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Aliases for PLA2G3 Gene

Aliases for PLA2G3 Gene

  • Phospholipase A2 Group III 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 3 3 4
  • SPLA2-III 3 4
  • Phosphatidylcholine 2-Acylhydrolase GIII 3
  • Group III Secretory Phospholipase A2 4
  • Group III Secreted Phospholipase A2 3
  • Group 3 Secretory Phospholipase A2 3
  • Phospholipase A2, Group III 2
  • GIII-SPLA2 3
  • GIII SPLA2 4
  • EC 3.1.1.4 4
  • SPLA2III 3

External Ids for PLA2G3 Gene

Previous GeneCards Identifiers for PLA2G3 Gene

  • GC22M028226
  • GC22M029855
  • GC22M031530
  • GC22M014492

Summaries for PLA2G3 Gene

Entrez Gene Summary for PLA2G3 Gene

  • This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]

GeneCards Summary for PLA2G3 Gene

PLA2G3 (Phospholipase A2 Group III) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Fat digestion and absorption. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity. An important paralog of this gene is PROCA1.

UniProtKB/Swiss-Prot for PLA2G3 Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl-phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1-palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis.

Tocris Summary for PLA2G3 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Additional gene information for PLA2G3 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G3 Gene

Genomics for PLA2G3 Gene

GeneHancer (GH) Regulatory Elements for PLA2G3 Gene

Promoters and enhancers for PLA2G3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I031139 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.8 +0.2 213 1.5 BCOR CTCF USF1 ZNF449 SIN3A ZIC2 ETS1 GLIS2 POLR2A EGR2 PLA2G3 SFI1 PIK3IP1 LOC105372995
GH22I031140 Enhancer 0.3 Ensembl 550.8 +1.3 1256 0.2 BCOR PLA2G3 LOC105372995
GH22I031141 Enhancer 0.2 Ensembl 550.8 +1.7 1656 0.2 PLA2G3 LOC105372995
GH22I031214 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.3 -78.8 -78774 9.7 HDGF FOXA2 ARID4B FEZF1 DMAP1 ZNF48 ETS1 YY1 ATF7 RUNX3 LIMK2 PLA2G3 RNF185 SFI1 ENSG00000214125 PIK3IP1 EIF4ENIF1 GC22M031223 RNU6-1128P
GH22I031097 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 12 +37.7 37706 10.5 PKNOX1 FOXA2 ARNT ARID4B SIN3A YY1 ZNF143 FOS DEK SP3 SELENOM TUG1 MORC2 RNF185 SF3A1 PRR14L DEPDC5 PES1 EIF4ENIF1 PATZ1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLA2G3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLA2G3 gene promoter:

Genomic Locations for PLA2G3 Gene

Genomic Locations for PLA2G3 Gene
chr22:31,134,807-31,140,757
(GRCh38/hg38)
Size:
5,951 bases
Orientation:
Minus strand
chr22:31,530,793-31,536,593
(GRCh37/hg19)

Genomic View for PLA2G3 Gene

Genes around PLA2G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G3 Gene

Proteins for PLA2G3 Gene

  • Protein details for PLA2G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZ20-PA2G3_HUMAN
    Recommended name:
    Group 3 secretory phospholipase A2
    Protein Accession:
    Q9NZ20
    Secondary Accessions:
    • O95768

    Protein attributes for PLA2G3 Gene

    Size:
    509 amino acids
    Molecular mass:
    57167 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD15617.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PLA2G3 Gene

Post-translational modifications for PLA2G3 Gene

  • In several cell types, the N- and C-termini are cleaved off.
  • N-glycosylation does not affect the catalytic activity, but is required for proper secretion. A nonglycosylated form was observed in several cell types.
  • Glycosylation at Asn167, Asn280, isoforms=325, Asn396, and isoforms=439

Other Protein References for PLA2G3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G3 Gene

Domains & Families for PLA2G3 Gene

Gene Families for PLA2G3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for PLA2G3 Gene

Suggested Antigen Peptide Sequences for PLA2G3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZ20

UniProtKB/Swiss-Prot:

PA2G3_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G3: view

Function for PLA2G3 Gene

Molecular function for PLA2G3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Arachidonic acid release is markedly increased by glypican, a glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl-phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1-palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis.
UniProtKB/Swiss-Prot Induction:
By IL1B/interleukin-1 beta and TNF in microvascular endothelial cells (at protein level).

Enzyme Numbers (IUBMB) for PLA2G3 Gene

Phenotypes From GWAS Catalog for PLA2G3 Gene

Gene Ontology (GO) - Molecular Function for PLA2G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0047498 calcium-dependent phospholipase A2 activity TAS 10713052
GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA --
genes like me logo Genes that share ontologies with PLA2G3: view
genes like me logo Genes that share phenotypes with PLA2G3: view

Animal Models for PLA2G3 Gene

MGI Knock Outs for PLA2G3:

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLA2G3 Gene

Localization for PLA2G3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G3 Gene

Secreted. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
lysosome 2
endosome 1

Gene Ontology (GO) - Cellular Components for PLA2G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 10713052
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA,IDA 20393563
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with PLA2G3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G3 Gene

Pathways & Interactions for PLA2G3 Gene

genes like me logo Genes that share pathways with PLA2G3: view

Gene Ontology (GO) - Biological Process for PLA2G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS 10713052
GO:0007288 sperm axoneme assembly IEA --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLA2G3: view

No data available for SIGNOR curated interactions for PLA2G3 Gene

Drugs & Compounds for PLA2G3 Gene

(13) Drugs for PLA2G3 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist 23
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
calcium Approved Nutra 0

(45) Additional Compounds for PLA2G3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)

(5) Tocris Compounds for PLA2G3 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G3: view

Transcripts for PLA2G3 Gene

mRNA/cDNA for PLA2G3 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLA2G3 Gene

Phospholipase A2, group III:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G3 Gene

No ASD Table

Relevant External Links for PLA2G3 Gene

GeneLoc Exon Structure for
PLA2G3
ECgene alternative splicing isoforms for
PLA2G3

Expression for PLA2G3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2G3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x11.5), Skin - Not Sun Exposed (Suprapubic) (x10.1), Esophagus - Mucosa (x9.7), Vagina (x5.5), and Cervix - Ectocervix (x5.3).

Protein differential expression in normal tissues from HIPED for PLA2G3 Gene

This gene is overexpressed in Milk (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G3 Gene



Protein tissue co-expression partners for PLA2G3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLA2G3 Gene:

PLA2G3

SOURCE GeneReport for Unigene cluster for PLA2G3 Gene:

Hs.149623

mRNA Expression by UniProt/SwissProt for PLA2G3 Gene:

Q9NZ20-PA2G3_HUMAN
Tissue specificity: Expressed in kidney, heart, liver, and skeletal muscle. Also present in placenta and peripheral blood leukocytes. Not detected in brain, colon, thymus, spleen and small intestine. In lung, expressed in bronchial epithelial cells and alveolar macrophages, but scarcely detected in alveolar epithelium, arterial walls and interstitial fibroblasts (at protein level). In joints of osteoarthritis and rheumatoid arthritis, expressed in endothelial cells (at protein level). In normal heart, detected in some vessels. In myocardial tissues with acute infarction, expressed in vascular endothelial cells adjacent to cardiomyocytes and those in lesions with granulation. Expression in cardiomyocytes is scarce (at protein level). In uterus, breast and colon cancers, detected in tumor cells and neighboring microvascular endothelium, but not in normal glandular tissues (at protein level).

Evidence on tissue expression from TISSUES for PLA2G3 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PLA2G3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G3 Gene

Orthologs for PLA2G3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G3 33 34
  • 99.02 (n)
dog
(Canis familiaris)
Mammalia PLA2G3 33 34
  • 84.62 (n)
cow
(Bos Taurus)
Mammalia PLA2G3 33 34
  • 82.61 (n)
mouse
(Mus musculus)
Mammalia Pla2g3 33 16 34
  • 77.24 (n)
rat
(Rattus norvegicus)
Mammalia Pla2g3 33
  • 77.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G3 34
  • 38 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLA2G3 34
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA2G3 34
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:123275 33
  • 46.42 (n)
PLA2G3 (1 of 2) 34
  • 24 (a)
OneToMany
PLA2G3 (2 of 2) 34
  • 20 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta GIIIspla2 34
  • 26 (a)
ManyToMany
CG30503 34
  • 25 (a)
ManyToMany
sPLA2 34
  • 24 (a)
ManyToMany
CG3009 34
  • 20 (a)
ManyToMany
CG42237 34
  • 14 (a)
ManyToMany
Species where no ortholog for PLA2G3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G3 Gene

ENSEMBL:
Gene Tree for PLA2G3 (if available)
TreeFam:
Gene Tree for PLA2G3 (if available)

Paralogs for PLA2G3 Gene

Paralogs for PLA2G3 Gene

genes like me logo Genes that share paralogs with PLA2G3: view

Variants for PLA2G3 Gene

Sequence variations from dbSNP and Humsavar for PLA2G3 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000061082 -- 31,136,016(-) C/G intron_variant
rs1000159644 -- 31,141,176(-) G/A upstream_transcript_variant
rs1001098417 -- 31,137,115(-) G/A intron_variant
rs1001645001 -- 31,136,512(-) A/G intron_variant
rs1001729228 -- 31,135,086(-) G/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G3 Gene

Variant ID Type Subtype PubMed ID
nsv829173 CNV loss 20364138
nsv527382 CNV loss 19592680
nsv1110864 OTHER inversion 24896259

Variation tolerance for PLA2G3 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.67; 96.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G3 Gene

Disorders for PLA2G3 Gene

Additional Disease Information for PLA2G3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLA2G3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G3 Gene

Publications for PLA2G3 Gene

  1. Novel human secreted phospholipase A(2) with homology to the group III bee venom enzyme. (PMID: 10713052) Valentin E … Lambeau G (The Journal of biological chemistry 2000) 2 3 4 58
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 44 58
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58
  5. Functional genomic screen for modulators of ciliogenesis and cilium length. (PMID: 20393563) Kim J … Gleeson JG (Nature 2010) 3 4 58

Products for PLA2G3 Gene

Sources for PLA2G3 Gene

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