This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated wit... See more...

Aliases for PLA2G2D Gene

Aliases for PLA2G2D Gene

  • Phospholipase A2 Group IID 2 3 5
  • Secretory-Type PLA, Stroma-Associated Homolog 3 4
  • Phosphatidylcholine 2-Acylhydrolase 2D 3 4
  • Group IID Secretory Phospholipase A2 3 4
  • GIID SPLA2 3 4
  • SPLA2-IID 3 4
  • PLA2IID 3 4
  • SPLASH 3 4
  • SPLA2S 2 3
  • Phospholipase A2, Group IID 2
  • Secretory Phospholipase A2s 3
  • EC 3.1.1.4 4
  • PLA2G2D 5

External Ids for PLA2G2D Gene

Previous GeneCards Identifiers for PLA2G2D Gene

  • GC01M020008
  • GC01M019473
  • GC01M019718
  • GC01M019907
  • GC01M020183
  • GC01M020311
  • GC01M020438
  • GC01M018684

Summaries for PLA2G2D Gene

Entrez Gene Summary for PLA2G2D Gene

  • This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

GeneCards Summary for PLA2G2D Gene

PLA2G2D (Phospholipase A2 Group IID) is a Protein Coding gene. Diseases associated with PLA2G2D include Surfactant Dysfunction and Gas Gangrene. Among its related pathways are Ras signaling pathway and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2A.

UniProtKB/Swiss-Prot Summary for PLA2G2D Gene

  • Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10455175, PubMed:10681567). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:10455175). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (By similarity). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (By similarity). May act in an autocrine and paracrine manner (By similarity). Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (By similarity). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity).

Tocris Summary for PLA2G2D Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G2D Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G2D Gene

Genomics for PLA2G2D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLA2G2D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J020184 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.2 -66.6 -66610 4 NCOR1 MYC IKZF1 ZNF592 CEBPA POLR2A NFIC YY1 CEBPB SMAD5 UBXN10 PLA2G2C UBXN10-AS1 PLA2G2D UBR4 HP1BP3
GH01J020119 Promoter/Enhancer 0.7 EPDnew Ensembl 250.7 -0.3 -334 1.4 SPI1 DPF2 PLA2G2D PLA2G2F
GH01J020058 Enhancer 0.8 Ensembl ENCODE 11.1 +59.2 59165 5.2 BCL11A NR2C1 RXRA IRF4 EBF1 SPI1 BATF IKZF1 BMI1 NR2F1 PLA2G5 PLA2G2D PLA2G2C OTUD3 VWA5B1 piR-43105-020 LOC100419911 lnc-PLA2G2F-4
GH01J020096 Enhancer 0.5 Ensembl 12.3 +23.4 23365 0.4 CEBPA CEBPB FOXA2 RXRA HNF4A REST HLF SP1 CEBPG PLA2G2D PLA2G2F PLA2G2C ENSG00000226664 lnc-PLA2G2D-1 RF00017-085 PLA2G5
GH01J020093 Enhancer 0.5 Ensembl ENCODE 12.3 +25.4 25387 0.8 CEBPB HLF PLA2G2D PLA2G2F PLA2G2C ENSG00000226664 PLA2G5 lnc-PLA2G2D-1 RF00017-085
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G2D on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G2D

Top Transcription factor binding sites by QIAGEN in the PLA2G2D gene promoter:
  • AP-2rep
  • AREB6
  • Evi-1
  • GATA-2
  • GATA-3
  • HNF-4alpha1
  • PPAR-gamma1
  • PPAR-gamma2
  • USF-1
  • USF1

Genomic Locations for PLA2G2D Gene

Latest Assembly
chr1:20,111,939-20,119,566
(GRCh38/hg38)
Size:
7,628 bases
Orientation:
Minus strand

Previous Assembly
chr1:20,438,432-20,446,029
(GRCh37/hg19 by Entrez Gene)
Size:
7,598 bases
Orientation:
Minus strand

chr1:20,438,432-20,446,050
(GRCh37/hg19 by Ensembl)
Size:
7,619 bases
Orientation:
Minus strand

Genomic View for PLA2G2D Gene

Genes around PLA2G2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2D Gene

Proteins for PLA2G2D Gene

  • Protein details for PLA2G2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNK4-PA2GD_HUMAN
    Recommended name:
    Group IID secretory phospholipase A2
    Protein Accession:
    Q9UNK4
    Secondary Accessions:
    • A0A087WZT4
    • A8K2Z1
    • B1AEL9
    • Q9UK01

    Protein attributes for PLA2G2D Gene

    Size:
    145 amino acids
    Molecular mass:
    16546 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G2D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G2D Gene

Post-translational modifications for PLA2G2D Gene

  • Glycosylation at Asn89
  • Modification sites at PhosphoSitePlus

Other Protein References for PLA2G2D Gene

Protein products for research

No data available for DME Specific Peptides for PLA2G2D Gene

Domains & Families for PLA2G2D Gene

Gene Families for PLA2G2D Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for PLA2G2D Gene

Suggested Antigen Peptide Sequences for PLA2G2D Gene

GenScript: Design optimal peptide antigens:
  • Secretory-type PLA, stroma-associated homolog (PA2GD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UNK4

UniProtKB/Swiss-Prot:

PA2GD_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2D: view

Function for PLA2G2D Gene

Molecular function for PLA2G2D Gene

UniProtKB/Swiss-Prot Function:
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10455175, PubMed:10681567). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:10455175). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (By similarity). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (By similarity). May act in an autocrine and paracrine manner (By similarity). Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (By similarity). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+); Xref=Rhea:RHEA:44604, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:64381, ChEBI:CHEBI:64612; Evidence={ECO:0000269|PubMed:10455175};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40911, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:73004, ChEBI:CHEBI:73007; Evidence={ECO:0000269|PubMed:10455175};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence={ECO:0000269|PubMed:10455175};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate; Xref=Rhea:RHEA:45472, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72829, ChEBI:CHEBI:75158; Evidence={ECO:0000250|UniProtKB:Q9WVF6};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+); Xref=Rhea:RHEA:40919, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72841, ChEBI:CHEBI:75158; Evidence={ECO:0000269|PubMed:10455175};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000255|PROSITE-ProRule:PRU10035, ECO:0000269|PubMed:10455175, ECO:0000269|PubMed:10681567};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence={ECO:0000269|PubMed:10455175};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence={ECO:0000269|PubMed:10455175, ECO:0000269|PubMed:10681567};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40811, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence={ECO:0000269|PubMed:10455175};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41231, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:74963, ChEBI:CHEBI:77016; Evidence={ECO:0000269|PubMed:10455175};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7-9. {ECO:0000269|PubMed:10455175};
GENATLAS Biochemistry:
phospholipase A2,group IID,secreted,predominantly expressed in the pancreas,spleen and less abundantly in the colon,thymus,placenta,small intestine and prostate,with several isoform putatively involved in inflammation and/or in the production of lipid mediators

Enzyme Numbers (IUBMB) for PLA2G2D Gene

Phenotypes From GWAS Catalog for PLA2G2D Gene

Gene Ontology (GO) - Molecular Function for PLA2G2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity TAS 10455175
GO:0005509 calcium ion binding IBA 21873635
GO:0005543 phospholipid binding IBA 21873635
GO:0008201 heparin binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLA2G2D: view
genes like me logo Genes that share phenotypes with PLA2G2D: view

Animal Models for PLA2G2D Gene

MGI Knock Outs for PLA2G2D:

Animal Models for research

  • Taconic Biosciences Mouse Models for PLA2G2D

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G2D

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G2D Gene

Localization for PLA2G2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2D Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G2D gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 2
lysosome 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PLA2G2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with PLA2G2D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G2D Gene

Pathways & Interactions for PLA2G2D Gene

genes like me logo Genes that share pathways with PLA2G2D: view

Pathways by source for PLA2G2D Gene

1 GeneGo (Thomson Reuters) pathway for PLA2G2D Gene
  • Immune response CD16 signaling in NK cells
7 Qiagen pathways for PLA2G2D Gene
  • Antioxidant Action of Vitamin-C
  • cAMP Pathway
  • Chemokine Signaling
  • DHA Signaling
  • Fc-EpsilonRI Pathway

Gene Ontology (GO) - Biological Process for PLA2G2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA --
GO:0002864 regulation of acute inflammatory response to antigenic stimulus ISS --
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS,IBA 21873635
GO:0006654 phosphatidic acid biosynthetic process TAS --
genes like me logo Genes that share ontologies with PLA2G2D: view

No data available for SIGNOR curated interactions for PLA2G2D Gene

Drugs & Compounds for PLA2G2D Gene

(16) Drugs for PLA2G2D Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lauric acid Approved, Experimental Pharma Target 0
Stearic acid Approved, Experimental Pharma Target 0
Clofazimine Approved, Investigational Pharma Tuberculosis drug 47
linoleic acid Approved, Experimental Pharma 0
Palmitic Acid Approved Pharma 27

(58) Additional Compounds for PLA2G2D Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
506-30-9
Beta-Cortolone
  • 1-Palmityl-2-palmitoleoyl-sn-glycero-3-phosphocholine
  • Gpcho(16:0/16:1)
  • Gpcho(16:0/16:1n7)
  • Gpcho(16:0/16:1W7)
  • Gpcho(32:1)
CE(22:0)
  • 1-Tetradecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
  • GPCho(14:0/18:0)
  • Phosphatidylcholine(14:0/18:0)
  • 1-Myristoyl-2-stearoylphosphatidylcholine
  • 1m-2S-PC
61510-09-6
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
3546-17-6

(5) Tocris Compounds for PLA2G2D Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7

(3) ApexBio Compounds for PLA2G2D Gene

Compound Action Cas Number
Clofazimine Tuberculosis drug 2030-63-9
CP-91149 Selective inhibitor of glycogen phosphorylase 186392-40-5
Varespladib (LY315920) HnsPLA inhibitor,potent and selective 172732-68-2
genes like me logo Genes that share compounds with PLA2G2D: view

Drug products for research

Transcripts for PLA2G2D Gene

mRNA/cDNA for PLA2G2D Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G2D

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for PLA2G2D Gene

GeneLoc Exon Structure for
PLA2G2D

Expression for PLA2G2D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G2D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G2D Gene

This gene is overexpressed in Spleen (x22.8) and Small Intestine - Terminal Ileum (x11.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G2D

SOURCE GeneReport for Unigene cluster for PLA2G2D Gene:

Hs.189507

mRNA Expression by UniProt/SwissProt for PLA2G2D Gene:

Q9UNK4-PA2GD_HUMAN
Tissue specificity: Highly expressed in pancreas and spleen and less abundantly in colon, thymus, placenta, small intestine, and prostate.

Evidence on tissue expression from TISSUES for PLA2G2D Gene

  • Pancreas(4.4)
  • Spleen(4.4)
  • Blood(4.3)
  • Lymph node(2.4)
  • Intestine(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with PLA2G2D: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G2D Gene

Orthologs for PLA2G2D Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLA2G2D 29 30
  • 99.54 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PLA2G2D 29 30
  • 83.68 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pla2g2d 29 16 30
  • 79.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pla2g2d 29
  • 78.7 (n)
Cow
(Bos Taurus)
Mammalia PLA2G2D4 30
  • 59 (a)
OneToMany
PLA2G2D3 30
  • 58 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia PLA2G2D 30
  • 53 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G2D 30
  • 46 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 52 (a)
OneToMany
Species where no ortholog for PLA2G2D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PLA2G2D Gene

ENSEMBL:
Gene Tree for PLA2G2D (if available)
TreeFam:
Gene Tree for PLA2G2D (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLA2G2D: view image
Alliance of Genome Resources:
Additional Orthologs for PLA2G2D

Paralogs for PLA2G2D Gene

(7) SIMAP similar genes for PLA2G2D Gene using alignment to 1 proteins:

  • PA2GD_HUMAN
genes like me logo Genes that share paralogs with PLA2G2D: view

Variants for PLA2G2D Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G2D Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs584367 -- p.Ser80Gly
rs62541890 -- p.Gln65His
rs62541891 -- p.His73Arg
rs62541892 -- p.His96Arg
rs62541900 -- p.Arg121Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLA2G2D Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLA2G2D Gene

Variant ID Type Subtype PubMed ID
esv1003821 CNV deletion 20482838
nsv1003802 CNV loss 25217958
nsv545731 CNV gain 21841781
nsv5520 CNV deletion 18451855

Variation tolerance for PLA2G2D Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G2D Gene

Human Gene Mutation Database (HGMD)
PLA2G2D
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G2D
Leiden Open Variation Database (LOVD)
PLA2G2D

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G2D Gene

Disorders for PLA2G2D Gene

MalaCards: The human disease database

(2) MalaCards diseases for PLA2G2D Gene - From: COP and GCD

Disorder Aliases PubMed IDs
surfactant dysfunction
  • interstitial lung disease due to surfactant deficiency
gas gangrene
  • gas bacillus infection
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLA2G2D

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PLA2G2D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G2D Gene

Publications for PLA2G2D Gene

  1. Cloning and characterization of novel mouse and human secretory phospholipase A(2)s. (PMID: 10455175) Ishizaki J … Hanasaki K (The Journal of biological chemistry 1999) 2 3 4 22
  2. A novel polymorphism in secretory phospholipase A2-IID is associated with body weight loss in chronic obstructive pulmonary disease. (PMID: 16002569) Takabatake N … Kubota I (American journal of respiratory and critical care medicine 2005) 3 22 40
  3. Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. (PMID: 10681567) Suzuki N … Hanasaki K (The Journal of biological chemistry 2000) 3 4 22
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 40
  5. Gly80Ser polymorphism of phospholipase A2-IID is associated with cytokine inducibility in A549 cells. (PMID: 19365107) Igarashi A … Kubota I (Respiration; international review of thoracic diseases 2009) 3 22

Products for PLA2G2D Gene

Sources for PLA2G2D Gene