Aliases for PLAA Gene
External Ids for PLAA Gene
Previous GeneCards Identifiers for PLAA Gene
GeneCards Summary for PLAA Gene
PLAA (Phospholipase A2 Activating Protein) is a Protein Coding gene. Diseases associated with PLAA include Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies and Conjugate Gaze Palsy. Among its related pathways are Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include binding and phospholipase A2 activator activity.
UniProtKB/Swiss-Prot Summary for PLAA Gene
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).