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This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008]
PLA2G4B (Phospholipase A2 Group IVB) is a Protein Coding gene. Diseases associated with PLA2G4B include Inflammatory Bowel Disease 12 and Inflammatory Bowel Disease 17. Among its related pathways are Acyl chain remodelling of PE and Phospholipase D signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is JMJD7-PLA2G4B.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004620 | phospholipase activity | IEA | -- |
GO:0004622 | lysophospholipase activity | NAS | 10358058 |
GO:0004623 | phospholipase A2 activity | IBA | 21873635 |
GO:0005509 | calcium ion binding | IBA,NAS | 10085124 |
GO:0005544 | calcium-dependent phospholipid binding | IBA,NAS | 10085124 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | 10085124 |
GO:0005737 | cytoplasm | IBA | -- |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0005768 | endosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Acyl chain remodelling of PE |
.30
|
|
2 | Glycerophospholipid biosynthesis | ||
3 | Linoleic acid metabolism | ||
4 | Metabolism |
.40
|
|
5 | Unfolded Protein Response (UPR) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006644 | phospholipid metabolic process | TAS | -- |
GO:0006654 | phosphatidic acid biosynthetic process | TAS | -- |
GO:0006954 | inflammatory response | NAS | 10085124 |
GO:0007567 | parturition | NAS | 10085124 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Clofazimine | Approved, Investigational | Pharma | Tuberculosis drug | 41 | ||
linoleic acid | Approved, Experimental | Pharma | Agonist, Full agonist, Activator, Pore Blocker, Channel blocker | 0 | ||
Palmitic Acid | Approved | Pharma | Agonist, Full agonist | 27 | ||
Stearic acid | Approved, Experimental | Pharma | 0 | |||
Water | Approved | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Arachidic acid |
|
506-30-9 |
|
|||
Heptadecanoic acid |
|
506-12-7 |
|
|||
Heptadecanoyl CoA |
|
3546-17-6 |
|
|||
LysoPC(14:0/0:0) |
|
20559-16-4 |
|
|||
LysoPC(14:1(9Z)) |
|
|
Compound | Action | Cas Number |
---|---|---|
AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
m-3M3FBS | Phospholipase C activator | 200933-14-8 |
o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
U 73122 | Phospholipase C inhibitor | 112648-68-7 |
Compound | Action | Cas Number |
---|---|---|
Clofazimine | Tuberculosis drug | 2030-63-9 |
CP-91149 | Selective inhibitor of glycogen phosphorylase | 186392-40-5 |
D609 | PC-PLC inhibitor | 83373-60-8 |
PACOCF3 | CPLA2 and iPLA2 inhibitor | 141022-99-3 |
U 73343 | 142878-12-4 | |
Varespladib (LY315920) | HnsPLA inhibitor,potent and selective | 172732-68-2 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PLA2G4B 30 |
|
||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | PLA2G4B 30 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | PLA2G4B 30 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Pla2g4b 30 17 31 |
|
ManyToMany | |
PLA2G4B 31 |
|
ManyToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Pla2g4b 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | PLA2G4B 30 |
|
||
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10133 32 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
726643 | Benign: not provided | 41,841,258(+) | C/T | SYNONYMOUS_VARIANT | |
rs2290552 | - | p.Met239Ile | |||
rs34807597 | - | p.Arg391His | |||
rs36126315 | - | p.Thr591Ile | |||
rs3816533 | - | p.Arg191Cys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2582n100 | CNV | gain | 25217958 |
nsv1035998 | CNV | gain | 25217958 |
nsv1038933 | CNV | gain | 25217958 |
nsv1050892 | CNV | gain | 25217958 |
nsv1506 | CNV | insertion | 18451855 |
nsv517631 | CNV | loss | 19592680 |
nsv9244 | CNV | gain | 18304495 |
nsv952613 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
inflammatory bowel disease 12 |
|
|
inflammatory bowel disease 17 |
|
|