Aliases for PLAAT1 Gene
External Ids for PLAAT1 Gene
Previous HGNC Symbols for PLAAT1 Gene
GeneCards Summary for PLAAT1 Gene
PLAAT1 (Phospholipase A And Acyltransferase 1) is a Protein Coding gene. Diseases associated with PLAAT1 include Poland Syndrome. Among its related pathways are Acyl chain remodelling of PE and Metabolism. An important paralog of this gene is PLAAT3.
UniProtKB/Swiss-Prot Summary for PLAAT1 Gene
Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:21880860, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:21880860, PubMed:22825852, PubMed:27623847). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:21880860). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (PubMed:21880860, PubMed:22825852, PubMed:27623847).