Aliases for PLA2G4E Gene
Aliases for PLA2G4E Gene
External Ids for PLA2G4E Gene
- HGNC: 24791
- Entrez Gene: 123745
- Ensembl: ENSG00000188089
- UniProtKB: Q3MJ16
Previous GeneCards Identifiers for PLA2G4E Gene
- GC15M040062
- GC15M042273
- GC15M019125
Summaries for PLA2G4E Gene
-
This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017]
GeneCards Summary for PLA2G4E Gene
PLA2G4E (Phospholipase A2 Group IVE) is a Protein Coding gene. Among its related pathways are Ovarian steroidogenesis and Metabolism. Gene Ontology (GO) annotations related to this gene include phospholipase A2 activity and phospholipase activity. An important paralog of this gene is PLA2G4D.
UniProtKB/Swiss-Prot for PLA2G4E Gene
-
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position.
-
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
Additional gene information for PLA2G4E Gene
No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G4E Gene
Genomics for PLA2G4E Gene
GeneHancer (GH) Regulatory Elements for PLA2G4E Gene
Promoters and enhancers for PLA2G4E Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PLA2G4E on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PLA2G4E gene promoter:
-
- POU3F2
- c-Jun
- Nkx5-1
- AP-1
- c-Fos
- FosB
- Fra-1
- JunB
- JunD
- Pax-3
Regulatory Element Products
Genomic Locations for PLA2G4E Gene
Genomic Locations for PLA2G4E Gene
- chr15:41,981,582-42,051,190
- (GRCh38/hg38)
- Size:
- 69,609 bases
- Orientation:
- Minus strand
- chr15:42,273,780-42,343,388
- (GRCh37/hg19)
- Size:
- 69,609 bases
- Orientation:
- Minus strand
Genomic View for PLA2G4E Gene
Genes around PLA2G4E on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q15.1 by Entrez Gene
- 15q15.1 by HGNC
- 15q15.1 by Ensembl
PLA2G4E Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLA2G4E Gene
Proteins for PLA2G4E Gene
-
Protein details for PLA2G4E Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q3MJ16-PA24E_HUMAN
- Recommended name:
- Cytosolic phospholipase A2 epsilon
- Protein Accession:
- Q3MJ16
- B7WPN2
- Q6ZSC0
Protein attributes for PLA2G4E Gene
- Size:
- 868 amino acids
- Molecular mass:
- 99190 Da
- Quaternary structure:
- No Data Available
Protein Expression for PLA2G4E Gene
Post-translational modifications for PLA2G4E Gene
Other Protein References for PLA2G4E Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PLA2G4E
-
Abcam antibodies for PLA2G4E
- Invitrogen Antibodies for PLA2G4E (AFLGC-PLA2G4E)
- GeneTex PLA2G4E Antibody for PLA2G4E
-
Boster Bio Antibodies for PLA2G4E
Protein Products
-
OriGene Purified Proteins for PLA2G4E
- Search Origene for MassSpec and Protein Over-expression Lysates for PLA2G4E
- Origene Custom Protein Services for PLA2G4E
- Novus Biologicals proteins for PLA2G4E
- Search GeneTex for Proteins for PLA2G4E
Assay Products
No data available for DME Specific Peptides for PLA2G4E Gene
Domains & Families for PLA2G4E Gene
Gene Families for PLA2G4E Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PLA2G4E Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PLA2G4E Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q3MJ16UniProtKB/Swiss-Prot:
PA24E_HUMAN :- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
- Domain:
-
- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
Function for PLA2G4E Gene
Molecular function for PLA2G4E Gene
- UniProtKB/Swiss-Prot Function:
- Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Stimulated by cytosolic Ca(2+).
Enzyme Numbers (IUBMB) for PLA2G4E Gene
Phenotypes From GWAS Catalog for PLA2G4E Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004622 | lysophospholipase activity | TAS | -- |
| GO:0004623 | phospholipase A2 activity | TAS | -- |
| GO:0008970 | phosphatidylcholine 1-acylhydrolase activity | TAS | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for PLA2G4E Gene
Animal Model Products
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-
CRISPR Products
-
OriGene CRISPR knockouts for PLA2G4E
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4E
- GenScript: Design CRISPR guide RNA sequences for PLA2G4E
miRNA for PLA2G4E Gene
- miRTarBase miRNAs that target PLA2G4E
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4E
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Clone Products
- Sino Biological Human cDNA Clone for PLA2G4E
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- genomics-online: cdna clones - Search results for available PLA2G4E gene related products
- orf clones - Search results for available PLA2G4E gene related products
- Applied Biological Materials Clones for PLA2G4E
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PLA2G4E
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G4E Gene
Localization for PLA2G4E Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4E Gene
- Cytoplasm, cytosol. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocates to lysosomal membranes in a calcium-dependent fashion. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| lysosome | 3 |
| nucleus | 2 |
| peroxisome | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G4E Gene
Pathways & Interactions for PLA2G4E Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycerophospholipid biosynthesis | ||
| 2 | Acyl chain remodelling of PE | ||
| 3 | Linoleic acid metabolism | ||
| 4 | Metabolism |
.37
|
|
| 5 | Phospholipase D signaling pathway | ||
Pathways by source for PLA2G4E Gene
1 BioSystems pathway for PLA2G4E Gene
9 Reactome pathways for PLA2G4E Gene
23 KEGG pathways for PLA2G4E Gene
Interacting Proteins for PLA2G4E Gene
GPS-Prot Interaction Network for PLA2G4E
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006644 | phospholipid metabolic process | TAS | -- |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0009395 | phospholipid catabolic process | IEA | -- |
| GO:0016042 | lipid catabolic process | IEA | -- |
No data available for SIGNOR curated interactions for PLA2G4E Gene
Drugs & Compounds for PLA2G4E Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Arachidic acid |
|
506-30-9 |
|
|||
| Heptadecanoic acid |
|
506-12-7 |
|
|||
| Heptadecanoyl CoA |
|
3546-17-6 |
|
|||
| PC(18:1(9Z)e/2:0) |
|
|
||||
| Pentadecanoic acid |
|
1002-84-2 |
|
(5) Tocris Compounds for PLA2G4E Gene
| Compound | Action | Cas Number |
|---|---|---|
| AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
| Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
| m-3M3FBS | Phospholipase C activator | 200933-14-8 |
| o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
| U 73122 | Phospholipase C inhibitor | 112648-68-7 |
Drug Products
Transcripts for PLA2G4E Gene
mRNA/cDNA for PLA2G4E Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (14) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000399518 5266 bps (uc021sjp.2)
- ENST00000547930 4066 bps (uc059ibp.1)
- ENST00000551073 826 bps (uc059ibq.1)
Unigene Clusters for PLA2G4E Gene
- Phospholipase A2, group IVE:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PLA2G4E
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4E
- genomics-online: gRNA clones - Search results for available PLA2G4E gene related products
- Applied Biological Materials CRISPR for PLA2G4E
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4E
- GenScript: Design CRISPR guide RNA sequences for PLA2G4E
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4E
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4E
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Clone Products
- Sino Biological Human cDNA Clone for PLA2G4E
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4E
- genomics-online: cdna clones - Search results for available PLA2G4E gene related products
- orf clones - Search results for available PLA2G4E gene related products
- Applied Biological Materials Clones for PLA2G4E
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PLA2G4E Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
- Lung (Respiratory System)
- Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for PLA2G4E Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x22.8), Skin - Not Sun Exposed (Suprapubic) (x18.4), and Minor Salivary Gland (x4.7).
This gene is overexpressed in Serum (56.1) and Pancreatic juice (12.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G4E Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PLA2G4E Gene:
PLA2G4ESOURCE GeneReport for Unigene cluster for PLA2G4E Gene:
Hs.668060Evidence on tissue expression from TISSUES for PLA2G4E Gene
- Heart(4)
- Lung(4)
Primer Products
-
OriGene qPCR primer pairs for PLA2G4E
- genomics-online: primer clones - Search results for available PLA2G4E gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4E Gene
Orthologs for PLA2G4E Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PLA2G4E 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PLA2G4E 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PLA2G4E 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Pla2g4e 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Pla2g4e 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | PLA2G4E 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC423226 33 |
|
||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pla2g4d 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for PLA2G4E was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for PLA2G4E Gene
- ENSEMBL:
- Gene Tree for PLA2G4E (if available)
- TreeFam:
- Gene Tree for PLA2G4E (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PLA2G4E: view image
Paralogs for PLA2G4E Gene
Variants for PLA2G4E Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs863223366 | benign, Abnormality of neuronal migration | 41,989,421(-) | T/C | coding_sequence_variant, missense_variant | |
| rs1000065610 | -- | 42,010,232(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000069146 | -- | 42,011,908(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000084664 | -- | 41,986,901(-) | A/G | intron_variant | |
| rs1000092481 | -- | 42,051,700(-) | A/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.25;
81.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLA2G4E Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PLA2G4E
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4E Gene
Disorders for PLA2G4E Gene
Additional Disease Information for PLA2G4E
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PLA2G4E Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G4E Gene
Publications for PLA2G4E Gene
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4 58
- Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. (PMID: 15866882) Ohto T … Shimizu T (The Journal of biological chemistry 2005) 2 3 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for PLA2G4E Gene
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- antibodies-online: Search results for 15 available PLA2G4E Antibodies ranked by validation data
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- GeneTex PLA2G4E Antibody for PLA2G4E
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- genomics-online: cdna clones - Search results for available PLA2G4E gene related products
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Sources for PLA2G4E Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
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