Aliases for PLA2G4F Gene
External Ids for PLA2G4F Gene
Previous GeneCards Identifiers for PLA2G4F Gene
GeneCards Summary for PLA2G4F Gene
PLA2G4F (Phospholipase A2 Group IVF) is a Protein Coding gene. Diseases associated with PLA2G4F include Ileocolitis and Inflammatory Bowel Disease 9. Among its related pathways are Ras signaling pathway and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include phospholipase A2 activity and lysophospholipase activity. An important paralog of this gene is PLA2G4B.
UniProtKB/Swiss-Prot Summary for PLA2G4F Gene
Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:29158256). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:29158256). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:29158256). In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (PubMed:29158256).
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.