PLA2G4B Gene (Protein Coding)

Phospholipase A2 Group IVB

GC15P041837
GIFtS:
39
This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion ... See more...

Aliases for PLA2G4B Gene

Aliases for PLA2G4B Gene

  • Phospholipase A2 Group IVB 2 3 4 5
  • CPLA2-Beta 2 3 4
  • Phospholipase A2, Group IVB (Cytosolic) 2 3
  • Cytosolic Phospholipase A2 Beta 3 4
  • Lysophospholipase A1 Group IVB 3 4
  • EC 3.1.1.4 4 50
  • HsT16992 2 3
  • EC 3.1.1.5 4
  • PLA2G4B 5

External Ids for PLA2G4B Gene

Previous GeneCards Identifiers for PLA2G4B Gene

  • GC15P037488
  • GC15P035016
  • GC15P039699
  • GC15P039836
  • GC15P039907
  • GC15P042120
  • GC15P042129
  • GC15P018979

Summaries for PLA2G4B Gene

Entrez Gene Summary for PLA2G4B Gene

  • This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLA2G4B Gene

PLA2G4B (Phospholipase A2 Group IVB) is a Protein Coding gene. Diseases associated with PLA2G4B include Inflammatory Bowel Disease 12 and Inflammatory Bowel Disease 17. Among its related pathways are Ras signaling pathway and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is JMJD7-PLA2G4B.

UniProtKB/Swiss-Prot Summary for PLA2G4B Gene

  • Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling.
  • [Isoform 3]: Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines.
  • [Isoform 5]: Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids.

Tocris Summary for PLA2G4B Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Additional gene information for PLA2G4B Gene

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G4B Gene

Genomics for PLA2G4B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PLA2G4B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH15J041837 Enhancer 1 Ensembl ENCODE dbSUPER 250.7 +0.8 828 1.6 CEBPB ZNF217 MBD2 ELF1 CTBP1 SIN3A SMARCE1 PKNOX1 MAZ SCRT1 PLA2G4B JMJD7 HSALNG0105387 JMJD7-PLA2G4B SPTBN5
GH15J041836 Enhancer 0.4 Ensembl dbSUPER 250.7 -1.5 -1474 0.2 ZNF341 PLA2G4B JMJD7 MAPKBP1 HSALNG0105386 JMJD7-PLA2G4B
GH15J041772 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.3 -61.8 -61777 6.4 BCLAF1 SP1 ZNF654 MYC ZNF600 SSRP1 ZNF580 ZNF592 KLF9 CEBPA MAPKBP1 JMJD7 CDAN1 MGA VPS39 INO80 SPTBN5 ENSG00000260814 DNAJC17 ENSG00000250379
GH15J041659 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.2 -176.7 -176653 3.8 BCLAF1 MYC ZNF600 ZNF592 POLR2A NFIC MXD4 NONO REST KLF11 HSALNG0105369 MGA JMJD7 INO80 RAD51-AS1 DNAJC17 MAPKBP1 ENSG00000261002 RAD51 GANC
GH15J041620 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 9.2 -216.0 -215974 2.8 ZNF600 ZNF580 ZMYM3 BRCA1 POLR2A ZIC2 ZBTB10 YY1 MXD4 KLF11 MGA RAD51-AS1 TMEM87A VPS39 GANC INO80 PLA2G4B LOC105370791 MAPKBP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G4B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G4B

Top Transcription factor binding sites by QIAGEN in the PLA2G4B gene promoter:
  • AP-2gamma
  • HEN1
  • Msx-1
  • PPAR-gamma1
  • PPAR-gamma2
  • SEF-1 (1)
  • STAT5A
  • USF-1
  • USF1
  • YY1

Genomic Locations for PLA2G4B Gene

Latest Assembly
chr15:41,837,775-41,848,147
(GRCh38/hg38)
Size:
10,373 bases
Orientation:
Plus strand

Previous Assembly
chr15:42,131,045-42,140,341
(GRCh37/hg19 by Entrez Gene)
Size:
9,297 bases
Orientation:
Plus strand

chr15:42,120,283-42,140,345
(GRCh37/hg19 by Ensembl)
Size:
20,063 bases
Orientation:
Plus strand

Genomic View for PLA2G4B Gene

Genes around PLA2G4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G4B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PLA2G4B Gene

Proteins for PLA2G4B Gene

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  • Protein details for PLA2G4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C869-PA24B_HUMAN
    Recommended name:
    Cytosolic phospholipase A2 beta
    Protein Accession:
    P0C869
    Secondary Accessions:
    • B4DRT9
    • O95712
    • Q19KD5
    • Q19KD6
    • Q59GF9
    • Q8TB10
    • Q9UKV7

    Protein attributes for PLA2G4B Gene

    Size:
    781 amino acids
    Molecular mass:
    87978 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92387.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.
    • [Isoform 3]: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.
    • [Isoform 5]: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.

    Alternative splice isoforms for PLA2G4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G4B Gene

Protein Expression for PLA2G4B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PLA2G4B Gene

P0C869:
  • EFSPYEVG
  • RAMTSLYG

Post-translational modifications for PLA2G4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G4B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PLA2G4B Gene

Gene Families for PLA2G4B Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PLA2G4B Gene

InterPro:

Suggested Antigen Peptide Sequences for PLA2G4B Gene

GenScript: Design optimal peptide antigens:
  • Phospholipase A2 group IVB (PA24B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C869

UniProtKB/Swiss-Prot:

PA24B_HUMAN :
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
Domain:
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
genes like me logo Genes that share domains with PLA2G4B: view

Function for PLA2G4B Gene

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Molecular function for PLA2G4B Gene

UniProtKB/Swiss-Prot Function:
Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling.
UniProtKB/Swiss-Prot Function:
[Isoform 3]: Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines.
UniProtKB/Swiss-Prot Function:
[Isoform 5]: Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence={ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence={ECO:0000269|PubMed:16617059};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence={ECO:0000269|PubMed:16617059};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence={ECO:0000269|PubMed:16617059};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence={ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence={ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:40571, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73003, ChEBI:CHEBI:76079; Evidence={ECO:0000269|PubMed:10358058};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence={ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
[Isoform 3]: Kinetic parameters: Note=The specific activity is 0.8 nmol/min/ug enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine as substrate. The specific activity is 0.3 nmol/min/ug enzyme with 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine as substrate. The specific activity is 1.6 nmol/min/ug enzyme with 1-hexadecanoyl-sn-glycero-3-phosphocholine as substrate. {ECO:0000269|PubMed:16617059};
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
[Isoform 5]: Kinetic parameters: Note=The specific activity is 2.1 nmol/min/ug enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine as substrate. The specific activity is 0.6 nmol/min/ug enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine as substrate. The specific activity is 140 nmol/min/ug enzyme with 1-hexadecanoyl-sn-glycero-3-phosphocholine as substrate. {ECO:0000269|PubMed:16617059};
UniProtKB/Swiss-Prot EnzymeRegulation:
[Isoform 5]: Stimulated by cytosolic Ca(2+).
GENATLAS Biochemistry:
phospholipase A2,group IVB,Ca2+ dependent,cytosolic,more highly expressed in cerebellum and pancreas and more abundantly in beta cells,paralog of PLA2G2A

Enzyme Numbers (IUBMB) for PLA2G4B Gene

Phenotypes From GWAS Catalog for PLA2G4B Gene

Gene Ontology (GO) - Molecular Function for PLA2G4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IEA --
GO:0004622 lysophospholipase activity NAS 10358058
GO:0004623 phospholipase A2 activity IBA 21873635
GO:0005509 calcium ion binding IBA,NAS 10085124
GO:0005544 calcium-dependent phospholipid binding IBA,NAS 10085124
genes like me logo Genes that share ontologies with PLA2G4B: view
genes like me logo Genes that share phenotypes with PLA2G4B: view

Animal Models for PLA2G4B Gene

MGI Knock Outs for PLA2G4B:
  • Pla2g4b Pla2g4b<tm1b(EUCOMM)Wtsi>

Animal Models for research

miRNA for PLA2G4B Gene

miRTarBase miRNAs that target PLA2G4B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4B

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G4B Gene

Localization for PLA2G4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4B Gene

[Isoform 3]: Cytoplasm, cytosol. Mitochondrion membrane. Peripheral membrane protein. Early endosome membrane. Peripheral membrane protein. Note=Translocates to membrane vesicles in a calcium-dependent fashion. {ECO:0000269 PubMed:16617059}.
[Isoform 5]: Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G4B gene
Compartment Confidence
extracellular 5
mitochondrion 5
endosome 5
cytosol 5
plasma membrane 1
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PLA2G4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10085124
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with PLA2G4B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G4B Gene

Pathways & Interactions for PLA2G4B Gene

genes like me logo Genes that share pathways with PLA2G4B: view

Gene Ontology (GO) - Biological Process for PLA2G4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006954 inflammatory response NAS 10085124
GO:0007567 parturition NAS 10085124
genes like me logo Genes that share ontologies with PLA2G4B: view

No data available for SIGNOR curated interactions for PLA2G4B Gene

Drugs & Compounds for PLA2G4B Gene

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(18) Drugs for PLA2G4B Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clofazimine Approved, Investigational Pharma Tuberculosis drug 47
linoleic acid Approved, Experimental Pharma 0
Palmitic Acid Approved Pharma 27
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0

(50) Additional Compounds for PLA2G4B Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
 506-30-9
CE(22:0)
  • 1-Tetradecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
  • GPCho(14:0/18:0)
  • Phosphatidylcholine(14:0/18:0)
  • 1-Myristoyl-2-stearoylphosphatidylcholine
  • 1m-2S-PC
 61510-09-6
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
 506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
 3546-17-6
Hydroxyclomipramine
  • 1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
  • 1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-icosatetraenoyl)-sn-glycero-3-phosphoethanolamine zwitterion
  • 1-(1-Enyl-stearoyl)-2-arachidonoyl-sn-glycero-3-phosphoethanolamine
  • 1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
  • 1-Alkenyl-2-acyl-glycerophosphoethanolamine
 97859-69-3

(5) Tocris Compounds for PLA2G4B Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7

(6) ApexBio Compounds for PLA2G4B Gene

Compound Action Cas Number
Clofazimine Tuberculosis drug 2030-63-9
CP-91149 Selective inhibitor of glycogen phosphorylase 186392-40-5
D609 PC-PLC inhibitor 83373-60-8
PACOCF3 CPLA2 and iPLA2 inhibitor 141022-99-3
U 73343 142878-12-4
Varespladib (LY315920) HnsPLA inhibitor,potent and selective 172732-68-2
genes like me logo Genes that share compounds with PLA2G4B: view

Drug products for research

Transcripts for PLA2G4B Gene

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mRNA/cDNA for PLA2G4B Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4B

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G4B Gene

No ASD Table

Relevant External Links for PLA2G4B Gene

GeneLoc Exon Structure for
PLA2G4B

Expression for PLA2G4B Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G4B Gene

mRNA expression in normal human tissues for PLA2G4B Gene
mRNA expression by GTEx for PLA2G4B GenemRNA expression by BioGPS for PLA2G4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G4B Gene

This gene is overexpressed in Brain - Cerebellum (x5.1) and Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for PLA2G4B Gene

This gene is overexpressed in Urine (33.8) and Cervix (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLA2G4B Gene



Protein tissue co-expression partners for PLA2G4B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G4B

mRNA Expression by UniProt/SwissProt for PLA2G4B Gene:

P0C869-PA24B_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas.

Evidence on tissue expression from TISSUES for PLA2G4B Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PLA2G4B: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4B Gene

Orthologs for PLA2G4B Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G4B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PLA2G4B 29
  • 98.82 (n)
-- 30
  • 98 (a)
 ManyToMany
-- 30
  • 97 (a)
 ManyToMany
Cow
(Bos Taurus)
 Mammalia PLA2G4B 29 30
  • 86.44 (n)
 OneToMany
Dog
(Canis familiaris)
 Mammalia PLA2G4B 29 30
  • 85.98 (n)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Pla2g4b 29 16 30
  • 83.29 (n)
 ManyToMany
PLA2G4B 30
  • 81 (a)
 ManyToMany
Rat
(Rattus norvegicus)
 Mammalia Pla2g4b 29
  • 83.07 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 69 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves PLA2G4B 29
  • 56.19 (n)
-- 30
  • 46 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 46 (a)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta CG10133 31
  • 41 (a)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 23 (a)
 ManyToMany
-- 30
  • 19 (a)
 ManyToMany
Species where no ortholog for PLA2G4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PLA2G4B Gene

ENSEMBL:
Gene Tree for PLA2G4B (if available)
TreeFam:
Gene Tree for PLA2G4B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLA2G4B: view image
Alliance of Genome Resources:
Additional Orthologs for PLA2G4B

Paralogs for PLA2G4B Gene

Paralogs for PLA2G4B Gene

(4) SIMAP similar genes for PLA2G4B Gene using alignment to 2 proteins:

  • PA24B_HUMAN
  • H3BSX5_HUMAN
genes like me logo Genes that share paralogs with PLA2G4B: view

Variants for PLA2G4B Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G4B Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
983095 Uncertain Significance: Neurodevelopmental disorder 41,847,819(+) C/T
NM_001114633.2(PLA2G4B):c.2305C>T (p.Arg769Cys) 		MISSENSE_VARIANT,THREE_PRIME_UTR
rs377316217 Benign: not provided 41,841,258(+) C/T
NM_001114633.1(PLA2G4B):c.420C>T (p.Ser140=) 		SYNONYMOUS
rs2290552 -- p.Met239Ile
rs34807597 -- p.Arg391His
rs36126315 -- p.Thr591Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLA2G4B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLA2G4B Gene

Variant ID Type Subtype PubMed ID
dgv2582n100 CNV gain 25217958
nsv1035998 CNV gain 25217958
nsv1038933 CNV gain 25217958
nsv1050892 CNV gain 25217958
nsv1506 CNV insertion 18451855
nsv517631 CNV loss 19592680
nsv9244 CNV gain 18304495
nsv952613 CNV deletion 24416366

Variation tolerance for PLA2G4B Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.93; 74.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G4B
Leiden Open Variation Database (LOVD)
PLA2G4B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4B Gene

Disorders for PLA2G4B Gene

MalaCards: The human disease database

(3) MalaCards diseases for PLA2G4B Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLA2G4B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PLA2G4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G4B Gene

Publications for PLA2G4B Gene

  1. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 40
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  3. Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. (PMID: 16617059) Ghosh M … Leslie CC (The Journal of biological chemistry 2006) 3 4
  4. Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2. (PMID: 10085124) Pickard RT … Sharp JD (The Journal of biological chemistry 1999) 3 4
  5. Molecular characterization of cytosolic phospholipase A2-beta. (PMID: 10358058) Song C … Kriz RW (The Journal of biological chemistry 1999) 3 4

ExternalLinks

View latest publications for PLA2G4B gene in Mastermind

Products for PLA2G4B Gene

Sources for PLA2G4B Gene