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Aliases for PLA2G4F Gene
Aliases for PLA2G4F Gene
External Ids for PLA2G4F Gene
- HGNC: 27396
- NCBI Entrez Gene: 255189
- Ensembl: ENSG00000168907
- UniProtKB/Swiss-Prot: Q68DD2
Previous GeneCards Identifiers for PLA2G4F Gene
- GC15M040221
- GC15M042433
- GC15M019282
Summaries for PLA2G4F Gene
GeneCards Summary for PLA2G4F Gene
PLA2G4F (Phospholipase A2 Group IVF) is a Protein Coding gene. Diseases associated with PLA2G4F include Ileocolitis and Inflammatory Bowel Disease 9. Among its related pathways are Ras signaling pathway and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include phospholipase A2 activity and lysophospholipase activity. An important paralog of this gene is PLA2G4B.
UniProtKB/Swiss-Prot Summary for PLA2G4F Gene
-
Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:29158256). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:29158256). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:29158256). In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (PubMed:29158256).
-
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
Additional gene information for PLA2G4F Gene
- HGNC (27396)
- NCBI Entrez Gene (255189)
- Ensembl (ENSG00000168907)
- UniProtKB/Swiss-Prot (Q68DD2)
- Open Targets Platform(ENSG00000168907)
- Monarch Initiative
- Alliance of Genome Resources
- Search for PLA2G4F at DataMed
- Search for PLA2G4F at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G4F Gene
Genomics for PLA2G4F Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PLA2G4F Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PLA2G4F on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G4F
- Top Transcription factor binding sites by QIAGEN in the PLA2G4F gene promoter:
-
- AML1a
- CUTL1
- E47
- Hand1
- HSF1 (long)
- HSF1short
- HTF
- Lmo2
- MZF-1
Genomic Locations for PLA2G4F Gene
Latest Assembly
- chr15:42,139,034-42,156,636
- (GRCh38/hg38)
- Size:
- 17,603 bases
- Orientation:
- Minus strand
Previous Assembly
- chr15:42,431,232-42,448,834
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 17,603 bases
- Orientation:
- Minus strand
Genomic View for PLA2G4F Gene
Genes around PLA2G4F on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q15.1 by HGNC
- 15q15.1 by Entrez Gene
- 15q15.1 by Ensembl
PLA2G4F Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLA2G4F Gene
Proteins for PLA2G4F Gene
-
Protein details for PLA2G4F Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q68DD2-PA24F_HUMAN
- Recommended name:
- Cytosolic phospholipase A2 zeta
- Protein Accession:
- Q68DD2
- Q6ZMC8
Protein attributes for PLA2G4F Gene
- Size:
- 849 amino acids
- Molecular mass:
- 95082 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
- No Data Available
Protein Expression for PLA2G4F Gene
Post-translational modifications for PLA2G4F Gene
Other Protein References for PLA2G4F Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ PLA2G4F Antibody
- Novus Biologicals Antibodies for PLA2G4F
- Invitrogen Antibodies for PLA2G4F (AFLGC-PLA2G4F)
- antibodies-online: Show 4 available CPLA2-zeta Antibodies ranked by validation data
-
Boster Bio Antibodies for PLA2G4F
-
Custom Antibody ServicesProSci Antibodies for PLA2G4F
-
Santa Cruz Biotechnology (SCBT) Antibodies for PLA2G4F
- Sino Biological Antibodies for PLA2G4F
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PLA2G4F
- Origene Custom Protein Services for PLA2G4F
- Novus Biologicals proteins for PLA2G4F
Assay products for research
No data available for DME Specific Peptides for PLA2G4F Gene
Domains & Families for PLA2G4F Gene
Gene Families for PLA2G4F Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PLA2G4F Gene
- InterPro:
- Blocks:
-
- C2 domain
- Lysophospholipase, catalytic domain
Suggested Antigen Peptide Sequences for PLA2G4F Gene
- GenScript: Design optimal peptide antigens:
-
- PLA2G4F protein (A2RRC4_HUMAN)
- Phospholipase A2, group IVF (A5PKZ7_HUMAN)
- Phospholipase A2, group IVF (A6H8K5_HUMAN)
- Phospholipase A2 group IVF (PA24F_HUMAN)
- PLA2G4F protein (Q8IUP3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q68DD2UniProtKB/Swiss-Prot:
PA24F_HUMAN :- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
- Domain:
-
- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
Function for PLA2G4F Gene
Molecular function for PLA2G4F Gene
- UniProtKB/Swiss-Prot Function:
- Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:29158256). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:29158256). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:29158256). In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (PubMed:29158256).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269|PubMed:29158256};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:38783, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73001, ChEBI:CHEBI:76071; Evidence={ECO:0000250|UniProtKB:Q50L41};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence={ECO:0000250|UniProtKB:Q50L41};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence={ECO:0000269|PubMed:29158256};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence={ECO:0000250|UniProtKB:Q50L41};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence={ECO:0000250|UniProtKB:Q50L41};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41271, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:77695, ChEBI:CHEBI:77696; Evidence={ECO:0000250|UniProtKB:Q50L41};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41067, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:55430, ChEBI:CHEBI:64496; Evidence={ECO:0000250|UniProtKB:Q50L41};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence={ECO:0000250|UniProtKB:Q50L41};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Stimulated by cytosolic Ca(2+).
Enzyme Numbers (IUBMB) for PLA2G4F Gene
Phenotypes From GWAS Catalog for PLA2G4F Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004620 | phospholipase activity | IEA | -- |
| GO:0004622 | lysophospholipase activity | IEA | -- |
| GO:0004623 | phospholipase A2 activity | IBA | 21873635 |
| GO:0005509 | calcium ion binding | IEA,IBA | 21873635 |
| GO:0005544 | calcium-dependent phospholipid binding | IBA | 21873635 |
Phenotypes for PLA2G4F Gene
- MGI mutant phenotypes for PLA2G4F:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PLA2G4F:
Animal Models for PLA2G4F Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PLA2G4F - Starting at $85 >
- * PLA2G4F CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PLA2G4F
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4F
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4F
miRNA for PLA2G4F Gene
- miRTarBase miRNAs that target PLA2G4F
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4F
- Browse OriGene Inhibitory RNA Products For PLA2G4F
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4F
Clone products for research
- Applied Biological Materials (abm): Clones for PLA2G4F - Starting at $45 >
- * PLA2G4F as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PLA2G4F
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4F
Cell Lines for research
-
Horizon Cell Lines for PLA2G4F
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G4F Gene
Localization for PLA2G4F Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4F Gene
- Cytoplasm, cytosol. Cell membrane. Peripheral membrane protein. Mitochondrion.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| plasma membrane | 3 |
| mitochondrion | 3 |
| extracellular | 2 |
| nucleus | 1 |
| lysosome | 0 |
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for PLA2G4F Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycerophospholipid biosynthesis | ||
| 2 | Acyl chain remodelling of PE | ||
| 3 | Linoleic acid metabolism | ||
| 4 | Metabolism |
.40
|
|
| 5 | Phospholipase D signaling pathway | ||
Pathways by source for PLA2G4F Gene
1 BioSystems pathway for PLA2G4F Gene
10 Reactome pathways for PLA2G4F Gene
23 KEGG pathways for PLA2G4F Gene
3 Qiagen pathways for PLA2G4F Gene
- cAMP Pathway
- Phospholipase-C Pathway
- Sperm Motility
Interacting Proteins for PLA2G4F Gene
GPS-Prot Interaction Network for PLA2G4F
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001516 | prostaglandin biosynthetic process | IEA | -- |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006644 | phospholipid metabolic process | TAS | -- |
| GO:0009395 | phospholipid catabolic process | IEA | -- |
| GO:0015908 | fatty acid transport | IEA | -- |
No data available for SIGNOR curated interactions for PLA2G4F Gene
Drugs & Compounds for PLA2G4F Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Arachidic acid |
|
506-30-9 |
|
|||
| CE(22:0) |
|
61510-09-6 |
|
|||
| Heptadecanoic acid |
|
506-12-7 |
|
|||
| Heptadecanoyl CoA |
|
3546-17-6 |
|
|||
| PC(18:1(9Z)e/2:0) |
|
|
(5) Tocris Compounds for PLA2G4F Gene
| Compound | Action | Cas Number |
|---|---|---|
| AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
| Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
| m-3M3FBS | Phospholipase C activator | 200933-14-8 |
| o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
| U 73122 | Phospholipase C inhibitor | 112648-68-7 |
Transcripts for PLA2G4F Gene
mRNA/cDNA for PLA2G4F Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000290497 3319 nts (view in UCSC)
- ENST00000397272 5587 nts (view in UCSC)
- ENST00000561627 584 nts (view in UCSC)
- ENST00000561893 780 nts (view in UCSC)
- ENST00000562320 1402 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PLA2G4F - Starting at $85 >
- * PLA2G4F CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PLA2G4F
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4F
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4F
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4F
- Browse OriGene Inhibitory RNA Products For PLA2G4F
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4F
Clone products for research
- Applied Biological Materials (abm): Clones for PLA2G4F - Starting at $45 >
- * PLA2G4F as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PLA2G4F
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4F
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - |
Relevant External Links for PLA2G4F Gene
- GeneLoc Exon Structure for
- PLA2G4F
Expression for PLA2G4F Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for PLA2G4F Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x15.4) and Skin - Sun Exposed (Lower leg) (x13.6).
This gene is overexpressed in Kidney (29.3), Brain (22.0), and Stomach (14.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G4F Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G4F
SOURCE GeneReport for Unigene cluster for PLA2G4F Gene:
Hs.231873mRNA Expression by UniProt/SwissProt for PLA2G4F Gene:
Q68DD2-PA24F_HUMAN
Tissue specificity:
Expressed in myocardium (at protein level).
Evidence on tissue expression from TISSUES for PLA2G4F Gene
- Intestine(4.3)
- Heart(4.1)
- Muscle(4)
- Skin(2.4)
Primer products for research
-
OriGene qPCR primer pairs for PLA2G4F
Gene Expression Assays for research
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4F Gene
Orthologs for PLA2G4F Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PLA2G4F 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PLA2G4F 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PLA2G4F 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pla2g4f 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pla2g4f 29 |
|
||
| Chicken (Gallus gallus) |
Aves | PLA2G4F 29 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | PLA2G4F 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pla2g4f 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC798864 29 |
|
||
| PLA2G4F (2 of 2) 30 |
|
OneToMany | |||
| PLA2G4F (1 of 2) 30 |
|
OneToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PLB1 32 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany |
- Species where no ortholog for PLA2G4F was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PLA2G4F Gene
- ENSEMBL:
- Gene Tree for PLA2G4F (if available)
- TreeFam:
- Gene Tree for PLA2G4F (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PLA2G4F: view image
- Alliance of Genome Resources:
- Additional Orthologs for PLA2G4F
Paralogs for PLA2G4F Gene
(5) SIMAP similar genes for PLA2G4F Gene using alignment to 11 proteins:
- PA24F_HUMAN
- A2RRC4_HUMAN
- A5PKZ7_HUMAN
- A6H8K5_HUMAN
- C9J281_HUMAN
- H3BMD0_HUMAN
- H3BNW4_HUMAN
- H3BPX7_HUMAN
- H3BSG9_HUMAN
- H7BXJ8_HUMAN
- Q8IUP3_HUMAN
Variants for PLA2G4F Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2664756 | CNV | deletion | 23128226 |
| esv2749622 | CNV | deletion | 23290073 |
| esv3385504 | CNV | duplication | 20981092 |
| esv3446241 | CNV | duplication | 20981092 |
| esv3636260 | CNV | loss | 21293372 |
| esv3892678 | CNV | loss | 25118596 |
| nsv1035998 | CNV | gain | 25217958 |
| nsv442371 | CNV | loss | 18776908 |
| nsv471683 | CNV | gain+loss | 15918152 |
| nsv569237 | CNV | loss | 21841781 |
| nsv832985 | CNV | loss | 17160897 |
| nsv9245 | CNV | gain | 18304495 |
| nsv952614 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.37;
76.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLA2G4F Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4F Gene
Disorders for PLA2G4F Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ileocolitis |
|
|
| inflammatory bowel disease 9 |
|
|
| inflammatory bowel disease 1 |
|
|
Search PLA2G4F in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PLA2G4F
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G4F Gene
Publications for PLA2G4F Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4
- Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. (PMID: 15866882) Ohto T … Shimizu T (The Journal of biological chemistry 2005) 2 3
- Heart failure-induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore. (PMID: 29158256) Moon SH … Gross RW (The Journal of biological chemistry 2018) 4
ExternalLinks
Products for PLA2G4F Gene
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- Invitrogen Antibodies for PLA2G4F (AFLGC-PLA2G4F)
- VectorBuilder Custom and pre-made DNA vectors for PLA2G4F (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PLA2G4F (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PLA2G4F (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PLA2G4F CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PLA2G4F
- antibodies-online: Show 4 available CPLA2-zeta Antibodies ranked by validation data
- antibodies-online: Search results for available CPLA2-zeta related products ranked by validation data
- antibodies-online: Search results for available CPLA2-zeta related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for PLA2G4F
- Search Santa Cruz Biotechnology (SCBT) for PLA2G4F siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4F
- Horizon Cell Lines for PLA2G4F
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4F
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for PLA2G4F
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4F
- Boster Bio Antibodies for PLA2G4F
- Browse Boster Bio ELISA Kits
Sources for PLA2G4F Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
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