Aliases for PLA2G4C Gene
Aliases for PLA2G4C Gene
External Ids for PLA2G4C Gene
- HGNC: 9037
- Entrez Gene: 8605
- Ensembl: ENSG00000105499
- OMIM: 603602
- UniProtKB: Q9UP65
Previous GeneCards Identifiers for PLA2G4C Gene
- GC19M049195
- GC19M048919
- GC19M053227
- GC19M053242
- GC19M048551
- GC19M044932
Summaries for PLA2G4C Gene
-
This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
GeneCards Summary for PLA2G4C Gene
PLA2G4C (Phospholipase A2 Group IVC) is a Protein Coding gene. Among its related pathways are Long-term depression and TCR Signaling (Qiagen). Gene Ontology (GO) annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is PLA2G4F.
UniProtKB/Swiss-Prot for PLA2G4C Gene
-
Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.
-
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
Additional gene information for PLA2G4C Gene
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G4C Gene
Genomics for PLA2G4C Gene
GeneHancer (GH) Regulatory Elements for PLA2G4C Gene
Promoters and enhancers for PLA2G4C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PLA2G4C on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PLA2G4C gene promoter:
-
- AREB6
- c-Ets-1
- Elk-1
- En-1
- GATA-1
- ISGF-3
- Pax-4a
- POU2F1
- POU2F1a
- STAT3
Genomic Locations for PLA2G4C Gene
Genomic Locations for PLA2G4C Gene
- chr19:48,047,843-48,110,853
- (GRCh38/hg38)
- Size:
- 63,011 bases
- Orientation:
- Minus strand
- chr19:48,551,100-48,614,109
- (GRCh37/hg19)
- Size:
- 63,010 bases
- Orientation:
- Minus strand
Genomic View for PLA2G4C Gene
Genes around PLA2G4C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
PLA2G4C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLA2G4C Gene
Proteins for PLA2G4C Gene
-
Protein details for PLA2G4C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UP65-PA24C_HUMAN
- Recommended name:
- Cytosolic phospholipase A2 gamma
- Protein Accession:
- Q9UP65
- B2RB71
- B4DI40
- O75457
- Q6IBI8
- Q9UG68
Protein attributes for PLA2G4C Gene
- Size:
- 541 amino acids
- Molecular mass:
- 60939 Da
- Quaternary structure:
- No Data Available
Protein Expression for PLA2G4C Gene
Post-translational modifications for PLA2G4C Gene
Other Protein References for PLA2G4C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-PLA2G4C Antibody
-
Custom Antibody ServicesOriGene Antibodies for PLA2G4C
- Novus Biologicals Antibodies for PLA2G4C
-
Abcam antibodies for PLA2G4C
- Invitrogen Antibodies for PLA2G4C (AFLGC-PLA2G4C)
-
Boster Bio Antibodies for PLA2G4C
Protein Products
- Atlas Antibodies PrEST Antigen PLA2G4C
-
OriGene Purified Proteins for PLA2G4C
- Search Origene for MassSpec and Protein Over-expression Lysates for PLA2G4C
- Origene Custom Protein Services for PLA2G4C
-
Abcam proteins for PLA2G4C
No data available for DME Specific Peptides for PLA2G4C Gene
Domains & Families for PLA2G4C Gene
Gene Families for PLA2G4C Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PLA2G4C Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PLA2G4C Gene
- GenScript: Design optimal peptide antigens:
-
- Phospholipase A2 group IVC (PA24C_HUMAN)
- PLA2G4C protein (Q6IBI8_HUMAN)
- Phospholipase A2, group IVC(Cytosolic, calcium-independent) (Q76EY9_HUMAN)
- Phospholipase A2, group IVC(Cytosolic, calcium-independent) (Q76EZ0_HUMAN)
- PLA2G4C protein (Q8WWC5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for PLA2G4C Gene
Function for PLA2G4C Gene
Molecular function for PLA2G4C Gene
- UniProtKB/Swiss-Prot Function:
- Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269 PubMed:10085124, ECO:0000269 PubMed:14529291, ECO:0000269 PubMed:9705332};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by palmitoyl-CoA (PubMed:14529291). Not regulated by calcium (PubMed:9705332, PubMed:10085124).
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: Vmax=218 pmol/min/mg enzyme {ECO:0000269 PubMed:10085124};
- GENATLAS Biochemistry:
- phospholipase A2,group IVB,Ca2+ independent,cytosolic,ubiquitously predominantly expressed in cardiac and skeletal muscle paralog of PLA2G2A
Enzyme Numbers (IUBMB) for PLA2G4C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004622 | lysophospholipase activity | TAS | -- |
| GO:0004623 | phospholipase A2 activity | IBA | 21873635 |
| GO:0005509 | calcium ion binding | IBA | 21873635 |
| GO:0005543 | phospholipid binding | NAS | 10085124 |
| GO:0005544 | calcium-dependent phospholipid binding | IBA | 21873635 |
Phenotypes for PLA2G4C Gene
- GenomeRNAi human phenotypes for PLA2G4C:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Increased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PLA2G4C
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PLA2G4C - Now 50% OFF >
- * PLA2G4C CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * PLA2G4C CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for PLA2G4C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4C
- genomics-online: gRNA clones - Search results for 119 available PLA2G4C gene related products
- Overview of 119 available PLA2G4C gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4C
miRNA for PLA2G4C Gene
- miRTarBase miRNAs that target PLA2G4C
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PLA2G4C
- Browse OriGene Inhibitory RNA Products For PLA2G4C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4C
- genomics-online: shRNA clones - Search results for 119 available PLA2G4C gene related products
- Overview of 119 available PLA2G4C gene related products
Clone Products
- Applied Biological Materials (abm): Clones for PLA2G4C - Now 50% OFF >
- * PLA2G4C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * PLA2G4C tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG225571
- MG225572
- MR225571
- MR225571L1
- MR225571L1V
- MR225571L2
- MR225571L2V
- MR225571L3
- MR225571L3V
- MR225571L4
- MR225571L4V
- MR225572
- MR225572L1
- MR225572L1V
- MR225572L2
- MR225572L2V
- MR225572L3
- MR225572L3V
- MR225572L4
- MR225572L4V
- RC209567
- RC209567L1
- RC209567L1V
- RC209567L2
- RC209567L2V
- RC209567L3
- RC209567L3V
- RC209567L4
- RC209567L4V
- RC228430
- RC228430L1
- RC228430L1V
- RC228430L2
- RC228430L2V
- RC228430L3
- RC228430L3V
- RC228430L4
- RC228430L4V
- RC228444
- RC228444L1
- RC228444L1V
- RC228444L2
- RC228444L2V
- RC228444L3
- RC228444L3V
- RC228444L4
- RC228444L4V
- RC509567
- RG209567
- RG228430
- RG228444
- RR204333
- RR204333L1
- RR204333L1V
- RR204333L2
- RR204333L2V
- RR204333L3
- RR204333L3V
- RR204333L4
- RR204333L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4C
Cell Line Products
-
Horizon Cell Lines for PLA2G4C
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G4C Gene
Localization for PLA2G4C Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4C Gene
- Membrane; Lipid-anchor.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| endoplasmic reticulum | 4 |
| nucleus | 3 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005635 | nuclear envelope | IBA | 21873635 |
| GO:0005654 | nucleoplasm | IBA | 21873635 |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0005829 | cytosol | TAS | 10085124 |
Pathways & Interactions for PLA2G4C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycerophospholipid biosynthesis | ||
| 2 | Linoleic acid metabolism | ||
| 3 | Acyl chain remodelling of PE | ||
| 4 | Immune response Fc epsilon RI pathway | ||
| 5 | Metabolism |
.40
|
|
Pathways by source for PLA2G4C Gene
1 BioSystems pathway for PLA2G4C Gene
9 Reactome pathways for PLA2G4C Gene
22 KEGG pathways for PLA2G4C Gene
6 GeneGo (Thomson Reuters) pathways for PLA2G4C Gene
11 Qiagen pathways for PLA2G4C Gene
Interacting Proteins for PLA2G4C Gene
GPS-Prot Interaction Network for PLA2G4C
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006644 | phospholipid metabolic process | TAS | 10085124 |
| GO:0006954 | inflammatory response | NAS | 10085124 |
| GO:0007567 | parturition | NAS | 10085124 |
| GO:0009395 | phospholipid catabolic process | IEA | -- |
No data available for SIGNOR curated interactions for PLA2G4C Gene
Drugs & Compounds for PLA2G4C Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| linoleic acid | Approved, Experimental | Pharma | Full agonist, Agonist, Pore Blocker, Channel blocker | 0 | ||
| Palmitic Acid | Approved | Pharma | Full agonist, Agonist | 25 | ||
| Stearic acid | Approved, Experimental | Pharma | 0 | |||
| Water | Approved | Pharma | 0 | |||
| alpha-linolenic acid | Approved, Investigational | Nutra | Full agonist, Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Arachidic acid |
|
506-30-9 |
|
|||
| Heptadecanoic acid |
|
506-12-7 |
|
|||
| Heptadecanoyl CoA |
|
3546-17-6 |
|
|||
| PC(18:1(9Z)e/2:0) |
|
|
||||
| Pentadecanoic acid |
|
1002-84-2 |
|
(5) Tocris Compounds for PLA2G4C Gene
| Compound | Action | Cas Number |
|---|---|---|
| AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
| Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
| m-3M3FBS | Phospholipase C activator | 200933-14-8 |
| o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
| U 73122 | Phospholipase C inhibitor | 112648-68-7 |
(1) ApexBio Compounds for PLA2G4C Gene
| Compound | Action | Cas Number |
|---|---|---|
| PACOCF3 | CPLA2 and iPLA2 inhibitor | 141022-99-3 |
Transcripts for PLA2G4C Gene
mRNA/cDNA for PLA2G4C Gene
- (3) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (114) Selected AceView cDNA sequences:
- (24) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000599111 2458 bps (ENST00000599111.5)
- ENST00000354276 2496 bps (ENST00000354276.7)
- ENST00000594790 876 bps (ENST00000594790.1)
- ENST00000599921 2486 bps (ENST00000599921.5)
- ENST00000596510 1770 bps (ENST00000596510.5)
Unigene Clusters for PLA2G4C Gene
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PLA2G4C - Now 50% OFF >
- * PLA2G4C CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * PLA2G4C CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for PLA2G4C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4C
- genomics-online: gRNA clones - Search results for 119 available PLA2G4C gene related products
- Overview of 119 available PLA2G4C gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4C
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PLA2G4C
- Browse OriGene Inhibitory RNA Products For PLA2G4C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4C
- genomics-online: shRNA clones - Search results for 119 available PLA2G4C gene related products
- Overview of 119 available PLA2G4C gene related products
Clone Products
- Applied Biological Materials (abm): Clones for PLA2G4C - Now 50% OFF >
- * PLA2G4C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * PLA2G4C tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG225571
- MG225572
- MR225571
- MR225571L1
- MR225571L1V
- MR225571L2
- MR225571L2V
- MR225571L3
- MR225571L3V
- MR225571L4
- MR225571L4V
- MR225572
- MR225572L1
- MR225572L1V
- MR225572L2
- MR225572L2V
- MR225572L3
- MR225572L3V
- MR225572L4
- MR225572L4V
- RC209567
- RC209567L1
- RC209567L1V
- RC209567L2
- RC209567L2V
- RC209567L3
- RC209567L3V
- RC209567L4
- RC209567L4V
- RC228430
- RC228430L1
- RC228430L1V
- RC228430L2
- RC228430L2V
- RC228430L3
- RC228430L3V
- RC228430L4
- RC228430L4V
- RC228444
- RC228444L1
- RC228444L1V
- RC228444L2
- RC228444L2V
- RC228444L3
- RC228444L3V
- RC228444L4
- RC228444L4V
- RC509567
- RG209567
- RG228430
- RG228444
- RR204333
- RR204333L1
- RR204333L1V
- RR204333L2
- RR204333L2V
- RR204333L3
- RR204333L3V
- RR204333L4
- RR204333L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4C
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | ^ | 10a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | · | 20c | ^ | 21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||
| SP14: |
Expression for PLA2G4C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for PLA2G4C Gene
This gene is overexpressed in Muscle - Skeletal (x5.4).
This gene is overexpressed in Serum (59.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G4C Gene
NURSA nuclear receptor signaling pathways regulating expression of PLA2G4C Gene:
PLA2G4CSOURCE GeneReport for Unigene cluster for PLA2G4C Gene:
Hs.631562mRNA Expression by UniProt/SwissProt for PLA2G4C Gene:
Q9UP65-PA24C_HUMAN
Tissue specificity:
Highly expressed in heart and skeletal muscle.
Evidence on tissue expression from TISSUES for PLA2G4C Gene
- Nervous system(4.9)
- Muscle(4.4)
- Liver(4.2)
- Pancreas(4.2)
- Blood(4)
Primer Products
-
OriGene qPCR primer pairs for PLA2G4C
-
OriGene qPCR primer pairs and template standards for PLA2G4C
- genomics-online: primer clones - Search results for 119 available PLA2G4C gene related products
- Overview of 119 available PLA2G4C gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4C Gene
Orthologs for PLA2G4C Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PLA2G4C 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Pla2g4c 17 35 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:101699 34 |
|
||
| PLA2G4C (3 of 5) 35 |
|
OneToMany | |||
| PLA2G4C (2 of 5) 35 |
|
OneToMany | |||
| PLA2G4C (1 of 5) 35 |
|
OneToMany | |||
| PLA2G4C (4 of 5) 35 |
|
OneToMany | |||
| PLA2G4C (5 of 5) 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany |
- Species where no ortholog for PLA2G4C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PLA2G4C Gene
- ENSEMBL:
- Gene Tree for PLA2G4C (if available)
- TreeFam:
- Gene Tree for PLA2G4C (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PLA2G4C: view image
Paralogs for PLA2G4C Gene
(5) SIMAP similar genes for PLA2G4C Gene using alignment to 12 proteins:
- PA24C_HUMAN
- M0QX83_HUMAN
- M0QY18_HUMAN
- M0QZB1_HUMAN
- M0R0F6_HUMAN
- M0R0M8_HUMAN
- M0R1B4_HUMAN
- M0R339_HUMAN
- M0R3I9_HUMAN
- Q76EY9_HUMAN
- Q76EZ0_HUMAN
- Q8WWC5_HUMAN
Variants for PLA2G4C Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000014696 | -- | 48,103,062(-) | G/A | intron_variant | |
| rs1000167431 | -- | 48,109,052(-) | G/C | intron_variant | |
| rs1000242388 | -- | 48,068,944(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000265144 | -- | 48,054,546(-) | A/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000315187 | -- | 48,069,913(-) | C/T | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3610n100 | CNV | gain | 25217958 |
| dgv3611n100 | CNV | gain | 25217958 |
| esv2666003 | CNV | deletion | 23128226 |
| esv3406045 | CNV | insertion | 20981092 |
| esv34181 | CNV | loss | 18971310 |
| esv3644572 | CNV | loss | 21293372 |
| esv3644573 | CNV | loss | 21293372 |
| esv3644574 | CNV | gain | 21293372 |
| esv3644575 | CNV | loss | 21293372 |
| esv3893228 | CNV | loss | 25118596 |
| nsv1058622 | CNV | gain | 25217958 |
| nsv1058785 | CNV | gain | 25217958 |
| nsv1062163 | CNV | gain | 25217958 |
| nsv2516 | CNV | insertion | 18451855 |
| nsv2517 | CNV | insertion | 18451855 |
| nsv833853 | CNV | loss | 17160897 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.09;
90.20% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLA2G4C Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4C Gene
Disorders for PLA2G4C Gene
Additional Disease Information for PLA2G4C
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PLA2G4C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G4C Gene
Publications for PLA2G4C Gene
- A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2. (PMID: 9705332) Underwood KW … Lin LL (The Journal of biological chemistry 1998) 2 3 4 23 58
- Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis. (PMID: 14529291) Jenkins CM … Gross RW (Biochemistry 2003) 3 4 23 58
- Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 45 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 58
- Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth. (PMID: 21184677) Plunkett J … Muglia LJ (BMC medical genomics 2010) 3 45 58
ExternalLinks
Products for PLA2G4C Gene
- Custom Antibody ServicesOriGene Antibodies for PLA2G4C
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- RC228444
- RC228444L1
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- RC228444L2
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- RC228444L3
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- RG209567
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- RR204333
- RR204333L1
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Sources for PLA2G4C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
- (87) IUPHAR
- (88) BioGPS
- (89) Illumina
- (90) COMPARTMENTS
- (91) HOMER
- (92) PaxDb
- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
- (116) GTR
- (117) Disease Ontology
- (118) Genetics Home Reference
- (119) MeSH
- (120) MedlinePlus
- (121) CDC
- (122) NINDS
- (123) NCBI Bookshelf
- (124) ClinVar
- (125) Gene Damage Index
- (126) ViGene Biosciences
- (127) HPO
- (128) UDN
- (129) VISTA
- (130) FANTOM5
- (131) ENCODE
- (132) ProSci
- (133) Horizon
- (134) NURSA
- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
- (140) St John's Lab
- (141) CIViC
- (142) ProteoGenix
- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare
- (169) Mastermind