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This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion ... See more...
Aliases for PLA2G4B Gene
Aliases for PLA2G4B Gene
External Ids for PLA2G4B Gene
- HGNC: 9036
- Entrez Gene: 100137049
- Ensembl: ENSG00000243708
- OMIM: 606088
- UniProtKB: P0C869
Previous GeneCards Identifiers for PLA2G4B Gene
- GC15P037488
- GC15P035016
- GC15P039699
- GC15P039836
- GC15P039907
- GC15P042120
- GC15P042129
- GC15P018979
Summaries for PLA2G4B Gene
-
This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008]
GeneCards Summary for PLA2G4B Gene
PLA2G4B (Phospholipase A2 Group IVB) is a Protein Coding gene. Diseases associated with PLA2G4B include Inflammatory Bowel Disease 12 and Inflammatory Bowel Disease 17. Among its related pathways are Acyl chain remodelling of PE and Phospholipase D signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is JMJD7-PLA2G4B.
UniProtKB/Swiss-Prot Summary for PLA2G4B Gene
-
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine.
-
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
Additional gene information for PLA2G4B Gene
- HGNC(9036)
- Entrez Gene(100137049)
- Ensembl(ENSG00000243708)
- OMIM(606088)
- UniProtKB(P0C869)
- Open Targets Platform(ENSG00000243708)
- Search for PLA2G4B at DataMed
- Search for PLA2G4B at HumanCyc
No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G4B Gene
Genomics for PLA2G4B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PLA2G4B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PLA2G4B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G4B
- Top Transcription factor binding sites by QIAGEN in the PLA2G4B gene promoter:
-
- AP-2gamma
- HEN1
- Msx-1
- PPAR-gamma1
- PPAR-gamma2
- SEF-1 (1)
- STAT5A
- USF-1
- USF1
- YY1
Genomic Locations for PLA2G4B Gene
Genomic Locations for PLA2G4B Gene
- chr15:41,837,775-41,848,148
- (GRCh38/hg38)
- Size:
- 10,374 bases
- Orientation:
- Plus strand
- chr15:42,120,283-42,140,346
- (GRCh37/hg19)
- Size:
- 20,064 bases
- Orientation:
- Plus strand
Genomic View for PLA2G4B Gene
Genes around PLA2G4B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q15.1 by HGNC
- 15q15.1 by Entrez Gene
- 15q15.1 by Ensembl
PLA2G4B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLA2G4B Gene
Proteins for PLA2G4B Gene
-
Protein details for PLA2G4B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C869-PA24B_HUMAN
- Recommended name:
- Cytosolic phospholipase A2 beta
- Protein Accession:
- P0C869
- B4DRT9
- O95712
- Q19KD5
- Q19KD6
- Q59GF9
- Q8TB10
- Q9UKV7
Protein attributes for PLA2G4B Gene
- Size:
- 781 amino acids
- Molecular mass:
- 87978 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAD92387.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 2]: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.
- [Isoform 3]: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.
- [Isoform 5]: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.
Alternative splice isoforms for PLA2G4B Gene
- UniProtKB/Swiss-Prot:
Protein Expression for PLA2G4B Gene
Selected DME Specific Peptides for PLA2G4B Gene
- P0C869:
-
- EFSPYEVG
- RAMTSLYG
Post-translational modifications for PLA2G4B Gene
Other Protein References for PLA2G4B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PLA2G4B Antibody
-
Custom Antibody ServicesOriGene Antibodies for PLA2G4B
-
Abcam antibodies for PLA2G4B
- Invitrogen Antibodies for PLA2G4B (AFLGC-PLA2G4B)
-
Boster Bio Antibodies for PLA2G4B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PLA2G4B
- Origene Custom Protein Services for PLA2G4B
Domains & Families for PLA2G4B Gene
Gene Families for PLA2G4B Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PLA2G4B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PLA2G4B Gene
- GenScript: Design optimal peptide antigens:
-
- Phospholipase A2 group IVB (PA24B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P0C869UniProtKB/Swiss-Prot:
PA24B_HUMAN :- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
- Domain:
-
- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
Function for PLA2G4B Gene
Molecular function for PLA2G4B Gene
- UniProtKB/Swiss-Prot Function:
- Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: Vmax=7.9 pmol/min/mg enzyme (isoform 5) {ECO:0000269|PubMed:10085124}; Vmax=3.6 pmol/min/ug enzyme with cAMP as substrate (isoform 4) {ECO:0000269|PubMed:10085124}; Vmax=140 nmol/min/ug enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 5) {ECO:0000269|PubMed:10085124}; Vmax=1.6 nmol/min/ug enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 3) {ECO:0000269|PubMed:10085124}; Vmax=2.1 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PC as substrate (isoform 5) {ECO:0000269|PubMed:10085124}; Vmax=0.6 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 5) {ECO:0000269|PubMed:10085124}; Vmax=0.8 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 3) {ECO:0000269|PubMed:10085124}; Vmax=0.3 nmol/min/ug enzyme with 1-16:0-2-[14C]18:2-PE as substrate (isoform 3) {ECO:0000269|PubMed:10085124};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Stimulated by cytosolic Ca(2+).
- GENATLAS Biochemistry:
- phospholipase A2,group IVB,Ca2+ dependent,cytosolic,more highly expressed in cerebellum and pancreas and more abundantly in beta cells,paralog of PLA2G2A
Enzyme Numbers (IUBMB) for PLA2G4B Gene
Phenotypes From GWAS Catalog for PLA2G4B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004620 | phospholipase activity | IEA | -- |
| GO:0004622 | lysophospholipase activity | NAS | 10358058 |
| GO:0004623 | phospholipase A2 activity | IBA | 21873635 |
| GO:0005509 | calcium ion binding | IBA,NAS | 10085124 |
| GO:0005544 | calcium-dependent phospholipid binding | IBA,NAS | 10085124 |
Phenotypes for PLA2G4B Gene
- MGI mutant phenotypes for PLA2G4B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PLA2G4B:
Animal Models for PLA2G4B Gene
- MGI Knock Outs for PLA2G4B:
-
- Pla2g4b Pla2g4b<tm1b(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PLA2G4B - Select products 50% OFF >
- * PLA2G4B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PLA2G4B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4B
miRNA for PLA2G4B Gene
- miRTarBase miRNAs that target PLA2G4B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4B
- Browse OriGene Inhibitory RNA Products For PLA2G4B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4B
Clone Products
- Applied Biological Materials (abm): Clones for PLA2G4B - Select products 50% OFF >
- * PLA2G4B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PLA2G4B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4B
Cell Line Products
-
Horizon Cell Lines for PLA2G4B
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G4B Gene
Localization for PLA2G4B Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4B Gene
- Cytoplasm, cytosol.
- [Isoform 3]: Mitochondrion membrane. Peripheral membrane protein. Early endosome membrane. Peripheral membrane protein. Note=Translocates to membrane vesicles in a calcium-dependent fashion.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| endosome | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | 10085124 |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G4B Gene
Pathways & Interactions for PLA2G4B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Acyl chain remodelling of PE |
.30
|
|
| 2 | Glycerophospholipid biosynthesis | ||
| 3 | Linoleic acid metabolism | ||
| 4 | Metabolism |
.40
|
|
| 5 | Unfolded Protein Response (UPR) | ||
Pathways by source for PLA2G4B Gene
14 Reactome pathways for PLA2G4B Gene
1 PharmGKB pathway for PLA2G4B Gene
23 KEGG pathways for PLA2G4B Gene
Interacting Proteins for PLA2G4B Gene
GPS-Prot Interaction Network for PLA2G4B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006644 | phospholipid metabolic process | TAS | -- |
| GO:0006654 | phosphatidic acid biosynthetic process | TAS | -- |
| GO:0006954 | inflammatory response | NAS | 10085124 |
| GO:0007567 | parturition | NAS | 10085124 |
No data available for SIGNOR curated interactions for PLA2G4B Gene
Drugs & Compounds for PLA2G4B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Clofazimine | Approved, Investigational | Pharma | Tuberculosis drug | 41 | ||
| linoleic acid | Approved, Experimental | Pharma | Agonist, Full agonist, Activator, Pore Blocker, Channel blocker | 0 | ||
| Palmitic Acid | Approved | Pharma | Agonist, Full agonist | 27 | ||
| Stearic acid | Approved, Experimental | Pharma | 0 | |||
| Water | Approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Arachidic acid |
|
506-30-9 |
|
|||
| Heptadecanoic acid |
|
506-12-7 |
|
|||
| Heptadecanoyl CoA |
|
3546-17-6 |
|
|||
| LysoPC(14:0/0:0) |
|
20559-16-4 |
|
|||
| LysoPC(14:1(9Z)) |
|
|
(5) Tocris Compounds for PLA2G4B Gene
| Compound | Action | Cas Number |
|---|---|---|
| AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
| Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
| m-3M3FBS | Phospholipase C activator | 200933-14-8 |
| o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
| U 73122 | Phospholipase C inhibitor | 112648-68-7 |
(6) ApexBio Compounds for PLA2G4B Gene
| Compound | Action | Cas Number |
|---|---|---|
| Clofazimine | Tuberculosis drug | 2030-63-9 |
| CP-91149 | Selective inhibitor of glycogen phosphorylase | 186392-40-5 |
| D609 | PC-PLC inhibitor | 83373-60-8 |
| PACOCF3 | CPLA2 and iPLA2 inhibitor | 141022-99-3 |
| U 73343 | 142878-12-4 | |
| Varespladib (LY315920) | HnsPLA inhibitor,potent and selective | 172732-68-2 |
Transcripts for PLA2G4B Gene
mRNA/cDNA for PLA2G4B Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000452633 2985 nts (view in UCSC)
- ENST00000458483 2734 nts (view in UCSC)
- ENST00000461382 1530 nts (view in UCSC)
- ENST00000483748 3035 nts (view in UCSC)
- ENST00000566076 379 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PLA2G4B - Select products 50% OFF >
- * PLA2G4B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PLA2G4B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4B
- Browse OriGene Inhibitory RNA Products For PLA2G4B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4B
Clone Products
- Applied Biological Materials (abm): Clones for PLA2G4B - Select products 50% OFF >
- * PLA2G4B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PLA2G4B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4B
Relevant External Links for PLA2G4B Gene
- GeneLoc Exon Structure for
- PLA2G4B
Expression for PLA2G4B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for PLA2G4B Gene
This gene is overexpressed in Brain - Cerebellum (x5.1) and Brain - Cerebellar Hemisphere (x4.2).
This gene is overexpressed in Urine (33.8) and Cervix (30.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLA2G4B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G4B
mRNA Expression by UniProt/SwissProt for PLA2G4B Gene:
P0C869-PA24B_HUMAN
Tissue specificity:
Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed.
Evidence on tissue expression from TISSUES for PLA2G4B Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for PLA2G4B
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4B Gene
Orthologs for PLA2G4B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PLA2G4B 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | PLA2G4B 30 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | PLA2G4B 30 31 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Pla2g4b 30 17 31 |
|
ManyToMany | |
| PLA2G4B 31 |
|
ManyToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Pla2g4b 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | PLA2G4B 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG10133 32 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for PLA2G4B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for PLA2G4B Gene
- ENSEMBL:
- Gene Tree for PLA2G4B (if available)
- TreeFam:
- Gene Tree for PLA2G4B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PLA2G4B: view image
Paralogs for PLA2G4B Gene
Variants for PLA2G4B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G4B Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 726643 | Benign: not provided | 41,841,258(+) | C/T | SYNONYMOUS_VARIANT | |
| rs2290552 | - | p.Met239Ile | |||
| rs34807597 | - | p.Arg391His | |||
| rs36126315 | - | p.Thr591Ile | |||
| rs3816533 | - | p.Arg191Cys |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2582n100 | CNV | gain | 25217958 |
| nsv1035998 | CNV | gain | 25217958 |
| nsv1038933 | CNV | gain | 25217958 |
| nsv1050892 | CNV | gain | 25217958 |
| nsv1506 | CNV | insertion | 18451855 |
| nsv517631 | CNV | loss | 19592680 |
| nsv9244 | CNV | gain | 18304495 |
| nsv952613 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.93;
74.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLA2G4B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PLA2G4B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4B Gene
Disorders for PLA2G4B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| inflammatory bowel disease 12 |
|
|
| inflammatory bowel disease 17 |
|
|
Search PLA2G4B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PLA2G4B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G4B Gene
Publications for PLA2G4B Gene
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 41
- Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. (PMID: 16617059) Ghosh M … Leslie CC (The Journal of biological chemistry 2006) 3 4
- Molecular characterization of cytosolic phospholipase A2-beta. (PMID: 10358058) Song C … Kriz RW (The Journal of biological chemistry 1999) 3 4
- Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2. (PMID: 10085124) Pickard RT … Sharp JD (The Journal of biological chemistry 1999) 3 4
ExternalLinks
Products for PLA2G4B Gene
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Sources for PLA2G4B Gene
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