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Aliases for PLA2G2C Gene

Aliases for PLA2G2C Gene

  • Phospholipase A2 Group IIC 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase-Like Protein GIIC 4
  • Phospholipase A2, Group IIC (Possible Pseudogene) 2
  • Phospholipase A2, Group IIC 2

External Ids for PLA2G2C Gene

Previous GeneCards Identifiers for PLA2G2C Gene

  • GC01U990213
  • GC01M019959
  • GC01M020349
  • GC01M020489
  • GC01M018736

Summaries for PLA2G2C Gene

GeneCards Summary for PLA2G2C Gene

PLA2G2C (Phospholipase A2 Group IIC) is a Protein Coding gene. Diseases associated with PLA2G2C include Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency and Gerstmann-Straussler Disease. Among its related pathways are Fat digestion and absorption and Pancreatic secretion. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity.

UniProtKB/Swiss-Prot for PLA2G2C Gene

  • Inactive phospholipase.

Tocris Summary for PLA2G2C Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Additional gene information for PLA2G2C Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G2C Gene

Genomics for PLA2G2C Gene

GeneHancer (GH) Regulatory Elements for PLA2G2C Gene

Promoters and enhancers for PLA2G2C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I020175 Promoter 0.7 EPDnew 550.8 +2.3 2268 0.1 POLR2A MAX PLA2G2C PLA2G2F VWA5B1 ENSG00000227066
GH01I020109 Enhancer 0.7 FANTOM5 ENCODE 10.8 +66.8 66779 1.7 FOSL1 SOX6 JUN BHLHE40 EBF1 FOS PLA2G2F PLA2G2C MUL1 UBXN10 NBL1 PLA2G2D LOC100419911
GH01I020101 Enhancer 0.7 ENCODE 10.7 +76.3 76321 0.2 CTCF FOXA2 RB1 MAX IRF4 RAD21 CC2D1A ARID2 VEZF1 SCRT2 PLA2G2F PLA2G2C ENSG00000226664 PLA2G2D LOC100419911
GH01I020058 Enhancer 0.6 ENCODE 10 +118.7 118741 0.2 SRF NR2F1 EBF1 BMI1 DPF2 BATF GABPA BCL11A IKZF1 RUNX3 PLA2G2C LOC100419911 PLA2G5 PLA2G2D
GH01I020151 Enhancer 1.1 Ensembl ENCODE 5.1 +24.4 24365 2.3 ELF3 RB1 ARID4B KLF17 SIN3A ZNF2 RAD21 ZNF335 GLIS2 ARID2 ENSG00000227066 GC01P020151 GC01P020152 PLA2G2C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLA2G2C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLA2G2C gene promoter:

Genomic Locations for PLA2G2C Gene

Genomic Locations for PLA2G2C Gene
16,172 bases
Minus strand

Genomic View for PLA2G2C Gene

Genes around PLA2G2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2C Gene

Proteins for PLA2G2C Gene

  • Protein details for PLA2G2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative inactive group IIC secretory phospholipase A2
    Protein Accession:
    Secondary Accessions:
    • Q7M4M6

    Protein attributes for PLA2G2C Gene

    149 amino acids
    Molecular mass:
    16844 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    • Sequence=CAI20258.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PLA2G2C Gene

Post-translational modifications for PLA2G2C Gene

No Post-translational modifications

Other Protein References for PLA2G2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G2C Gene

Domains & Families for PLA2G2C Gene

Gene Families for PLA2G2C Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PLA2G2C Gene

Suggested Antigen Peptide Sequences for PLA2G2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phospholipase A2 family.
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2C: view

Function for PLA2G2C Gene

Molecular function for PLA2G2C Gene

GENATLAS Biochemistry:
phospholipase A2,group IIC,Ca2+ dependent,non pancreatic,secreted,likely pseudogene
UniProtKB/Swiss-Prot Function:
Inactive phospholipase.

Gene Ontology (GO) - Molecular Function for PLA2G2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA --
GO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA --
genes like me logo Genes that share ontologies with PLA2G2C: view
genes like me logo Genes that share phenotypes with PLA2G2C: view

miRNA for PLA2G2C Gene

miRTarBase miRNAs that target PLA2G2C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G2C Gene

Localization for PLA2G2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2C Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G2C gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
golgi apparatus 2
endosome 2
cytoskeleton 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PLA2G2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLA2G2C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G2C Gene

Pathways & Interactions for PLA2G2C Gene

genes like me logo Genes that share pathways with PLA2G2C: view

Gene Ontology (GO) - Biological Process for PLA2G2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0050482 arachidonic acid secretion IEA --
genes like me logo Genes that share ontologies with PLA2G2C: view

No data available for SIGNOR curated interactions for PLA2G2C Gene

Drugs & Compounds for PLA2G2C Gene

(4) Drugs for PLA2G2C Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
D609 Pharma PC-PLC inhibitor 0
SPK-601 Pharma Potent PC-PLC inhibitor,antimicrobial agent 0
U 73343 Pharma 0

(7) Additional Compounds for PLA2G2C Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-eicosenoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/20:1)
  • GPCho(16:0/20:1n9)
  • GPCho(16:0/20:1w9)
  • GPCho(36:1)
Phosphatidylcholines Group C
  • 1-Docosadienyl-2-(10Z,13Z,16Z-docosatrienoyl)-sn-glycero-3-phosphocholine
  • GPCho(22:2/22:3)
  • GPCho(22:2n6/22:3n6)
  • GPCho(22:2w6/22:3w6)
  • GPCho(44:5)

(5) Tocris Compounds for PLA2G2C Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7

(3) ApexBio Compounds for PLA2G2C Gene

Compound Action Cas Number
D609 PC-PLC inhibitor 83373-60-8
SPK-601 Potent PC-PLC inhibitor,antimicrobial agent 1096687-52-3
U 73343 142878-12-4
genes like me logo Genes that share compounds with PLA2G2C: view

Drug Products

Transcripts for PLA2G2C Gene

mRNA/cDNA for PLA2G2C Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLA2G2C Gene

Phospholipase A2, group IIC:
Representative Sequences:

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Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2C Gene

No ASD Table

Relevant External Links for PLA2G2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLA2G2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2G2C Gene

mRNA differential expression in normal tissues according to GTEx for PLA2G2C Gene

This gene is overexpressed in Colon - Sigmoid (x14.9) and Esophagus - Muscularis (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of PLA2G2C Gene:


SOURCE GeneReport for Unigene cluster for PLA2G2C Gene:


Evidence on tissue expression from TISSUES for PLA2G2C Gene

  • Blood(2.8)
  • Nervous system(2.6)
  • Muscle(2.4)
  • Heart(2.3)
  • Kidney(2.3)
  • Lung(2.3)
  • Liver(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with PLA2G2C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G2C Gene

Orthologs for PLA2G2C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLA2G2C 34
  • 84 (a)
(Bos Taurus)
Mammalia PLA2G2C 33 34
  • 76.92 (n)
(Mus musculus)
Mammalia Pla2g2c 33 16 34
  • 75.06 (n)
(Rattus norvegicus)
Mammalia Pla2g2c 33
  • 73.7 (n)
(Canis familiaris)
Mammalia PLA2G2C 34
  • 69 (a)
(Monodelphis domestica)
Mammalia PLA2G2C 34
  • 55 (a)
(Gallus gallus)
Aves PLA2G2A 34
  • 33 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 39 (a)
Species where no ortholog for PLA2G2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G2C Gene

Gene Tree for PLA2G2C (if available)
Gene Tree for PLA2G2C (if available)

Paralogs for PLA2G2C Gene

(7) SIMAP similar genes for PLA2G2C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLA2G2C: view

No data available for Paralogs for PLA2G2C Gene

Variants for PLA2G2C Gene

Sequence variations from dbSNP and Humsavar for PLA2G2C Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000030539 -- 20,179,180(-) T/C upstream_transcript_variant
rs1000099080 -- 20,172,635(-) T/G intron_variant
rs1000146214 -- 20,179,308(-) G/A upstream_transcript_variant
rs1000282639 -- 20,173,048(-) C/T intron_variant
rs1000453322 -- 20,171,811(-) GAG/GAGAG intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G2C Gene

Variant ID Type Subtype PubMed ID
nsv545731 CNV gain 21841781
nsv1122306 CNV deletion 24896259
esv3585417 CNV loss 21293372
esv3585416 CNV loss 21293372
esv3585415 CNV loss 21293372
esv3553899 CNV deletion 23714750
esv2674305 CNV deletion 23128226
esv2674003 CNV deletion 23128226
esv26523 CNV loss 19812545
esv26309 CNV loss 19812545
esv2606339 CNV deletion 19546169
esv2380061 CNV deletion 18987734

Variation tolerance for PLA2G2C Gene

Gene Damage Index Score: 9.68; 89.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G2C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G2C Gene

Disorders for PLA2G2C Gene

MalaCards: The human disease database

(3) MalaCards diseases for PLA2G2C Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLA2G2C

genes like me logo Genes that share disorders with PLA2G2C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G2C Gene

Publications for PLA2G2C Gene

  1. Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human. (PMID: 8838795) Tischfield JA … Lusis AJ (Genomics 1996) 2 3 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  3. Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. (PMID: 9745929) Schröder HC … Müller WE (Neurotoxicology 1998) 3 58
  4. HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes. (PMID: 9377118) Mavoungou E … Russo-Marie F (Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1997) 3 58
  5. Novel gene exon homologous to pancreatic phospholipase A2: sequence and chromosomal mapping of both human genes. (PMID: 2708461) Seilhamer JJ … Lusis AJ (Journal of cellular biochemistry 1989) 4 58

Products for PLA2G2C Gene

Sources for PLA2G2C Gene

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