains & Families for PLAAT4 Gene

Gene Families for PLAAT4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PLAAT4 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLAAT4 Gene

GenScript: Design optimal peptide antigens:
  • Tazarotene-induced gene 3 protein (TIG3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UL19

UniProtKB/Swiss-Prot:

PLAT4_HUMAN :
  • Belongs to the H-rev107 family.
Family:
  • Belongs to the H-rev107 family.
genes like me logo Genes that share domains with PLAAT4: view

Function for PLAAT4 Gene

Molecular function for PLAAT4 Gene

UniProtKB/Swiss-Prot Function:
Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852). Promotes keratinocyte differentiation via activation of TGM1 (PubMed:17762858).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22605381, ECO:0000269 PubMed:22825852}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22605381, ECO:0000269 PubMed:22825852}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18690; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40487, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:76078; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40488; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:38783, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73001, ChEBI:CHEBI:76071; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38784; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40571, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73003, ChEBI:CHEBI:76079; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40572; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate; Xref=Rhea:RHEA:45164, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73008, ChEBI:CHEBI:76090; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45165; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41348, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73009, ChEBI:CHEBI:76091; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41349; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate; Xref=Rhea:RHEA:53496, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57875, ChEBI:CHEBI:137403; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53497; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:53524, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:74667, ChEBI:CHEBI:138218, ChEBI:CHEBI:138220; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53525; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(9Z-octadecenoyl)-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:53528, ChEBI:CHEBI:15378, ChEBI:CHEBI:74667, ChEBI:CHEBI:76078, ChEBI:CHEBI:138218, ChEBI:CHEBI:138222; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53529; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=400 uM for dipalmitoyl-PC {ECO:0000269 PubMed:19615464}; Vmax=530 nmol/min/mg enzyme with dipalmitoyl-PC as substrate {ECO:0000269 PubMed:19615464}; Vmax=240 nmol/min/mg enzyme with dipalmitoyl-PE as substrate {ECO:0000269 PubMed:19615464}; pH dependence: Optimum pH is 8. {ECO:0000269 PubMed:19615464};
UniProtKB/Swiss-Prot Induction:
By all-trans-retinoic acid and synthetic retinoids.

Enzyme Numbers (IUBMB) for PLAAT4 Gene

Phenotypes From GWAS Catalog for PLAAT4 Gene

Gene Ontology (GO) - Molecular Function for PLAAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IDA 20100577
GO:0005515 protein binding IPI 17762858
GO:0008970 phospholipase A1 activity IDA,IEA 22825852
GO:0016410 N-acyltransferase activity IDA 22825852
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PLAAT4: view
genes like me logo Genes that share phenotypes with PLAAT4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAAT4

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLAAT4 Gene

Localization for PLAAT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAAT4 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAAT4 gene
Compartment Confidence
cytosol 4
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PLAAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA,IEA 17762858
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLAAT4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLAAT4 Gene

Pathways & Interactions for PLAAT4 Gene

genes like me logo Genes that share pathways with PLAAT4: view

Gene Ontology (GO) - Biological Process for PLAAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IDA,IEA 20100577
GO:0008285 negative regulation of cell proliferation IEA --
GO:0016042 lipid catabolic process IEA --
GO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with PLAAT4: view

No data available for SIGNOR curated interactions for PLAAT4 Gene

Drugs & Compounds for PLAAT4 Gene

(1) Drugs for PLAAT4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PLAAT4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PLAAT4: view

Transcripts for PLAAT4 Gene

mRNA/cDNA for PLAAT4 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAAT4

Alternative Splicing Database (ASD) splice patterns (SP) for PLAAT4 Gene

No ASD Table

Relevant External Links for PLAAT4 Gene

GeneLoc Exon Structure for
PLAAT4
ECgene alternative splicing isoforms for
PLAAT4

Expression for PLAAT4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLAAT4 Gene:

PLAAT4

SOURCE GeneReport for Unigene cluster for PLAAT4 Gene:

Hs.17466

mRNA Expression by UniProt/SwissProt for PLAAT4 Gene:

Q9UL19-PLAT4_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PLAAT4 Gene

  • Lung(4.5)
  • Skin(4.4)
  • Spleen(4.3)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAAT4 Gene

Orthologs for PLAAT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAAT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RARRES3 33 32
  • 99.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RARRES3 33 32
  • 75.57 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 43 (a)
ManyToMany
-- 33
  • 40 (a)
ManyToMany
-- 33
  • 39 (a)
ManyToMany
-- 33
  • 34 (a)
ManyToMany
-- 33
  • 26 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100330001 32
  • 58.49 (n)
CR383676.3 33
  • 50 (a)
ManyToMany
CU138503.3 33
  • 45 (a)
ManyToMany
zgc:92249 33
  • 45 (a)
ManyToMany
zgc:154040 33
  • 43 (a)
ManyToMany
Species where no ortholog for PLAAT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLAAT4 Gene

ENSEMBL:
Gene Tree for PLAAT4 (if available)
TreeFam:
Gene Tree for PLAAT4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLAAT4: view image

Paralogs for PLAAT4 Gene

Paralogs for PLAAT4 Gene

genes like me logo Genes that share paralogs with PLAAT4: view

Variants for PLAAT4 Gene

Sequence variations from dbSNP and Humsavar for PLAAT4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000127828 -- 63,536,331(+) C/T upstream_transcript_variant
rs1000132274 -- 63,541,093(+) A/C/G intron_variant
rs1000160666 -- 63,536,521(+) T/C upstream_transcript_variant
rs1000341352 -- 63,544,396(+) C/A intron_variant
rs1000466034 -- 63,537,634(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLAAT4 Gene

Variant ID Type Subtype PubMed ID
nsv468588 CNV loss 19166990
nsv509417 CNV insertion 20534489
nsv555179 CNV loss 21841781
nsv975940 CNV duplication 23825009

Variation tolerance for PLAAT4 Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAAT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAAT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAAT4 Gene

Disorders for PLAAT4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLAAT4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
poland syndrome
  • poland syndactyly
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLAAT4

genes like me logo Genes that share disorders with PLAAT4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAAT4 Gene

Publications for PLAAT4 Gene

  1. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PMID: 19615464) Uyama T … Ueda N (Biochimica et biophysica acta 2009) 3 4 23 56
  2. Cloning and characterization of a novel retinoid-inducible gene 1(RIG1) deriving from human gastric cancer cells. (PMID: 10687848) Huang SL … Jiang SY (Molecular and cellular endocrinology 2000) 3 4 23 56
  3. Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. (PMID: 9843971) DiSepio D … Nagpal S (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 23 56
  4. Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family. (PMID: 22825852) Uyama T … Ueda N (The Journal of biological chemistry 2012) 3 4 56
  5. Expression of the class II tumor suppressor gene RIG1 is directly regulated by p53 tumor suppressor in cancer cell lines. (PMID: 22616991) Hsu TH … Chang TC (FEBS letters 2012) 2 3 56

Products for PLAAT4 Gene

Sources for PLAAT4 Gene