This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding dif... See more...

Aliases for PLA2G4C Gene

Aliases for PLA2G4C Gene

  • Phospholipase A2 Group IVC 2 3 4 5
  • CPLA2-Gamma 2 3 4
  • Phospholipase A2, Group IVC (Cytosolic, Calcium-Independent) 2 3
  • Cytosolic Lysophospholipid O-Acyltransferase 3 4
  • Cytosolic Phospholipase A2 Gamma 3 4
  • Cytosolic Lysophospholipase 3 4
  • EC 3.1.1.4 4
  • EC 3.1.1.5 4
  • EC 2.3.1.- 4
  • PLA2G4C 5

External Ids for PLA2G4C Gene

Previous GeneCards Identifiers for PLA2G4C Gene

  • GC19M049195
  • GC19M048919
  • GC19M053227
  • GC19M053242
  • GC19M048551
  • GC19M044932

Summaries for PLA2G4C Gene

Entrez Gene Summary for PLA2G4C Gene

  • This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for PLA2G4C Gene

PLA2G4C (Phospholipase A2 Group IVC) is a Protein Coding gene. Diseases associated with PLA2G4C include Pulmonary Systemic Sclerosis. Among its related pathways are Ras signaling pathway and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is PLA2G4F.

UniProtKB/Swiss-Prot Summary for PLA2G4C Gene

  • Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis (PubMed:19501189, PubMed:9705332, PubMed:10085124, PubMed:10358058, PubMed:28336330). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:19501189, PubMed:9705332, PubMed:10085124, PubMed:10358058, PubMed:28336330). Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids (PubMed:19501189, PubMed:15944408). Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency (PubMed:19501189, PubMed:15944408). In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles (PubMed:28336330).
  • (Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV) (PubMed:23015700, PubMed:28336330). In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur (PubMed:23015700). Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly (PubMed:23015700, PubMed:28336330).
  • (Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission.

Tocris Summary for PLA2G4C Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G4C Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G4C Gene

Genomics for PLA2G4C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLA2G4C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G4C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G4C

Top Transcription factor binding sites by QIAGEN in the PLA2G4C gene promoter:
  • AREB6
  • c-Ets-1
  • Elk-1
  • En-1
  • GATA-1
  • ISGF-3
  • Pax-4a
  • POU2F1
  • POU2F1a
  • STAT3

Genomic Locations for PLA2G4C Gene

Latest Assembly
chr19:48,047,843-48,111,383
(GRCh38/hg38)
Size:
63,541 bases
Orientation:
Minus strand

Previous Assembly
chr19:48,551,103-48,614,074
(GRCh37/hg19 by Entrez Gene)
Size:
62,972 bases
Orientation:
Minus strand

chr19:48,551,100-48,614,074
(GRCh37/hg19 by Ensembl)
Size:
62,975 bases
Orientation:
Minus strand

Genomic View for PLA2G4C Gene

Genes around PLA2G4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G4C Gene

Proteins for PLA2G4C Gene

  • Protein details for PLA2G4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UP65-PA24C_HUMAN
    Recommended name:
    Cytosolic phospholipase A2 gamma
    Protein Accession:
    Q9UP65
    Secondary Accessions:
    • B2RB71
    • B4DI40
    • O75457
    • Q6IBI8
    • Q9UG68

    Protein attributes for PLA2G4C Gene

    Size:
    541 amino acids
    Molecular mass:
    60939 Da
    Quaternary structure:
    • (Microbial infection) Interacts with HCV non-structural protein 4B/NS4B; this interaction likely initiates the recruitment of replication complexes to lipid droplets.

    Alternative splice isoforms for PLA2G4C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G4C Gene

Post-translational modifications for PLA2G4C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLA2G4C Gene

Domains & Families for PLA2G4C Gene

Gene Families for PLA2G4C Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PLA2G4C Gene

InterPro:
Blocks:
  • Lysophospholipase, catalytic domain

Suggested Antigen Peptide Sequences for PLA2G4C Gene

GenScript: Design optimal peptide antigens:
  • Phospholipase A2 group IVC (PA24C_HUMAN)
  • PLA2G4C protein (Q6IBI8_HUMAN)
  • Phospholipase A2, group IVC(Cytosolic, calcium-independent) (Q76EY9_HUMAN)
  • Phospholipase A2, group IVC(Cytosolic, calcium-independent) (Q76EZ0_HUMAN)
  • PLA2G4C protein (Q8WWC5_HUMAN)
genes like me logo Genes that share domains with PLA2G4C: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PLA2G4C Gene

Function for PLA2G4C Gene

Molecular function for PLA2G4C Gene

UniProtKB/Swiss-Prot Function:
Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis (PubMed:19501189, PubMed:9705332, PubMed:10085124, PubMed:10358058, PubMed:28336330). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:19501189, PubMed:9705332, PubMed:10085124, PubMed:10358058, PubMed:28336330). Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids (PubMed:19501189, PubMed:15944408). Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency (PubMed:19501189, PubMed:15944408). In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles (PubMed:28336330).
UniProtKB/Swiss-Prot Function:
(Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV) (PubMed:23015700, PubMed:28336330). In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur (PubMed:23015700). Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly (PubMed:23015700, PubMed:28336330).
UniProtKB/Swiss-Prot Function:
(Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:14529291, ECO:0000269|PubMed:9705332};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence={ECO:0000269|PubMed:9705332};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence={ECO:0000269|PubMed:9705332};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence={ECO:0000269|PubMed:9705332};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence={ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:14529291, ECO:0000269|PubMed:9705332};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41067, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:55430, ChEBI:CHEBI:64496; Evidence={ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:9705332};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40571, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73003, ChEBI:CHEBI:76079; Evidence={ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:9705332};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence={ECO:0000269|PubMed:14529291, ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence={ECO:0000269|PubMed:14529291, ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40879, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence={ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40899, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998, ChEBI:CHEBI:73004, ChEBI:CHEBI:73005; Evidence={ECO:0000269|PubMed:19501189};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63764, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999, ChEBI:CHEBI:73004, ChEBI:CHEBI:143890; Evidence={ECO:0000269|PubMed:19501189};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63768, ChEBI:CHEBI:73004, ChEBI:CHEBI:73005, ChEBI:CHEBI:143890; Evidence={ECO:0000269|PubMed:19501189};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:63656, ChEBI:CHEBI:16870, ChEBI:CHEBI:64496, ChEBI:CHEBI:72744, ChEBI:CHEBI:72998; Evidence={ECO:0000269|PubMed:19501189};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:63772, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998, ChEBI:CHEBI:77288, ChEBI:CHEBI:77303; Evidence={ECO:0000269|PubMed:19501189};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63760, ChEBI:CHEBI:64496, ChEBI:CHEBI:72744, ChEBI:CHEBI:73004, ChEBI:CHEBI:143890; Evidence={ECO:0000269|PubMed:19501189};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63788, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003, ChEBI:CHEBI:75036, ChEBI:CHEBI:78268; Evidence={ECO:0000269|PubMed:19501189};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63776, ChEBI:CHEBI:55430, ChEBI:CHEBI:64496, ChEBI:CHEBI:75036, ChEBI:CHEBI:78268; Evidence={ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63784, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002, ChEBI:CHEBI:77288, ChEBI:CHEBI:149549; Evidence={ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63780, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003, ChEBI:CHEBI:77288, ChEBI:CHEBI:77295; Evidence={ECO:0000269|PubMed:15944408};.
UniProtKB/Swiss-Prot Induction:
(Microbial infection) Up-regulated by HCV.
UniProtKB/Swiss-Prot Induction:
(Microbial infection) Transcriptionally up-regulated by HTLV-1 Tax.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=40 uM for 1-O-hexadecyl-sn-glycero-3-phosphocholine (O-acyltransferase activity) {ECO:0000269|PubMed:15944408}; Vmax=218 pmol/min/mg enzyme {ECO:0000269|PubMed:10085124}; pH dependence: Optimum pH is 6.5 for lysophospholipase activity, and 8-9 for O-acyltransferase activity. {ECO:0000269|PubMed:19501189}; Temperature dependence: Optimum temperature is 40 degrees Celsius for lysophospholipase activity, and 50 degrees Celsius for O-acyltransferase activity. Lysophospholipase activity is present even at 0 degrees Celsius and its rate increases with temperature up to 40 degrees Celsius. O-acyltransferase activity is low below 25 degrees Celsius, but increases sharply between 30 and 40 degrees Celsius and peaked near 50 degrees Celsius. {ECO:0000269|PubMed:19501189};
UniProtKB/Swiss-Prot EnzymeRegulation:
Not regulated by calcium, coenzyme A or ATP (PubMed:9705332, PubMed:10085124, PubMed:15944408). Lysophospholipase activity is inhibited by palmitoyl-CoA (PubMed:14529291). Lysophospholipase and O-acyltransferase activities are inhibited by methylarachidonoylfluorophosphonate (PubMed:19501189). Lysophospholipase activity is inhibited by phosphatidate or lysophosphatidate (PubMed:19501189). O-acyltransferase activity is up-regulated at low concentration (10-20 uM) of phosphatidate or lysophosphatidate, but inhibited at higher concentrations (PubMed:19501189).
GENATLAS Biochemistry:
phospholipase A2,group IVB,Ca2+ independent,cytosolic,ubiquitously predominantly expressed in cardiac and skeletal muscle paralog of PLA2G2A

Enzyme Numbers (IUBMB) for PLA2G4C Gene

Phenotypes From GWAS Catalog for PLA2G4C Gene

Gene Ontology (GO) - Molecular Function for PLA2G4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IEA --
GO:0004622 lysophospholipase activity TAS --
GO:0004623 phospholipase A2 activity IBA 21873635
GO:0005509 calcium ion binding IBA 21873635
GO:0005515 protein binding IPI 32814053
genes like me logo Genes that share ontologies with PLA2G4C: view
genes like me logo Genes that share phenotypes with PLA2G4C: view

miRNA for PLA2G4C Gene

miRTarBase miRNAs that target PLA2G4C

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4C

Clone products for research

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G4C Gene

Localization for PLA2G4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4C Gene

Cell membrane. Lipid-anchor. Endoplasmic reticulum membrane. Lipid-anchor. Mitochondrion membrane. Lipid-anchor. Lipid droplet. Note=Translocates from endoplasmic reticulum to lipid droplets in response to oleate. {ECO:0000269 PubMed:28336330}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G4C gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
nucleus 4
cytosol 4
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLA2G4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IBA 21873635
GO:0005654 nucleoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with PLA2G4C: view

Pathways & Interactions for PLA2G4C Gene

genes like me logo Genes that share pathways with PLA2G4C: view

Pathways by source for PLA2G4C Gene

6 GeneGo (Thomson Reuters) pathways for PLA2G4C Gene
  • Development Alpha-2 adrenergic receptor activation of ERK
  • Development_Leptin signaling via JAK/STAT and MAPK cascades
  • Immune response CCR3 signaling in eosinophils
  • Immune response CD16 signaling in NK cells
  • Immune response Fc epsilon RI pathway
11 Qiagen pathways for PLA2G4C Gene
  • Antioxidant Action of Vitamin-C
  • cAMP Pathway
  • CCR3 Pathway in Eosinophils
  • Chemokine Signaling
  • DHA Signaling

Gene Ontology (GO) - Biological Process for PLA2G4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS 10085124
GO:0006663 platelet activating factor biosynthetic process IDA 19501189
GO:0006954 inflammatory response NAS 10085124
GO:0007567 parturition NAS 10085124
genes like me logo Genes that share ontologies with PLA2G4C: view

No data available for SIGNOR curated interactions for PLA2G4C Gene

Drugs & Compounds for PLA2G4C Gene

(12) Drugs for PLA2G4C Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
linoleic acid Approved, Experimental Pharma 0
Palmitic Acid Approved Pharma 27
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
alpha-Linolenic acid Approved, Investigational Nutra 0

(17) Additional Compounds for PLA2G4C Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
506-30-9
CE(22:0)
  • 1-Tetradecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
  • GPCho(14:0/18:0)
  • Phosphatidylcholine(14:0/18:0)
  • 1-Myristoyl-2-stearoylphosphatidylcholine
  • 1m-2S-PC
61510-09-6
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
3546-17-6
PC(18:1(9Z)e/2:0)
  • (2-Acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)

(5) Tocris Compounds for PLA2G4C Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7

(1) ApexBio Compounds for PLA2G4C Gene

Compound Action Cas Number
PACOCF3 CPLA2 and iPLA2 inhibitor 141022-99-3
genes like me logo Genes that share compounds with PLA2G4C: view

Drug products for research

Transcripts for PLA2G4C Gene

mRNA/cDNA for PLA2G4C Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4C

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G4C Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5:
SP6: - - - - - - - - - -
SP7:
SP8: - - - - - - - - -
SP9: - -
SP10: - - - -
SP11: - -
SP12: - - - - - - - - - - -
SP13:
SP14:

ExUns: 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21
SP1: - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PLA2G4C Gene

GeneLoc Exon Structure for
PLA2G4C

Expression for PLA2G4C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G4C Gene

This gene is overexpressed in Muscle - Skeletal (x5.4).

Protein differential expression in normal tissues from HIPED for PLA2G4C Gene

This gene is overexpressed in Serum (59.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G4C Gene



Protein tissue co-expression partners for PLA2G4C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G4C

SOURCE GeneReport for Unigene cluster for PLA2G4C Gene:

Hs.631562

mRNA Expression by UniProt/SwissProt for PLA2G4C Gene:

Q9UP65-PA24C_HUMAN
Tissue specificity: Highly expressed in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for PLA2G4C Gene

  • Nervous system(4.9)
  • Muscle(4.4)
  • Liver(4.3)
  • Pancreas(4.3)
  • Blood(4.3)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with PLA2G4C: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4C Gene

Orthologs for PLA2G4C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G4C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLA2G4C 29 30
  • 98.99 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pla2g4c 29 16 30
  • 68.7 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 47 (a)
OneToMany
-- 30
  • 44 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 41 (a)
OneToMany
-- 30
  • 36 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 34 (a)
OneToMany
-- 30
  • 33 (a)
OneToMany
-- 30
  • 33 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii zgc:101699 29
  • 48.64 (n)
PLA2G4C (3 of 5) 30
  • 29 (a)
OneToMany
PLA2G4C (2 of 5) 30
  • 27 (a)
OneToMany
PLA2G4C (1 of 5) 30
  • 27 (a)
OneToMany
PLA2G4C (4 of 5) 30
  • 27 (a)
OneToMany
PLA2G4C (5 of 5) 30
  • 25 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 19 (a)
ManyToMany
-- 30
  • 19 (a)
ManyToMany
Species where no ortholog for PLA2G4C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PLA2G4C Gene

ENSEMBL:
Gene Tree for PLA2G4C (if available)
TreeFam:
Gene Tree for PLA2G4C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLA2G4C: view image
Alliance of Genome Resources:
Additional Orthologs for PLA2G4C

Paralogs for PLA2G4C Gene

Paralogs for PLA2G4C Gene

(5) SIMAP similar genes for PLA2G4C Gene using alignment to 12 proteins:

  • PA24C_HUMAN
  • M0QX83_HUMAN
  • M0QY18_HUMAN
  • M0QZB1_HUMAN
  • M0R0F6_HUMAN
  • M0R0M8_HUMAN
  • M0R1B4_HUMAN
  • M0R339_HUMAN
  • M0R3I9_HUMAN
  • Q76EY9_HUMAN
  • Q76EZ0_HUMAN
  • Q8WWC5_HUMAN
genes like me logo Genes that share paralogs with PLA2G4C: view

Variants for PLA2G4C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G4C Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs115349574 Benign: not provided 48,098,226(-) G/C
NM_003706.3(PLA2G4C):c.481C>G (p.Pro161Ala)
MISSENSE
rs11564533 Benign: not provided 48,099,719(-) A/G
NM_003706.3(PLA2G4C):c.399T>C (p.Ser133=)
SYNONYMOUS
rs11564638 Benign: not provided 48,062,024(-) C/Tp.Asp411Asn
NM_003706.3(PLA2G4C):c.1231G>A (p.Asp411Asn)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs3218742 Benign: not provided 48,074,825(-) A/G
NM_003706.3(PLA2G4C):c.948T>C (p.Asn316=)
SYNONYMOUS
rs11564522 -- p.Glu21Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLA2G4C Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLA2G4C Gene

Variant ID Type Subtype PubMed ID
dgv3610n100 CNV gain 25217958
dgv3611n100 CNV gain 25217958
esv2666003 CNV deletion 23128226
esv3406045 CNV insertion 20981092
esv34181 CNV loss 18971310
esv3644572 CNV loss 21293372
esv3644573 CNV loss 21293372
esv3644574 CNV gain 21293372
esv3644575 CNV loss 21293372
esv3893228 CNV loss 25118596
nsv1058622 CNV gain 25217958
nsv1058785 CNV gain 25217958
nsv1062163 CNV gain 25217958
nsv2516 CNV insertion 18451855
nsv2517 CNV insertion 18451855
nsv833853 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for PLA2G4C Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.09; 90.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G4C Gene

Human Gene Mutation Database (HGMD)
PLA2G4C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G4C
Leiden Open Variation Database (LOVD)
PLA2G4C

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4C Gene

Disorders for PLA2G4C Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLA2G4C Gene - From: COP

Disorder Aliases PubMed IDs
pulmonary systemic sclerosis
  • lung disease with systemic sclerosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLA2G4C

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PLA2G4C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G4C Gene

Publications for PLA2G4C Gene

  1. A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2. (PMID: 9705332) Underwood KW … Lin LL (The Journal of biological chemistry 1998) 2 3 4 22
  2. Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma). (PMID: 19501189) Yamashita A … Sugiura T (Biochimica et biophysica acta 2009) 3 4 22
  3. Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma). (PMID: 15944408) Yamashita A … Waku K (Journal of biochemistry 2005) 3 4 22
  4. Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis. (PMID: 14529291) Jenkins CM … Gross RW (Biochemistry 2003) 3 4 22
  5. Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation. (PMID: 28336330) Su X … Chen X (Biochimica et biophysica acta. Molecular and cell biology of lipids 2017) 3 4

Products for PLA2G4C Gene

Sources for PLA2G4C Gene