Aliases for PLA2G2D Gene
External Ids for PLA2G2D Gene
Previous GeneCards Identifiers for PLA2G2D Gene
This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
GeneCards Summary for PLA2G2D Gene
PLA2G2D (Phospholipase A2 Group IID) is a Protein Coding gene. Diseases associated with PLA2G2D include Bladder Diverticulum and Hemopneumothorax. Among its related pathways are Glycerophospholipid biosynthesis and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2A.
UniProtKB/Swiss-Prot for PLA2G2D Gene
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.