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The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009]
PLA2G4D (Phospholipase A2 Group IVD) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include phospholipase A2 activity and phospholipase activity. An important paralog of this gene is JMJD7-PLA2G4B.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004620 | phospholipase activity | IEA | -- |
GO:0004623 | phospholipase A2 activity | IBA | 21873635 |
GO:0005509 | calcium ion binding | IBA | 21873635 |
GO:0005544 | calcium-dependent phospholipid binding | IBA | 21873635 |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glycerophospholipid biosynthesis | ||
2 | Acyl chain remodelling of PE |
.30
|
|
3 | Linoleic acid metabolism | ||
4 | Metabolism |
.40
|
|
5 | Phospholipase D signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006631 | fatty acid metabolic process | IEA | -- |
GO:0006644 | phospholipid metabolic process | TAS | -- |
GO:0006654 | phosphatidic acid biosynthetic process | TAS | -- |
GO:0009395 | phospholipid catabolic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
linoleic acid | Approved, Experimental | Pharma | Agonist, Full agonist, Activator, Pore Blocker, Channel blocker | 0 | ||
Palmitic Acid | Approved | Pharma | Agonist, Full agonist | 27 | ||
Stearic acid | Approved, Experimental | Pharma | 0 | |||
Water | Approved | Pharma | 0 | |||
alpha-linolenic acid | Approved, Investigational | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Arachidic acid |
|
506-30-9 |
|
|||
Heptadecanoic acid |
|
506-12-7 |
|
|||
Heptadecanoyl CoA |
|
3546-17-6 |
|
|||
PC(18:1(9Z)e/2:0) |
|
|
||||
Pentadecanoic acid |
|
1002-84-2 |
|
Compound | Action | Cas Number |
---|---|---|
AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
m-3M3FBS | Phospholipase C activator | 200933-14-8 |
o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
U 73122 | Phospholipase C inhibitor | 112648-68-7 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PLA2G4D 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PLA2G4D 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PLA2G4D 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pla2g4d 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pla2g4d 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | PLA2G4D 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PLA2G4D 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
768702 | Benign: not provided | 42,081,493(-) | G/A | SYNONYMOUS_VARIANT | |
790690 | Benign: not provided | 42,081,094(-) | G/A | MISSENSE_VARIANT | |
rs563112904 | Benign: not specified | 42,086,199(-) | A/C | INTRON_VARIANT | |
rs11635685 | - | p.Pro275Arg | |||
rs17690899 | - | p.Ala649Gly |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3636255 | CNV | loss | 21293372 |
nsv1035998 | CNV | gain | 25217958 |
nsv1043641 | CNV | gain | 25217958 |
nsv436201 | CNV | deletion | 17901297 |
nsv471683 | CNV | gain+loss | 15918152 |
nsv832985 | CNV | loss | 17160897 |
No disorders were found for PLA2G4D Gene.