Aliases for PLAAT3 Gene

Aliases for PLAAT3 Gene

  • Phospholipase A And Acyltransferase 3 2 3 4 5
  • HRAS-Like Suppressor 3 2 3 4
  • HREV107-3 2 3 4
  • HREV107 2 3 4
  • AdPLA 2 3 4
  • Adipose-Specific Phospholipase A2 3 4
  • Renal Carcinoma Antigen NY-REN-65 3 4
  • Group XVI Phospholipase A1/A2 3 4
  • Phospholipase A2 Group XVI 2 3
  • H-Rev 107 Protein Homolog 3 4
  • HRAS-Like Suppressor 1 3 4
  • Adipose-Specific PLA2 2 3
  • H-REV107-1 2 3
  • HREV107-1 3 4
  • H-REV107 3 4
  • HRASLS3 3 4
  • PLA2G16 3 4
  • PLAAT-3 2 3
  • HRSL3 3 4
  • Phospholipase A/Acyltransferase‐3 2
  • Ca-Independent Phospholipase A1/2 3
  • Phospholipase A/Acyltransferase-3 3
  • Phospholipase A2, Group XVI 2
  • Group XVI Phospholipase A2 3
  • EC 3.1.1.32 4
  • MGC118754. 2
  • EC 2.3.1.- 4
  • EC 3.1.1.4 4
  • PLAAT3 5

External Ids for PLAAT3 Gene

Previous HGNC Symbols for PLAAT3 Gene

  • HRASLS3
  • PLA2G16

Previous GeneCards Identifiers for PLAAT3 Gene

  • GC11M063574

Summaries for PLAAT3 Gene

GeneCards Summary for PLAAT3 Gene

PLAAT3 (Phospholipase A And Acyltransferase 3) is a Protein Coding gene. Diseases associated with PLAAT3 include Poland Syndrome. Among its related pathways are Ras signaling pathway and Acyl chain remodelling of PE. An important paralog of this gene is PLAAT2.

UniProtKB/Swiss-Prot Summary for PLAAT3 Gene

  • Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852).
  • (Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm (PubMed:28077878). May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection (PubMed:28077878). Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome (PubMed:28077878). May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery (PubMed:28077878). The lipid-modifying enzyme activity is required for this process (PubMed:28077878).

Gene Wiki entry for PLAAT3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLAAT3 Gene

Genomics for PLAAT3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLAAT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J063612 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 280.5 +3.6 3618 3.4 IKZF1 ETS1 HES1 ZBTB7B ZIC2 SIN3A ZNF395 GTF2E2 VEZF1 ZNF341 PLAAT3 ATL3 LOC107984336 lnc-PLA2G16-1 LOC105369335 PLAAT2
GH11J063616 Enhancer 0.8 Ensembl ENCODE 274 -1.0 -1047 2.1 CEBPA MAFF ZNF316 NFE2 MAFK ZBTB33 MAFG IKZF1 NR2F1 MEIS2 PLAAT3 ENSG00000203520 LOC107984336 lnc-PLA2G16-1 piR-41099 ATL3
GH11J063617 Enhancer 0.3 Ensembl 262.4 +0.6 625 0.6 CEBPB CEBPG PLAAT3 ENSG00000203520 LOC107984336 lnc-PLA2G16-1 ATL3 PLAAT2
GH11J063608 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 20.2 +7.1 7135 3.2 ZIC2 SIN3A ZNF341 RXRA RARA KLF9 ZBTB33 JUND HNF4A FOXA1 LGALS12 PLAAT3 PLAAT5 LOC107984336 lnc-PLA2G16-1 LOC105369335 PLAAT2
GH11J063602 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 19.2 +13.9 13926 2.4 CEBPA KDM6A THAP11 SMAD4 SAP130 RARA TEAD3 MYNN BCL6 DRAP1 PLAAT3 ATL3 RTN3 LOC107984336 lnc-PLA2G16-1 LOC105369335 PLAAT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLAAT3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLAAT3

Genomic Locations for PLAAT3 Gene

Latest Assembly
chr11:63,573,195-63,616,926
(GRCh38/hg38)
Size:
43,732 bases
Orientation:
Minus strand

Previous Assembly
chr11:63,341,934-63,381,909
(GRCh37/hg19 by Entrez Gene)
Size:
39,976 bases
Orientation:
Minus strand

chr11:63,340,667-63,384,355
(GRCh37/hg19 by Ensembl)
Size:
43,689 bases
Orientation:
Minus strand

Genomic View for PLAAT3 Gene

Genes around PLAAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAAT3 Gene

Proteins for PLAAT3 Gene

  • Protein details for PLAAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53816-PLAT3_HUMAN
    Recommended name:
    Phospholipase A and acyltransferase 3
    Protein Accession:
    P53816
    Secondary Accessions:
    • B2R7Q4
    • B7XAK5
    • Q3SYI3
    • Q9HDD1

    Protein attributes for PLAAT3 Gene

    Size:
    162 amino acids
    Molecular mass:
    17937 Da
    Quaternary structure:
    • Interacts with PPP2R1A; this interaction might decrease PP2A activity.

    Three dimensional structures from OCA and Proteopedia for PLAAT3 Gene

neXtProt entry for PLAAT3 Gene

Post-translational modifications for PLAAT3 Gene

  • Ubiquitination at Lys73 and Lys91
  • Modification sites at PhosphoSitePlus

Other Protein References for PLAAT3 Gene

No data available for DME Specific Peptides for PLAAT3 Gene

Domains & Families for PLAAT3 Gene

Gene Families for PLAAT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PLAAT3 Gene

InterPro:
Blocks:
  • NC
ProtoNet:

Suggested Antigen Peptide Sequences for PLAAT3 Gene

GenScript: Design optimal peptide antigens:
  • Renal carcinoma antigen NY-REN-65 (PAG16_HUMAN)
  • PLA2G16 protein (Q3MI98_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P53816

UniProtKB/Swiss-Prot:

PLAT3_HUMAN :
  • Belongs to the H-rev107 family.
Family:
  • Belongs to the H-rev107 family.
genes like me logo Genes that share domains with PLAAT3: view

Function for PLAAT3 Gene

Molecular function for PLAAT3 Gene

UniProtKB/Swiss-Prot Function:
Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm (PubMed:28077878). May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection (PubMed:28077878). Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome (PubMed:28077878). May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery (PubMed:28077878). The lipid-modifying enzyme activity is required for this process (PubMed:28077878).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269|PubMed:19047760, ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:20837014, ECO:0000269|PubMed:22605381, ECO:0000269|PubMed:22825852, ECO:0000269|PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence={ECO:0000269|PubMed:19047760, ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:20837014, ECO:0000269|PubMed:22605381, ECO:0000269|PubMed:22825852, ECO:0000269|PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence={ECO:0000269|PubMed:19615464};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40487, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:76078; Evidence={ECO:0000269|PubMed:19615464};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:38783, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73001, ChEBI:CHEBI:76071; Evidence={ECO:0000269|PubMed:19615464};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence={ECO:0000269|PubMed:19615464};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence={ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40571, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73003, ChEBI:CHEBI:76079; Evidence={ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence={ECO:0000269|PubMed:19615464};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate; Xref=Rhea:RHEA:45164, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73008, ChEBI:CHEBI:76090; Evidence={ECO:0000269|PubMed:19615464};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence={ECO:0000269|PubMed:19615464};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41348, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73009, ChEBI:CHEBI:76091; Evidence={ECO:0000269|PubMed:19615464};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate; Xref=Rhea:RHEA:53496, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57875, ChEBI:CHEBI:137403; Evidence={ECO:0000269|PubMed:22605381};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:53500, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:78215, ChEBI:CHEBI:137403; Evidence={ECO:0000269|PubMed:22605381};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:53524, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:74667, ChEBI:CHEBI:138218, ChEBI:CHEBI:138220; Evidence={ECO:0000269|PubMed:22605381};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(9Z-octadecenoyl)-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:53528, ChEBI:CHEBI:15378, ChEBI:CHEBI:74667, ChEBI:CHEBI:76078, ChEBI:CHEBI:138218, ChEBI:CHEBI:138222; Evidence={ECO:0000269|PubMed:22605381};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine = 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:54544, ChEBI:CHEBI:138197, ChEBI:CHEBI:138216, ChEBI:CHEBI:138266, ChEBI:CHEBI:138267; Evidence={ECO:0000269|PubMed:22605381};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate; Xref=Rhea:RHEA:56432, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:72998, ChEBI:CHEBI:73000; Evidence={ECO:0000269|PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:56436, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73000, ChEBI:CHEBI:76076; Evidence={ECO:0000269|PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:56440, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73858, ChEBI:CHEBI:75026; Evidence={ECO:0000269|PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate; Xref=Rhea:RHEA:56444, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:75026, ChEBI:CHEBI:76078; Evidence={ECO:0000269|PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence={ECO:0000269|PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40971, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73002, ChEBI:CHEBI:76084; Evidence={ECO:0000269|PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:56448, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669, ChEBI:CHEBI:76071; Evidence={ECO:0000269|PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:41384, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999; Evidence={ECO:0000269|PubMed:19047760};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40923, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669; Evidence={ECO:0000269|PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:41360, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:78097; Evidence={ECO:0000250|UniProtKB:P53817};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:56428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28733, ChEBI:CHEBI:30245, ChEBI:CHEBI:42027; Evidence={ECO:0000250|UniProtKB:Q8R3U1};.
UniProtKB/Swiss-Prot Induction:
By IFNG and IRF1.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=300 uM for dipalmitoyl-PC {ECO:0000269|PubMed:19615464}; Vmax=2.57 umol/min/mg enzyme with dipalmitoyl-PC as substrate {ECO:0000269|PubMed:19615464}; Vmax=267 nmol/min/mg enzyme with dipalmitoyl-PE as substrate {ECO:0000269|PubMed:19615464}; pH dependence: Optimum pH is 9. {ECO:0000269|PubMed:19615464};

Enzyme Numbers (IUBMB) for PLAAT3 Gene

Phenotypes From GWAS Catalog for PLAAT3 Gene

Gene Ontology (GO) - Molecular Function for PLAAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IBA,IDA 19047760
GO:0005515 protein binding IPI 16189514
GO:0008970 phospholipase A1 activity IBA,IDA 19047760
GO:0016410 N-acyltransferase activity IDA 22825852
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PLAAT3: view
genes like me logo Genes that share phenotypes with PLAAT3: view

Animal Models for PLAAT3 Gene

MGI Knock Outs for PLAAT3:

miRNA for PLAAT3 Gene

miRTarBase miRNAs that target PLAAT3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAAT3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLAAT3 Gene

Localization for PLAAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAAT3 Gene

Cell membrane. Single-pass membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Peroxisome membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAAT3 gene
Compartment Confidence
cytosol 5
plasma membrane 4
peroxisome 4
endoplasmic reticulum 3
mitochondrion 2
lysosome 2
extracellular 1
cytoskeleton 1
nucleus 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLAAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IBA 21873635
GO:0005777 peroxisome ISS --
GO:0005778 peroxisomal membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with PLAAT3: view

Pathways & Interactions for PLAAT3 Gene

genes like me logo Genes that share pathways with PLAAT3: view

SIGNOR curated interactions for PLAAT3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for PLAAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006641 triglyceride metabolic process ISS --
GO:0006644 phospholipid metabolic process IDA 20100577
GO:0007031 peroxisome organization ISS --
GO:0008654 phospholipid biosynthetic process IEA --
genes like me logo Genes that share ontologies with PLAAT3: view

Drugs & Compounds for PLAAT3 Gene

(4) Drugs for PLAAT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
linoleic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
alpha-Linolenic acid Approved, Investigational Nutra 0
arachidonic acid Experimental Pharma 41
genes like me logo Genes that share compounds with PLAAT3: view

Transcripts for PLAAT3 Gene

mRNA/cDNA for PLAAT3 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAAT3

Alternative Splicing Database (ASD) splice patterns (SP) for PLAAT3 Gene

No ASD Table

Relevant External Links for PLAAT3 Gene

GeneLoc Exon Structure for
PLAAT3

Expression for PLAAT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLAAT3

SOURCE GeneReport for Unigene cluster for PLAAT3 Gene:

Hs.502775

mRNA Expression by UniProt/SwissProt for PLAAT3 Gene:

P53816-PLAT3_HUMAN
Tissue specificity: Widely expressed. low expression, if any, in hematopoietic cells and thymus. In testis, confined to round spermatids. Expressed in normal ovarian epithelial cells. Down-regulated in some ovarian carcinomas and testicular germ cell tumors. Highly expressed in white adipose tissue (PubMed:19136964).

Evidence on tissue expression from TISSUES for PLAAT3 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Intestine(4.4)
  • Muscle(2.6)
  • Kidney(2.4)
  • Heart(2.4)
genes like me logo Genes that share expression patterns with PLAAT3: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAAT3 Gene

Orthologs for PLAAT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAAT3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLA2G16 30 31
  • 97.33 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC476045 30
  • 87.24 (n)
-- 31
  • 85 (a)
OneToMany
-- 31
  • 75 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia PLA2G16 30 31
  • 84.7 (n)
OneToMany
-- 31
  • 74 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Pla2g16 30 31
  • 83.74 (n)
OneToOne
Plaat3 17
Rat
(Rattus norvegicus)
Mammalia Pla2g16 30
  • 83.23 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 78 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 52 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 64 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-229n2.6 31
  • 26 (a)
ManyToMany
Species where no ortholog for PLAAT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PLAAT3 Gene

ENSEMBL:
Gene Tree for PLAAT3 (if available)
TreeFam:
Gene Tree for PLAAT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLAAT3: view image

Paralogs for PLAAT3 Gene

Paralogs for PLAAT3 Gene

genes like me logo Genes that share paralogs with PLAAT3: view

Variants for PLAAT3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLAAT3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLAAT3 Gene

Variant ID Type Subtype PubMed ID
esv32927 CNV gain 17666407
esv33275 CNV loss 17666407
esv3626646 CNV gain 21293372
esv3626647 CNV gain 21293372
nsv1138041 CNV deletion 24896259
nsv352 CNV insertion 18451855
nsv472513 CNV novel sequence insertion 20440878

Variation tolerance for PLAAT3 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAAT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLAAT3 Gene

Disorders for PLAAT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLAAT3 Gene - From: COP

Disorder Aliases PubMed IDs
poland syndrome
  • poland syndactyly
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLAAT3

genes like me logo Genes that share disorders with PLAAT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAAT3 Gene

Publications for PLAAT3 Gene

  1. Transcriptional and translational downregulation of H-REV107, a class II tumour suppressor gene located on human chromosome 11q11-12. (PMID: 9771974) Husmann K … Schäfer R (Oncogene 1998) 2 3 4 23
  2. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PMID: 19615464) Uyama T … Ueda N (Biochimica et biophysica acta 2009) 3 4 23
  3. The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory factor-1 and is involved in IFNgamma-induced cell death in human ovarian carcinoma cells. (PMID: 11973642) Sers C … Schäfer R (Oncogene 2002) 3 4 23
  4. PLA2G16 represents a switch between entry and clearance of Picornaviridae. (PMID: 28077878) Staring J … Brummelkamp TR (Nature 2017) 3 4
  5. LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. (PMID: 25383759) Golczak M … Palczewski K (Nature chemical biology 2015) 3 4

Products for PLAAT3 Gene

Sources for PLAAT3 Gene