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Aliases for PLA2G2E Gene

Aliases for PLA2G2E Gene

  • Phospholipase A2 Group IIE 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 2E 3 4
  • GIIE SPLA2 3 4
  • SPLA2-IIE 3 4
  • Group IIE Secretory Phospholipase A2 3
  • Phospholipase A2, Group IIE 2
  • EC 3.1.1.4 4

External Ids for PLA2G2E Gene

Previous GeneCards Identifiers for PLA2G2E Gene

  • GC01M019816
  • GC01M019281
  • GC01M019392
  • GC01M019716
  • GC01M019992
  • GC01M020119
  • GC01M020247
  • GC01M018492

Summaries for PLA2G2E Gene

GeneCards Summary for PLA2G2E Gene

PLA2G2E (Phospholipase A2 Group IIE) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2A.

UniProtKB/Swiss-Prot for PLA2G2E Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

Tocris Summary for PLA2G2E Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Additional gene information for PLA2G2E Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G2E Gene

Genomics for PLA2G2E Gene

GeneHancer (GH) Regulatory Elements for PLA2G2E Gene

Promoters and enhancers for PLA2G2E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I019923 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.8 0.0 -33 0.1 PLA2G2E RN7SL304P
GH01I019974 Enhancer 1.1 Ensembl ENCODE 11.4 -51.6 -51645 1.8 FOXA2 MLX ARID4B SIN3A IRF4 YY1 TCF12 GATA2 ZNF416 ZNF143 OTUD3 PLA2G2E EMC1 PLA2G2A NBL1 RN7SL304P
GH01I019474 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5 +446.4 446368 5.2 HDGF HDAC1 PKNOX1 NFXL1 TCF12 ZNF121 GATA2 EGR1 SCRT2 ZNF143 AKR7A2 CAPZB PLA2G2E UBR4 TMCO4 PIR41915
GH01I019892 Enhancer 0.5 ENCODE 11.2 +30.8 30847 1.3 JUND JUN FOS SPI1 OTUD3 PLA2G2E CAMK2N1 LOC105376823 PIR55587
GH01I019432 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.4 +471.8 471776 39.4 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 CAPZB EMC1 NBL1 RNU4-28P HTR6 AKR7A2 OTUD3 AKR7A3 PQLC2 UBR4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLA2G2E on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLA2G2E gene promoter:

Genomic Locations for PLA2G2E Gene

Genomic Locations for PLA2G2E Gene
chr1:19,920,009-19,923,617
(GRCh38/hg38)
Size:
3,609 bases
Orientation:
Minus strand
chr1:20,246,502-20,250,110
(GRCh37/hg19)

Genomic View for PLA2G2E Gene

Genes around PLA2G2E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G2E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G2E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2E Gene

Proteins for PLA2G2E Gene

  • Protein details for PLA2G2E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZK7-PA2GE_HUMAN
    Recommended name:
    Group IIE secretory phospholipase A2
    Protein Accession:
    Q9NZK7
    Secondary Accessions:
    • Q5VXJ8

    Protein attributes for PLA2G2E Gene

    Size:
    142 amino acids
    Molecular mass:
    15989 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PLA2G2E Gene

Post-translational modifications for PLA2G2E Gene

No Post-translational modifications

Other Protein References for PLA2G2E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G2E Gene

Domains & Families for PLA2G2E Gene

Gene Families for PLA2G2E Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for PLA2G2E Gene

Suggested Antigen Peptide Sequences for PLA2G2E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZK7

UniProtKB/Swiss-Prot:

PA2GE_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2E: view

Function for PLA2G2E Gene

Molecular function for PLA2G2E Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

Enzyme Numbers (IUBMB) for PLA2G2E Gene

Phenotypes From GWAS Catalog for PLA2G2E Gene

Gene Ontology (GO) - Molecular Function for PLA2G2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA --
genes like me logo Genes that share ontologies with PLA2G2E: view
genes like me logo Genes that share phenotypes with PLA2G2E: view

Animal Models for PLA2G2E Gene

MGI Knock Outs for PLA2G2E:

Animal Model Products

miRNA for PLA2G2E Gene

miRTarBase miRNAs that target PLA2G2E

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G2E Gene

Localization for PLA2G2E Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2E Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G2E gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PLA2G2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with PLA2G2E: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G2E Gene

Pathways & Interactions for PLA2G2E Gene

genes like me logo Genes that share pathways with PLA2G2E: view

Gene Ontology (GO) - Biological Process for PLA2G2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS 10681567
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006954 inflammatory response TAS 10681567
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLA2G2E: view

No data available for SIGNOR curated interactions for PLA2G2E Gene

Drugs & Compounds for PLA2G2E Gene

(25) Drugs for PLA2G2E Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aminosalicylic Acid Approved Pharma Target, unknown 31
Glycerol Approved, Investigational Pharma Target 175
Nimesulide Approved, Investigational, Withdrawn Pharma Target Non-steroidal anti-inflammatory drug 11
Oxyphenbutazone Approved, Withdrawn Pharma Target 0
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist 23

(45) Additional Compounds for PLA2G2E Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)

(5) Tocris Compounds for PLA2G2E Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G2E: view

Transcripts for PLA2G2E Gene

mRNA/cDNA for PLA2G2E Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2E Gene

No ASD Table

Relevant External Links for PLA2G2E Gene

GeneLoc Exon Structure for
PLA2G2E
ECgene alternative splicing isoforms for
PLA2G2E

Expression for PLA2G2E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2G2E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G2E Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x43.9) and Skin - Sun Exposed (Lower leg) (x4.3).

Protein differential expression in normal tissues from HIPED for PLA2G2E Gene

This gene is overexpressed in Hair follicle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G2E Gene



Protein tissue co-expression partners for PLA2G2E Gene

NURSA nuclear receptor signaling pathways regulating expression of PLA2G2E Gene:

PLA2G2E

SOURCE GeneReport for Unigene cluster for PLA2G2E Gene:

Hs.272372

mRNA Expression by UniProt/SwissProt for PLA2G2E Gene:

Q9NZK7-PA2GE_HUMAN
Tissue specificity: Restricted to the brain, heart, lung, and placenta.
genes like me logo Genes that share expression patterns with PLA2G2E: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G2E Gene

Orthologs for PLA2G2E Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G2E 33 34
  • 98.59 (n)
cow
(Bos Taurus)
Mammalia PLA2G2E 33 34
  • 86.38 (n)
dog
(Canis familiaris)
Mammalia PLA2G2E 33 34
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Pla2g2e 33 16 34
  • 81.92 (n)
oppossum
(Monodelphis domestica)
Mammalia PLA2G2E 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G2E 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G2E 33 34
  • 60.1 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496855 33
  • 51.63 (n)
Species where no ortholog for PLA2G2E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G2E Gene

ENSEMBL:
Gene Tree for PLA2G2E (if available)
TreeFam:
Gene Tree for PLA2G2E (if available)

Paralogs for PLA2G2E Gene

(8) SIMAP similar genes for PLA2G2E Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLA2G2E: view

Variants for PLA2G2E Gene

Sequence variations from dbSNP and Humsavar for PLA2G2E Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000932949 -- 19,923,178(-) G/A/C intron_variant
rs1001054964 -- 19,920,775(-) C/T intron_variant
rs1001180617 -- 19,923,280(-) G/A intron_variant
rs1001436590 -- 19,922,713(-) ATCATCA/ATCA coding_sequence_variant, inframe_deletion
rs1002943569 -- 19,920,770(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G2E Gene

Variant ID Type Subtype PubMed ID
nsv545730 CNV loss 21841781
nsv460717 CNV loss 19166990

Variation tolerance for PLA2G2E Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G2E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G2E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G2E Gene

Disorders for PLA2G2E Gene

Additional Disease Information for PLA2G2E

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLA2G2E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G2E Gene

Publications for PLA2G2E Gene

  1. Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. (PMID: 10681567) Suzuki N … Hanasaki K (The Journal of biological chemistry 2000) 2 3 4 58
  2. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 44 58
  3. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PMID: 20228799) McGovern DP … Seielstad M (Nature genetics 2010) 3 44 58
  4. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. (PMID: 19915572) UK IBD Genetics Consortium … Strachan DP (Nature genetics 2009) 3 44 58
  5. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PMID: 19122664) Silverberg MS … Duerr RH (Nature genetics 2009) 3 44 58

Products for PLA2G2E Gene

Sources for PLA2G2E Gene

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