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Aliases for PLA2G2F Gene

Aliases for PLA2G2F Gene

  • Phospholipase A2 Group IIF 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 2F 3 4
  • GIIF SPLA2 3 4
  • SPLA2-IIF 3 4
  • Group IIF Secretory Phospholipase A2 3
  • Phospholipase A2, Group IIF 2
  • EC 3.1.1.4 4

External Ids for PLA2G2F Gene

Previous GeneCards Identifiers for PLA2G2F Gene

  • GC01P020037
  • GC01P019500
  • GC01P019611
  • GC01P019935
  • GC01P020211
  • GC01P020338
  • GC01P020465
  • GC01P018711

Summaries for PLA2G2F Gene

GeneCards Summary for PLA2G2F Gene

PLA2G2F (Phospholipase A2 Group IIF) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2D.

UniProtKB/Swiss-Prot for PLA2G2F Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.

Tocris Summary for PLA2G2F Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Additional gene information for PLA2G2F Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G2F Gene

Genomics for PLA2G2F Gene

GeneHancer (GH) Regulatory Elements for PLA2G2F Gene

Promoters and enhancers for PLA2G2F Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I020139 Promoter 0.5 EPDnew 550.8 0.0 -19 0.1 PLA2G2F PLA2G2D
GH01I020109 Enhancer 0.7 FANTOM5 ENCODE 12.1 -28.7 -28681 1.7 FOSL1 SOX6 JUN BHLHE40 EBF1 FOS PLA2G2F PLA2G2C MUL1 UBXN10 NBL1 PLA2G2D LOC100419911
GH01I020101 Enhancer 0.7 ENCODE 11.7 -38.2 -38223 0.2 CTCF FOXA2 RB1 MAX IRF4 RAD21 CC2D1A ARID2 VEZF1 SCRT2 PLA2G2F PLA2G2C ENSG00000226664 PLA2G2D LOC100419911
GH01I020175 Promoter 0.7 EPDnew 11.1 +35.8 35830 0.1 POLR2A MAX PLA2G2C PLA2G2F VWA5B1 ENSG00000227066
GH01I020110 Enhancer 0.5 ENCODE 11.9 -29.7 -29741 0.1 FOSL1 CTCF EBF1 FOS PLA2G2F PLA2G2C PLA2G2D LOC100419911
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLA2G2F on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLA2G2F gene promoter:

Genomic Locations for PLA2G2F Gene

Genomic Locations for PLA2G2F Gene
chr1:20,139,326-20,150,386
(GRCh38/hg38)
Size:
11,061 bases
Orientation:
Plus strand
chr1:20,465,819-20,476,879
(GRCh37/hg19)

Genomic View for PLA2G2F Gene

Genes around PLA2G2F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G2F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2F Gene

Proteins for PLA2G2F Gene

  • Protein details for PLA2G2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM2-PA2GF_HUMAN
    Recommended name:
    Group IIF secretory phospholipase A2
    Protein Accession:
    Q9BZM2
    Secondary Accessions:
    • Q5R385
    • Q8N217
    • Q9H506

    Protein attributes for PLA2G2F Gene

    Size:
    168 amino acids
    Molecular mass:
    18658 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G2F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G2F Gene

Post-translational modifications for PLA2G2F Gene

  • Glycosylation at isoforms=292, isoforms=2102, Asn123, and isoforms=2144
  • Modification sites at PhosphoSitePlus

Other Protein References for PLA2G2F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G2F Gene

Domains & Families for PLA2G2F Gene

Gene Families for PLA2G2F Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PLA2G2F Gene

Suggested Antigen Peptide Sequences for PLA2G2F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZM2

UniProtKB/Swiss-Prot:

PA2GF_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2F: view

Function for PLA2G2F Gene

Molecular function for PLA2G2F Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.

Enzyme Numbers (IUBMB) for PLA2G2F Gene

Phenotypes From GWAS Catalog for PLA2G2F Gene

Gene Ontology (GO) - Molecular Function for PLA2G2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA --
genes like me logo Genes that share ontologies with PLA2G2F: view
genes like me logo Genes that share phenotypes with PLA2G2F: view

Animal Models for PLA2G2F Gene

MGI Knock Outs for PLA2G2F:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G2F Gene

Localization for PLA2G2F Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2F Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G2F gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 1

Gene Ontology (GO) - Cellular Components for PLA2G2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PLA2G2F: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G2F Gene

Pathways & Interactions for PLA2G2F Gene

genes like me logo Genes that share pathways with PLA2G2F: view

Gene Ontology (GO) - Biological Process for PLA2G2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008150 biological_process ND --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLA2G2F: view

No data available for SIGNOR curated interactions for PLA2G2F Gene

Drugs & Compounds for PLA2G2F Gene

(11) Drugs for PLA2G2F Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist 23
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
calcium Approved Nutra 0

(45) Additional Compounds for PLA2G2F Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)

(5) Tocris Compounds for PLA2G2F Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G2F: view

Transcripts for PLA2G2F Gene

mRNA/cDNA for PLA2G2F Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLA2G2F Gene

Phospholipase A2, group IIF:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2F Gene

No ASD Table

Relevant External Links for PLA2G2F Gene

GeneLoc Exon Structure for
PLA2G2F
ECgene alternative splicing isoforms for
PLA2G2F

Expression for PLA2G2F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2G2F Gene

mRNA differential expression in normal tissues according to GTEx for PLA2G2F Gene

This gene is overexpressed in Bladder (x20.3), Skin - Not Sun Exposed (Suprapubic) (x15.9), and Skin - Sun Exposed (Lower leg) (x15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G2F Gene



NURSA nuclear receptor signaling pathways regulating expression of PLA2G2F Gene:

PLA2G2F

SOURCE GeneReport for Unigene cluster for PLA2G2F Gene:

Hs.302034

mRNA Expression by UniProt/SwissProt for PLA2G2F Gene:

Q9BZM2-PA2GF_HUMAN
Tissue specificity: Expressed at high levels in placenta, testis, thymus and at lower levels in heart, kidney, liver and prostate.

Evidence on tissue expression from TISSUES for PLA2G2F Gene

  • Heart(4)
  • Lung(4)
  • Spleen(4)
genes like me logo Genes that share expression patterns with PLA2G2F: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G2F Gene

Orthologs for PLA2G2F Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G2F 33 34
  • 98.1 (n)
dog
(Canis familiaris)
Mammalia PLA2G2F 33 34
  • 83.17 (n)
cow
(Bos Taurus)
Mammalia PLA2G2F 33 34
  • 82.9 (n)
mouse
(Mus musculus)
Mammalia Pla2g2f 33 16 34
  • 80.45 (n)
rat
(Rattus norvegicus)
Mammalia Pla2g2f 33
  • 80.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G2F 34
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLA2G2F 34
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
OneToMany
Species where no ortholog for PLA2G2F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G2F Gene

ENSEMBL:
Gene Tree for PLA2G2F (if available)
TreeFam:
Gene Tree for PLA2G2F (if available)

Paralogs for PLA2G2F Gene

(7) SIMAP similar genes for PLA2G2F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLA2G2F: view

Variants for PLA2G2F Gene

Sequence variations from dbSNP and Humsavar for PLA2G2F Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000157925 -- 20,141,742(+) C/T intron_variant
rs1000166259 -- 20,144,892(+) T/C intron_variant
rs1000270590 -- 20,146,852(+) C/T intron_variant
rs1000431844 -- 20,150,575(+) C/T downstream_transcript_variant
rs1000509031 -- 20,141,603(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G2F Gene

Variant ID Type Subtype PubMed ID
esv3585414 CNV loss 21293372
nsv1003802 CNV loss 25217958
nsv545731 CNV gain 21841781

Variation tolerance for PLA2G2F Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G2F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G2F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G2F Gene

Disorders for PLA2G2F Gene

Additional Disease Information for PLA2G2F

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLA2G2F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G2F Gene

Publications for PLA2G2F Gene

  1. Cloning and recombinant expression of human group IIF-secreted phospholipase A(2). (PMID: 11112443) Valentin E … Lambeau G (Biochemical and biophysical research communications 2000) 2 3 4 58
  2. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Cellular arachidonate-releasing function and inflammation-associated expression of group IIF secretory phospholipase A2. (PMID: 11877435) Murakami M … Kudo I (The Journal of biological chemistry 2002) 3 22 58

Products for PLA2G2F Gene

Sources for PLA2G2F Gene

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