Aliases for PLA2G4A Gene
Aliases for PLA2G4A Gene
External Ids for PLA2G4A Gene
- HGNC: 9035
- Entrez Gene: 5321
- Ensembl: ENSG00000116711
- OMIM: 600522
- UniProtKB: P47712
Previous HGNC Symbols for PLA2G4A Gene
- PLA2G4
Previous GeneCards Identifiers for PLA2G4A Gene
- GC01P184323
- GC01P182226
- GC01P183317
- GC01P184037
- GC01P184013
- GC01P183529
- GC01P185064
- GC01P158032
Summaries for PLA2G4A Gene
-
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
GeneCards Summary for PLA2G4A Gene
PLA2G4A (Phospholipase A2 Group IVA) is a Protein Coding gene. Diseases associated with PLA2G4A include Cryptogenic Multifocal Ulcerous Stenosing Enteritis and Cytosolic Phospholipase-A2 Alpha Deficiency Associated Bleeding Disorder. Among its related pathways are Development EGFR signaling via small GTPases and COPI-independent Golgi-to-ER retrograde traffic. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G4F.
UniProtKB/Swiss-Prot for PLA2G4A Gene
-
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
-
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
Additional gene information for PLA2G4A Gene
- Monarch Initiative
- Search for PLA2G4A at DataMed
- Search for PLA2G4A at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G4A Gene
Genomics for PLA2G4A Gene
GeneHancer (GH) Regulatory Elements for PLA2G4A Gene
Promoters and enhancers for PLA2G4A Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01I186828 | Promoter/Enhancer | 2.1 | EPDnew FANTOM5 Ensembl ENCODE | 554.9 | +0.7 | 714 | 2.6 | ZSCAN4 MZF1 SIN3A FEZF1 RFX5 GTF3C2 ZNF335 ZNF213 ZNF366 ZSCAN5C | PLA2G4A TPR OCLM PTGS2 GC01P187071 | |
| GH01I186848 | Promoter/Enhancer | 1.5 | EPDnew FANTOM5 Ensembl | 567.6 | +20.5 | 20512 | 1.8 | FOXA2 ZSCAN4 BATF IRF4 RELA NFATC1 FOSL2 FOS IKZF2 RUNX3 | PLA2G4A ODR4 ENSG00000228238 PTGS2 GC01P187071 | |
| GH01I186739 | Enhancer | 0.5 | FANTOM5 | 10.8 | -89.9 | -89912 | 0.6 | JUNB BATF RUNX3 SPI1 | PTGS2 PLA2G4A PACERR ODR4 | |
| GH01I186819 | Enhancer | 0.9 | FANTOM5 Ensembl ENCODE | 4.8 | -9.4 | -9399 | 1 | FOS BATF RUNX3 SPI1 | PTGS2 PLA2G4A PACERR | |
| GH01I186978 | Enhancer | 0.8 | FANTOM5 Ensembl | 3.6 | +150.0 | 149963 | 0.7 | POLR2A IKZF1 ZNF547 MAFG EBF1 IKZF2 SPI1 RELA | PTGS2 PLA2G4A GC01P187071 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PLA2G4A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PLA2G4A gene promoter:
Regulatory Element Products
Genomic Locations for PLA2G4A Gene
Genomic Locations for PLA2G4A Gene
- chr1:186,828,900-186,988,981
- (GRCh38/hg38)
- Size:
- 160,082 bases
- Orientation:
- Plus strand
- chr1:186,798,032-186,958,113
- (GRCh37/hg19)
Genomic View for PLA2G4A Gene
Genes around PLA2G4A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q31.1 by Ensembl
- 1q31.1 by Entrez Gene
- 1q31.1 by HGNC
PLA2G4A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLA2G4A Gene
Proteins for PLA2G4A Gene
-
Protein details for PLA2G4A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P47712-PA24A_HUMAN
- Recommended name:
- Cytosolic phospholipase A2
- Protein Accession:
- P47712
- B1AKG4
- Q29R80
Protein attributes for PLA2G4A Gene
- Size:
- 749 amino acids
- Molecular mass:
- 85239 Da
- Quaternary structure:
-
- Interacts with KAT5.
Protein Expression for PLA2G4A Gene
Post-translational modifications for PLA2G4A Gene
- Activated by phosphorylation at both Ser-505 and Ser-727.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PLA2G4A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PLA2G4A (PLA2G4A)
-
Custom Antibody ServicesOriGene Antibodies for PLA2G4A
- Novus Biologicals Antibodies for PLA2G4A
-
Cloud-Clone Corp. Antibodies for PLA2G4A
- Invitrogen Antibodies for PLA2G4A
- GeneTex PLA2G4A antibody for PLA2G4A
-
Custom Antibody ServicesProSci Antibodies for PLA2G4A
-
Santa Cruz Biotechnology (SCBT) Antibodies for PLA2G4A
Protein Products
- R&D Systems Proteins and Enzymes for PLA2G4A
-
OriGene Purified Proteins for PLA2G4A
- Search Origene for MassSpec and Protein Over-expression Lysates for PLA2G4A
- Origene Custom Protein Services for PLA2G4A
-
Cloud-Clone Corp. Proteins for PLA2G4A
- Search GeneTex for Proteins for PLA2G4A
Assay Products
No data available for DME Specific Peptides for PLA2G4A Gene
Domains & Families for PLA2G4A Gene
Gene Families for PLA2G4A Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for PLA2G4A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PLA2G4A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P47712UniProtKB/Swiss-Prot:
PA24A_HUMAN :- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
- Domain:
-
- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
Function for PLA2G4A Gene
Molecular function for PLA2G4A Gene
- GENATLAS Biochemistry:
- phospholipase A2,group IV,Ca2+ dependent,cytosolic,releasing arachidonic acid from membrane phospholipids,initiating the biosynthesis of prostaglandins,leukotrienes and platelet-activating factor
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: Vmax=2.7 umol/min/mg enzyme for the phospholipase A2 reaction {ECO:0000269 PubMed:8083230}; Vmax=4.6 umol/min/mg enzyme for the lysophosphatase reaction {ECO:0000269 PubMed:8083230};
- UniProtKB/Swiss-Prot CatalyticActivity:
- Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+).
- UniProtKB/Swiss-Prot Function:
- Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Phenotypes From GWAS Catalog for PLA2G4A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004622 | lysophospholipase activity | TAS | -- |
| GO:0004623 | phospholipase A2 activity | TAS | -- |
| GO:0005509 | calcium ion binding | IDA | 9430701 |
| GO:0005544 | calcium-dependent phospholipid binding | IDA | 9665851 |
| GO:0008970 | phosphatidylcholine 1-acylhydrolase activity | TAS | -- |
Phenotypes for PLA2G4A Gene
- MGI mutant phenotypes for PLA2G4A:
-
inferred from 2 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- GenomeRNAi human phenotypes for PLA2G4A:
Animal Model Products
-
Taconic Biosciences Mouse Models for PLA2G4A
- Cyagen custom Knockout/knockin (KOKI) mouse models for PLA2G4A
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PLA2G4A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLA2G4A gene
- Search ViGene Biosciences for PLA2G4A
CRISPR Products
-
OriGene CRISPR knockouts for PLA2G4A
- genomics-online: gRNA clones - Search results for available PLA2G4A gene related products
- Applied Biological Materials CRISPR for PLA2G4A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4A
- GenScript: Design CRISPR guide RNA sequences for PLA2G4A
miRNA for PLA2G4A Gene
- miRTarBase miRNAs that target PLA2G4A
-
- hsa-mir-124-3p (MIRT022551)
- hsa-mir-30a-5p (MIRT028507)
- hsa-mir-146b-5p (MIRT041616)
- hsa-mir-10a-5p (MIRT047518)
- hsa-mir-449c-5p (MIRT052653)
- hsa-mir-7977 (MIRT671764)
- hsa-mir-3157-5p (MIRT671765)
- hsa-mir-24-3p (MIRT671766)
- hsa-mir-4284 (MIRT671767)
- hsa-mir-4755-3p (MIRT671768)
- hsa-mir-342-3p (MIRT671769)
- hsa-mir-4691-3p (MIRT671770)
- hsa-mir-1228-3p (MIRT671771)
- hsa-mir-665 (MIRT700757)
- hsa-mir-6771-5p (MIRT700758)
- hsa-mir-4763-3p (MIRT700759)
- hsa-mir-1207-5p (MIRT700760)
- hsa-mir-7160-5p (MIRT700761)
- hsa-mir-6722-3p (MIRT700762)
- hsa-mir-1909-3p (MIRT700763)
- hsa-mir-6884-5p (MIRT700764)
- hsa-mir-485-5p (MIRT700765)
- hsa-mir-1827 (MIRT700766)
- hsa-mir-4649-3p (MIRT700767)
- hsa-mir-6746-5p (MIRT700768)
- hsa-mir-5690 (MIRT700769)
- hsa-mir-2114-5p (MIRT700770)
- hsa-mir-5588-3p (MIRT700771)
- hsa-mir-6783-5p (MIRT700772)
- hsa-mir-4478 (MIRT700773)
- hsa-mir-4419b (MIRT700774)
- hsa-mir-3929 (MIRT700775)
- hsa-mir-940 (MIRT700776)
- hsa-mir-6893-5p (MIRT700777)
- hsa-mir-6808-5p (MIRT700778)
- hsa-mir-2115-3p (MIRT763808)
- hsa-mir-4310 (MIRT768545)
- hsa-mir-4711-5p (MIRT771391)
- hsa-mir-4738-3p (MIRT771830)
- hsa-mir-548av-3p (MIRT774242)
- hsa-mir-7157-5p (MIRT781561)
miRNA Products
- Search ViGene Biosciences for PLA2G4A
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4A
- Browse OriGene Inhibitory RNA Products For PLA2G4A
- genomics-online: shRNA clones - Search results for available PLA2G4A gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PLA2G4A gene
Clone Products
- Sino Biological Human cDNA Clone for PLA2G4A
- VectorBuilder custom plasmid, inducible vectors for PLA2G4A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLA2G4A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PLA2G4A gene related products
- orf clones - Search results for available PLA2G4A gene related products
- Applied Biological Materials Clones for PLA2G4A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PLA2G4A
-
ViGene Biosciences adenoviral particle packaged cDNA for PLA2G4A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PLA2G4A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLA2G4A gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G4A Gene
Localization for PLA2G4A Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4A Gene
- Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| endoplasmic reticulum | 5 |
| cytosol | 5 |
| nucleus | 3 |
| golgi apparatus | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
Pathways & Interactions for PLA2G4A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycerophospholipid biosynthesis | ||
| 2 | Acyl chain remodelling of PE |
.30
|
|
| 3 | DAG and IP3 signaling | ||
| 4 | Immune response Fc epsilon RI pathway | ||
| 5 | Linoleic acid metabolism | ||
Pathways by source for PLA2G4A Gene
3 Sino Biological pathways for PLA2G4A Gene
8 BioSystems pathways for PLA2G4A Gene
31 Reactome pathways for PLA2G4A Gene
4 PharmGKB pathways for PLA2G4A Gene
23 KEGG pathways for PLA2G4A Gene
8 GeneGo (Thomson Reuters) pathways for PLA2G4A Gene
1 R&D Systems pathway for PLA2G4A Gene
12 Qiagen pathways for PLA2G4A Gene
1 Cell Signaling Technology pathway for PLA2G4A Gene
Interacting Proteins for PLA2G4A Gene
SIGNOR curated interactions for PLA2G4A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006644 | phospholipid metabolic process | TAS | -- |
| GO:0006654 | phosphatidic acid biosynthetic process | TAS | -- |
| GO:0006663 | platelet activating factor biosynthetic process | NAS | 9430701 |
| GO:0006690 | icosanoid metabolic process | NAS | 9430701 |
Drugs & Compounds for PLA2G4A Gene
(93) Drugs for PLA2G4A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fluticasone propionate | Approved | Pharma | Target, inhibitor, antagonist | Selective high affinity glucocorticoid receptor agonist | 0 | |
| Fluocinolone Acetonide | Approved, Investigational, Vet_approved | Pharma | Enzyme, inhibitor, binder | 44 | ||
| Quinacrine | Approved, Investigational | Pharma | Target, inhibitor | 6 | ||
| Carbachol | Approved | Pharma | Full agonist, Agonist, Enzyme, inducer | 3 | ||
| Carbenicillin | Approved, Investigational | Pharma | Enzyme, inhibitor | 1 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Arachidic acid |
|
506-30-9 |
|
|||
| Glycerylphosphorylethanolamine |
|
1190-00-7 |
|
|||
| Heptadecanoic acid |
|
506-12-7 |
|
|||
| Heptadecanoyl CoA |
|
3546-17-6 |
|
|||
| LysoPC(0:0/18:0) |
|
|
(5) Tocris Compounds for PLA2G4A Gene
| Compound | Action | Cas Number |
|---|---|---|
| AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
| Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
| m-3M3FBS | Phospholipase C activator | 200933-14-8 |
| o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
| U 73122 | Phospholipase C inhibitor | 112648-68-7 |
(6) ApexBio Compounds for PLA2G4A Gene
| Compound | Action | Cas Number |
|---|---|---|
| AACOCF3 | Inhibitor of cPLA2/anandamide hydrolysis/FAAH | 149301-79-1 |
| CAY10650 | cPLA2α inhibitor,highly potent | 1233706-88-1 |
| Clofazimine | Tuberculosis drug | 2030-63-9 |
| CP-91149 | Selective inhibitor of glycogen phosphorylase | 186392-40-5 |
| PACOCF3 | CPLA2 and iPLA2 inhibitor | 141022-99-3 |
| Varespladib (LY315920) | HnsPLA inhibitor,potent and selective | 172732-68-2 |
Transcripts for PLA2G4A Gene
mRNA/cDNA for PLA2G4A Gene
- (4) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (28) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PLA2G4A Gene
CRISPR Products
-
OriGene CRISPR knockouts for PLA2G4A
- genomics-online: gRNA clones - Search results for available PLA2G4A gene related products
- Applied Biological Materials CRISPR for PLA2G4A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4A
- GenScript: Design CRISPR guide RNA sequences for PLA2G4A
miRNA Products
- Search ViGene Biosciences for PLA2G4A
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4A
- Browse OriGene Inhibitory RNA Products For PLA2G4A
- genomics-online: shRNA clones - Search results for available PLA2G4A gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PLA2G4A gene
Clone Products
- Sino Biological Human cDNA Clone for PLA2G4A
- VectorBuilder custom plasmid, inducible vectors for PLA2G4A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLA2G4A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PLA2G4A gene related products
- orf clones - Search results for available PLA2G4A gene related products
- Applied Biological Materials Clones for PLA2G4A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PLA2G4A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Adult Endothelial Cells Blood Brain Barrier
- Gut Tube (Gastrointestinal Tract)
- Lung (Respiratory System)
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Brain (Nervous System)
- Adult Endothelial Cells Blood Brain Barrier
- Lower Urinary Tract (Urinary System)
- Kidney (Urinary System)
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for PLA2G4A Gene
This gene is overexpressed in Bladder (x4.0).
This gene is overexpressed in Peripheral blood mononuclear cells (16.3) and Uterus (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLA2G4A Gene
NURSA nuclear receptor signaling pathways regulating expression of PLA2G4A Gene:
PLA2G4ASOURCE GeneReport for Unigene cluster for PLA2G4A Gene:
Hs.497200mRNA Expression by UniProt/SwissProt for PLA2G4A Gene:
P47712-PA24A_HUMAN
Tissue specificity:
Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
Evidence on tissue expression from TISSUES for PLA2G4A Gene
- Blood(4.5)
- Lung(2.1)
- Nervous system(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4A Gene
Germ Layers:
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
Regions:
Abdomen:
- intestine
- large intestine
- small intestine
General:
- blood
- blood vessel
- red blood cell
Primer Products
-
OriGene qPCR primer pairs for PLA2G4A
- genomics-online: primer clones - Search results for available PLA2G4A gene related products
Gene Expression Assay Products
Orthologs for PLA2G4A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PLA2G4A 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PLA2G4A 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PLA2G4A 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PLA2G4A 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PLA2G4A 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Pla2g4a 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Pla2g4a 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | PLA2G4A 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PLA2G4A 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pla2g4a 33 |
|
||
| Str.20412 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | pla2g4a-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pla2g4a 34 |
|
OneToMany | |
| cpla2 33 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2704 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6135 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2601 33 |
|
- Species where no ortholog for PLA2G4A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PLA2G4A Gene
(3) SIMAP similar genes for PLA2G4A Gene using alignment to 4 proteins:
Variants for PLA2G4A Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs121434634 | pathogenic, Phospholipase a2, group IV a, deficiency of | 186,894,164(+) | T/C | coding_sequence_variant, missense_variant | |
| rs121434635 | pathogenic, Phospholipase a2, group IV a, deficiency of | 186,956,219(+) | G/A | coding_sequence_variant, missense_variant | |
| VAR_035826 | A breast cancer sample | p.His442Gln | |||
| rs1000032699 | -- | 186,933,864(+) | A/G | intron_variant | |
| rs1000038276 | -- | 186,940,819(+) | C/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1010484 | CNV | insertion | 20482838 |
| esv1093925 | CNV | insertion | 17803354 |
| esv2720350 | CNV | deletion | 23290073 |
| esv2762854 | CNV | gain | 21179565 |
| esv3339194 | CNV | insertion | 20981092 |
| esv3543755 | CNV | deletion | 23714750 |
| nsv1079016 | OTHER | inversion | 25765185 |
| nsv3877 | CNV | insertion | 18451855 |
| nsv466272 | CNV | loss | 19166990 |
| nsv548406 | CNV | loss | 21841781 |
| nsv548407 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
51.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.90;
35.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLA2G4A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4A Gene
Disorders for PLA2G4A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cryptogenic multifocal ulcerous stenosing enteritis |
|
|
| cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder |
|
|
| krabbe disease |
|
|
| mood disorder |
|
|
| schizophrenia |
|
Search PLA2G4A in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PA24A_HUMAN- Note=PLA2G4A mutations resulting in phospholipase A2 deficiency have been found in a patient affected by recurrent episodes of multiple complicated ulcers of the small intestine, not due to cyclooxygenase inhibitors use. Disease features also include platelet dysfunction, and globally decreased eicosanoid synthesis (PubMed:18451993). {ECO:0000269 PubMed:18451993}.
Additional Disease Information for PLA2G4A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PLA2G4A Gene
Publications for PLA2G4A Gene
- Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2. (PMID: 9430701) Perisic O … Williams RL (The Journal of biological chemistry 1998) 3 4 22 58
- Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. (PMID: 9468497) Börsch-Haubold AG … Gelb MH (The Journal of biological chemistry 1998) 3 4 22 58
- Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2. (PMID: 9665851) Xu GY … Cumming DA (Journal of molecular biology 1998) 3 4 22 58
- Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. (PMID: 8702602) Pickard RT … Sharp JD (The Journal of biological chemistry 1996) 3 4 22 58
- Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2. (PMID: 8083230) Sharp JD … Brems DN (The Journal of biological chemistry 1994) 3 4 22 58
Products for PLA2G4A Gene
- R&D Systems Antibodies for PLA2G4A (PLA2G4A)
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- Novus Biologicals Antibodies for PLA2G4A
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- Cloud-Clone Corp. Antibodies for PLA2G4A
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for PLA2G4A
- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Invitrogen Antibodies for PLA2G4A
- ApexBio compounds for PLA2G4A
- Cyagen custom Knockout/knockin (KOKI) mouse models for PLA2G4A
- VectorBuilder custom plasmid, inducible vectors for PLA2G4A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLA2G4A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 120 available PLA2G4A Antibodies ranked by validation data
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- GeneTex PLA2G4A antibody for PLA2G4A
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- ViGene Biosciences adenoviral particle packaged cDNA for PLA2G4A gene
- ViGene Biosciences lentiviral particle packaged cDNA for PLA2G4A gene
- ViGene Biosciences ready-to-package AAV shRNAs for PLA2G4A gene
- Search ViGene Biosciences for PLA2G4A
- Santa Cruz Biotechnology (SCBT) Antibodies for PLA2G4A
- Search Santa Cruz Biotechnology (SCBT) for PLA2G4A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4A
- Custom Antibody ServicesProSci Antibodies for PLA2G4A
- Search for PLA2G4A Proteins at ProSci
- Horizon Cell Lines for PLA2G4A
- genomics-online: cdna clones - Search results for available PLA2G4A gene related products
- orf clones - Search results for available PLA2G4A gene related products
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Sources for PLA2G4A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems