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PLAAT3 (Phospholipase A And Acyltransferase 3) is a Protein Coding gene. Diseases associated with PLAAT3 include Monofixation Syndrome and Abnormal Retinal Correspondence. Among its related pathways are Ras signaling pathway and Acyl chain remodelling of PE. An important paralog of this gene is PLAAT2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004623 | phospholipase A2 activity | IDA | 19047760 |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0008970 | phospholipase A1 activity | IDA,IEA | 19047760 |
GO:0016410 | N-acyltransferase activity | IDA | 22825852 |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005777 | peroxisome | ISS | -- |
GO:0005778 | peroxisomal membrane | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Acyl chain remodelling of PE | ||
2 | Glycerophospholipid biosynthesis | ||
3 | Linoleic acid metabolism | ||
4 | Metabolism |
.40
|
|
5 | Ras signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006641 | triglyceride metabolic process | ISS | -- |
GO:0006644 | phospholipid metabolic process | IDA | 20100577 |
GO:0007031 | peroxisome organization | ISS | -- |
GO:0008654 | phospholipid biosynthetic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
linoleic acid | Approved, Experimental | Pharma | Full agonist, Agonist, Pore Blocker, Channel blocker | 0 | ||
Water | Approved | Pharma | 0 | |||
alpha-linolenic acid | Approved, Investigational | Nutra | Full agonist, Agonist | 0 | ||
arachidonic acid | Experimental | Pharma | Activator, Agonist, Inhibitor, Activation, Potentiation | 38 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PLA2G16 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | LOC476045 32 |
|
||
-- 33 |
|
OneToMany | |||
-- 33 |
|
OneToMany | |||
cow (Bos Taurus) |
Mammalia | PLA2G16 33 32 |
|
OneToMany | |
-- 33 |
|
OneToMany | |||
mouse (Mus musculus) |
Mammalia | Pla2g16 33 32 |
|
OneToOne | |
Plaat3 17 |
|
||||
rat (Rattus norvegicus) |
Mammalia | Pla2g16 32 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
zebrafish (Danio rerio) |
Actinopterygii | si:ch211-229n2.6 33 |
|
ManyToMany |
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000036247 | -- | 63,614,173(-) | GG/G | 5_prime_UTR_variant, intron_variant | |
rs1000073148 | -- | 63,604,260(-) | T/A | intron_variant | |
rs1000227954 | -- | 63,587,678(-) | A/C | intron_variant | |
rs1000357723 | -- | 63,600,804(-) | A/G | intron_variant | |
rs1000429992 | -- | 63,613,913(-) | G/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv32927 | CNV | gain | 17666407 |
esv33275 | CNV | loss | 17666407 |
esv3626646 | CNV | gain | 21293372 |
esv3626647 | CNV | gain | 21293372 |
nsv1138041 | CNV | deletion | 24896259 |
nsv352 | CNV | insertion | 18451855 |
nsv472513 | CNV | novel sequence insertion | 20440878 |
Disorder | Aliases | PubMed IDs |
---|---|---|
monofixation syndrome |
|
|
abnormal retinal correspondence |
|
|
aniseikonia |
|
|
binocular vision disease |
|
|
accommodative esotropia |
|
|