Aliases for PLA2G7 Gene
- Phospholipase A2 Group VII 2 3 5
- Phospholipase A2, Group VII (Platelet-Activating Factor Acetylhydrolase, Plasma) 2 3
- 1-Alkyl-2-Acetylglycerophosphocholine Esterase 3 4
- 2-Acetyl-1-Alkylglycerophosphocholine Esterase 3 4
- LDL-Associated Phospholipase A2 3 4
- Group-VIIA Phospholipase A2 3 4
- PAF 2-Acylhydrolase 3 4
- PAF Acetylhydrolase 3 4
- LDL-PLA(2) 3 4
External Ids for PLA2G7 Gene
Previous GeneCards Identifiers for PLA2G7 Gene
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
GeneCards Summary for PLA2G7 Gene
PLA2G7 (Phospholipase A2 Group VII) is a Protein Coding gene. Diseases associated with PLA2G7 include Platelet-Activating Factor Acetylhydrolase Deficiency and Ige Responsiveness, Atopic. Among its related pathways are PAK Pathway and Lissencephaly gene (LIS1) in neuronal migration and development. Gene Ontology (GO) annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is PAFAH2.
UniProtKB/Swiss-Prot for PLA2G7 Gene
Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.