This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine su... See more...

Aliases for PLA2G5 Gene

Aliases for PLA2G5 Gene

  • Phospholipase A2 Group V 2 3 4 5
  • Phosphatidylcholine 2-Acylhydrolase 5 3 4
  • PLA2-10 3 4
  • Calcium-Dependent Phospholipase A2 3
  • Ca2+-Dependent Phospholipase A2 3
  • Phospholipase A2, Group V 2
  • EC 3.1.1.4 4
  • HVPLA(2) 3
  • GV-PLA2 3
  • PLA2G5 5
  • FRFB 3

External Ids for PLA2G5 Gene

Previous GeneCards Identifiers for PLA2G5 Gene

  • GC01P019967
  • GC01P019431
  • GC01P019866
  • GC01P020142
  • GC01P020269
  • GC01P020354
  • GC01P018642

Summaries for PLA2G5 Gene

Entrez Gene Summary for PLA2G5 Gene

  • This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLA2G5 Gene

PLA2G5 (Phospholipase A2 Group V) is a Protein Coding gene. Diseases associated with PLA2G5 include Fleck Retina, Familial Benign and Late-Onset Retinal Degeneration. Among its related pathways are Sweet Taste Signaling and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity. An important paralog of this gene is PLA2G2A.

UniProtKB/Swiss-Prot Summary for PLA2G5 Gene

  • Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:8300559). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (PubMed:8300559, PubMed:14998370, PubMed:23533611). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes (PubMed:23533611). Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines (PubMed:25725101). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells (PubMed:12124392, PubMed:12796497). In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way (PubMed:12796497). In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (PubMed:12124392). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis (By similarity). May regulate antigen processing in antigen-presenting cells (By similarity). In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370).

Tocris Summary for PLA2G5 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G5 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G5 Gene

Genomics for PLA2G5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLA2G5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J020070 Promoter 0.8 EPDnew Ensembl 610.1 +42.6 42594 1.3 NR2F2 PLA2G5 piR-43105-020 lnc-PLA2G2D-2 lnc-PLA2G2F-4 PLA2G2D
GH01J020080 Enhancer 1 FANTOM5 Ensembl ENCODE 15.9 +52.2 52222 2.8 IKZF2 EED ARID3A RELB RUNX3 BCLAF1 BCL11A NBN NR2F2 IKZF1 PLA2G5 UBXN10 HTR6 NBL1 lnc-PLA2G2D-2 piR-43105-020 PLA2G2D
GH01J020032 Promoter/Enhancer 1 FANTOM5 Ensembl 13.3 +2.7 2722 5.4 SP1 ZBTB11 YY1 NCOR1 NR2F2 TAL1 ZFP91 IRF9 ZBTB40 NR4A1 piR-59056-001 PLA2G5 PLA2G2A lnc-PLA2G2F-4 lnc-PLA2G5-1 LOC100419911 PLA2G2D
GH01J020077 Enhancer 0.7 ENCODE 14.6 +50.2 50150 0.9 RELA TCF12 IKZF2 TRIM22 EED DPF2 RELB RUNX3 CBFB ARNT PLA2G5 lnc-PLA2G2D-2 piR-43105-020 PLA2G2D
GH01J020058 Enhancer 0.8 Ensembl ENCODE 11.7 +32.1 32122 5.4 IKZF2 EED DPF2 RUNX3 GATAD2B GABPA BCL11A NR2F2 IKZF1 BMI1 PLA2G5 PLA2G2D PLA2G2C OTUD3 VWA5B1 piR-43105-020 LOC100419911 lnc-PLA2G2F-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G5

Top Transcription factor binding sites by QIAGEN in the PLA2G5 gene promoter:
  • AhR
  • ATF6
  • C/EBPalpha
  • CHOP-10
  • Evi-1
  • GATA-1
  • HNF-3beta
  • HSF2
  • RORalpha2

Genomic Locations for PLA2G5 Gene

Genomic Locations for PLA2G5 Gene
chr1:20,028,179-20,091,911
(GRCh38/hg38)
Size:
63,733 bases
Orientation:
Plus strand
chr1:20,354,672-20,418,394
(GRCh37/hg19)
Size:
63,723 bases
Orientation:
Plus strand

Genomic View for PLA2G5 Gene

Genes around PLA2G5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G5 Gene

Proteins for PLA2G5 Gene

  • Protein details for PLA2G5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P39877-PA2G5_HUMAN
    Recommended name:
    Phospholipase A2 group V
    Protein Accession:
    P39877
    Secondary Accessions:
    • Q8N435

    Protein attributes for PLA2G5 Gene

    Size:
    138 amino acids
    Molecular mass:
    15674 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PLA2G5 Gene

neXtProt entry for PLA2G5 Gene

Post-translational modifications for PLA2G5 Gene

  • This enzyme lacks one of the seven disulfide bonds found in similar PLA2 proteins.

No data available for DME Specific Peptides for PLA2G5 Gene

Domains & Families for PLA2G5 Gene

Gene Families for PLA2G5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted secreted proteins

Protein Domains for PLA2G5 Gene

Suggested Antigen Peptide Sequences for PLA2G5 Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidylcholine 2-acylhydrolase 5 (PA2G5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P39877

UniProtKB/Swiss-Prot:

PA2G5_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G5: view

Function for PLA2G5 Gene

Molecular function for PLA2G5 Gene

UniProtKB/Swiss-Prot Function:
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:8300559). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (PubMed:8300559, PubMed:14998370, PubMed:23533611). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes (PubMed:23533611). Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines (PubMed:25725101). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells (PubMed:12124392, PubMed:12796497). In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way (PubMed:12796497). In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (PubMed:12124392). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis (By similarity). May regulate antigen processing in antigen-presenting cells (By similarity). In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000255|PROSITE-ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036, ECO:0000269|PubMed:23533611, ECO:0000269|PubMed:8300559};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence={ECO:0000269|PubMed:23533611, ECO:0000269|PubMed:8300559};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence={ECO:0000269|PubMed:23533611, ECO:0000269|PubMed:8300559};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence={ECO:0000269|PubMed:14998370};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence={ECO:0000269|PubMed:8300559};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+); Xref=Rhea:RHEA:41215, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:74243, ChEBI:CHEBI:133606; Evidence={ECO:0000269|PubMed:8300559};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+); Xref=Rhea:RHEA:44524, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:84472, ChEBI:CHEBI:84475; Evidence={ECO:0000250|UniProtKB:P97391};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45424, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:78097, ChEBI:CHEBI:85217; Evidence={ECO:0000269|PubMed:14998370};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+); Xref=Rhea:RHEA:40467, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:77256, ChEBI:CHEBI:77259; Evidence={ECO:0000269|PubMed:23533611};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+); Xref=Rhea:RHEA:40463, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:77253, ChEBI:CHEBI:77259; Evidence={ECO:0000269|PubMed:23533611};.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon M2 macrophage polarization in response to IL4, CSF1 or IL10.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.5. Activity remains high up to pH 9.0. {ECO:0000269|PubMed:8300559};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by cardiolipin.
GENATLAS Biochemistry:
phospholipase A2,group V,Ca2+ dependent,cytosolic,strongly expressed in heart

Enzyme Numbers (IUBMB) for PLA2G5 Gene

Phenotypes From GWAS Catalog for PLA2G5 Gene

Gene Ontology (GO) - Molecular Function for PLA2G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IBA 21873635
GO:0005509 calcium ion binding IBA --
GO:0005543 phospholipid binding IBA 21873635
GO:0008201 heparin binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLA2G5: view
genes like me logo Genes that share phenotypes with PLA2G5: view

Animal Models for PLA2G5 Gene

MGI Knock Outs for PLA2G5:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA2G5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G5 Gene

Localization for PLA2G5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G5 Gene

Secreted. Cell membrane. Cytoplasmic vesicle, phagosome. Recycling endosome. Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G5 gene
Compartment Confidence
extracellular 5
lysosome 4
plasma membrane 3
cytosol 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for PLA2G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0032009 early phagosome ISS --
GO:0032010 phagolysosome ISS --
genes like me logo Genes that share ontologies with PLA2G5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G5 Gene

Pathways & Interactions for PLA2G5 Gene

genes like me logo Genes that share pathways with PLA2G5: view

Pathways by source for PLA2G5 Gene

2 GeneGo (Thomson Reuters) pathways for PLA2G5 Gene
  • Anandamide biosynthesis and metabolism
  • Immune response CD16 signaling in NK cells
7 Qiagen pathways for PLA2G5 Gene
  • Antioxidant Action of Vitamin-C
  • cAMP Pathway
  • Chemokine Signaling
  • DHA Signaling
  • Fc-EpsilonRI Pathway

UniProtKB/Swiss-Prot P39877-PA2G5_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.
  • Pathway: Lipid metabolism; leukotriene B4 biosynthesis.
  • Pathway: Lipid metabolism; leukotriene C4 biosynthesis.

Gene Ontology (GO) - Biological Process for PLA2G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS,IBA 21873635
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006663 platelet activating factor biosynthetic process IEA --
GO:0010518 positive regulation of phospholipase activity IDA 22837859
genes like me logo Genes that share ontologies with PLA2G5: view

No data available for SIGNOR curated interactions for PLA2G5 Gene

Drugs & Compounds for PLA2G5 Gene

(16) Drugs for PLA2G5 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
linoleic acid Approved, Experimental Pharma Agonist, Full agonist, Activator, Pore Blocker, Channel blocker 0
Palmitic Acid Approved Pharma Agonist, Full agonist 27
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
alpha-linolenic acid Approved, Investigational Nutra 0

(47) Additional Compounds for PLA2G5 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
  • Eicosanoic acid
506-30-9
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
3546-17-6
LysoPC(14:0/0:0)
  • 1-C14:0-Lysophosphatidylcholine betaine
  • 1-Myristoyl-glycero-3-phosphocholine
  • 1-Myristoyl-sn-glycero-3-phosphocholine betaine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine betaine
20559-16-4
LysoPC(14:1(9Z))
  • 1-(9Z-Tetradecenoyl)-sn-glycero-3-phosphocholine
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC 14:1(9Z)/0:0
  • LPC(14:1(9Z)/0:0)
  • LysoPC 14:1(9Z)/0:0

(5) Tocris Compounds for PLA2G5 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7

(3) ApexBio Compounds for PLA2G5 Gene

Compound Action Cas Number
Anti-Inflammatory Peptide 1 PLA2 inhibitor 118850-71-8
D609 PC-PLC inhibitor 83373-60-8
Halobetasol Propionate 66852-54-8
genes like me logo Genes that share compounds with PLA2G5: view

Drug Products

Transcripts for PLA2G5 Gene

mRNA/cDNA for PLA2G5 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G5

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - -
SP8: -
SP9: - - - - - - - - -
SP10: - - - - - -

Relevant External Links for PLA2G5 Gene

GeneLoc Exon Structure for
PLA2G5

Expression for PLA2G5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G5 Gene

This gene is overexpressed in Heart - Atrial Appendage (x12.2), Ovary (x7.0), Heart - Left Ventricle (x7.0), and Artery - Coronary (x6.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G5

SOURCE GeneReport for Unigene cluster for PLA2G5 Gene:

Hs.319438

mRNA Expression by UniProt/SwissProt for PLA2G5 Gene:

P39877-PA2G5_HUMAN
Tissue specificity: Heart, placenta and less abundantly, in lung. Detected in the outer and inner plexiform layers of the retina (at protein level) (PubMed:22137173). Expressed in monocytes and macrophages (PubMed:25725101).

Evidence on tissue expression from TISSUES for PLA2G5 Gene

  • Nervous system(4.3)
  • Stomach(4.1)
  • Heart(2.6)
  • Muscle(2.6)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G5 Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Regions:
Head and neck:
  • eye
  • head
genes like me logo Genes that share expression patterns with PLA2G5: view

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PLA2G5 Gene

Orthologs for PLA2G5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLA2G5 30 31
  • 99.76 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PLA2G5 30 31
  • 86.96 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pla2g5 30
  • 79.32 (n)
Cow
(Bos Taurus)
Mammalia PLA2G5 30 31
  • 79.23 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pla2g5 30 17 31
  • 79.08 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G5 31
  • 53 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 49 (a)
OneToMany
-- 31
  • 42 (a)
OneToMany
Chicken
(Gallus gallus)
Aves PLA2G5 30 31
  • 55.96 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 42 (a)
OneToMany
Species where no ortholog for PLA2G5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PLA2G5 Gene

ENSEMBL:
Gene Tree for PLA2G5 (if available)
TreeFam:
Gene Tree for PLA2G5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLA2G5: view image

Paralogs for PLA2G5 Gene

(7) SIMAP similar genes for PLA2G5 Gene using alignment to 1 proteins:

  • PA2G5_HUMAN
genes like me logo Genes that share paralogs with PLA2G5: view

Variants for PLA2G5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G5 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
812376 Pathogenic: Late-onset retinal degeneration 20,089,882(+) C/CG FRAMESHIFT_VARIANT
837217 Uncertain Significance: not provided 20,090,643(+) G/A MISSENSE_VARIANT
845737 Uncertain Significance: not provided 20,089,824(+) TGGA/T INFRAME_DELETION
846719 Uncertain Significance: not provided 20,086,175(+) G/A MISSENSE_VARIANT
857967 Uncertain Significance: not provided 20,086,083(+) G/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for PLA2G5 Gene

Structural Variations from Database of Genomic Variants (DGV) for PLA2G5 Gene

Variant ID Type Subtype PubMed ID
esv2164449 CNV deletion 18987734
esv2435763 CNV deletion 19546169
esv25446 CNV loss 19812545
esv2665474 CNV deletion 23128226
esv3585413 CNV loss 21293372
nsv1003802 CNV loss 25217958
nsv519515 CNV loss 19592680
nsv545731 CNV gain 21841781
nsv5520 CNV deletion 18451855

Variation tolerance for PLA2G5 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G5 Gene

Human Gene Mutation Database (HGMD)
PLA2G5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G5 Gene

Disorders for PLA2G5 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PLA2G5 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
fleck retina, familial benign
  • frfb
late-onset retinal degeneration
  • retinitis pigmentosa
alcoholic gastritis
  • alcoholic gastritis, with hemorrhage
myxopapillary ependymoma
  • ependymoma myxopapillary
malignant ependymoma
  • ependymal neoplasm
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PA2G5_HUMAN
  • Fleck retina, familial benign (FRFB) [MIM:228980]: An autosomal recessive condition associated with a distinctive retinal appearance and no apparent visual or electrophysiologic deficits. Affected individuals are asymptomatic, but fundus examination reveals a striking pattern of diffuse, yellow-white, fleck-like lesions extending to the far periphery of the retina but sparing the foveal region. {ECO:0000269 PubMed:22137173, ECO:0000269 PubMed:25549071}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PLA2G5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PLA2G5: view

No data available for Genatlas for PLA2G5 Gene

Publications for PLA2G5 Gene

  1. Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study. (PMID: 17545304) Wootton PT … Talmud PJ (Human molecular genetics 2007) 3 23 41
  2. Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. (PMID: 12796497) Muñoz NM … Cho W (The Journal of biological chemistry 2003) 3 4 23
  3. Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group IVA phospholipase A2. (PMID: 12124392) Kim YJ … Cho W (The Journal of biological chemistry 2002) 3 4 23
  4. Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2. (PMID: 8300559) Chen J … Tischfield JA (The Journal of biological chemistry 1994) 2 3 4
  5. Phospholipase A2 group v in benign familial fleck retina in a set of triplets. (PMID: 25549071) Bin NJ … Subrayan V (Retina (Philadelphia, Pa.) 2015) 3 4

Products for PLA2G5 Gene

  • Signalway ELISA kits for PLA2G5
  • Signalway Proteins for PLA2G5

Sources for PLA2G5 Gene