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The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009] See more...
Aliases for PLA2G4D Gene
Aliases for PLA2G4D Gene
External Ids for PLA2G4D Gene
- HGNC: 30038
- NCBI Entrez Gene: 283748
- Ensembl: ENSG00000159337
- OMIM®: 612864
- UniProtKB/Swiss-Prot: Q86XP0
Previous GeneCards Identifiers for PLA2G4D Gene
- GC15M040075
- GC15M040146
- GC15M042359
- GC15M019207
Summaries for PLA2G4D Gene
-
The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009]
GeneCards Summary for PLA2G4D Gene
PLA2G4D (Phospholipase A2 Group IVD) is a Protein Coding gene. Diseases associated with PLA2G4D include Immunodeficiency 29. Among its related pathways are Activation of cAMP-Dependent PKA and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include phospholipase A2 activity and phospholipase activity. An important paralog of this gene is PLA2G4B.
UniProtKB/Swiss-Prot Summary for PLA2G4D Gene
-
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560). Has a preference for linoleic acid at the sn-2 position (PubMed:14709560).
-
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
Additional gene information for PLA2G4D Gene
- HGNC (30038)
- NCBI Entrez Gene (283748)
- Ensembl (ENSG00000159337)
- OMIM® (612864)
- UniProtKB/Swiss-Prot (Q86XP0)
- Open Targets Platform(ENSG00000159337)
- Search for PLA2G4D at DataMed
- Search for PLA2G4D at HumanCyc
No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G4D Gene
Genomics for PLA2G4D Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PLA2G4D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PLA2G4D on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G4D
- Top Transcription factor binding sites by QIAGEN in the PLA2G4D gene promoter:
-
- AML1a
- C/EBPalpha
- GCNF
- GCNF-1
- GCNF-2
- IRF-1
- MAZR
- PPAR-gamma1
- PPAR-gamma2
- XBP-1
Genomic Locations for PLA2G4D Gene
Latest Assembly
- chr15:42,067,009-42,094,562
- (GRCh38/hg38)
- Size:
- 27,554 bases
- Orientation:
- Minus strand
Previous Assembly
- chr15:42,359,207-42,386,760
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 27,554 bases
- Orientation:
- Minus strand
- chr15:42,359,207-42,386,752
- (GRCh37/hg19 by Ensembl)
- Size:
- 27,546 bases
- Orientation:
- Minus strand
Genomic View for PLA2G4D Gene
Genes around PLA2G4D on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q15.1 by HGNC
- 15q15.1 by Entrez Gene
- 15q15.1 by Ensembl
PLA2G4D Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLA2G4D Gene
Proteins for PLA2G4D Gene
-
Protein details for PLA2G4D Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86XP0-PA24D_HUMAN
- Recommended name:
- Cytosolic phospholipase A2 delta
- Protein Accession:
- Q86XP0
- Q8N176
Protein attributes for PLA2G4D Gene
- Size:
- 818 amino acids
- Molecular mass:
- 91952 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH34571.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 2]: May be due to an intron retention.
Three dimensional structures from OCA and Proteopedia for PLA2G4D Gene
Protein Expression for PLA2G4D Gene
Selected DME Specific Peptides for PLA2G4D Gene
- Q86XP0:
-
- EFSPYEVG
- RAMTSLYG
Post-translational modifications for PLA2G4D Gene
Other Protein References for PLA2G4D Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for PLA2G4D
- Novus Biologicals Antibodies for PLA2G4D
-
Abcam antibodies for PLA2G4D
- Invitrogen Antibodies for PLA2G4D (AFLGC-PLA2G4D)
- antibodies-online: Show 3 available PLA2G4D Antibodies ranked by validation data
-
Boster Bio Antibodies for PLA2G4D
-
Custom Antibody ServicesProSci Antibodies for PLA2G4D
-
Santa Cruz Biotechnology (SCBT) Antibodies for PLA2G4D
Protein products for research
-
OriGene Purified Proteins for PLA2G4D
- Search Origene for MassSpec and Protein Over-expression Lysates for PLA2G4D
- Origene Custom Protein Services for PLA2G4D
-
Abcam proteins for PLA2G4D
Assay products for research
Domains & Families for PLA2G4D Gene
Gene Families for PLA2G4D Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PLA2G4D Gene
- InterPro:
- Blocks:
-
- C2 domain
- Lysophospholipase, catalytic domain
- ProtoNet:
Suggested Antigen Peptide Sequences for PLA2G4D Gene
- GenScript: Design optimal peptide antigens:
-
- Phospholipase A2 group IVD (PA24D_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q86XP0UniProtKB/Swiss-Prot:
PA24D_HUMAN :- The N-terminal C2 domain mediates the association with lipid membranes upon calcium binding (Probable). An additional second C2 domain may stand in between the C2 domain and the PLA2c domain (Probable).
- Domain:
-
- The N-terminal C2 domain mediates the association with lipid membranes upon calcium binding (Probable). An additional second C2 domain may stand in between the C2 domain and the PLA2c domain (Probable).
Function for PLA2G4D Gene
Molecular function for PLA2G4D Gene
- UniProtKB/Swiss-Prot Function:
- Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560). Has a preference for linoleic acid at the sn-2 position (PubMed:14709560).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269|PubMed:14709560};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence={ECO:0000269|PubMed:14709560};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence={ECO:0000269|PubMed:14709560};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence={ECO:0000269|PubMed:14709560};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence={ECO:0000250|UniProtKB:Q50L43};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence={ECO:0000250|UniProtKB:Q50L43};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: Vmax=9.23 pmol/min/mg enzyme with 1-palmitoyl-2-arachidonyl-phosphatidylcholine as substrate {ECO:0000269|PubMed:14709560}; Vmax=58.56 pmol/min/mg enzyme with 1-palmitoyl-2-linoleoyl-phosphatidylcholine as substrate {ECO:0000269|PubMed:14709560}; Vmax=11 pmol/min/mg enzyme with 1-palmitoyl-2-oleoyl-phosphatidylcholine as substrate {ECO:0000269|PubMed:14709560};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Stimulated by cytosolic Ca(2+).
Enzyme Numbers (IUBMB) for PLA2G4D Gene
Phenotypes From GWAS Catalog for PLA2G4D Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004620 | phospholipase activity | IEA | -- |
| GO:0004623 | phospholipase A2 activity | IBA | 21873635 |
| GO:0005509 | calcium ion binding | IBA | 21873635 |
| GO:0005544 | calcium-dependent phospholipid binding | IBA | 21873635 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PLA2G4D Gene
- MGI mutant phenotypes for PLA2G4D:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PLA2G4D:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased viability ratio
- Decreased viability after Maraba virus infection
- Decreased viability in pancreas lineage
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased cilium length after serum starvation
- Decreased epidermal growth factor receptor (EGFR) surface abundance
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PLA2G4D - Starting at $85 >
- * PLA2G4D CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PLA2G4D
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4D
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4D
miRNA for PLA2G4D Gene
- miRTarBase miRNAs that target PLA2G4D
-
- hsa-miR-651-5p (MIRT531196)
- hsa-miR-3613-3p (MIRT531197)
- hsa-miR-6507-5p (MIRT531198)
- hsa-miR-513c-3p (MIRT531199)
- hsa-miR-513a-3p (MIRT531200)
- hsa-miR-3606-3p (MIRT531201)
- hsa-miR-186-5p (MIRT531202)
- hsa-miR-4474-3p (MIRT531203)
- hsa-miR-4663 (MIRT531204)
- hsa-miR-548v (MIRT531205)
- hsa-miR-4772-5p (MIRT531206)
- hsa-miR-1233-3p (MIRT531207)
- hsa-miR-1225-3p (MIRT531208)
- hsa-miR-6751-3p (MIRT531209)
- hsa-miR-1199-5p (MIRT531210)
- hsa-miR-5690 (MIRT531211)
- hsa-miR-1288-5p (MIRT531212)
- hsa-miR-154-5p (MIRT531213)
- hsa-miR-383-5p (MIRT531214)
- hsa-miR-5683 (MIRT531215)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4D
- Browse OriGene Inhibitory RNA Products For PLA2G4D
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4D
Clone products for research
- Applied Biological Materials (abm): Clones for PLA2G4D - Starting at $45 >
- * PLA2G4D as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PLA2G4D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4D
Cell Lines for research
-
Horizon Cell Lines for PLA2G4D
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G4D Gene
Localization for PLA2G4D Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4D Gene
- Cytoplasm, cytosol. Membrane. Peripheral membrane protein. Cytoplasmic side. Note=Translocates to perinuclear membranes that may correspond to endoplasmic reticulum or Golgi in a calcium-dependent fashion. {ECO:0000250 UniProtKB:Q50L43}.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| nucleus | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G4D Gene
Pathways & Interactions for PLA2G4D Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycerophospholipid biosynthesis | ||
| 2 | Acyl chain remodelling of PE |
.30
|
|
| 3 | Linoleic acid metabolism | ||
| 4 | Metabolism |
.40
|
|
| 5 | Phospholipase D signaling pathway | ||
Pathways by source for PLA2G4D Gene
1 BioSystems pathway for PLA2G4D Gene
11 Reactome pathways for PLA2G4D Gene
23 KEGG pathways for PLA2G4D Gene
3 Qiagen pathways for PLA2G4D Gene
- cAMP Pathway
- Phospholipase-C Pathway
- Sperm Motility
UniProtKB/Swiss-Prot Q86XP0-PA24D_HUMAN
- Pathway: Lipid metabolism; fatty acid metabolism.
Interacting Proteins for PLA2G4D Gene
GPS-Prot Interaction Network for PLA2G4D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0006644 | phospholipid metabolic process | TAS | -- |
| GO:0006654 | phosphatidic acid biosynthetic process | TAS | -- |
| GO:0009395 | phospholipid catabolic process | IEA | -- |
No data available for SIGNOR curated interactions for PLA2G4D Gene
Drugs & Compounds for PLA2G4D Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Arachidic acid |
|
506-30-9 |
|
|||
| CE(22:0) |
|
61510-09-6 |
|
|||
| Heptadecanoic acid |
|
506-12-7 |
|
|||
| Heptadecanoyl CoA |
|
3546-17-6 |
|
|||
| PC(18:1(9Z)e/2:0) |
|
|
(5) Tocris Compounds for PLA2G4D Gene
| Compound | Action | Cas Number |
|---|---|---|
| AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
| Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
| m-3M3FBS | Phospholipase C activator | 200933-14-8 |
| o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
| U 73122 | Phospholipase C inhibitor | 112648-68-7 |
Transcripts for PLA2G4D Gene
mRNA/cDNA for PLA2G4D Gene
- 1 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000290472 4266 nts (view in UCSC)
- ENST00000560132 588 nts (view in UCSC)
- ENST00000560932 3316 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PLA2G4D - Starting at $85 >
- * PLA2G4D CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PLA2G4D
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4D
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4D
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4D
- Browse OriGene Inhibitory RNA Products For PLA2G4D
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4D
Clone products for research
- Applied Biological Materials (abm): Clones for PLA2G4D - Starting at $45 >
- * PLA2G4D as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PLA2G4D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4D
Relevant External Links for PLA2G4D Gene
- GeneLoc Exon Structure for
- PLA2G4D
Expression for PLA2G4D Gene
mRNA differential expression in normal tissues according to GTEx for PLA2G4D Gene
This gene is overexpressed in Vagina (x17.0), Skin - Sun Exposed (Lower leg) (x12.6), Skin - Not Sun Exposed (Suprapubic) (x12.4), and Cervix - Ectocervix (x4.9).
This gene is overexpressed in Cervix (56.4) and Urine (10.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G4D Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G4D
SOURCE GeneReport for Unigene cluster for PLA2G4D Gene:
Hs.380225mRNA Expression by UniProt/SwissProt for PLA2G4D Gene:
Q86XP0-PA24D_HUMAN
Tissue specificity:
Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues (PubMed:14709560). Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin (PubMed:14709560).
Evidence on tissue expression from TISSUES for PLA2G4D Gene
- Nervous system(4.3)
Primer products for research
-
OriGene qPCR primer pairs for PLA2G4D
-
OriGene qPCR primer pairs and template standards for PLA2G4D
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4D Gene
Orthologs for PLA2G4D Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PLA2G4D 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PLA2G4D 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PLA2G4D 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pla2g4d 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pla2g4d 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PLA2G4D 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PLA2G4D 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for PLA2G4D was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for PLA2G4D Gene
- ENSEMBL:
- Gene Tree for PLA2G4D (if available)
- TreeFam:
- Gene Tree for PLA2G4D (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PLA2G4D: view image
Paralogs for PLA2G4D Gene
Variants for PLA2G4D Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G4D Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs116725664 | Benign: not provided | 42,081,493(-) |
G/A NM_178034.4(PLA2G4D):c.943C>T (p.Leu315=) |
SYNONYMOUS | |
| rs563112904 | Benign: not specified | 42,086,199(-) |
A/C NM_178034.4(PLA2G4D):c.387+14T>G |
INTRON | |
| rs56985825 | Benign: not provided | 42,081,094(-) |
G/A NM_178034.4(PLA2G4D):c.997C>T (p.Arg333Trp) |
MISSENSE | |
| rs11635685 | - |
p.Pro275Arg |
|||
| rs17690899 | - |
p.Ala649Gly |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3636255 | CNV | loss | 21293372 |
| nsv1035998 | CNV | gain | 25217958 |
| nsv1043641 | CNV | gain | 25217958 |
| nsv436201 | CNV | deletion | 17901297 |
| nsv471683 | CNV | gain+loss | 15918152 |
| nsv832985 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.85;
97.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLA2G4D Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PLA2G4D
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4D Gene
Disorders for PLA2G4D Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 29 |
|
|
Search PLA2G4D in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PLA2G4D
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G4D Gene
Publications for PLA2G4D Gene
- Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin. (PMID: 14709560) Chiba H … Imai Y (The Journal of biological chemistry 2004) 2 3 4 23
- A family based study of the genetic association between the PLA2G4D gene and schizophrenia. (PMID: 16213696) Tao R … Wei J (Prostaglandins, leukotrienes, and essential fatty acids 2005) 3 4 41
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- [Study on the genetic association between the polymorphism of cytosolic phospholipase A2 family genes and schizophrenia]. (PMID: 18686860) Yu Q … Yu YQ (Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2008) 3 41
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for PLA2G4D Gene
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- antibodies-online: Show 3 available PLA2G4D Antibodies ranked by validation data
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- Boster Bio Antibodies for PLA2G4D
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Sources for PLA2G4D Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
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