Aliases for PLA2G4D Gene
External Ids for PLA2G4D Gene
Previous GeneCards Identifiers for PLA2G4D Gene
The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009]
GeneCards Summary for PLA2G4D Gene
PLA2G4D (Phospholipase A2 Group IVD) is a Protein Coding gene. Diseases associated with PLA2G4D include Immunodeficiency 29. Among its related pathways are Ras signaling pathway and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include phospholipase A2 activity and phospholipase activity. An important paralog of this gene is PLA2G4B.
UniProtKB/Swiss-Prot Summary for PLA2G4D Gene
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560). Has a preference for linoleic acid at the sn-2 position (PubMed:14709560).
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.