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Aliases for PLA2G4C Gene

Aliases for PLA2G4C Gene

  • Phospholipase A2 Group IVC 2 3 4 5
  • Phospholipase A2, Group IVC (Cytosolic, Calcium-Independent) 2 3
  • CPLA2-Gamma 3 4
  • Cytosolic Phospholipase A2 Gamma 3
  • EC 4

External Ids for PLA2G4C Gene

Previous GeneCards Identifiers for PLA2G4C Gene

  • GC19M049195
  • GC19M048919
  • GC19M053227
  • GC19M053242
  • GC19M048551
  • GC19M044932

Summaries for PLA2G4C Gene

Entrez Gene Summary for PLA2G4C Gene

  • This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for PLA2G4C Gene

PLA2G4C (Phospholipase A2 Group IVC) is a Protein Coding gene. Among its related pathways are Ovarian steroidogenesis and LDL Oxidation in Atherogenesis. Gene Ontology (GO) annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is PLA2G4F.

UniProtKB/Swiss-Prot for PLA2G4C Gene

  • Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.

Tocris Summary for PLA2G4C Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G4C Gene

Additional gene information for PLA2G4C Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G4C Gene

Genomics for PLA2G4C Gene

GeneHancer (GH) Regulatory Elements for PLA2G4C Gene

Promoters and enhancers for PLA2G4C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J048109 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 662.7 +0.1 121 1.8 HDGF SIN3A ZNF48 YY1 GLIS2 ZNF143 ZFP91 ATF7 NCOA1 MIER2 PLA2G4C ZC3H4 CYTH2 GRWD1 NOP53-AS1 BICRA SNRNP70 RASIP1 LIG1 KDELR1
GH19J048253 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.2 -146.6 -146599 7.1 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 MEF2D CARD8-AS1 CARD8 BICRA KDELR1 GRWD1 SNRNP70 NOP53-AS1 NOP53 RPL18 SNORD23
GH19J048168 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.8 -59.7 -59654 3.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 LIG1 ZSWIM9 BICRA KDELR1 GRWD1 CCDC9 PLA2G4C NOP53 NOP53-AS1 RPL18
GH19J048106 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.3 +3.0 3042 1.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS DEK SP5 PLA2G4C EMP3 PLA2G4C-AS1
GH19J048121 Enhancer 0.9 ENCODE dbSUPER 18.7 -12.2 -12176 3.8 CTCF HDGF SOX13 PKNOX1 JUN BACH1 MAX ATF7 IKZF2 SOX5 PLA2G4C LIG1 ENSG00000269534 ENSG00000269321
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G4C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLA2G4C gene promoter:
  • ISGF-3
  • STAT3
  • Elk-1
  • c-Ets-1
  • GATA-1
  • POU2F1
  • POU2F1a
  • Pax-4a
  • AREB6
  • En-1

Genomic Locations for PLA2G4C Gene

Genomic Locations for PLA2G4C Gene
63,011 bases
Minus strand
63,010 bases
Minus strand

Genomic View for PLA2G4C Gene

Genes around PLA2G4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G4C Gene

Proteins for PLA2G4C Gene

  • Protein details for PLA2G4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytosolic phospholipase A2 gamma
    Protein Accession:
    Secondary Accessions:
    • B2RB71
    • B4DI40
    • O75457
    • Q6IBI8
    • Q9UG68

    Protein attributes for PLA2G4C Gene

    541 amino acids
    Molecular mass:
    60939 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G4C Gene


neXtProt entry for PLA2G4C Gene

Post-translational modifications for PLA2G4C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLA2G4C Gene

Domains & Families for PLA2G4C Gene

Gene Families for PLA2G4C Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PLA2G4C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLA2G4C: view

No data available for UniProtKB/Swiss-Prot for PLA2G4C Gene

Function for PLA2G4C Gene

Molecular function for PLA2G4C Gene

UniProtKB/Swiss-Prot Function:
Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by palmitoyl-CoA (PubMed:14529291). Not regulated by calcium (PubMed:9705332, PubMed:10085124).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Vmax=218 pmol/min/mg enzyme {ECO:0000269 PubMed:10085124};
GENATLAS Biochemistry:
phospholipase A2,group IVB,Ca2+ independent,cytosolic,ubiquitously predominantly expressed in cardiac and skeletal muscle paralog of PLA2G2A

Enzyme Numbers (IUBMB) for PLA2G4C Gene

Gene Ontology (GO) - Molecular Function for PLA2G4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity TAS --
GO:0004623 phospholipase A2 activity TAS --
GO:0005543 phospholipid binding NAS 10085124
GO:0008970 phosphatidylcholine 1-acylhydrolase activity TAS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLA2G4C: view
genes like me logo Genes that share phenotypes with PLA2G4C: view

Animal Model Products

miRNA for PLA2G4C Gene

miRTarBase miRNAs that target PLA2G4C

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G4C Gene

Localization for PLA2G4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4C Gene

Membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G4C gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
nucleus 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLA2G4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005654 nucleoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS 10085124
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with PLA2G4C: view

Pathways & Interactions for PLA2G4C Gene

genes like me logo Genes that share pathways with PLA2G4C: view

Interacting Proteins for PLA2G4C Gene

Gene Ontology (GO) - Biological Process for PLA2G4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS 10085124
GO:0006954 inflammatory response NAS 10085124
GO:0007567 parturition NAS 10085124
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with PLA2G4C: view

No data available for SIGNOR curated interactions for PLA2G4C Gene

Drugs & Compounds for PLA2G4C Gene

(11) Drugs for PLA2G4C Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist 23
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
calcium Approved Nutra 0

(14) Additional Compounds for PLA2G4C Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
  • Eicosanoic acid
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
  • (2-Acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Pentadecanoic acid
  • 15:00
  • C15
  • C15:0
  • N-Pentadecanoic acid
  • Pentadecylic acid

(5) Tocris Compounds for PLA2G4C Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G4C: view

Transcripts for PLA2G4C Gene

Unigene Clusters for PLA2G4C Gene

Phospholipase A2, group IVC (cytosolic, calcium-independent):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G4C Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP6: - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - -
SP10: - - - -
SP11: - -
SP12: - - - - - - - - - - -

ExUns: 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21
SP1: - - -
SP2: -
SP7: -

Relevant External Links for PLA2G4C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLA2G4C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2G4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G4C Gene

This gene is overexpressed in Muscle - Skeletal (x5.4).

Protein differential expression in normal tissues from HIPED for PLA2G4C Gene

This gene is overexpressed in Serum (59.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G4C Gene

Protein tissue co-expression partners for PLA2G4C Gene

NURSA nuclear receptor signaling pathways regulating expression of PLA2G4C Gene:


SOURCE GeneReport for Unigene cluster for PLA2G4C Gene:


mRNA Expression by UniProt/SwissProt for PLA2G4C Gene:

Tissue specificity: Highly expressed in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for PLA2G4C Gene

  • Nervous system(4.9)
  • Muscle(4.4)
  • Liver(4.2)
  • Pancreas(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with PLA2G4C: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4C Gene

Orthologs for PLA2G4C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G4C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLA2G4C 34 33
  • 98.99 (n)
(Mus musculus)
Mammalia Pla2g4c 16 34 33
  • 68.7 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
-- 34
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 41 (a)
-- 34
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
-- 34
  • 33 (a)
-- 34
  • 33 (a)
(Danio rerio)
Actinopterygii zgc:101699 33
  • 48.64 (n)
PLA2G4C (3 of 5) 34
  • 29 (a)
PLA2G4C (2 of 5) 34
  • 27 (a)
PLA2G4C (1 of 5) 34
  • 27 (a)
PLA2G4C (4 of 5) 34
  • 27 (a)
PLA2G4C (5 of 5) 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
-- 34
  • 19 (a)
Species where no ortholog for PLA2G4C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G4C Gene

Gene Tree for PLA2G4C (if available)
Gene Tree for PLA2G4C (if available)
Evolutionary constrained regions (ECRs) for PLA2G4C: view image

Paralogs for PLA2G4C Gene

Paralogs for PLA2G4C Gene

(5) SIMAP similar genes for PLA2G4C Gene using alignment to 12 proteins:

  • M0QX83_HUMAN
  • M0QY18_HUMAN
  • M0R0F6_HUMAN
  • M0R0M8_HUMAN
  • M0R1B4_HUMAN
  • M0R339_HUMAN
  • M0R3I9_HUMAN
  • Q76EY9_HUMAN
  • Q76EZ0_HUMAN
genes like me logo Genes that share paralogs with PLA2G4C: view

Variants for PLA2G4C Gene

Sequence variations from dbSNP and Humsavar for PLA2G4C Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000014696 -- 48,103,062(-) G/A intron_variant
rs1000167431 -- 48,109,052(-) G/C intron_variant
rs1000242388 -- 48,068,944(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000265144 -- 48,054,546(-) A/C genic_downstream_transcript_variant, intron_variant
rs1000315187 -- 48,069,913(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G4C Gene

Variant ID Type Subtype PubMed ID
dgv3610n100 CNV gain 25217958
dgv3611n100 CNV gain 25217958
esv2666003 CNV deletion 23128226
esv3406045 CNV insertion 20981092
esv34181 CNV loss 18971310
esv3644572 CNV loss 21293372
esv3644573 CNV loss 21293372
esv3644574 CNV gain 21293372
esv3644575 CNV loss 21293372
esv3893228 CNV loss 25118596
nsv1058622 CNV gain 25217958
nsv1058785 CNV gain 25217958
nsv1062163 CNV gain 25217958
nsv2516 CNV insertion 18451855
nsv2517 CNV insertion 18451855
nsv833853 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for PLA2G4C Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.09; 90.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G4C Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4C Gene

Disorders for PLA2G4C Gene

Additional Disease Information for PLA2G4C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLA2G4C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G4C Gene

Publications for PLA2G4C Gene

  1. A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2. (PMID: 9705332) Underwood KW … Lin LL (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis. (PMID: 14529291) Jenkins CM … Gross RW (Biochemistry 2003) 3 4 22 58
  3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth. (PMID: 21184677) Plunkett J … Muglia LJ (BMC medical genomics 2010) 3 44 58

Products for PLA2G4C Gene

Sources for PLA2G4C Gene

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