The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefS... See more...

Aliases for PLAAT2 Gene

Aliases for PLAAT2 Gene

  • Phospholipase A And Acyltransferase 2 2 3 4 5
  • HRAS Like Suppressor 2 2 3
  • HRASLS2 3 4
  • Phospholipase A/Acyltransferase-2 3
  • Phospholipase A/Acyltransferase‐2 2
  • HRAS-Like Suppressor 2 4
  • EC 3.1.1.32 4
  • EC 2.3.1.- 4
  • EC 3.1.1.4 4
  • PLA1/2-2 3
  • PLAAT-2 3

External Ids for PLAAT2 Gene

Previous HGNC Symbols for PLAAT2 Gene

  • HRASLS2

Summaries for PLAAT2 Gene

Entrez Gene Summary for PLAAT2 Gene

  • The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016]

GeneCards Summary for PLAAT2 Gene

PLAAT2 (Phospholipase A And Acyltransferase 2) is a Protein Coding gene. Diseases associated with PLAAT2 include Poland Syndrome. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. An important paralog of this gene is PLAAT3.

UniProtKB/Swiss-Prot Summary for PLAAT2 Gene

  • Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22825852, PubMed:22605381). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22825852, PubMed:22605381). Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor (PubMed:22605381). Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity (PubMed:22825852).

Additional gene information for PLAAT2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLAAT2 Gene

Genomics for PLAAT2 Gene

GeneHancer (GH) Regulatory Elements for PLAAT2 Gene

Promoters and enhancers for PLAAT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLAAT2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PLAAT2 Gene

Genomic Locations for PLAAT2 Gene
chr11:63,552,759-63,565,089
(GRCh38/hg38)
Size:
12,331 bases
Orientation:
Minus strand
chr11:63,320,242-63,330,855
(GRCh37/hg19)
Size:
10,614 bases
Orientation:
Minus strand

Genomic View for PLAAT2 Gene

Genes around PLAAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAAT2 Gene

Proteins for PLAAT2 Gene

  • Protein details for PLAAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWW9-PLAT2_HUMAN
    Recommended name:
    Phospholipase A and acyltransferase 2
    Protein Accession:
    Q9NWW9
    Secondary Accessions:
    • B9A7L8

    Protein attributes for PLAAT2 Gene

    Size:
    162 amino acids
    Molecular mass:
    17394 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PLAAT2 Gene

neXtProt entry for PLAAT2 Gene

Post-translational modifications for PLAAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLAAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLAAT2 Gene

Domains & Families for PLAAT2 Gene

Gene Families for PLAAT2 Gene

Protein Domains for PLAAT2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLAAT2 Gene

GenScript: Design optimal peptide antigens:
  • HRAS-like suppressor 2 (HRSL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NWW9

UniProtKB/Swiss-Prot:

PLAT2_HUMAN :
  • Belongs to the H-rev107 family.
Family:
  • Belongs to the H-rev107 family.
genes like me logo Genes that share domains with PLAAT2: view

Function for PLAAT2 Gene

Molecular function for PLAAT2 Gene

UniProtKB/Swiss-Prot Function:
Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22825852, PubMed:22605381). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22825852, PubMed:22605381). Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor (PubMed:22605381). Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity (PubMed:22825852).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22605381, ECO:0000269 PubMed:22825852}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22605381, ECO:0000269 PubMed:22825852}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18690; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45192, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:62537, ChEBI:CHEBI:64612; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45193; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45188, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875, ChEBI:CHEBI:62537, ChEBI:CHEBI:64612; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45189; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40487, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:76078; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40488; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:38783, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73001, ChEBI:CHEBI:76071; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38784; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40571, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73003, ChEBI:CHEBI:76079; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40572; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate; Xref=Rhea:RHEA:45164, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73008, ChEBI:CHEBI:76090; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45165; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40432; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41348, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73009, ChEBI:CHEBI:76091; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41349; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45172, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:76078, ChEBI:CHEBI:78097; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45173; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45176, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:78097; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22825852}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45177; Evidence={ECO:0000269 PubMed:19615464, ECO:0000269 PubMed:22825852};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:53500, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:78215, ChEBI:CHEBI:137403; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53501; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:53524, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:74667, ChEBI:CHEBI:138218, ChEBI:CHEBI:138220; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53525; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(9Z-octadecenoyl)-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:53528, ChEBI:CHEBI:15378, ChEBI:CHEBI:74667, ChEBI:CHEBI:76078, ChEBI:CHEBI:138218, ChEBI:CHEBI:138222; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53529; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:54484, ChEBI:CHEBI:138194, ChEBI:CHEBI:138195, ChEBI:CHEBI:138197, ChEBI:CHEBI:138198; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54485; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:54488, ChEBI:CHEBI:72999, ChEBI:CHEBI:138195, ChEBI:CHEBI:138199, ChEBI:CHEBI:138200; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54489; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:54492, ChEBI:CHEBI:138195, ChEBI:CHEBI:138197, ChEBI:CHEBI:138216, ChEBI:CHEBI:138217; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54493; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate; Xref=Rhea:RHEA:53496, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57875, ChEBI:CHEBI:137403; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53497; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine = 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:54544, ChEBI:CHEBI:138197, ChEBI:CHEBI:138216, ChEBI:CHEBI:138266, ChEBI:CHEBI:138267; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54545; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=300 uM for dipalmitoyl-PC {ECO:0000269 PubMed:19615464}; Vmax=670 nmol/min/mg enzyme with dipalmitoyl-PC as substrate {ECO:0000269 PubMed:19615464}; Vmax=122 nmol/min/mg enzyme with dipalmitoyl-PE as substrate {ECO:0000269 PubMed:19615464}; Vmax=103 nmol/min/mg enzyme using dipalmitoyl-PC as an acyl donor and PE as an acyl acceptor {ECO:0000269 PubMed:19615464}; pH dependence: Optimum pH is 8. {ECO:0000269 PubMed:19615464};

Enzyme Numbers (IUBMB) for PLAAT2 Gene

Phenotypes From GWAS Catalog for PLAAT2 Gene

Gene Ontology (GO) - Molecular Function for PLAAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IDA 22825852
GO:0008970 phospholipase A1 activity IDA,IEA 22825852
GO:0016410 N-acyltransferase activity IDA 22825852
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with PLAAT2: view
genes like me logo Genes that share phenotypes with PLAAT2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAAT2

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLAAT2 Gene

Localization for PLAAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAAT2 Gene

Cytoplasm. Membrane; Single-pass membrane protein. Note=Exhibits a granular pattern in the cytoplasm with preferential perinuclear localization. {ECO:0000269 PubMed:18163183}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAAT2 gene
Compartment Confidence
cytosol 4
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLAAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLAAT2: view

Pathways & Interactions for PLAAT2 Gene

genes like me logo Genes that share pathways with PLAAT2: view

Interacting Proteins for PLAAT2 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000255695 for PLAAT2 Gene via STRING

Symbol External ID(s) Details
UBAC1

Gene Ontology (GO) - Biological Process for PLAAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS --
GO:0070292 N-acylphosphatidylethanolamine metabolic process IDA 22825852
genes like me logo Genes that share ontologies with PLAAT2: view

No data available for SIGNOR curated interactions for PLAAT2 Gene

Drugs & Compounds for PLAAT2 Gene

(2) Drugs for PLAAT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphorylcolamine Experimental Pharma 0

(1) Additional Compounds for PLAAT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-palmitoyl-phosphoethanolamine
genes like me logo Genes that share compounds with PLAAT2: view

Transcripts for PLAAT2 Gene

mRNA/cDNA for PLAAT2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLAAT2

Alternative Splicing Database (ASD) splice patterns (SP) for PLAAT2 Gene

No ASD Table

Relevant External Links for PLAAT2 Gene

GeneLoc Exon Structure for
PLAAT2
ECgene alternative splicing isoforms for
PLAAT2

Expression for PLAAT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLAAT2 Gene:

PLAAT2

SOURCE GeneReport for Unigene cluster for PLAAT2 Gene:

Hs.272805

mRNA Expression by UniProt/SwissProt for PLAAT2 Gene:

Q9NWW9-PLAT2_HUMAN
Tissue specificity: Expressed in liver, kidney, small intestine testis and colon (PubMed:19615464). Undetectable in testis, placenta, salivary gland and fetal brain (PubMed:18163183).

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAAT2 Gene

Orthologs for PLAAT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRASLS2 33 32
  • 99.59 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 63 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-229n2.7 33
  • 28 (a)
ManyToMany
Species where no ortholog for PLAAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLAAT2 Gene

ENSEMBL:
Gene Tree for PLAAT2 (if available)
TreeFam:
Gene Tree for PLAAT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLAAT2: view image

Paralogs for PLAAT2 Gene

Paralogs for PLAAT2 Gene

genes like me logo Genes that share paralogs with PLAAT2: view

Variants for PLAAT2 Gene

Sequence variations from dbSNP and Humsavar for PLAAT2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000200410 -- 63,564,175(-) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000374891 -- 63,557,478(-) G/T intron_variant
rs1000407303 -- 63,557,776(-) G/A intron_variant
rs1001346669 -- 63,556,382(-) A/G intron_variant
rs1001420368 -- 63,555,989(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLAAT2 Gene

Variant ID Type Subtype PubMed ID
esv3626646 CNV gain 21293372
esv3626647 CNV gain 21293372
nsv352 CNV insertion 18451855
nsv509417 CNV insertion 20534489

Variation tolerance for PLAAT2 Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAAT2 Gene

Disorders for PLAAT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLAAT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
poland syndrome
  • poland syndactyly
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLAAT2

genes like me logo Genes that share disorders with PLAAT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAAT2 Gene

Publications for PLAAT2 Gene

  1. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PMID: 19615464) Uyama T … Ueda N (Biochimica et biophysica acta 2009) 3 4 23 56
  2. Cloning and functional characterization of the HRASLS2 gene. (PMID: 18163183) Shyu RY … Jiang SY (Amino acids 2008) 3 4 23 56
  3. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. (PMID: 22605381) Golczak M … Palczewski K (The Journal of biological chemistry 2012) 3 4 56
  4. Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family. (PMID: 22825852) Uyama T … Ueda N (The Journal of biological chemistry 2012) 3 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for PLAAT2 Gene

Sources for PLAAT2 Gene