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This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport in... See more...
Aliases for PLA2G4E Gene
Aliases for PLA2G4E Gene
External Ids for PLA2G4E Gene
- HGNC: 24791
- NCBI Entrez Gene: 123745
- Ensembl: ENSG00000188089
- UniProtKB/Swiss-Prot: Q3MJ16
Previous GeneCards Identifiers for PLA2G4E Gene
- GC15M040062
- GC15M042273
- GC15M019125
Summaries for PLA2G4E Gene
-
This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017]
GeneCards Summary for PLA2G4E Gene
PLA2G4E (Phospholipase A2 Group IVE) is a Protein Coding gene. Diseases associated with PLA2G4E include Congenital Disorder Of Glycosylation, Type Iic and Cerebral Creatine Deficiency Syndrome 3. Among its related pathways are Ras signaling pathway and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include phospholipase A2 activity and phospholipase activity. An important paralog of this gene is PLA2G4D.
UniProtKB/Swiss-Prot Summary for PLA2G4E Gene
-
Calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain (PubMed:29447909). Transfers the sn-1 fatty acyl chain of phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethanolamine (fatty acyl acceptor) to generate N-acyl phosphatidylethanolamine (NAPE). Similarly can use plasmenylethanolamine as a fatty acyl acceptor to form N-acyl plasmenylethanolamine (N-Acyl-PlsEt). Both NAPE and N-Acyl-PlsEt can serve as precursors of bioactive NAEs like N-arachidonoyl phosphatidylethanolamine also called anandamide (PubMed:29447909, PubMed:30517655). Has weak phospholipase A2 and lysophospholipase activities (By similarity). Regulates intracellular membrane trafficking that requires modulation of membrane curvature as it occurs by enrichment in lysophospholipids. Promotes tubule formation involved in clathrin-independent endocytotic trafficking and cargo recycling (By similarity).
-
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
Additional gene information for PLA2G4E Gene
- HGNC (24791)
- NCBI Entrez Gene (123745)
- Ensembl (ENSG00000188089)
- UniProtKB/Swiss-Prot (Q3MJ16)
- Open Targets Platform(ENSG00000188089)
- Alliance of Genome Resources
- Search for PLA2G4E at DataMed
- Search for PLA2G4E at HumanCyc
No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G4E Gene
Genomics for PLA2G4E Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PLA2G4E Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH15J042050 | Enhancer | 0.3 | Ensembl ENCODE | 255.8 | +0.3 | 314 | 1.1 | PLA2G4E PLA2G4E-AS1 EHD4 PLA2G4F ENSG00000260814 LOC105370793 | ||
| GH15J042049 | Enhancer | 0.2 | Ensembl | 250.7 | +1.7 | 1689 | 0.2 | PLA2G4E PLA2G4E-AS1 EHD4 PLA2G4F LOC105370793 | ||
| GH15J042051 | Enhancer | 0.2 | Ensembl | 250.7 | +1.1 | 1089 | 0.2 | PLA2G4E PLA2G4E-AS1 EHD4 PLA2G4F LOC105370793 | ||
| GH15J041931 | Enhancer | 1.5 | FANTOM5 ENCODE CraniofacialAtlas dbSUPER | 10 | +111.0 | 110967 | 16.6 | BCLAF1 ZNF207 ZNF600 JUND POLR2A NFIC ZIC2 BCL11A CEBPB DEK | EHD4 LTK PLA2G4E-AS1 ENSG00000174171 SPTBN5 MAPKBP1 PLA2G4E RPAP1 TYRO3 OIP5 | |
| GH15J041925 | Enhancer | 1.3 | FANTOM5 ENCODE dbSUPER | 9.9 | +122.8 | 122751 | 6.6 | BCLAF1 SP1 ZNF600 JUND ZNF580 ZMYM3 CEBPA ZNF10 BRCA1 ZIC2 | HSALNG0105397 SPTBN5 EHD4 ENSG00000174171 PLA2G4E-AS1 JMJD7 JMJD7-PLA2G4B ENSG00000250379 MAPKBP1 PLA2G4E |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PLA2G4E on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G4E
- Top Transcription factor binding sites by QIAGEN in the PLA2G4E gene promoter:
-
- AP-1
- c-Fos
- c-Jun
- FosB
- Fra-1
- JunB
- JunD
- Nkx5-1
- Pax-3
- POU3F2
Genomic Locations for PLA2G4E Gene
Latest Assembly
- chr15:41,981,582-42,051,190
- (GRCh38/hg38)
- Size:
- 69,609 bases
- Orientation:
- Minus strand
Previous Assembly
- chr15:42,273,780-42,342,901
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 69,122 bases
- Orientation:
- Minus strand
Genomic View for PLA2G4E Gene
Genes around PLA2G4E on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q15.1 by HGNC
- 15q15.1 by Entrez Gene
- 15q15.1 by Ensembl
PLA2G4E Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLA2G4E Gene
Proteins for PLA2G4E Gene
-
Protein details for PLA2G4E Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q3MJ16-PA24E_HUMAN
- Recommended name:
- Cytosolic phospholipase A2 epsilon
- Protein Accession:
- Q3MJ16
- B7WPN2
- Q6ZSC0
Protein attributes for PLA2G4E Gene
- Size:
- 868 amino acids
- Molecular mass:
- 99190 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
- No Data Available
Protein Expression for PLA2G4E Gene
Post-translational modifications for PLA2G4E Gene
Other Protein References for PLA2G4E Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for PLA2G4E
-
Abcam antibodies for PLA2G4E
- Invitrogen Antibodies for PLA2G4E (AFLGC-Pla2g4e)
-
Boster Bio Antibodies for PLA2G4E
Protein products for research
-
OriGene Purified Proteins for PLA2G4E
- Search Origene for MassSpec and Protein Over-expression Lysates for PLA2G4E
- Origene Custom Protein Services for PLA2G4E
- Novus Biologicals proteins for PLA2G4E
Assay products for research
No data available for DME Specific Peptides for PLA2G4E Gene
Domains & Families for PLA2G4E Gene
Gene Families for PLA2G4E Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PLA2G4E Gene
- InterPro:
- Blocks:
-
- C2 domain
- Lysophospholipase, catalytic domain
Suggested Antigen Peptide Sequences for PLA2G4E Gene
- GenScript: Design optimal peptide antigens:
-
- Phospholipase A2 group IVE (PA24E_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q3MJ16UniProtKB/Swiss-Prot:
PA24E_HUMAN :- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
- Domain:
-
- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
Function for PLA2G4E Gene
Molecular function for PLA2G4E Gene
- UniProtKB/Swiss-Prot Function:
- Calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain (PubMed:29447909). Transfers the sn-1 fatty acyl chain of phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethanolamine (fatty acyl acceptor) to generate N-acyl phosphatidylethanolamine (NAPE). Similarly can use plasmenylethanolamine as a fatty acyl acceptor to form N-acyl plasmenylethanolamine (N-Acyl-PlsEt). Both NAPE and N-Acyl-PlsEt can serve as precursors of bioactive NAEs like N-arachidonoyl phosphatidylethanolamine also called anandamide (PubMed:29447909, PubMed:30517655). Has weak phospholipase A2 and lysophospholipase activities (By similarity). Regulates intracellular membrane trafficking that requires modulation of membrane curvature as it occurs by enrichment in lysophospholipids. Promotes tubule formation involved in clathrin-independent endocytotic trafficking and cargo recycling (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45188, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875, ChEBI:CHEBI:62537, ChEBI:CHEBI:64612; Evidence={ECO:0000269|PubMed:29447909, ECO:0000269|PubMed:30517655};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:55252, ChEBI:CHEBI:15378, ChEBI:CHEBI:73000, ChEBI:CHEBI:74986, ChEBI:CHEBI:76076, ChEBI:CHEBI:78097; Evidence={ECO:0000250|UniProtKB:Q50L42};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:55248, ChEBI:CHEBI:15378, ChEBI:CHEBI:74986, ChEBI:CHEBI:75026, ChEBI:CHEBI:76078, ChEBI:CHEBI:85292; Evidence={ECO:0000250|UniProtKB:Q50L42};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45172, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:74986, ChEBI:CHEBI:76078, ChEBI:CHEBI:78097; Evidence={ECO:0000269|PubMed:29447909, ECO:0000269|PubMed:30517655};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:55256, ChEBI:CHEBI:15378, ChEBI:CHEBI:60657, ChEBI:CHEBI:74986, ChEBI:CHEBI:76079, ChEBI:CHEBI:85277; Evidence={ECO:0000250|UniProtKB:Q50L42};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:55260, ChEBI:CHEBI:15378, ChEBI:CHEBI:74986, ChEBI:CHEBI:76088, ChEBI:CHEBI:85291; Evidence={ECO:0000250|UniProtKB:Q50L42};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:63592, ChEBI:CHEBI:15378, ChEBI:CHEBI:72999, ChEBI:CHEBI:76078, ChEBI:CHEBI:78340, ChEBI:CHEBI:138663; Evidence={ECO:0000250|UniProtKB:Q50L42};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000250|UniProtKB:Q50L42};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence={ECO:0000250|UniProtKB:Q50L42};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence={ECO:0000250|UniProtKB:Q50L42};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Optimum pH is 8. {ECO:0000269|PubMed:29447909};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Stimulated by cytosolic Ca(2+). Stimulated by anionic phospholipids such as phosphatidylserines, phosphatidates and phosphatidylinositols.
Enzyme Numbers (IUBMB) for PLA2G4E Gene
Phenotypes From GWAS Catalog for PLA2G4E Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004620 | phospholipase activity | IEA | -- |
| GO:0004623 | phospholipase A2 activity | IBA | 21873635 |
| GO:0005509 | calcium ion binding | IBA | 21873635 |
| GO:0005544 | calcium-dependent phospholipid binding | IBA | 21873635 |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | IEA,ISS | -- |
Phenotypes for PLA2G4E Gene
- MGI mutant phenotypes for PLA2G4E:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PLA2G4E:
Animal Models for PLA2G4E Gene
- MGI Knock Outs for PLA2G4E:
-
- Pla2g4e Pla2g4e<tm2b(EUCOMM)Hmgu>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PLA2G4E - Starting at $85 >
- * PLA2G4E CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PLA2G4E
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4E
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4E
miRNA for PLA2G4E Gene
- miRTarBase miRNAs that target PLA2G4E
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4E
- Browse OriGene Inhibitory RNA Products For PLA2G4E
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4E
Clone products for research
- Applied Biological Materials (abm): Clones for PLA2G4E - Starting at $45 >
- * PLA2G4E as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PLA2G4E
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4E
Cell Lines for research
-
Horizon Cell Lines for PLA2G4E
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G4E Gene
Localization for PLA2G4E Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4E Gene
- Cytoplasm, cytosol. Early endosome membrane. Peripheral membrane protein. Cytoplasmic side. Lysosome membrane. Peripheral membrane protein. Cytoplasmic side. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Note=Targeted to clathrin-independent endocytotic vesicles through binding to phosphoinositides, especially phosphatidylinositol 4,5-bisphosphates. {ECO:0000250 UniProtKB:Q50L42}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| endosome | 4 |
| cytosol | 4 |
| lysosome | 4 |
| nucleus | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | ISS | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G4E Gene
Pathways & Interactions for PLA2G4E Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycerophospholipid biosynthesis | ||
| 2 | Acyl chain remodelling of PE | ||
| 3 | Linoleic acid metabolism | ||
| 4 | Metabolism |
.40
|
|
| 5 | Phospholipase D signaling pathway | ||
Pathways by source for PLA2G4E Gene
1 BioSystems pathway for PLA2G4E Gene
9 Reactome pathways for PLA2G4E Gene
23 KEGG pathways for PLA2G4E Gene
Interacting Proteins for PLA2G4E Gene
GPS-Prot Interaction Network for PLA2G4E
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006644 | phospholipid metabolic process | TAS | -- |
| GO:0009395 | phospholipid catabolic process | IEA | -- |
| GO:0016042 | lipid catabolic process | IEA | -- |
| GO:0036149 | phosphatidylinositol acyl-chain remodeling | TAS | -- |
No data available for SIGNOR curated interactions for PLA2G4E Gene
Drugs & Compounds for PLA2G4E Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Arachidic acid |
|
506-30-9 |
|
|||
| CE(22:0) |
|
61510-09-6 |
|
|||
| Heptadecanoic acid |
|
506-12-7 |
|
|||
| Heptadecanoyl CoA |
|
3546-17-6 |
|
|||
| PC(18:1(9Z)e/2:0) |
|
|
(5) Tocris Compounds for PLA2G4E Gene
| Compound | Action | Cas Number |
|---|---|---|
| AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
| Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
| m-3M3FBS | Phospholipase C activator | 200933-14-8 |
| o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
| U 73122 | Phospholipase C inhibitor | 112648-68-7 |
Transcripts for PLA2G4E Gene
mRNA/cDNA for PLA2G4E Gene
- 2 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000399518 5266 nts (view in UCSC)
- ENST00000547930 4066 nts (view in UCSC)
- ENST00000551073 826 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PLA2G4E - Starting at $85 >
- * PLA2G4E CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PLA2G4E
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4E
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4E
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4E
- Browse OriGene Inhibitory RNA Products For PLA2G4E
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4E
Clone products for research
- Applied Biological Materials (abm): Clones for PLA2G4E - Starting at $45 >
- * PLA2G4E as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PLA2G4E
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4E
Relevant External Links for PLA2G4E Gene
- GeneLoc Exon Structure for
- PLA2G4E
Expression for PLA2G4E Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
- Lung (Respiratory System)
- Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for PLA2G4E Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x22.8), Skin - Not Sun Exposed (Suprapubic) (x18.4), and Minor Salivary Gland (x4.7).
This gene is overexpressed in Serum (56.1) and Pancreatic juice (12.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G4E Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G4E
SOURCE GeneReport for Unigene cluster for PLA2G4E Gene:
Hs.668060Evidence on tissue expression from TISSUES for PLA2G4E Gene
- Heart(4.1)
- Lung(4)
Primer products for research
-
OriGene qPCR primer pairs for PLA2G4E
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4E Gene
Orthologs for PLA2G4E Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PLA2G4E 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PLA2G4E 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PLA2G4E 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pla2g4e 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Pla2g4e 29 16 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | PLA2G4E 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LOC423226 29 |
|
||
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pla2g4d 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany |
- Species where no ortholog for PLA2G4E was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for PLA2G4E Gene
- ENSEMBL:
- Gene Tree for PLA2G4E (if available)
- TreeFam:
- Gene Tree for PLA2G4E (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PLA2G4E: view image
- Alliance of Genome Resources:
- Additional Orthologs for PLA2G4E
Paralogs for PLA2G4E Gene
Variants for PLA2G4E Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G4E Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs114855106 | Benign: not provided | 42,013,699(-) |
C/T NM_001206670.1(PLA2G4E):c.242G>A (p.Arg81Gln) |
MISSENSE | |
| rs116431025 | Benign: not provided | 41,984,605(-) |
G/A NM_001206670.1(PLA2G4E):c.2217C>T (p.Thr739=) |
SYNONYMOUS | |
| rs59021651 | Benign: not provided | 42,001,193(-) |
G/A NM_001206670.1(PLA2G4E):c.637C>T (p.His213Tyr) |
MISSENSE | |
| rs59786885 | Benign: not provided | 41,999,977(-) |
C/G NM_001206670.1(PLA2G4E):c.876G>C (p.Lys292Asn) |
MISSENSE | |
| rs7180369 | Benign: not provided | 42,050,517(-) |
A/G NM_001206670.1(PLA2G4E):c.183+4T>C |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.25;
81.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLA2G4E Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4E Gene
Disorders for PLA2G4E Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| congenital disorder of glycosylation, type iic |
|
|
| cerebral creatine deficiency syndrome 3 |
|
|
| cerebral creatine deficiency syndrome |
|
|
| ileocolitis |
|
|
Search PLA2G4E in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PLA2G4E
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G4E Gene
Publications for PLA2G4E Gene
- The role of intracellular anionic phospholipids in the production of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ɛ. (PMID: 30517655) Binte Mustafiz SS … Ueda N (Journal of biochemistry 2019) 3 4
- Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca2+-dependent N-acyltransferase. (PMID: 29447909) Hussain Z … Ueda N (Biochimica et biophysica acta. Molecular and cell biology of lipids 2018) 3 4
- Cytosolic phospholipase A₂ε drives recycling through the clathrin-independent endocytic route. (PMID: 24413173) Capestrano M … Polishchuk RS (Journal of cell science 2014) 3 4
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4
ExternalLinks
Products for PLA2G4E Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PLA2G4E
- Search Origene for MassSpec and Protein Over-expression Lysates for PLA2G4E
- Origene Custom Protein Services for PLA2G4E
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4E
- Browse OriGene Inhibitory RNA Products For PLA2G4E
- OriGene qPCR primer pairs for PLA2G4E
- OriGene CRISPR knockouts for PLA2G4E
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PLA2G4E
- Sino Biological Human cDNA Clone for PLA2G4E
- Browse Sino Biological Recombinant Proteins
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PLA2G4E
- Novus Biologicals proteins for PLA2G4E
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- VectorBuilder Custom and pre-made DNA vectors for PLA2G4E (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PLA2G4E (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PLA2G4E (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PLA2G4E CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PLA2G4E
- antibodies-online: Show 5 available PLA2G4E Antibodies ranked by validation data
- Compare Top PLA2G4E Antibodies
- antibodies-online: Search results for available PLA2G4E related products ranked by validation data
- antibodies-online: Search results for available PLA2G4E related products ranked by validation data
- Horizon Cell Lines for PLA2G4E
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4E
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4E
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PLA2G4E
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4E
- Boster Bio Antibodies for PLA2G4E
- Browse Boster Bio ELISA Kits
Sources for PLA2G4E Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources