Aliases for PLA2G4B Gene
External Ids for PLA2G4B Gene
Previous GeneCards Identifiers for PLA2G4B Gene
This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008]
GeneCards Summary for PLA2G4B Gene
PLA2G4B (Phospholipase A2 Group IVB) is a Protein Coding gene. Diseases associated with PLA2G4B include Inflammatory Bowel Disease 12 and Inflammatory Bowel Disease 17. Among its related pathways are Acyl chain remodelling of PE and Phospholipase D signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is JMJD7-PLA2G4B.
UniProtKB/Swiss-Prot Summary for PLA2G4B Gene
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.