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PLA2G4F (Phospholipase A2 Group IVF) is a Protein Coding gene. Diseases associated with PLA2G4F include Ileocolitis and Inflammatory Bowel Disease 9. Among its related pathways are Sweet Taste Signaling and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include phospholipase A2 activity and lysophospholipase activity. An important paralog of this gene is JMJD7-PLA2G4B.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004620 | phospholipase activity | IEA | -- |
GO:0004622 | lysophospholipase activity | IEA | -- |
GO:0004623 | phospholipase A2 activity | IBA | 21873635 |
GO:0005509 | calcium ion binding | IEA,IBA | 21873635 |
GO:0005544 | calcium-dependent phospholipid binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | -- |
GO:0005764 | lysosome | IEA | -- |
GO:0005765 | lysosomal membrane | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glycerophospholipid biosynthesis | ||
2 | Acyl chain remodelling of PE | ||
3 | Linoleic acid metabolism | ||
4 | Metabolism |
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5 | Phospholipase D signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001516 | prostaglandin biosynthetic process | IEA | -- |
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006644 | phospholipid metabolic process | TAS | -- |
GO:0009395 | phospholipid catabolic process | IEA | -- |
GO:0015908 | fatty acid transport | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
linoleic acid | Approved, Experimental | Pharma | Agonist, Full agonist, Activator, Pore Blocker, Channel blocker | 0 | ||
Palmitic Acid | Approved | Pharma | Agonist, Full agonist | 27 | ||
Stearic acid | Approved, Experimental | Pharma | 0 | |||
Water | Approved | Pharma | 0 | |||
alpha-linolenic acid | Approved, Investigational | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Arachidic acid |
|
506-30-9 |
|
|||
Heptadecanoic acid |
|
506-12-7 |
|
|||
Heptadecanoyl CoA |
|
3546-17-6 |
|
|||
PC(18:1(9Z)e/2:0) |
|
|
||||
Pentadecanoic acid |
|
1002-84-2 |
|
Compound | Action | Cas Number |
---|---|---|
AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
m-3M3FBS | Phospholipase C activator | 200933-14-8 |
o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
U 73122 | Phospholipase C inhibitor | 112648-68-7 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PLA2G4F 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PLA2G4F 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PLA2G4F 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pla2g4f 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pla2g4f 30 |
|
||
Chicken (Gallus gallus) |
Aves | PLA2G4F 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | PLA2G4F 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pla2g4f 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC798864 30 |
|
||
PLA2G4F (2 of 2) 31 |
|
OneToMany | |||
PLA2G4F (1 of 2) 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PLB1 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2664756 | CNV | deletion | 23128226 |
esv2749622 | CNV | deletion | 23290073 |
esv3385504 | CNV | duplication | 20981092 |
esv3446241 | CNV | duplication | 20981092 |
esv3636260 | CNV | loss | 21293372 |
esv3892678 | CNV | loss | 25118596 |
nsv1035998 | CNV | gain | 25217958 |
nsv442371 | CNV | loss | 18776908 |
nsv471683 | CNV | gain+loss | 15918152 |
nsv569237 | CNV | loss | 21841781 |
nsv832985 | CNV | loss | 17160897 |
nsv9245 | CNV | gain | 18304495 |
nsv952614 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ileocolitis |
|
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inflammatory bowel disease 9 |
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inflammatory bowel disease 1 |
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