Aliases for PLA2G7 Gene
- Phospholipase A2 Group VII 2 3 5
- PAFAH 2 3 4
- Phospholipase A2, Group VII (Platelet-Activating Factor Acetylhydrolase, Plasma) 2 3
- 1-Alkyl-2-Acetylglycerophosphocholine Esterase 3 4
- 2-Acetyl-1-Alkylglycerophosphocholine Esterase 3 4
- Platelet-Activating Factor Acetylhydrolase 3 4
- LDL-Associated Phospholipase A2 3 4
- Group-VIIA Phospholipase A2 3 4
- PAF 2-Acylhydrolase 3 4
External Ids for PLA2G7 Gene
Previous GeneCards Identifiers for PLA2G7 Gene
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
GeneCards Summary for PLA2G7 Gene
PLA2G7 (Phospholipase A2 Group VII) is a Protein Coding gene. Diseases associated with PLA2G7 include Platelet-Activating Factor Acetylhydrolase Deficiency and Ige Responsiveness, Atopic. Among its related pathways are Lissencephaly gene (LIS1) in neuronal migration and development and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is PAFAH2.
UniProtKB/Swiss-Prot Summary for PLA2G7 Gene
Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:7700381, PubMed:8624782, PubMed:2040620, PubMed:16371369, PubMed:17090529, PubMed:10066756). At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:2040620, PubMed:10504265). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position (PubMed:2040620). Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (PubMed:2040620, PubMed:8624782). Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent proinflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed:10504265, PubMed:10066756, PubMed:7592717, PubMed:11590221, PubMed:7700381, PubMed:18434304, PubMed:16371369, PubMed:8675689, PubMed:8624782). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled proinflammatory effects (PubMed:2040620, PubMed:7700381). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (PubMed:17090529). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (PubMed:16371369).
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.