This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport in... See more...

Aliases for PLA2G4E Gene

Aliases for PLA2G4E Gene

  • Phospholipase A2 Group IVE 2 3 4 5
  • Cytosolic Phospholipase A2 Epsilon 3 4
  • CPLA2-Epsilon 3 4
  • Phospholipase A2, Group IVE 2
  • EC 3.1.1.4 4

External Ids for PLA2G4E Gene

Previous GeneCards Identifiers for PLA2G4E Gene

  • GC15M040062
  • GC15M042273
  • GC15M019125

Summaries for PLA2G4E Gene

Entrez Gene Summary for PLA2G4E Gene

  • This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017]

GeneCards Summary for PLA2G4E Gene

PLA2G4E (Phospholipase A2 Group IVE) is a Protein Coding gene. Diseases associated with PLA2G4E include Congenital Disorder Of Glycosylation, Type Iic and Inflammatory Bowel Disease 9. Among its related pathways are Oxytocin signaling pathway and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include phospholipase A2 activity and phospholipase activity. An important paralog of this gene is PLA2G4D.

UniProtKB/Swiss-Prot Summary for PLA2G4E Gene

  • Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position.

Tocris Summary for PLA2G4E Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Additional gene information for PLA2G4E Gene

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G4E Gene

Genomics for PLA2G4E Gene

GeneHancer (GH) Regulatory Elements for PLA2G4E Gene

Promoters and enhancers for PLA2G4E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J042050 Enhancer 0.3 Ensembl ENCODE 505.8 +0.2 235 1.3 PLA2G4E EHD4 PLA2G4E-AS1 PLA2G4F ENSG00000260814 LOC105370793
GH15J042052 Enhancer 0.2 Ensembl 500.7 +1.3 1289 0.2 PLA2G4E EHD4 PLA2G4E-AS1 PLA2G4F LOC105370793
GH15J041931 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10 +111.0 110967 16.6 JUND FOS TEAD4 EP300 ZIC2 REST MEF2C TRIM22 TEAD1 ZNF341 EHD4 LTK PLA2G4E-AS1 SPTBN5 ENSG00000174171 MAPKBP1 PLA2G4E RPAP1 TYRO3 OIP5
GH15J041925 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 9.9 +122.8 122751 6.6 ZNF217 TCF12 SP1 JUND FOS ZNF10 EP300 ZIC2 FOXA1 TRIM28 SPTBN5 EHD4 ENSG00000174171 PLA2G4E-AS1 ENSG00000250379 JMJD7 JMJD7-PLA2G4B MAPKBP1 PLA2G4E RPAP1
GH15J041959 Enhancer 1 ENCODE dbSUPER 10.2 +90.1 90134 3.1 ZIC2 TEAD1 ATF2 ZNF341 FOXA2 BCL11A ZNF263 CEBPB ZBTB33 KLF8 piR-45471-193 piR-46662-201 piR-55650-202 PLA2G4D PLA2G4E RNU6-1169P MAPKBP1 EHD4 piR-35674-163
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G4E on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G4E

Top Transcription factor binding sites by QIAGEN in the PLA2G4E gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • Fra-1
  • JunB
  • JunD
  • Nkx5-1
  • Pax-3
  • POU3F2

Genomic Locations for PLA2G4E Gene

Genomic Locations for PLA2G4E Gene
chr15:41,981,582-42,051,190
(GRCh38/hg38)
Size:
69,609 bases
Orientation:
Minus strand
chr15:42,273,780-42,343,388
(GRCh37/hg19)
Size:
69,609 bases
Orientation:
Minus strand

Genomic View for PLA2G4E Gene

Genes around PLA2G4E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G4E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G4E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G4E Gene

Proteins for PLA2G4E Gene

  • Protein details for PLA2G4E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MJ16-PA24E_HUMAN
    Recommended name:
    Cytosolic phospholipase A2 epsilon
    Protein Accession:
    Q3MJ16
    Secondary Accessions:
    • B7WPN2
    • Q6ZSC0

    Protein attributes for PLA2G4E Gene

    Size:
    868 amino acids
    Molecular mass:
    99190 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G4E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G4E Gene

Post-translational modifications for PLA2G4E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G4E Gene

No data available for DME Specific Peptides for PLA2G4E Gene

Domains & Families for PLA2G4E Gene

Gene Families for PLA2G4E Gene

Protein Domains for PLA2G4E Gene

Blocks:
  • C2 domain
  • Lysophospholipase, catalytic domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLA2G4E Gene

GenScript: Design optimal peptide antigens:
  • Phospholipase A2 group IVE (PA24E_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q3MJ16

UniProtKB/Swiss-Prot:

PA24E_HUMAN :
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
Domain:
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
genes like me logo Genes that share domains with PLA2G4E: view

Function for PLA2G4E Gene

Molecular function for PLA2G4E Gene

UniProtKB/Swiss-Prot Function:
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by cytosolic Ca(2+).

Enzyme Numbers (IUBMB) for PLA2G4E Gene

Phenotypes From GWAS Catalog for PLA2G4E Gene

Gene Ontology (GO) - Molecular Function for PLA2G4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IBA 21873635
GO:0005509 calcium ion binding IBA 21873635
GO:0005544 calcium-dependent phospholipid binding IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLA2G4E: view
genes like me logo Genes that share phenotypes with PLA2G4E: view

Animal Models for PLA2G4E Gene

MGI Knock Outs for PLA2G4E:
  • Pla2g4e Pla2g4e<tm2b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4E

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G4E Gene

Localization for PLA2G4E Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4E Gene

Cytoplasm, cytosol. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocates to lysosomal membranes in a calcium-dependent fashion. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G4E gene
Compartment Confidence
cytosol 5
lysosome 3
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for PLA2G4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PLA2G4E: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G4E Gene

Pathways & Interactions for PLA2G4E Gene

genes like me logo Genes that share pathways with PLA2G4E: view

Gene Ontology (GO) - Biological Process for PLA2G4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0009395 phospholipid catabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0036149 phosphatidylinositol acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with PLA2G4E: view

No data available for SIGNOR curated interactions for PLA2G4E Gene

Drugs & Compounds for PLA2G4E Gene

(10) Drugs for PLA2G4E Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
linoleic acid Approved, Experimental Pharma Full agonist, Agonist, Pore Blocker, Channel blocker 0
Palmitic Acid Approved Pharma Full agonist, Agonist 25
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
alpha-linolenic acid Approved, Investigational Nutra Full agonist, Agonist 0

(11) Additional Compounds for PLA2G4E Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
  • Eicosanoic acid
506-30-9
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
3546-17-6
PC(18:1(9Z)e/2:0)
  • (2-Acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Pentadecanoic acid
  • 15:00
  • C15
  • C15:0
  • N-Pentadecanoic acid
  • Pentadecylic acid
1002-84-2

(5) Tocris Compounds for PLA2G4E Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G4E: view

Transcripts for PLA2G4E Gene

mRNA/cDNA for PLA2G4E Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4E

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G4E Gene

No ASD Table

Relevant External Links for PLA2G4E Gene

GeneLoc Exon Structure for
PLA2G4E

Expression for PLA2G4E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G4E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G4E Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x22.8), Skin - Not Sun Exposed (Suprapubic) (x18.4), and Minor Salivary Gland (x4.7).

Protein differential expression in normal tissues from HIPED for PLA2G4E Gene

This gene is overexpressed in Serum (56.1) and Pancreatic juice (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G4E Gene



Protein tissue co-expression partners for PLA2G4E Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G4E

SOURCE GeneReport for Unigene cluster for PLA2G4E Gene:

Hs.668060

Evidence on tissue expression from TISSUES for PLA2G4E Gene

  • Heart(4)
  • Lung(4)
genes like me logo Genes that share expression patterns with PLA2G4E: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4E Gene

Orthologs for PLA2G4E Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G4E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G4E 31 30
  • 96.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G4E 31 30
  • 87.35 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PLA2G4E 31 30
  • 85.08 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g4e 30
  • 83.04 (n)
mouse
(Mus musculus)
Mammalia Pla2g4e 17 31 30
  • 82.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 79 (a)
OneToMany
-- 31
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PLA2G4E 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC423226 30
  • 61.12 (n)
-- 31
  • 55 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 51 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 48 (a)
OneToMany
-- 31
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g4d 30
  • 53.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 23 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
Species where no ortholog for PLA2G4E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G4E Gene

ENSEMBL:
Gene Tree for PLA2G4E (if available)
TreeFam:
Gene Tree for PLA2G4E (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLA2G4E: view image

Paralogs for PLA2G4E Gene

Paralogs for PLA2G4E Gene

(5) SIMAP similar genes for PLA2G4E Gene using alignment to 3 proteins:

  • PA24E_HUMAN
  • B7WPN2_HUMAN
  • C9JK77_HUMAN
genes like me logo Genes that share paralogs with PLA2G4E: view

Variants for PLA2G4E Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G4E Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
714593 Benign: not provided 42,013,699(-) C/T MISSENSE_VARIANT
714594 Benign: not provided 42,050,517(-) A/G INTRON_VARIANT
776876 Benign: not provided 41,999,977(-) C/G MISSENSE_VARIANT
776877 Benign: not provided 42,001,193(-) G/A MISSENSE_VARIANT
777441 Benign: not provided 41,984,605(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PLA2G4E Gene

Structural Variations from Database of Genomic Variants (DGV) for PLA2G4E Gene

Variant ID Type Subtype PubMed ID
nsv1035998 CNV gain 25217958
nsv1038933 CNV gain 25217958
nsv1043641 CNV gain 25217958
nsv471683 CNV gain+loss 15918152
nsv517183 CNV loss 19592680
nsv523658 CNV gain 19592680
nsv526982 CNV loss 19592680
nsv569235 CNV loss 21841781
nsv827307 CNV loss 20364138

Variation tolerance for PLA2G4E Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.25; 81.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G4E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G4E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4E Gene

Disorders for PLA2G4E Gene

MalaCards: The human disease database

(2) MalaCards diseases for PLA2G4E Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLA2G4E

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PLA2G4E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G4E Gene

Publications for PLA2G4E Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  2. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4 54
  3. Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. (PMID: 15866882) Ohto T … Shimizu T (The Journal of biological chemistry 2005) 2 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for PLA2G4E Gene

Sources for PLA2G4E Gene