Aliases for PLA2G4C Gene
External Ids for PLA2G4C Gene
Previous GeneCards Identifiers for PLA2G4C Gene
This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
GeneCards Summary for PLA2G4C Gene
PLA2G4C (Phospholipase A2 Group IVC) is a Protein Coding gene. Diseases associated with PLA2G4C include Pulmonary Systemic Sclerosis. Among its related pathways are Oxytocin signaling pathway and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is PLA2G4F.
UniProtKB/Swiss-Prot Summary for PLA2G4C Gene
Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.