Aliases for PLA2G4D Gene
External Ids for PLA2G4D Gene
Previous GeneCards Identifiers for PLA2G4D Gene
The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009]
GeneCards Summary for PLA2G4D Gene
PLA2G4D (Phospholipase A2 Group IVD) is a Protein Coding gene. Diseases associated with PLA2G4D include Immunodeficiency 29. Among its related pathways are Activation of cAMP-Dependent PKA and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include phospholipase A2 activity and phospholipase activity. An important paralog of this gene is PLA2G4B.
UniProtKB/Swiss-Prot Summary for PLA2G4D Gene
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560). Has a preference for linoleic acid at the sn-2 position (PubMed:14709560).
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.