Aliases for PLAAT3 Gene

Aliases for PLAAT3 Gene

  • Phospholipase A And Acyltransferase 3 2 3 4 5
  • HRAS-Like Suppressor 3 2 3 4
  • Adipose-Specific Phospholipase A2 3 4
  • Renal Carcinoma Antigen NY-REN-65 3 4
  • Group XVI Phospholipase A1/A2 3 4
  • Phospholipase A2 Group XVI 2 3
  • H-Rev 107 Protein Homolog 3 4
  • HRAS-Like Suppressor 1 3 4
  • Adipose-Specific PLA2 2 3
  • HREV107-1 3 4
  • HREV107-3 3 4
  • H-REV107 3 4
  • HRASLS3 3 4
  • PLA2G16 3 4
  • HREV107 3 4
  • AdPLA 3 4
  • HRSL3 3 4
  • Ca-Independent Phospholipase A1/2 3
  • Phospholipase A/Acyltransferase-3 3
  • Phospholipase A/Acyltransferase‐3 2
  • Phospholipase A2, Group XVI 2
  • Group XVI Phospholipase A2 3
  • EC 3.1.1.32 4
  • H-REV107-1 3
  • EC 2.3.1.- 4
  • EC 3.1.1.4 4
  • PLAAT-3 3

External Ids for PLAAT3 Gene

Previous HGNC Symbols for PLAAT3 Gene

  • HRASLS3
  • PLA2G16

Summaries for PLAAT3 Gene

GeneCards Summary for PLAAT3 Gene

PLAAT3 (Phospholipase A And Acyltransferase 3) is a Protein Coding gene. Diseases associated with PLAAT3 include Monofixation Syndrome and Abnormal Retinal Correspondence. Among its related pathways are Ras signaling pathway and Acyl chain remodelling of PE. An important paralog of this gene is PLAAT2.

UniProtKB/Swiss-Prot Summary for PLAAT3 Gene

  • Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852).
  • (Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm (PubMed:28077878). May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection (PubMed:28077878). Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome (PubMed:28077878). May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery (PubMed:28077878). The lipid-modifying enzyme activity is required for this process (PubMed:28077878).

Gene Wiki entry for PLAAT3 Gene

Additional gene information for PLAAT3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLAAT3 Gene

Genomics for PLAAT3 Gene

GeneHancer (GH) Regulatory Elements for PLAAT3 Gene

Promoters and enhancers for PLAAT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J063612 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 780.5 +3.6 3618 3.4 POLR2A USF2 ELF1 L3MBTL2 TEAD4 CBFA2T2 ZSCAN21 EGR1 IKZF1 ZIC2 PLAAT3 ATL3 ENSG00000203520 lnc-PLA2G16-1 LOC105369335
GH11J063616 Enhancer 0.7 Ensembl ENCODE 773.9 -1.0 -1047 2.1 MAFK PKNOX1 CEBPA ZNF316 NFE2 MAFG IKZF1 NR2F1 ZBTB33 CUX1 PLAAT3 ENSG00000203520 lnc-PLA2G16-1 piR-41099
GH11J063617 Enhancer 0.3 Ensembl 762.4 +0.6 625 0.6 CEBPG CEBPB PLAAT3 ENSG00000203520 lnc-PLA2G16-1 ATL3 LOC105369335
GH11J063608 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 20.1 +7.1 7135 3.2 CTCF FOXA1 RAD21 ELF3 SP1 SP7 PPARG EGR1 GLIS2 ZIC2 LGALS12 PLAAT3 PLAAT5 ENSG00000203520 lnc-PLA2G16-1 LOC105369335
GH11J063602 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 19.3 +13.6 13625 2.6 RBPJ NR2F1 NR2F6 CREB1 MIXL1 HLF CEBPG PPARG HNF1A SP5 PLAAT3 ATL3 RTN3 ENSG00000203520 lnc-PLA2G16-1 LOC105369335
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLAAT3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PLAAT3 Gene

Genomic Locations for PLAAT3 Gene
chr11:63,573,195-63,616,926
(GRCh38/hg38)
Size:
43,732 bases
Orientation:
Minus strand
chr11:63,340,667-63,384,355
(GRCh37/hg19)
Size:
43,689 bases
Orientation:
Minus strand

Genomic View for PLAAT3 Gene

Genes around PLAAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAAT3 Gene

Proteins for PLAAT3 Gene

  • Protein details for PLAAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53816-PLAT3_HUMAN
    Recommended name:
    Phospholipase A and acyltransferase 3
    Protein Accession:
    P53816
    Secondary Accessions:
    • B2R7Q4
    • B7XAK5
    • Q3SYI3
    • Q9HDD1

    Protein attributes for PLAAT3 Gene

    Size:
    162 amino acids
    Molecular mass:
    17937 Da
    Quaternary structure:
    • Interacts with PPP2R1A; this interaction might decrease PP2A activity.

    Three dimensional structures from OCA and Proteopedia for PLAAT3 Gene

neXtProt entry for PLAAT3 Gene

Post-translational modifications for PLAAT3 Gene

  • Ubiquitination at Lys73 and Lys91
  • Modification sites at PhosphoSitePlus

Other Protein References for PLAAT3 Gene

No data available for DME Specific Peptides for PLAAT3 Gene

Domains & Families for PLAAT3 Gene

Gene Families for PLAAT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PLAAT3 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLAAT3 Gene

GenScript: Design optimal peptide antigens:
  • Renal carcinoma antigen NY-REN-65 (PAG16_HUMAN)
  • PLA2G16 protein (Q3MI98_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P53816

UniProtKB/Swiss-Prot:

PLAT3_HUMAN :
  • Belongs to the H-rev107 family.
Family:
  • Belongs to the H-rev107 family.
genes like me logo Genes that share domains with PLAAT3: view

Function for PLAAT3 Gene

Molecular function for PLAAT3 Gene

UniProtKB/Swiss-Prot Function:
Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm (PubMed:28077878). May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection (PubMed:28077878). Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome (PubMed:28077878). May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery (PubMed:28077878). The lipid-modifying enzyme activity is required for this process (PubMed:28077878).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269 PubMed:19047760, ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:20837014, ECO:0000269 PubMed:22605381, ECO:0000269 PubMed:22825852, ECO:0000269 PubMed:22923616}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence={ECO:0000269 PubMed:19047760, ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:20837014, ECO:0000269 PubMed:22605381, ECO:0000269 PubMed:22825852, ECO:0000269 PubMed:22923616}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18690; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40487, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:76078; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40488; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:38783, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73001, ChEBI:CHEBI:76071; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38784; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22923616}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40571, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73003, ChEBI:CHEBI:76079; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22923616}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40572; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22923616};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate; Xref=Rhea:RHEA:45164, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73008, ChEBI:CHEBI:76090; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45165; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40432; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41348, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73009, ChEBI:CHEBI:76091; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41349; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate; Xref=Rhea:RHEA:53496, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57875, ChEBI:CHEBI:137403; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53497; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:53500, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:78215, ChEBI:CHEBI:137403; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53501; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:53524, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:74667, ChEBI:CHEBI:138218, ChEBI:CHEBI:138220; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53525; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(9Z-octadecenoyl)-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:53528, ChEBI:CHEBI:15378, ChEBI:CHEBI:74667, ChEBI:CHEBI:76078, ChEBI:CHEBI:138218, ChEBI:CHEBI:138222; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53529; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine = 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:54544, ChEBI:CHEBI:138197, ChEBI:CHEBI:138216, ChEBI:CHEBI:138266, ChEBI:CHEBI:138267; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54545; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate; Xref=Rhea:RHEA:56432, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:72998, ChEBI:CHEBI:73000; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56433; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:56436, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73000, ChEBI:CHEBI:76076; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56437; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:56440, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73858, ChEBI:CHEBI:75026; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56441; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate; Xref=Rhea:RHEA:56444, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:75026, ChEBI:CHEBI:76078; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56445; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40812; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40971, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73002, ChEBI:CHEBI:76084; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40972; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:56448, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669, ChEBI:CHEBI:76071; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56449; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:41384, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41385; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40923, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40924; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:41360, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:78097; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41361; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:56428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28733, ChEBI:CHEBI:30245, ChEBI:CHEBI:42027; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56429; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=300 uM for dipalmitoyl-PC {ECO:0000269 PubMed:19615464}; Vmax=2.57 umol/min/mg enzyme with dipalmitoyl-PC as substrate {ECO:0000269 PubMed:19615464}; Vmax=267 nmol/min/mg enzyme with dipalmitoyl-PE as substrate {ECO:0000269 PubMed:19615464}; pH dependence: Optimum pH is 9. {ECO:0000269 PubMed:19615464};
UniProtKB/Swiss-Prot Induction:
By IFNG and IRF1.

Enzyme Numbers (IUBMB) for PLAAT3 Gene

Phenotypes From GWAS Catalog for PLAAT3 Gene

Gene Ontology (GO) - Molecular Function for PLAAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IDA 19047760
GO:0005515 protein binding IPI 16189514
GO:0008970 phospholipase A1 activity IDA,IEA 19047760
GO:0016410 N-acyltransferase activity IDA 22825852
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PLAAT3: view
genes like me logo Genes that share phenotypes with PLAAT3: view

Animal Models for PLAAT3 Gene

MGI Knock Outs for PLAAT3:

Animal Model Products

CRISPR Products

miRNA for PLAAT3 Gene

miRTarBase miRNAs that target PLAAT3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLAAT3 Gene

Localization for PLAAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAAT3 Gene

Cell membrane; Single-pass membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Peroxisome membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAAT3 gene
Compartment Confidence
peroxisome 4
cytosol 4
plasma membrane 3
endoplasmic reticulum 2
lysosome 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLAAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005777 peroxisome ISS --
GO:0005778 peroxisomal membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with PLAAT3: view

Pathways & Interactions for PLAAT3 Gene

genes like me logo Genes that share pathways with PLAAT3: view

SIGNOR curated interactions for PLAAT3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for PLAAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006641 triglyceride metabolic process ISS --
GO:0006644 phospholipid metabolic process IDA 20100577
GO:0007031 peroxisome organization ISS --
GO:0008654 phospholipid biosynthetic process IEA --
genes like me logo Genes that share ontologies with PLAAT3: view

Drugs & Compounds for PLAAT3 Gene

(4) Drugs for PLAAT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
linoleic acid Approved, Experimental Pharma Full agonist, Agonist, Pore Blocker, Channel blocker 0
Water Approved Pharma 0
alpha-linolenic acid Approved, Investigational Nutra Full agonist, Agonist 0
arachidonic acid Experimental Pharma Activator, Agonist, Inhibitor, Activation, Potentiation 38
genes like me logo Genes that share compounds with PLAAT3: view

Transcripts for PLAAT3 Gene

mRNA/cDNA for PLAAT3 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAAT3 Gene

No ASD Table

Relevant External Links for PLAAT3 Gene

GeneLoc Exon Structure for
PLAAT3
ECgene alternative splicing isoforms for
PLAAT3

Expression for PLAAT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PLAAT3 Gene:

PLAAT3

SOURCE GeneReport for Unigene cluster for PLAAT3 Gene:

Hs.502775

mRNA Expression by UniProt/SwissProt for PLAAT3 Gene:

P53816-PLAT3_HUMAN
Tissue specificity: Widely expressed. low expression, if any, in hematopoietic cells and thymus. In testis, confined to round spermatids. Expressed in normal ovarian epithelial cells. Down-regulated in some ovarian carcinomas and testicular germ cell tumors. Highly expressed in white adipose tissue (PubMed:19136964).

Evidence on tissue expression from TISSUES for PLAAT3 Gene

  • Nervous system(4.9)
  • Intestine(4.3)
  • Liver(4.3)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with PLAAT3: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAAT3 Gene

Orthologs for PLAAT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAAT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G16 33 32
  • 97.33 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC476045 32
  • 87.24 (n)
-- 33
  • 85 (a)
OneToMany
-- 33
  • 75 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PLA2G16 33 32
  • 84.7 (n)
OneToMany
-- 33
  • 74 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pla2g16 33 32
  • 83.74 (n)
OneToOne
Plaat3 17
rat
(Rattus norvegicus)
Mammalia Pla2g16 32
  • 83.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 64 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-229n2.6 33
  • 26 (a)
ManyToMany
Species where no ortholog for PLAAT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLAAT3 Gene

ENSEMBL:
Gene Tree for PLAAT3 (if available)
TreeFam:
Gene Tree for PLAAT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLAAT3: view image

Paralogs for PLAAT3 Gene

Paralogs for PLAAT3 Gene

genes like me logo Genes that share paralogs with PLAAT3: view

Variants for PLAAT3 Gene

Sequence variations from dbSNP and Humsavar for PLAAT3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000036247 -- 63,614,173(-) GG/G 5_prime_UTR_variant, intron_variant
rs1000073148 -- 63,604,260(-) T/A intron_variant
rs1000227954 -- 63,587,678(-) A/C intron_variant
rs1000357723 -- 63,600,804(-) A/G intron_variant
rs1000429992 -- 63,613,913(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLAAT3 Gene

Variant ID Type Subtype PubMed ID
esv32927 CNV gain 17666407
esv33275 CNV loss 17666407
esv3626646 CNV gain 21293372
esv3626647 CNV gain 21293372
nsv1138041 CNV deletion 24896259
nsv352 CNV insertion 18451855
nsv472513 CNV novel sequence insertion 20440878

Variation tolerance for PLAAT3 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAAT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAAT3 Gene

Disorders for PLAAT3 Gene

MalaCards: The human disease database

(11) MalaCards diseases for PLAAT3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
monofixation syndrome
abnormal retinal correspondence
aniseikonia
binocular vision disease
  • simultaneous visual perception without fusion
accommodative esotropia
  • esotropia with accommodative compensation
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLAAT3

genes like me logo Genes that share disorders with PLAAT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAAT3 Gene

Publications for PLAAT3 Gene

  1. Transcriptional and translational downregulation of H-REV107, a class II tumour suppressor gene located on human chromosome 11q11-12. (PMID: 9771974) Husmann K … Schäfer R (Oncogene 1998) 2 3 4 23 56
  2. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PMID: 19615464) Uyama T … Ueda N (Biochimica et biophysica acta 2009) 3 4 23 56
  3. The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory factor-1 and is involved in IFNgamma-induced cell death in human ovarian carcinoma cells. (PMID: 11973642) Sers C … Schäfer R (Oncogene 2002) 3 4 23 56
  4. PLA2G16 represents a switch between entry and clearance of Picornaviridae. (PMID: 28077878) Staring J … Brummelkamp TR (Nature 2017) 3 4 56
  5. LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. (PMID: 25383759) Golczak M … Palczewski K (Nature chemical biology 2015) 3 4 56

Products for PLAAT3 Gene

Sources for PLAAT3 Gene