Aliases for PLA2G2F Gene

Aliases for PLA2G2F Gene

  • Phospholipase A2 Group IIF 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 2F 3 4
  • Group IIF Secretory Phospholipase A2 3 4
  • GIIF SPLA2 3 4
  • SPLA2-IIF 3 4
  • Phospholipase A2, Group IIF 2
  • EC 3.1.1.4 4
  • GIIFsPLA2 3
  • PLA2G2F 5

External Ids for PLA2G2F Gene

Previous GeneCards Identifiers for PLA2G2F Gene

  • GC01P020037
  • GC01P019500
  • GC01P019611
  • GC01P019935
  • GC01P020211
  • GC01P020338
  • GC01P020465
  • GC01P018711

Summaries for PLA2G2F Gene

GeneCards Summary for PLA2G2F Gene

PLA2G2F (Phospholipase A2 Group IIF) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2D.

UniProtKB/Swiss-Prot Summary for PLA2G2F Gene

  • May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity). Phospholipase A2, which catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:11112443). Hydrolyzes phosphatidylethanolamine more efficiently than phosphatidylcholine, with only a modest preference for arachidonic acid versus linoelic acid at the sn-2 position. Comparable activity toward 1-palmitoyl-2-oleoyl-phosphatidylserine vesicles to that toward 1-palmitoyl-2-oleoyl-phosphatidylglycerol (By similarity). Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference (PubMed:11112443).

Tocris Summary for PLA2G2F Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Additional gene information for PLA2G2F Gene

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G2F Gene

Genomics for PLA2G2F Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLA2G2F Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J020139 Promoter/Enhancer 0.5 EPDnew Ensembl 600.7 0.0 -22 0.2 PLA2G2F PLA2G2D
GH01J020141 Enhancer 0.3 Ensembl 600.7 +1.1 1078 0.4 FOXA1 MCM7 PLA2G2F lnc-PLA2G2F-2 UBXN10
GH01J020111 Enhancer 0.9 FANTOM5 Ensembl ENCODE 12.1 -29.1 -29123 2.8 JUND SOX6 CTCF FOSL1 EBF1 BHLHE40 ATF3 JUN GLIS1 FOS PLA2G2F PLA2G2C MUL1 UBXN10 AKR7A3 NBL1 RF00017-094 PLA2G2D lnc-PLA2G2F-3 PLA2G5
GH01J020101 Enhancer 0.8 Ensembl ENCODE 11.8 -38.0 -38022 1 CTCF FOXA1 ZNF143 REST RAD21 TRIM22 YY1 SCRT2 ZNF444 FOXA2 RF00017-094 PLA2G2F PLA2G2C ENSG00000226664 NBL1 lnc-PLA2G2D-1 PLA2G2D PLA2G5
GH01J020093 Enhancer 0.6 Ensembl ENCODE 11.7 -45.2 -45222 1.4 CEBPB KLF9 HLF PLA2G2D PLA2G2F PLA2G2C ENSG00000226664 PLA2G5 lnc-PLA2G2D-1 RF00017-094
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G2F on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G2F

Top Transcription factor binding sites by QIAGEN in the PLA2G2F gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • Egr-2
  • GATA-2
  • GATA-3
  • HOXA3
  • LCR-F1
  • RREB-1
  • Zic3

Genomic Locations for PLA2G2F Gene

Genomic Locations for PLA2G2F Gene
chr1:20,139,323-20,150,386
(GRCh38/hg38)
Size:
11,064 bases
Orientation:
Plus strand
chr1:20,465,819-20,476,879
(GRCh37/hg19)
Size:
11,061 bases
Orientation:
Plus strand

Genomic View for PLA2G2F Gene

Genes around PLA2G2F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G2F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2F Gene

Proteins for PLA2G2F Gene

  • Protein details for PLA2G2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM2-PA2GF_HUMAN
    Recommended name:
    Group IIF secretory phospholipase A2
    Protein Accession:
    Q9BZM2
    Secondary Accessions:
    • Q5R385
    • Q8N217
    • Q9H506

    Protein attributes for PLA2G2F Gene

    Size:
    168 amino acids
    Molecular mass:
    18658 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: No signal peptide could be predicted in this isoform, challenging its subcellular location within the secretory pathway and hence the formation of disulfide bonds, which are required for its activity.

    Alternative splice isoforms for PLA2G2F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G2F Gene

Post-translational modifications for PLA2G2F Gene

  • Glycosylation at Asn92, Asn102, Asn123, and Asn144
  • Modification sites at PhosphoSitePlus

Other Protein References for PLA2G2F Gene

No data available for DME Specific Peptides for PLA2G2F Gene

Domains & Families for PLA2G2F Gene

Gene Families for PLA2G2F Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PLA2G2F Gene

InterPro:
Blocks:
  • Phospholipase A2
ProtoNet:

Suggested Antigen Peptide Sequences for PLA2G2F Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidylcholine 2-acylhydrolase 2F (PA2GF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BZM2

UniProtKB/Swiss-Prot:

PA2GF_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2F: view

Function for PLA2G2F Gene

Molecular function for PLA2G2F Gene

UniProtKB/Swiss-Prot Function:
May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity). Phospholipase A2, which catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:11112443). Hydrolyzes phosphatidylethanolamine more efficiently than phosphatidylcholine, with only a modest preference for arachidonic acid versus linoelic acid at the sn-2 position. Comparable activity toward 1-palmitoyl-2-oleoyl-phosphatidylserine vesicles to that toward 1-palmitoyl-2-oleoyl-phosphatidylglycerol (By similarity). Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference (PubMed:11112443).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000255|PROSITE-ProRule:PRU10035, ECO:0000269|PubMed:11112443};.

Enzyme Numbers (IUBMB) for PLA2G2F Gene

Phenotypes From GWAS Catalog for PLA2G2F Gene

Gene Ontology (GO) - Molecular Function for PLA2G2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IBA,NAS 11112443
GO:0005509 calcium ion binding IBA --
GO:0005543 phospholipid binding IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLA2G2F: view
genes like me logo Genes that share phenotypes with PLA2G2F: view

Animal Models for PLA2G2F Gene

MGI Knock Outs for PLA2G2F:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G2F

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G2F Gene

Localization for PLA2G2F Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2F Gene

[Isoform 1]: Secreted. Cell membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G2F gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 3
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PLA2G2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PLA2G2F: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G2F Gene

Pathways & Interactions for PLA2G2F Gene

genes like me logo Genes that share pathways with PLA2G2F: view

Pathways by source for PLA2G2F Gene

1 GeneGo (Thomson Reuters) pathway for PLA2G2F Gene
  • Immune response CD16 signaling in NK cells
7 Qiagen pathways for PLA2G2F Gene
  • Antioxidant Action of Vitamin-C
  • cAMP Pathway
  • Chemokine Signaling
  • DHA Signaling
  • Fc-EpsilonRI Pathway

Gene Ontology (GO) - Biological Process for PLA2G2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IBA 21873635
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PLA2G2F: view

No data available for SIGNOR curated interactions for PLA2G2F Gene

Drugs & Compounds for PLA2G2F Gene

(11) Drugs for PLA2G2F Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
linoleic acid Approved, Experimental Pharma Agonist, Full agonist, Activator, Pore Blocker, Channel blocker 0
Palmitic Acid Approved Pharma Agonist, Full agonist 27
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
alpha-linolenic acid Approved, Investigational Nutra 0

(46) Additional Compounds for PLA2G2F Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
  • Eicosanoic acid
506-30-9
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
3546-17-6
LysoPC(14:0/0:0)
  • 1-C14:0-Lysophosphatidylcholine betaine
  • 1-Myristoyl-glycero-3-phosphocholine
  • 1-Myristoyl-sn-glycero-3-phosphocholine betaine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine betaine
20559-16-4
LysoPC(14:1(9Z))
  • 1-(9Z-Tetradecenoyl)-sn-glycero-3-phosphocholine
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC 14:1(9Z)/0:0
  • LPC(14:1(9Z)/0:0)
  • LysoPC 14:1(9Z)/0:0

(5) Tocris Compounds for PLA2G2F Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G2F: view

Transcripts for PLA2G2F Gene

mRNA/cDNA for PLA2G2F Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G2F

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2F Gene

No ASD Table

Relevant External Links for PLA2G2F Gene

GeneLoc Exon Structure for
PLA2G2F

Expression for PLA2G2F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G2F Gene

mRNA differential expression in normal tissues according to GTEx for PLA2G2F Gene

This gene is overexpressed in Bladder (x20.3), Skin - Not Sun Exposed (Suprapubic) (x15.9), and Skin - Sun Exposed (Lower leg) (x15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G2F Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G2F

SOURCE GeneReport for Unigene cluster for PLA2G2F Gene:

Hs.302034

mRNA Expression by UniProt/SwissProt for PLA2G2F Gene:

Q9BZM2-PA2GF_HUMAN
Tissue specificity: Expressed at high levels in placenta, testis, thymus and at lower levels in heart, kidney, liver and prostate (PubMed:11112443). Highly expressed in rheumatoid arthritic tissues, including synovial lining cells in the intima, capillary endothelial cells and plasma cells (PubMed:11877435).

Evidence on tissue expression from TISSUES for PLA2G2F Gene

  • Heart(4.2)
  • Lung(4.1)
  • Spleen(4)
genes like me logo Genes that share expression patterns with PLA2G2F: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G2F Gene

Orthologs for PLA2G2F Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2F Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLA2G2F 30 31
  • 98.1 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PLA2G2F 30 31
  • 83.17 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PLA2G2F 30 31
  • 82.9 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pla2g2f 30
  • 80.45 (n)
Mouse
(Mus musculus)
Mammalia Pla2g2f 30 17 31
  • 80.45 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G2F 31
  • 66 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PLA2G2F 31
  • 63 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 45 (a)
OneToMany
Species where no ortholog for PLA2G2F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PLA2G2F Gene

ENSEMBL:
Gene Tree for PLA2G2F (if available)
TreeFam:
Gene Tree for PLA2G2F (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLA2G2F: view image

Paralogs for PLA2G2F Gene

(7) SIMAP similar genes for PLA2G2F Gene using alignment to 1 proteins:

  • PA2GF_HUMAN
genes like me logo Genes that share paralogs with PLA2G2F: view

Variants for PLA2G2F Gene

Additional dbSNP identifiers (rs#s) for PLA2G2F Gene

Structural Variations from Database of Genomic Variants (DGV) for PLA2G2F Gene

Variant ID Type Subtype PubMed ID
esv3585414 CNV loss 21293372
nsv1003802 CNV loss 25217958
nsv545731 CNV gain 21841781

Variation tolerance for PLA2G2F Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G2F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G2F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G2F Gene

Disorders for PLA2G2F Gene

Additional Disease Information for PLA2G2F

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for PLA2G2F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G2F Gene

Publications for PLA2G2F Gene

  1. Cellular arachidonate-releasing function and inflammation-associated expression of group IIF secretory phospholipase A2. (PMID: 11877435) Murakami M … Kudo I (The Journal of biological chemistry 2002) 3 4 23
  2. Cloning and recombinant expression of human group IIF-secreted phospholipase A(2). (PMID: 11112443) Valentin E … Lambeau G (Biochemical and biophysical research communications 2000) 2 3 4
  3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 41
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for PLA2G2F Gene

Sources for PLA2G2F Gene