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This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracel... See more...
Aliases for PLA2G4A Gene
Aliases for PLA2G4A Gene
External Ids for PLA2G4A Gene
- HGNC: 9035
- Entrez Gene: 5321
- Ensembl: ENSG00000116711
- OMIM: 600522
- UniProtKB: P47712
Previous HGNC Symbols for PLA2G4A Gene
- PLA2G4
Previous GeneCards Identifiers for PLA2G4A Gene
- GC01P184323
- GC01P182226
- GC01P183317
- GC01P184037
- GC01P184013
- GC01P183529
- GC01P185064
- GC01P158032
Summaries for PLA2G4A Gene
-
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
GeneCards Summary for PLA2G4A Gene
PLA2G4A (Phospholipase A2 Group IVA) is a Protein Coding gene. Diseases associated with PLA2G4A include Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets and Cryptogenic Multifocal Ulcerous Stenosing Enteritis. Among its related pathways are Oxytocin signaling pathway and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G4F.
UniProtKB/Swiss-Prot Summary for PLA2G4A Gene
-
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
-
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
Additional gene information for PLA2G4A Gene
- Monarch Initiative
- Search for PLA2G4A at DataMed
- Search for PLA2G4A at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G4A Gene
Genomics for PLA2G4A Gene
GeneHancer (GH) Regulatory Elements for PLA2G4A Gene
Promoters and enhancers for PLA2G4A Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J186828 | Promoter/Enhancer | 2 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas | 504.8 | +1.0 | 965 | 3.1 | ZSCAN5C USF1 ZBTB26 POLR2A ZNF266 ZNF316 ZBTB17 MAFF SRF MAFK | PLA2G4A TPR OCLM PTGS2 piR-56133-014 | |
| GH01J186849 | Enhancer | 0.8 | FANTOM5 | 17.5 | +20.6 | 20602 | 0.3 | TCF12 EP300 RELA BCL11A ESRRA FOSL2 NBN SPI1 ATF3 NR3C1 | PLA2G4A PTGS2 piR-56133-014 | |
| GH01J186848 | Enhancer | 0.6 | FANTOM5 | 17.7 | +20.1 | 20088 | 0.2 | SIX5 ATF3 ZNF112 FOXP1 YY1 ZBTB33 ZNF114 MAFK BCL6B BCL3 | ENSG00000228238 PLA2G4A PDC-AS1 ODR4 PTGS2 piR-56133-014 | |
| GH01J186738 | Enhancer | 0.8 | FANTOM5 Ensembl | 10.8 | -90.0 | -89980 | 1.4 | BATF JUNB SPI1 NFIC CEBPB CREM MTA2 GABPA EZH2 ARID3A | PTGS2 PLA2G4A PACERR ODR4 HSALNG0009106 RF00994-073 | |
| GH01J186882 | Enhancer | 0.4 | Ensembl | 11.6 | +53.7 | 53701 | 0.8 | ATF2 JUND ATF7 NR3C1 JUN | PLA2G4A piR-56133-014 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PLA2G4A on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G4A
- Top Transcription factor binding sites by QIAGEN in the PLA2G4A gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- CRE-BP1
- GR
- GR-alpha
- PPAR-gamma1
- PPAR-gamma2
- STAT5A
Genomic Locations for PLA2G4A Gene
Genomic Locations for PLA2G4A Gene
- chr1:186,828,900-186,988,981
- (GRCh38/hg38)
- Size:
- 160,082 bases
- Orientation:
- Plus strand
- chr1:186,798,032-186,958,113
- (GRCh37/hg19)
- Size:
- 160,082 bases
- Orientation:
- Plus strand
Genomic View for PLA2G4A Gene
Genes around PLA2G4A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q31.1 by HGNC
- 1q31.1 by Entrez Gene
- 1q31.1 by Ensembl
PLA2G4A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLA2G4A Gene
Proteins for PLA2G4A Gene
-
Protein details for PLA2G4A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P47712-PA24A_HUMAN
- Recommended name:
- Cytosolic phospholipase A2
- Protein Accession:
- P47712
- B1AKG4
- Q29R80
Protein attributes for PLA2G4A Gene
- Size:
- 749 amino acids
- Molecular mass:
- 85239 Da
- Quaternary structure:
-
- Interacts with KAT5.
Protein Expression for PLA2G4A Gene
Post-translational modifications for PLA2G4A Gene
- Activated by phosphorylation at both Ser-505 and Ser-727.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PLA2G4A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Phospho-c-PLA2 (Ser505) Antibody and Immunotag™ c-PLA2 Antibody
- Creative Diagnostics Anti-PLA2G4A monoclonal antibody
- Creative Biolabs Recombinant Anti-Human PLA2G4A Antibody
-
Custom Antibody ServicesOriGene Antibodies for PLA2G4A
- Novus Biologicals Antibodies for PLA2G4A
- Invitrogen Antibodies for PLA2G4A (AFLGC-PLA2G4A)
- antibodies-online: Show 90 available PLA2G4A Antibodies ranked by validation data
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-
Recommended
- 113 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 34 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 52 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
-
Custom Antibody ServicesProSci Antibodies for PLA2G4A
-
Santa Cruz Biotechnology (SCBT) Antibodies for PLA2G4A
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PLA2G4A
- Origene Custom Protein Services for PLA2G4A
Assay Products
- RayBiotech Custom Human PLA2G4A ELISA
- Aviva Systems Biology PLA2G4A ELISA Kit (Human) : 96 Wells (OKEH01172)
-
Custom Assay ServicesOriGene ELISA Kits for PLA2G4A
- antibodies-online: Show 57 available PLA2G4A Elisa Kits ranked by validation data
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-
Quality Products:
- ABIN456996
- ABIN1114555
- ABIN5524703
- ABIN5669402
- ABIN5594696
- ABIN626378
- ABIN454933
- ABIN6386011
- ABIN4884173
- ABIN2946908
- ABIN1114403
- ABIN578516
- ABIN5524704
- ABIN5670225
- ABIN627723
- ABIN2950339
- ABIN6229198
- ABIN2685202
- ABIN5068757
- ABIN454934
- ABIN1114556
- ABIN5524705
- ABIN5670909
- ABIN5594697
- ABIN626902
- ABIN2946911
- ABIN6229201
- ABIN6229202
- ABIN5068756
- ABIN774651
- ABIN1561374
- ABIN6229200
No data available for DME Specific Peptides for PLA2G4A Gene
Domains & Families for PLA2G4A Gene
Gene Families for PLA2G4A Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for PLA2G4A Gene
- Blocks:
-
- C2 domain
- Inorganic pyrophosphatase
- Lysophospholipase, catalytic domain
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PLA2G4A Gene
- GenScript: Design optimal peptide antigens:
-
- Phospholipase A2 group IVA (PA24A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P47712UniProtKB/Swiss-Prot:
PA24A_HUMAN :- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
- Domain:
-
- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
Function for PLA2G4A Gene
Molecular function for PLA2G4A Gene
- UniProtKB/Swiss-Prot Function:
- Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+).
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: Vmax=2.7 umol/min/mg enzyme for the phospholipase A2 reaction {ECO:0000269 PubMed:8083230}; Vmax=4.6 umol/min/mg enzyme for the lysophosphatase reaction {ECO:0000269 PubMed:8083230};
- GENATLAS Biochemistry:
- phospholipase A2,group IV,Ca2+ dependent,cytosolic,releasing arachidonic acid from membrane phospholipids,initiating the biosynthesis of prostaglandins,leukotrienes and platelet-activating factor
Phenotypes From GWAS Catalog for PLA2G4A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004622 | lysophospholipase activity | IEA | -- |
| GO:0004623 | phospholipase A2 activity | IBA,NAS | 8381049 |
| GO:0005509 | calcium ion binding | IBA,IDA | 9430701 |
| GO:0005544 | calcium-dependent phospholipid binding | IDA,IBA | 9665851 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PLA2G4A Gene
- MGI mutant phenotypes for PLA2G4A:
-
inferred from 2 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- reproductive system phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for PLA2G4A:
Animal Models for PLA2G4A Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for PLA2G4A
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PLA2G4A - Select products 50% OFF >
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-
OriGene CRISPR knockouts for PLA2G4A
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-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4A
miRNA for PLA2G4A Gene
- miRTarBase miRNAs that target PLA2G4A
-
- hsa-mir-124-3p (MIRT022551)
- hsa-mir-30a-5p (MIRT028507)
- hsa-mir-146b-5p (MIRT041616)
- hsa-mir-10a-5p (MIRT047518)
- hsa-mir-449c-5p (MIRT052653)
- hsa-mir-7977 (MIRT671764)
- hsa-mir-3157-5p (MIRT671765)
- hsa-mir-24-3p (MIRT671766)
- hsa-mir-4284 (MIRT671767)
- hsa-mir-4755-3p (MIRT671768)
- hsa-mir-342-3p (MIRT671769)
- hsa-mir-4691-3p (MIRT671770)
- hsa-mir-1228-3p (MIRT671771)
- hsa-mir-665 (MIRT700757)
- hsa-mir-6771-5p (MIRT700758)
- hsa-mir-4763-3p (MIRT700759)
- hsa-mir-1207-5p (MIRT700760)
- hsa-mir-7160-5p (MIRT700761)
- hsa-mir-6722-3p (MIRT700762)
- hsa-mir-1909-3p (MIRT700763)
- hsa-mir-6884-5p (MIRT700764)
- hsa-mir-485-5p (MIRT700765)
- hsa-mir-1827 (MIRT700766)
- hsa-mir-4649-3p (MIRT700767)
- hsa-mir-6746-5p (MIRT700768)
- hsa-mir-5690 (MIRT700769)
- hsa-mir-2114-5p (MIRT700770)
- hsa-mir-5588-3p (MIRT700771)
- hsa-mir-6783-5p (MIRT700772)
- hsa-mir-4478 (MIRT700773)
- hsa-mir-4419b (MIRT700774)
- hsa-mir-3929 (MIRT700775)
- hsa-mir-940 (MIRT700776)
- hsa-mir-6893-5p (MIRT700777)
- hsa-mir-6808-5p (MIRT700778)
- hsa-mir-2115-3p (MIRT763808)
- hsa-mir-4310 (MIRT768545)
- hsa-mir-4711-5p (MIRT771391)
- hsa-mir-4738-3p (MIRT771830)
- hsa-mir-548av-3p (MIRT774242)
- hsa-mir-7157-5p (MIRT781561)
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for PLA2G4A - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PLA2G4A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4A
- genomics-online: cdna clones - Search results for available PLA2G4A gene related products
- orf clones - Search results for available PLA2G4A gene related products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PLA2G4A Gene
Localization for PLA2G4A Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4A Gene
- Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 4 |
| nucleus | 4 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| lysosome | 2 |
| endosome | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005783 | endoplasmic reticulum | IBA,IEA | 21873635 |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
Pathways & Interactions for PLA2G4A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycerophospholipid biosynthesis | ||
| 2 | Acyl chain remodelling of PE |
.30
|
|
| 3 | DAG and IP3 signaling |
Neurophysiological process PGE2-induced pain processing
.38
|
|
| 4 | Immune response Fc epsilon RI pathway |
Immune response Fc epsilon RI pathway
.44
|
|
| 5 | Linoleic acid metabolism | ||
Pathways by source for PLA2G4A Gene
3 Sino Biological pathways for PLA2G4A Gene
8 BioSystems pathways for PLA2G4A Gene
31 Reactome pathways for PLA2G4A Gene
4 PharmGKB pathways for PLA2G4A Gene
23 KEGG pathways for PLA2G4A Gene
8 GeneGo (Thomson Reuters) pathways for PLA2G4A Gene
- Anandamide biosynthesis and metabolism
- Development A1 receptor signaling
- Development Alpha-2 adrenergic receptor activation of ERK
- Development_Leptin signaling via JAK/STAT and MAPK cascades
- Immune response CCR3 signaling in eosinophils
1 R&D Systems pathway for PLA2G4A Gene
12 Qiagen pathways for PLA2G4A Gene
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- cAMP Pathway
- CCR3 Pathway in Eosinophils
- Chemokine Signaling
1 Cell Signaling Technology pathway for PLA2G4A Gene
Interacting Proteins for PLA2G4A Gene
GPS-Prot Interaction Network for PLA2G4A
SIGNOR curated interactions for PLA2G4A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006644 | phospholipid metabolic process | TAS | -- |
| GO:0006654 | phosphatidic acid biosynthetic process | TAS | -- |
| GO:0006663 | platelet activating factor biosynthetic process | NAS | 9430701 |
| GO:0006690 | icosanoid metabolic process | NAS | 9430701 |
Drugs & Compounds for PLA2G4A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fluticasone propionate | Approved | Pharma | Target, inhibitor, antagonist | Selective high affinity glucocorticoid receptor agonist | 0 | |
| Carbenicillin | Approved, Investigational | Pharma | Enzyme, inhibitor | 1 | ||
| Epirubicin | Approved | Pharma | Enzyme, inhibitor | 468 | ||
| Orlistat | Approved, Investigational | Pharma | Enzyme, inhibitor | Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity | 60 | |
| Urethane | Approved, Withdrawn | Pharma | Enzyme, substrate | 13 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Arachidic acid |
|
506-30-9 |
|
|||
| Glycerylphosphorylethanolamine |
|
1190-00-7 |
|
|||
| Heptadecanoic acid |
|
506-12-7 |
|
|||
| Heptadecanoyl CoA |
|
3546-17-6 |
|
|||
| LysoPC(0:0/18:0) |
|
4421-58-3 |
|
(5) Tocris Compounds for PLA2G4A Gene
| Compound | Action | Cas Number |
|---|---|---|
| AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
| Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
| m-3M3FBS | Phospholipase C activator | 200933-14-8 |
| o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
| U 73122 | Phospholipase C inhibitor | 112648-68-7 |
(6) ApexBio Compounds for PLA2G4A Gene
| Compound | Action | Cas Number |
|---|---|---|
| AACOCF3 | Inhibitor of cPLA2/anandamide hydrolysis/FAAH | 149301-79-1 |
| CAY10650 | cPLA2α inhibitor,highly potent | 1233706-88-1 |
| Clofazimine | Tuberculosis drug | 2030-63-9 |
| CP-91149 | Selective inhibitor of glycogen phosphorylase | 186392-40-5 |
| PACOCF3 | CPLA2 and iPLA2 inhibitor | 141022-99-3 |
| Varespladib (LY315920) | HnsPLA inhibitor,potent and selective | 172732-68-2 |
Transcripts for PLA2G4A Gene
mRNA/cDNA for PLA2G4A Gene
- 2 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000367466 2879 bps (ENST00000367466.4)
- ENST00000466600 850 bps (ENST00000466600.1)
CRISPR Products
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PLA2G4A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4A
- genomics-online: gRNA clones - Search results for available PLA2G4A gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4A
- Browse OriGene Inhibitory RNA Products For PLA2G4A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4A
- genomics-online: shRNA clones - Search results for available PLA2G4A gene related products
Clone Products
- Applied Biological Materials (abm): Clones for PLA2G4A - Select products 50% OFF >
- * PLA2G4A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PLA2G4A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4A
- genomics-online: cdna clones - Search results for available PLA2G4A gene related products
- orf clones - Search results for available PLA2G4A gene related products
Relevant External Links for PLA2G4A Gene
- GeneLoc Exon Structure for
- PLA2G4A
Expression for PLA2G4A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Adult Endothelial Cells Blood Brain Barrier
- Gut Tube (Gastrointestinal Tract)
- Lung (Respiratory System)
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Brain (Nervous System)
- Adult Endothelial Cells Blood Brain Barrier
- Lower Urinary Tract (Urinary System)
- Kidney (Urinary System)
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for PLA2G4A Gene
This gene is overexpressed in Bladder (x4.0).
This gene is overexpressed in Peripheral blood mononuclear cells (16.3) and Uterus (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLA2G4A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G4A
SOURCE GeneReport for Unigene cluster for PLA2G4A Gene:
Hs.497200mRNA Expression by UniProt/SwissProt for PLA2G4A Gene:
P47712-PA24A_HUMAN
Tissue specificity:
Expressed in various tissues such as macrophages, neutrophils, fibroblasts and lung endothelium. Expressed in platelets (at protein level) (PubMed:25102815).
Evidence on tissue expression from TISSUES for PLA2G4A Gene
- Blood(4.5)
- Lung(2.1)
- Nervous system(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4A Gene
Germ Layers:
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
Regions:
Abdomen:
- intestine
- large intestine
- small intestine
General:
- blood
- blood vessel
- red blood cell
Primer Products
-
OriGene qPCR primer pairs for PLA2G4A
-
OriGene qPCR primer pairs and template standards for PLA2G4A
- genomics-online: primer clones - Search results for available PLA2G4A gene related products
Gene Expression Assay Products
Orthologs for PLA2G4A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PLA2G4A 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PLA2G4A 31 30 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PLA2G4A 31 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PLA2G4A 31 30 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PLA2G4A 31 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Pla2g4a 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Pla2g4a 17 31 30 |
|
||
| chicken (Gallus gallus) |
Aves | PLA2G4A 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PLA2G4A 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pla2g4a 30 |
|
||
| Str.20412 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | pla2g4a-prov 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pla2g4a 31 |
|
OneToMany | |
| cpla2 31 30 30 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2704 30 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6135 31 |
|
OneToOne | |
| Cin.2601 30 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2601 30 |
|
- Species where no ortholog for PLA2G4A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PLA2G4A Gene
- ENSEMBL:
- Gene Tree for PLA2G4A (if available)
- TreeFam:
- Gene Tree for PLA2G4A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PLA2G4A: view image
Paralogs for PLA2G4A Gene
Variants for PLA2G4A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G4A Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 721606 | Benign: not provided | 186,965,587(+) | G/A | SYNONYMOUS_VARIANT | |
| 725133 | Likely Benign: not provided | 186,979,349(+) | C/T | SYNONYMOUS_VARIANT | |
| 734303 | Benign: not provided | 186,894,188(+) | G/A | MISSENSE_VARIANT | |
| 738215 | Benign: not provided | 186,932,874(+) | G/A | MISSENSE_VARIANT | |
| 741451 | Likely Benign: not provided | 186,893,141(+) | T/C | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1010484 | CNV | insertion | 20482838 |
| esv1093925 | CNV | insertion | 17803354 |
| esv2720350 | CNV | deletion | 23290073 |
| esv2762854 | CNV | gain | 21179565 |
| esv3339194 | CNV | insertion | 20981092 |
| esv3543755 | CNV | deletion | 23714750 |
| nsv1079016 | OTHER | inversion | 25765185 |
| nsv3877 | CNV | insertion | 18451855 |
| nsv466272 | CNV | loss | 19166990 |
| nsv548406 | CNV | loss | 21841781 |
| nsv548407 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
51.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.90;
35.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLA2G4A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4A Gene
Disorders for PLA2G4A Gene
(11) MalaCards diseases for PLA2G4A Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastrointestinal ulceration, recurrent, with dysfunctional platelets |
|
|
| cryptogenic multifocal ulcerous stenosing enteritis |
|
|
| penis squamous cell carcinoma |
|
|
| hypereosinophilic syndrome |
|
|
| mood disorder |
|
|
Search PLA2G4A in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PA24A_HUMAN- Gastrointestinal ulceration, recurrent, with dysfunctional platelets (GURDP) [MIM:618372]: An autosomal recessive disorder characterized by recurrent gastrointestinal mucosal ulcers, gastrointestinal bleeding, chronic anemia, iron deficiency, and abdominal pain. Disease features also include platelet dysfunction, and globally decreased eicosanoid synthesis. {ECO:0000269 PubMed:18451993, ECO:0000269 PubMed:23268370, ECO:0000269 PubMed:25102815}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for PLA2G4A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PLA2G4A Gene
Publications for PLA2G4A Gene
- Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. (PMID: 9468497) Börsch-Haubold AG … Gelb MH (The Journal of biological chemistry 1998) 3 4 23 54
- Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2. (PMID: 9665851) Xu GY … Cumming DA (Journal of molecular biology 1998) 3 4 23 54
- Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2. (PMID: 9430701) Perisic O … Williams RL (The Journal of biological chemistry 1998) 3 4 23 54
- Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. (PMID: 8702602) Pickard RT … Sharp JD (The Journal of biological chemistry 1996) 3 4 23 54
- Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2. (PMID: 8083230) Sharp JD … Brems DN (The Journal of biological chemistry 1994) 3 4 23 54
ExternalLinks
Products for PLA2G4A Gene
- Custom Antibody ServicesOriGene Antibodies for PLA2G4A
- Custom Assay ServicesOriGene ELISA Kits for PLA2G4A
- Search Origene for MassSpec and Protein Over-expression Lysates for PLA2G4A
- Origene Custom Protein Services for PLA2G4A
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G4A
- Browse OriGene Inhibitory RNA Products For PLA2G4A
- OriGene qPCR primer pairs for PLA2G4A
- OriGene qPCR primer pairs and template standards for PLA2G4A
- OriGene CRISPR knockouts for PLA2G4A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PLA2G4A
- Sino Biological Human cDNA Clone for PLA2G4A
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PLA2G4A
- Novus Biologicals proteins and lysates for PLA2G4A
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for PLA2G4A
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PLA2G4A (AFLGC-PLA2G4A)
- ApexBio compounds for PLA2G4A
- VectorBuilder Custom and pre-made DNA vectors for PLA2G4A (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PLA2G4A (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PLA2G4A (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PLA2G4A CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PLA2G4A
- antibodies-online: Show 90 available PLA2G4A Antibodies ranked by validation data
- Compare Top PLA2G4A Antibodies
- Recommended
- 113 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 34 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 52 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- antibodies-online: Show 57 available PLA2G4A Elisa Kits ranked by validation data
- Compare Top PLA2G4A Elisa Kits
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- ABIN456996
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- ABIN626378
- ABIN454933
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- ABIN4884173
- ABIN2946908
- ABIN1114403
- ABIN578516
- ABIN5524704
- ABIN5670225
- ABIN627723
- ABIN2950339
- ABIN6229198
- ABIN2685202
- ABIN5068757
- ABIN454934
- ABIN1114556
- ABIN5524705
- ABIN5670909
- ABIN5594697
- ABIN626902
- ABIN2946911
- ABIN6229201
- ABIN6229202
- ABIN5068756
- ABIN774651
- ABIN1561374
- ABIN6229200
- antibodies-online: Show 11 available PLA2G4A Proteins ranked by validation data
- Compare Top PLA2G4A Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PLA2G4A
- Search Santa Cruz Biotechnology (SCBT) for PLA2G4A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4A
- Custom Antibody ServicesProSci Antibodies for PLA2G4A
- Search for PLA2G4A Proteins at ProSci
- Horizon Cell Lines for PLA2G4A
- genomics-online: cdna clones - Search results for available PLA2G4A gene related products
- orf clones - Search results for available PLA2G4A gene related products
- genomics-online: gRNA clones - Search results for available PLA2G4A gene related products
- genomics-online: primer clones - Search results for available PLA2G4A gene related products
- genomics-online: shRNA clones - Search results for available PLA2G4A gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G4A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G4A
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PLA2G4A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G4A
Sources for PLA2G4A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody