Aliases for PLA2G4F Gene

Aliases for PLA2G4F Gene

  • Phospholipase A2 Group IVF 2 3 4 5
  • Cytosolic Phospholipase A2 Zeta 3 4
  • CPLA2-Zeta 3 4
  • Phospholipase A2, Group IVF 2
  • EC 3.1.1.4 4
  • PLA2G4F/Z 2
  • PLA2G4FZ 3
  • PLA2G4F 5

External Ids for PLA2G4F Gene

Previous GeneCards Identifiers for PLA2G4F Gene

  • GC15M040221
  • GC15M042433
  • GC15M019282

Summaries for PLA2G4F Gene

GeneCards Summary for PLA2G4F Gene

PLA2G4F (Phospholipase A2 Group IVF) is a Protein Coding gene. Diseases associated with PLA2G4F include Ileocolitis and Inflammatory Bowel Disease 9. Among its related pathways are Sweet Taste Signaling and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include phospholipase A2 activity and lysophospholipase activity. An important paralog of this gene is JMJD7-PLA2G4B.

UniProtKB/Swiss-Prot Summary for PLA2G4F Gene

  • Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity).

Tocris Summary for PLA2G4F Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Additional gene information for PLA2G4F Gene

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G4F Gene

Genomics for PLA2G4F Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLA2G4F Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J042155 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 600.7 +0.4 384 1.7 REST MNT CTBP1 PKNOX1 SIN3A CTCF GATA3 DPF2 ZNF18 STAT5A PLA2G4F LRRC57 HSALNG0105405 PLA2G4D
GH15J042158 Enhancer 0.9 Ensembl ENCODE 600.7 -2.0 -1965 2 IKZF1 JUND ZIC2 PKNOX1 DPF2 HDAC1 MGA CTBP1 NFE2 HDAC2 PLA2G4F piR-39496 MIR627 GANC VPS39
GH15J042359 Promoter/Enhancer 1.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -203.5 -203544 1.6 SPI1 CAPN3 LRRC57 PLA2G4F ZNF106 STARD9 ENSG00000258461 piR-38257-006
GH15J042065 Enhancer 1 Ensembl ENCODE 11.6 +90.9 90930 2.6 CREB1 GATAD2A CTCF ZSCAN4 RXRB PATZ1 REST RAD21 ZNF740 SOX13 PLA2G4E-AS1 PLA2G4D PLA2G4F EHD4 GANC HSALNG0105403 PLA2G4E lnc-PLA2G4E-1
GH15J042118 Enhancer 0.8 Ensembl ENCODE 12 +35.4 35435 5.6 FOXA1 ZNF341 SCRT2 CEBPB NFE2 MYNN SCRT1 MAFG ZFHX2 GATA3 PLA2G4D PLA2G4F PLA2G4E EHD4 PLA2G4E-AS1 HAUS2 RPAP1 HSALNG0105405
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G4F on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G4F

Top Transcription factor binding sites by QIAGEN in the PLA2G4F gene promoter:
  • AML1a
  • CUTL1
  • E47
  • Hand1
  • HSF1 (long)
  • HSF1short
  • HTF
  • Lmo2
  • MZF-1

Genomic Locations for PLA2G4F Gene

Genomic Locations for PLA2G4F Gene
chr15:42,139,034-42,156,636
(GRCh38/hg38)
Size:
17,603 bases
Orientation:
Minus strand
chr15:42,433,332-42,448,839
(GRCh37/hg19)
Size:
15,508 bases
Orientation:
Minus strand

Genomic View for PLA2G4F Gene

Genes around PLA2G4F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G4F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G4F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G4F Gene

Proteins for PLA2G4F Gene

  • Protein details for PLA2G4F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DD2-PA24F_HUMAN
    Recommended name:
    Cytosolic phospholipase A2 zeta
    Protein Accession:
    Q68DD2
    Secondary Accessions:
    • Q6ZMC8

    Protein attributes for PLA2G4F Gene

    Size:
    849 amino acids
    Molecular mass:
    95082 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G4F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G4F Gene

Post-translational modifications for PLA2G4F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G4F Gene

No data available for DME Specific Peptides for PLA2G4F Gene

Domains & Families for PLA2G4F Gene

Gene Families for PLA2G4F Gene

Protein Domains for PLA2G4F Gene

InterPro:
Blocks:
  • C2 domain
  • Lysophospholipase, catalytic domain
ProtoNet:

Suggested Antigen Peptide Sequences for PLA2G4F Gene

GenScript: Design optimal peptide antigens:
  • PLA2G4F protein (A2RRC4_HUMAN)
  • Phospholipase A2, group IVF (A5PKZ7_HUMAN)
  • Phospholipase A2, group IVF (A6H8K5_HUMAN)
  • Phospholipase A2 group IVF (PA24F_HUMAN)
  • PLA2G4F protein (Q8IUP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q68DD2

UniProtKB/Swiss-Prot:

PA24F_HUMAN :
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
Domain:
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
genes like me logo Genes that share domains with PLA2G4F: view

Function for PLA2G4F Gene

Molecular function for PLA2G4F Gene

UniProtKB/Swiss-Prot Function:
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by cytosolic Ca(2+).

Enzyme Numbers (IUBMB) for PLA2G4F Gene

Phenotypes From GWAS Catalog for PLA2G4F Gene

Gene Ontology (GO) - Molecular Function for PLA2G4F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IEA --
GO:0004622 lysophospholipase activity IEA --
GO:0004623 phospholipase A2 activity IBA 21873635
GO:0005509 calcium ion binding IEA,IBA 21873635
GO:0005544 calcium-dependent phospholipid binding IBA 21873635
genes like me logo Genes that share ontologies with PLA2G4F: view
genes like me logo Genes that share phenotypes with PLA2G4F: view

Animal Models for PLA2G4F Gene

MGI Knock Outs for PLA2G4F:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4F

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G4F Gene

Localization for PLA2G4F Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4F Gene

Cytoplasm, cytosol. Lysosome membrane. Peripheral membrane protein. Cytoplasmic side. Note=Translocates to lysosomal membranes in a calcium-dependent fashion. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G4F gene
Compartment Confidence
cytosol 4
plasma membrane 3
lysosome 3
extracellular 2
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLA2G4F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PLA2G4F: view

Pathways & Interactions for PLA2G4F Gene

genes like me logo Genes that share pathways with PLA2G4F: view

Pathways by source for PLA2G4F Gene

3 Qiagen pathways for PLA2G4F Gene
  • cAMP Pathway
  • Phospholipase-C Pathway
  • Sperm Motility

Interacting Proteins for PLA2G4F Gene

Gene Ontology (GO) - Biological Process for PLA2G4F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0009395 phospholipid catabolic process IEA --
GO:0015908 fatty acid transport IEA --
genes like me logo Genes that share ontologies with PLA2G4F: view

No data available for SIGNOR curated interactions for PLA2G4F Gene

Drugs & Compounds for PLA2G4F Gene

(10) Drugs for PLA2G4F Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
linoleic acid Approved, Experimental Pharma Agonist, Full agonist, Activator, Pore Blocker, Channel blocker 0
Palmitic Acid Approved Pharma Agonist, Full agonist 27
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
alpha-linolenic acid Approved, Investigational Nutra 0

(11) Additional Compounds for PLA2G4F Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
  • Eicosanoic acid
506-30-9
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
3546-17-6
PC(18:1(9Z)e/2:0)
  • (2-Acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Pentadecanoic acid
  • 15:00
  • C15
  • C15:0
  • N-Pentadecanoic acid
  • Pentadecylic acid
1002-84-2

(5) Tocris Compounds for PLA2G4F Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G4F: view

Transcripts for PLA2G4F Gene

mRNA/cDNA for PLA2G4F Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4F

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G4F Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: -
SP2: - -
SP3:
SP4: -

Relevant External Links for PLA2G4F Gene

GeneLoc Exon Structure for
PLA2G4F

Expression for PLA2G4F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G4F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G4F Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x15.4) and Skin - Sun Exposed (Lower leg) (x13.6).

Protein differential expression in normal tissues from HIPED for PLA2G4F Gene

This gene is overexpressed in Kidney (29.3), Brain (22.0), and Stomach (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G4F Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G4F

SOURCE GeneReport for Unigene cluster for PLA2G4F Gene:

Hs.231873

Evidence on tissue expression from TISSUES for PLA2G4F Gene

  • Intestine(4.3)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with PLA2G4F: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4F Gene

Orthologs for PLA2G4F Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLA2G4F Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLA2G4F 30 31
  • 98.94 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PLA2G4F 30 31
  • 85.87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PLA2G4F 30 31
  • 84.85 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pla2g4f 30 17 31
  • 79.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pla2g4f 30
  • 79.23 (n)
Chicken
(Gallus gallus)
Aves PLA2G4F 30
  • 61.16 (n)
Lizard
(Anolis carolinensis)
Reptilia PLA2G4F 31
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pla2g4f 30
  • 58.79 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC798864 30
  • 50.54 (n)
PLA2G4F (2 of 2) 31
  • 38 (a)
OneToMany
PLA2G4F (1 of 2) 31
  • 38 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLB1 33
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
Species where no ortholog for PLA2G4F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PLA2G4F Gene

ENSEMBL:
Gene Tree for PLA2G4F (if available)
TreeFam:
Gene Tree for PLA2G4F (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLA2G4F: view image

Paralogs for PLA2G4F Gene

Paralogs for PLA2G4F Gene

(5) SIMAP similar genes for PLA2G4F Gene using alignment to 11 proteins:

  • PA24F_HUMAN
  • A2RRC4_HUMAN
  • A5PKZ7_HUMAN
  • A6H8K5_HUMAN
  • C9J281_HUMAN
  • H3BMD0_HUMAN
  • H3BNW4_HUMAN
  • H3BPX7_HUMAN
  • H3BSG9_HUMAN
  • H7BXJ8_HUMAN
  • Q8IUP3_HUMAN
genes like me logo Genes that share paralogs with PLA2G4F: view

Variants for PLA2G4F Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G4F Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs1356410 - p.Met740Val
rs636604 - p.Gly30Val

Additional dbSNP identifiers (rs#s) for PLA2G4F Gene

Structural Variations from Database of Genomic Variants (DGV) for PLA2G4F Gene

Variant ID Type Subtype PubMed ID
esv2664756 CNV deletion 23128226
esv2749622 CNV deletion 23290073
esv3385504 CNV duplication 20981092
esv3446241 CNV duplication 20981092
esv3636260 CNV loss 21293372
esv3892678 CNV loss 25118596
nsv1035998 CNV gain 25217958
nsv442371 CNV loss 18776908
nsv471683 CNV gain+loss 15918152
nsv569237 CNV loss 21841781
nsv832985 CNV loss 17160897
nsv9245 CNV gain 18304495
nsv952614 CNV deletion 24416366

Variation tolerance for PLA2G4F Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.37; 76.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G4F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G4F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4F Gene

Disorders for PLA2G4F Gene

MalaCards: The human disease database

(3) MalaCards diseases for PLA2G4F Gene - From: DISEASES

Disorder Aliases PubMed IDs
ileocolitis
  • iieocolitis
inflammatory bowel disease 9
  • ibd9
inflammatory bowel disease 1
  • ibd1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLA2G4F

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PLA2G4F: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G4F Gene

Publications for PLA2G4F Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4
  4. Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. (PMID: 15866882) Ohto T … Shimizu T (The Journal of biological chemistry 2005) 2 3
  5. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X … REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component International (PloS one 2013) 3

Products for PLA2G4F Gene

Sources for PLA2G4F Gene