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Aliases for PLAAT3 Gene
Aliases for PLAAT3 Gene
- Phospholipase A And Acyltransferase 3 2 3 4 5
- HRAS-Like Suppressor 3 2 3 4
- Adipose-Specific Phospholipase A2 3 4
- Renal Carcinoma Antigen NY-REN-65 3 4
- Group XVI Phospholipase A1/A2 3 4
- Phospholipase A2 Group XVI 2 3
- H-Rev 107 Protein Homolog 3 4
- HRAS-Like Suppressor 1 3 4
- Adipose-Specific PLA2 2 3
- HREV107-1 3 4
- HREV107-3 3 4
- H-REV107 3 4
- HRASLS3 3 4
External Ids for PLAAT3 Gene
- HGNC: 17825
- Entrez Gene: 11145
- Ensembl: ENSG00000176485
- OMIM: 613867
- UniProtKB: P53816
Previous HGNC Symbols for PLAAT3 Gene
- HRASLS3
- PLA2G16
Summaries for PLAAT3 Gene
GeneCards Summary for PLAAT3 Gene
PLAAT3 (Phospholipase A And Acyltransferase 3) is a Protein Coding gene. Diseases associated with PLAAT3 include Monofixation Syndrome and Abnormal Retinal Correspondence. Among its related pathways are Ras signaling pathway and Acyl chain remodelling of PE. An important paralog of this gene is PLAAT2.
UniProtKB/Swiss-Prot Summary for PLAAT3 Gene
-
Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852).
-
(Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm (PubMed:28077878). May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection (PubMed:28077878). Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome (PubMed:28077878). May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery (PubMed:28077878). The lipid-modifying enzyme activity is required for this process (PubMed:28077878).
Additional gene information for PLAAT3 Gene
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLAAT3 Gene
Genomics for PLAAT3 Gene
GeneHancer (GH) Regulatory Elements for PLAAT3 Gene
Promoters and enhancers for PLAAT3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PLAAT3 on UCSC Golden Path with GeneCards custom track
Genomic Locations for PLAAT3 Gene
Genomic Locations for PLAAT3 Gene
- chr11:63,573,195-63,616,926
- (GRCh38/hg38)
- Size:
- 43,732 bases
- Orientation:
- Minus strand
- chr11:63,340,667-63,384,355
- (GRCh37/hg19)
- Size:
- 43,689 bases
- Orientation:
- Minus strand
Genomic View for PLAAT3 Gene
Genes around PLAAT3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.3-q13.1 by HGNC
- 11q12.3-q13.1 by Entrez Gene
- 11q13.1 by Ensembl
PLAAT3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLAAT3 Gene
Proteins for PLAAT3 Gene
-
Protein details for PLAAT3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P53816-PLAT3_HUMAN
- Recommended name:
- Phospholipase A and acyltransferase 3
- Protein Accession:
- P53816
- B2R7Q4
- B7XAK5
- Q3SYI3
- Q9HDD1
Protein attributes for PLAAT3 Gene
- Size:
- 162 amino acids
- Molecular mass:
- 17937 Da
- Quaternary structure:
-
- Interacts with PPP2R1A; this interaction might decrease PP2A activity.
Post-translational modifications for PLAAT3 Gene
Other Protein References for PLAAT3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Creative Biolabs
- Recombinant Anti-Human PLA2G16 Antibody
- Recombinant Anti-Human PLA2G16 Antibody Fab Fragment
- Mouse Anti-PLA2G16 Recombinant Antibody (CBFYH-2707)
- Mouse Anti-PLA2G16 Recombinant Antibody (1B12)
- Recombinant Mouse anti-Human PLA2G16 Monoclonal antibody (EML1135)
- Mouse Anti-PLA2G16 Recombinant Antibody (1A5)
- Novus Biologicals Antibodies for PLAAT3
-
Abcam antibodies for PLAAT3
- Invitrogen Antibodies for PLAAT3 (AFLGC-PLA2G16)
-
Biorbyt antibodies for PLAAT3
Protein Products
- G Biosciences Human PLA2G16/HRSL3, Liquid
- Creative Biomart Recombinant Human PLA2G16 and Recombinant Human PLA2G16 293 Cell Lysate
-
OriGene Purified Proteins for PLAAT3
- Search Origene for MassSpec and Protein Over-expression Lysates for PLAAT3
- Origene Custom Protein Services for PLAAT3
-
ProSci Proteins for PLAAT3
-
Abcam proteins for PLAAT3
Assay Products
- Creative Diagnostics Human PLA2G16 ELISA Matched Antibody Pair
No data available for DME Specific Peptides for PLAAT3 Gene
Domains & Families for PLAAT3 Gene
Gene Families for PLAAT3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for PLAAT3 Gene
- GenScript: Design optimal peptide antigens:
-
- Renal carcinoma antigen NY-REN-65 (PAG16_HUMAN)
- PLA2G16 protein (Q3MI98_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P53816- Family:
-
- Belongs to the H-rev107 family.
Function for PLAAT3 Gene
Molecular function for PLAAT3 Gene
- UniProtKB/Swiss-Prot Function:
- Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm (PubMed:28077878). May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection (PubMed:28077878). Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome (PubMed:28077878). May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery (PubMed:28077878). The lipid-modifying enzyme activity is required for this process (PubMed:28077878).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269 PubMed:19047760, ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:20837014, ECO:0000269 PubMed:22605381, ECO:0000269 PubMed:22825852, ECO:0000269 PubMed:22923616}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence={ECO:0000269 PubMed:19047760, ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:20837014, ECO:0000269 PubMed:22605381, ECO:0000269 PubMed:22825852, ECO:0000269 PubMed:22923616}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18690; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40487, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:76078; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40488; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:38783, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73001, ChEBI:CHEBI:76071; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38784; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22923616}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22923616};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40571, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73003, ChEBI:CHEBI:76079; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22923616}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40572; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22923616};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate; Xref=Rhea:RHEA:45164, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73008, ChEBI:CHEBI:76090; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45165; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40432; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41348, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73009, ChEBI:CHEBI:76091; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41349; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate; Xref=Rhea:RHEA:53496, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57875, ChEBI:CHEBI:137403; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53497; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:53500, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:78215, ChEBI:CHEBI:137403; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53501; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:53524, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:74667, ChEBI:CHEBI:138218, ChEBI:CHEBI:138220; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53525; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(9Z-octadecenoyl)-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:53528, ChEBI:CHEBI:15378, ChEBI:CHEBI:74667, ChEBI:CHEBI:76078, ChEBI:CHEBI:138218, ChEBI:CHEBI:138222; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53529; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine = 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:54544, ChEBI:CHEBI:138197, ChEBI:CHEBI:138216, ChEBI:CHEBI:138266, ChEBI:CHEBI:138267; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54545; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate; Xref=Rhea:RHEA:56432, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:72998, ChEBI:CHEBI:73000; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56433; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:56436, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73000, ChEBI:CHEBI:76076; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56437; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:56440, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73858, ChEBI:CHEBI:75026; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56441; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate; Xref=Rhea:RHEA:56444, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:75026, ChEBI:CHEBI:76078; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56445; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40812; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40971, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73002, ChEBI:CHEBI:76084; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40972; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:56448, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669, ChEBI:CHEBI:76071; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56449; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:41384, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41385; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40923, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40924; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:41360, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:78097; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41361; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:56428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28733, ChEBI:CHEBI:30245, ChEBI:CHEBI:42027; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56429; Evidence=. ;.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=300 uM for dipalmitoyl-PC {ECO:0000269 PubMed:19615464}; Vmax=2.57 umol/min/mg enzyme with dipalmitoyl-PC as substrate {ECO:0000269 PubMed:19615464}; Vmax=267 nmol/min/mg enzyme with dipalmitoyl-PE as substrate {ECO:0000269 PubMed:19615464}; pH dependence: Optimum pH is 9. {ECO:0000269 PubMed:19615464};
- UniProtKB/Swiss-Prot Induction:
- By IFNG and IRF1.
Enzyme Numbers (IUBMB) for PLAAT3 Gene
Phenotypes From GWAS Catalog for PLAAT3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004623 | phospholipase A2 activity | IDA | 19047760 |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008970 | phospholipase A1 activity | IDA,IEA | 19047760 |
| GO:0016410 | N-acyltransferase activity | IDA | 22825852 |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for PLAAT3 Gene
- MGI mutant phenotypes for PLAAT3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PLAAT3:
Animal Models for PLAAT3 Gene
- MGI Knock Outs for PLAAT3:
-
- Plaat3 Plaat3<tm1.1Hsul>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for PLAAT3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLAAT3
- genomics-online: gRNA clones - Search for available PLA2G16 gRNA products
- Overview of 102 available PLA2G16 gene related products
- Applied Biological Materials (abm): CRISPR Clones for PLAAT3 - Select products 50% OFF >
- * PLAAT3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * PLAAT3 CRISPR applications: KO, Activation, Repression, and more - Browse All
miRNA for PLAAT3 Gene
- miRTarBase miRNAs that target PLAAT3
-
- hsa-mir-4662a-5p (MIRT496881)
- hsa-mir-7114-3p (MIRT496882)
- hsa-mir-1180-5p (MIRT496883)
- hsa-mir-4750-3p (MIRT496884)
- hsa-mir-186-3p (MIRT496885)
- hsa-mir-548m (MIRT496886)
- hsa-mir-5692a (MIRT544837)
- hsa-mir-548c-3p (MIRT544838)
- hsa-mir-574-5p (MIRT569830)
- hsa-mir-1303 (MIRT569831)
- hsa-mir-6867-5p (MIRT569832)
- hsa-mir-223-5p (MIRT569833)
- hsa-mir-335-3p (MIRT641153)
- hsa-mir-1305 (MIRT641154)
- hsa-mir-6787-3p (MIRT641155)
- hsa-mir-611 (MIRT641156)
- hsa-mir-3131 (MIRT641157)
- hsa-mir-1207-3p (MIRT641158)
- hsa-mir-8083 (MIRT641159)
- hsa-mir-512-5p (MIRT641160)
- hsa-mir-6832-3p (MIRT655003)
- hsa-mir-6823-3p (MIRT655004)
- hsa-mir-6885-3p (MIRT655005)
- hsa-mir-4659b-3p (MIRT655006)
- hsa-mir-4659a-3p (MIRT655007)
- hsa-mir-6809-3p (MIRT655008)
- hsa-mir-6833-3p (MIRT655009)
- hsa-mir-4768-5p (MIRT655010)
- hsa-mir-500a-3p (MIRT655011)
- hsa-mir-4753-3p (MIRT655012)
- hsa-mir-3160-5p (MIRT655013)
- hsa-mir-6804-3p (MIRT655014)
- hsa-mir-1236-3p (MIRT655015)
- hsa-mir-6515-3p (MIRT655016)
- hsa-mir-3667-3p (MIRT655017)
- hsa-mir-6734-3p (MIRT655018)
- hsa-mir-6800-3p (MIRT655019)
- hsa-mir-5089-5p (MIRT655020)
- hsa-mir-3166 (MIRT655021)
- hsa-mir-6506-5p (MIRT655022)
- hsa-mir-619-5p (MIRT655023)
- hsa-mir-150-5p (MIRT655024)
- hsa-mir-4692 (MIRT655025)
- hsa-mir-4514 (MIRT655026)
- hsa-mir-6511a-5p (MIRT655027)
- hsa-mir-1910-3p (MIRT655028)
- hsa-mir-4661-5p (MIRT655029)
- hsa-mir-129-5p (MIRT673553)
- hsa-mir-8055 (MIRT673554)
- hsa-mir-744-3p (MIRT673555)
- hsa-mir-6864-3p (MIRT673556)
- hsa-mir-3672 (MIRT673557)
- hsa-mir-6794-3p (MIRT673558)
- hsa-mir-4423-5p (MIRT673559)
- hsa-mir-6501-5p (MIRT673560)
- hsa-mir-4524a-3p (MIRT673561)
- hsa-mir-367-5p (MIRT673562)
- hsa-mir-1267 (MIRT673563)
- hsa-mir-1304-3p (MIRT673564)
- hsa-mir-4639-3p (MIRT673565)
- hsa-mir-5007-5p (MIRT673566)
- hsa-mir-3664-5p (MIRT673567)
- hsa-mir-4797-5p (MIRT673568)
- hsa-mir-4430 (MIRT680139)
- hsa-mir-3652 (MIRT680140)
- hsa-mir-6516-5p (MIRT681457)
- hsa-mir-455-3p (MIRT681458)
- hsa-mir-650 (MIRT681459)
- hsa-mir-3612 (MIRT681460)
- hsa-mir-2467-3p (MIRT681461)
- hsa-mir-6086 (MIRT681462)
- hsa-mir-377-5p (MIRT681463)
- hsa-mir-1827 (MIRT681464)
- hsa-mir-6840-3p (MIRT681465)
- hsa-mir-665 (MIRT681466)
- hsa-mir-4459 (MIRT681467)
- hsa-mir-4257 (MIRT681468)
- hsa-mir-4695-5p (MIRT681469)
- hsa-mir-548s (MIRT684939)
- hsa-mir-4684-5p (MIRT684940)
- hsa-mir-3926 (MIRT684941)
- hsa-mir-3190-5p (MIRT684942)
- hsa-mir-3675-3p (MIRT684943)
- hsa-mir-1273d (MIRT684944)
- hsa-mir-147a (MIRT783857)
- hsa-mir-30a-3p (MIRT784495)
- hsa-mir-30d-3p (MIRT784541)
- hsa-mir-30e-3p (MIRT784548)
- hsa-mir-5010-3p (MIRT786992)
- hsa-mir-622 (MIRT788130)
- hsa-mir-6818-5p (MIRT788938)
- hsa-mir-6844 (MIRT789053)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PLAAT3
- Browse OriGene Inhibitory RNA Products For PLAAT3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAAT3
- genomics-online: shRNA clones - Search for available PLA2G16 shRNA products
- Overview of 102 available PLA2G16 gene related products
Clone Products
-
- MG201283
- MR201283
- MR201283L3
- MR201283L3V
- MR201283L4
- MR201283L4V
- RC200242
- RC200242L1
- RC200242L1V
- RC200242L2
- RC200242L2V
- RC200242L3
- RC200242L3V
- RC200242L4
- RC200242L4V
- RC225152
- RC225152L3
- RC225152L3V
- RC225152L4
- RC225152L4V
- RG200242
- RG225152
- RR212152
- RR212152L1
- RR212152L1V
- RR212152L2
- RR212152L2V
- RR212152L3
- RR212152L3V
- RR212152L4
- RR212152L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLAAT3
- Applied Biological Materials (abm): Clones for PLAAT3 - Select products 50% OFF >
- * PLAAT3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * PLAAT3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for PLAAT3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLAAT3 Gene
Localization for PLAAT3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLAAT3 Gene
- Cell membrane; Single-pass membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Peroxisome membrane.
| Compartment | Confidence |
|---|---|
| peroxisome | 4 |
| cytosol | 4 |
| plasma membrane | 3 |
| endoplasmic reticulum | 2 |
| lysosome | 1 |
| mitochondrion | 0 |
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005777 | peroxisome | ISS | -- |
| GO:0005778 | peroxisomal membrane | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
Pathways & Interactions for PLAAT3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Acyl chain remodelling of PE | ||
| 2 | Glycerophospholipid biosynthesis | ||
| 3 | Linoleic acid metabolism | ||
| 4 | Metabolism |
.40
|
|
| 5 | Ras signaling pathway | ||
Pathways by source for PLAAT3 Gene
1 BioSystems pathway for PLAAT3 Gene
8 Reactome pathways for PLAAT3 Gene
8 KEGG pathways for PLAAT3 Gene
Interacting Proteins for PLAAT3 Gene
Selected Interacting proteins:
P53816-PLAT3_HUMAN
ENSP00000320337
for PLAAT3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PLAAT3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006641 | triglyceride metabolic process | ISS | -- |
| GO:0006644 | phospholipid metabolic process | IDA | 20100577 |
| GO:0007031 | peroxisome organization | ISS | -- |
| GO:0008654 | phospholipid biosynthetic process | IEA | -- |
Drugs & Compounds for PLAAT3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| linoleic acid | Approved, Experimental | Pharma | Full agonist, Agonist, Pore Blocker, Channel blocker | 0 | ||
| Water | Approved | Pharma | 0 | |||
| alpha-linolenic acid | Approved, Investigational | Nutra | Full agonist, Agonist | 0 | ||
| arachidonic acid | Experimental | Pharma | Activator, Agonist, Inhibitor, Activation, Potentiation | 38 |
Drug Products
- G Biosciences Human PLA2G16/HRSL3, Liquid
- Creative Biomart Recombinant Human PLA2G16 and Recombinant Human PLA2G16 293 Cell Lysate
Transcripts for PLAAT3 Gene
mRNA/cDNA for PLAAT3 Gene
- (2) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (240) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000323646 2594 bps (ENST00000323646.9)
- ENST00000394613 678 bps (ENST00000394613.3)
- ENST00000415826 1099 bps (ENST00000415826.1)
- ENST00000540943 243 bps (ENST00000540943.1)
- ENST00000544269 430 bps (ENST00000544269.1)
CRISPR Products
-
OriGene CRISPR knockouts for PLAAT3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLAAT3
- genomics-online: gRNA clones - Search for available PLA2G16 gRNA products
- Overview of 102 available PLA2G16 gene related products
- Applied Biological Materials (abm): CRISPR Clones for PLAAT3 - Select products 50% OFF >
- * PLAAT3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * PLAAT3 CRISPR applications: KO, Activation, Repression, and more - Browse All
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PLAAT3
- Browse OriGene Inhibitory RNA Products For PLAAT3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAAT3
- genomics-online: shRNA clones - Search for available PLA2G16 shRNA products
- Overview of 102 available PLA2G16 gene related products
Clone Products
-
- MG201283
- MR201283
- MR201283L3
- MR201283L3V
- MR201283L4
- MR201283L4V
- RC200242
- RC200242L1
- RC200242L1V
- RC200242L2
- RC200242L2V
- RC200242L3
- RC200242L3V
- RC200242L4
- RC200242L4V
- RC225152
- RC225152L3
- RC225152L3V
- RC225152L4
- RC225152L4V
- RG200242
- RG225152
- RR212152
- RR212152L1
- RR212152L1V
- RR212152L2
- RR212152L2V
- RR212152L3
- RR212152L3V
- RR212152L4
- RR212152L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLAAT3
- Applied Biological Materials (abm): Clones for PLAAT3 - Select products 50% OFF >
- * PLAAT3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * PLAAT3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for PLAAT3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Bone (Muscoskeletal System)
- Eye (Sensory Organs)
NURSA nuclear receptor signaling pathways regulating expression of PLAAT3 Gene:
PLAAT3SOURCE GeneReport for Unigene cluster for PLAAT3 Gene:
Hs.502775mRNA Expression by UniProt/SwissProt for PLAAT3 Gene:
P53816-PLAT3_HUMAN
Tissue specificity:
Widely expressed. low expression, if any, in hematopoietic cells and thymus. In testis, confined to round spermatids. Expressed in normal ovarian epithelial cells. Down-regulated in some ovarian carcinomas and testicular germ cell tumors. Highly expressed in white adipose tissue (PubMed:19136964).
Evidence on tissue expression from TISSUES for PLAAT3 Gene
- Nervous system(4.9)
- Intestine(4.3)
- Liver(4.3)
- Muscle(2.4)
Primer Products
-
OriGene qPCR primer pairs for PLAAT3
-
OriGene qPCR primer pairs and template standards for PLAAT3
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAAT3 Gene
Orthologs for PLAAT3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PLA2G16 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LOC476045 32 |
|
||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | PLA2G16 33 32 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Pla2g16 33 32 |
|
OneToOne | |
| Plaat3 17 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Pla2g16 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-229n2.6 33 |
|
ManyToMany |
- Species where no ortholog for PLAAT3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PLAAT3 Gene
- ENSEMBL:
- Gene Tree for PLAAT3 (if available)
- TreeFam:
- Gene Tree for PLAAT3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PLAAT3: view image
Paralogs for PLAAT3 Gene
Variants for PLAAT3 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000036247 | -- | 63,614,173(-) | GG/G | 5_prime_UTR_variant, intron_variant | |
| rs1000073148 | -- | 63,604,260(-) | T/A | intron_variant | |
| rs1000227954 | -- | 63,587,678(-) | A/C | intron_variant | |
| rs1000357723 | -- | 63,600,804(-) | A/G | intron_variant | |
| rs1000429992 | -- | 63,613,913(-) | G/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv32927 | CNV | gain | 17666407 |
| esv33275 | CNV | loss | 17666407 |
| esv3626646 | CNV | gain | 21293372 |
| esv3626647 | CNV | gain | 21293372 |
| nsv1138041 | CNV | deletion | 24896259 |
| nsv352 | CNV | insertion | 18451855 |
| nsv472513 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.05;
21.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLAAT3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PLAAT3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAAT3 Gene
Disorders for PLAAT3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| monofixation syndrome |
|
|
| abnormal retinal correspondence |
|
|
| aniseikonia |
|
|
| binocular vision disease |
|
|
| accommodative esotropia |
|
|
Search PLAAT3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PLAAT3
No data available for UniProtKB/Swiss-Prot and Genatlas for PLAAT3 Gene
Publications for PLAAT3 Gene
- Transcriptional and translational downregulation of H-REV107, a class II tumour suppressor gene located on human chromosome 11q11-12. (PMID: 9771974) Husmann K … Schäfer R (Oncogene 1998) 2 3 4 23 56
- Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PMID: 19615464) Uyama T … Ueda N (Biochimica et biophysica acta 2009) 3 4 23 56
- The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory factor-1 and is involved in IFNgamma-induced cell death in human ovarian carcinoma cells. (PMID: 11973642) Sers C … Schäfer R (Oncogene 2002) 3 4 23 56
- PLA2G16 represents a switch between entry and clearance of Picornaviridae. (PMID: 28077878) Staring J … Brummelkamp TR (Nature 2017) 3 4 56
- LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. (PMID: 25383759) Golczak M … Palczewski K (Nature chemical biology 2015) 3 4 56
Products for PLAAT3 Gene
- Custom Antibody ServicesOriGene Antibodies for PLAAT3
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- Browse OriGene Inhibitory RNA Products For PLAAT3
- OriGene qPCR primer pairs for PLAAT3
- OriGene qPCR primer pairs and template standards for PLAAT3
- OriGene CRISPR knockouts for PLAAT3
- MG201283
- MR201283
- MR201283L3
- MR201283L3V
- MR201283L4
- MR201283L4V
- RC200242
- RC200242L1
- RC200242L1V
- RC200242L2
- RC200242L2V
- RC200242L3
- RC200242L3V
- RC200242L4
- RC200242L4V
- RC225152
- RC225152L3
- RC225152L3V
- RC225152L4
- RC225152L4V
- RG200242
- RG225152
- RR212152
- RR212152L1
- RR212152L1V
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- RR212152L2V
- RR212152L3
- RR212152L3V
- RR212152L4
- RR212152L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins and lysates for PLAAT3
- Browse Antibodies
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- Abcam antibodies for PLAAT3
- Abcam proteins for PLAAT3
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- Browse Primary Antibodies
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- Invitrogen Antibodies for PLAAT3 (AFLGC-PLA2G16)
- antibodies-online: Show 17 available PLA2G16 Antibodies ranked by validation data
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- antibodies-online: Search results for available PLA2G16 related products ranked by validation data
- antibodies-online: Show 15 available PLA2G16 Proteins ranked by validation data
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- ProSci Proteins for PLAAT3
- Horizon Cell Lines for PLAAT3
- genomics-online: cdna clones - Search for available PLA2G16 CDNA products
- Overview of 102 available PLA2G16 gene related products
- orf clones - Search for available PLA2G16 ORF products
- Overview of 102 available PLA2G16 gene related products
- genomics-online: gRNA clones - Search for available PLA2G16 gRNA products
- Overview of 102 available PLA2G16 gene related products
- genomics-online: primer clones - Search for available PLA2G16 Primer products
- Overview of 102 available PLA2G16 gene related products
- genomics-online: shRNA clones - Search for available PLA2G16 shRNA products
- Overview of 102 available PLA2G16 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLAAT3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLAAT3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PLAAT3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAAT3
- Biorbyt antibodies for PLAAT3
Sources for PLAAT3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
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- (40) dbSNP
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- (44) BGMUT
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- (46) Atlas
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- (65) Qiagen
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- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
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- (107) diseasecard
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- (125) ENCODE
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- (127) Horizon
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- (130) VectorBuilder
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- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
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- (155) miR2Disease
- (156) DiseaseEnhancer
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- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource