Aliases for PLA2G2C Gene

Aliases for PLA2G2C Gene

  • Phospholipase A2 Group IIC 2 3 5
  • Putative Inactive Group IIC Secretory Phospholipase A2 3 4
  • Phosphatidylcholine 2-Acylhydrolase-Like Protein GIIC 3 4
  • Phospholipase A2, Group IIC (Possible Pseudogene) 2 3
  • UBXN10 Antisense RNA 1 2 3
  • Phospholipase A2, Group IIC 2
  • UBXN10-AS1 3
  • PLA2G2C 5

External Ids for PLA2G2C Gene

Previous HGNC Symbols for PLA2G2C Gene

  • UBXN10-AS1

Previous GeneCards Identifiers for PLA2G2C Gene

  • GC01U990213
  • GC01M019959
  • GC01M020349
  • GC01M020489
  • GC01M018736

Summaries for PLA2G2C Gene

GeneCards Summary for PLA2G2C Gene

PLA2G2C (Phospholipase A2 Group IIC) is a Protein Coding gene. Among its related pathways are Linoleic acid metabolism and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity. An important paralog of this gene is PLA2G2D.

UniProtKB/Swiss-Prot Summary for PLA2G2C Gene

Tocris Summary for PLA2G2C Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Additional gene information for PLA2G2C Gene

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G2C Gene

Genomics for PLA2G2C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLA2G2C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G2C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G2C

Top Transcription factor binding sites by QIAGEN in the PLA2G2C gene promoter:
  • aMEF-2
  • AML1a
  • C/EBPalpha
  • CHOP-10
  • E47
  • Egr-3
  • HEN1
  • MEF-2
  • MEF-2A
  • Nkx2-2

Genomic Locations for PLA2G2C Gene

Genomic Locations for PLA2G2C Gene
chr1:20,161,253-20,186,518
(GRCh38/hg38)
Size:
25,266 bases
Orientation:
Minus strand
chr1:20,487,746-20,503,917
(GRCh37/hg19)
Size:
16,172 bases
Orientation:
Minus strand

Genomic View for PLA2G2C Gene

Genes around PLA2G2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2C Gene

Proteins for PLA2G2C Gene

  • Protein details for PLA2G2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5R387-PA2GC_HUMAN
    Recommended name:
    Putative inactive group IIC secretory phospholipase A2
    Protein Accession:
    Q5R387
    Secondary Accessions:
    • Q7M4M6

    Protein attributes for PLA2G2C Gene

    Size:
    149 amino acids
    Molecular mass:
    16844 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PLA2G2C Gene

Post-translational modifications for PLA2G2C Gene

No Post-translational modifications

Other Protein References for PLA2G2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G2C Gene

Domains & Families for PLA2G2C Gene

Gene Families for PLA2G2C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PLA2G2C Gene

Suggested Antigen Peptide Sequences for PLA2G2C Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidylcholine 2-acylhydrolase-like protein GIIC (PA2GC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5R387

UniProtKB/Swiss-Prot:

PA2GC_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2C: view

Function for PLA2G2C Gene

Molecular function for PLA2G2C Gene

UniProtKB/Swiss-Prot Function:
Inactive phospholipase.
GENATLAS Biochemistry:
phospholipase A2,group IIC,Ca2+ dependent,non pancreatic,secreted,likely pseudogene

Phenotypes From GWAS Catalog for PLA2G2C Gene

Gene Ontology (GO) - Molecular Function for PLA2G2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IEA,IBA 21873635
GO:0005509 calcium ion binding IEA --
GO:0005543 phospholipid binding IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLA2G2C: view
genes like me logo Genes that share phenotypes with PLA2G2C: view

Animal Models for PLA2G2C Gene

MGI Knock Outs for PLA2G2C:
  • Pla2g2c Pla2g2c<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for PLA2G2C Gene

miRTarBase miRNAs that target PLA2G2C

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G2C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G2C Gene

Localization for PLA2G2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2C Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G2C gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PLA2G2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLA2G2C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G2C Gene

Pathways & Interactions for PLA2G2C Gene

genes like me logo Genes that share pathways with PLA2G2C: view

Interacting Proteins for PLA2G2C Gene

Gene Ontology (GO) - Biological Process for PLA2G2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0050482 arachidonic acid secretion IEA --
genes like me logo Genes that share ontologies with PLA2G2C: view

No data available for SIGNOR curated interactions for PLA2G2C Gene

Drugs & Compounds for PLA2G2C Gene

(4) Drugs for PLA2G2C Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D609 Pharma PC-PLC inhibitor 0
U 73343 Pharma 0
Calcium Nutra 6556
AACOCF3 Pharma Inhibitor of cPLA2/anandamide hydrolysis/FAAH, Phospholipase A2 inhibitor 0

(8) Additional Compounds for PLA2G2C Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-Acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7
Phosphatidylcholines Group B
  • 1-Hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
  • 2-(9Z,12Z-Octadecadienoyl)-1-hexadecyl-sn-glycero-3-phosphocholine
  • PC Ae C34:2
  • PC(16:0E/18:2(9Z,12Z))
  • PC(O-34:2)
88542-95-4
Phosphatidylcholines Group C
  • (2R)-2,3-Bis[(1Z)-hexadec-1-en-1-yloxy]propyl 2-(trimethylazaniumyl)ethyl phosphoric acid
  • (2R)-2-[(1Z)-Hexadec-1-en-1-yloxy]-3-[(1Z,11Z)-octadeca-1,11-dien-1-yloxy]propyl 2-(trimethylazaniumyl)ethyl phosphoric acid
  • (2R)-3-[(1Z)-Hexadec-1-en-1-yloxy]-2-[(1Z,11Z)-octadeca-1,11-dien-1-yloxy]propyl 2-(trimethylazaniumyl)ethyl phosphoric acid
  • (2R)-2-[(1Z)-Octadec-1-en-1-yloxy]-3-[(1Z,11Z)-octadeca-1,11-dien-1-yloxy]propyl 2-(trimethylazaniumyl)ethyl phosphoric acid
  • (2R)-3-[(1Z)-Hexadec-1-en-1-yloxy]-2-[(1Z,9Z)-octadeca-1,9-dien-1-yloxy]propyl 2-(trimethylazaniumyl)ethyl phosphoric acid
edelfosine
77286-66-9

(5) Tocris Compounds for PLA2G2C Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7

(2) ApexBio Compounds for PLA2G2C Gene

Compound Action Cas Number
D609 PC-PLC inhibitor 83373-60-8
U 73343 142878-12-4
genes like me logo Genes that share compounds with PLA2G2C: view

Drug Products

Transcripts for PLA2G2C Gene

mRNA/cDNA for PLA2G2C Gene

3 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G2C

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2C Gene

No ASD Table

Relevant External Links for PLA2G2C Gene

GeneLoc Exon Structure for
PLA2G2C

Expression for PLA2G2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for PLA2G2C Gene

This gene is overexpressed in Colon - Sigmoid (x14.9) and Esophagus - Muscularis (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G2C

SOURCE GeneReport for Unigene cluster for PLA2G2C Gene:

Hs.512512
genes like me logo Genes that share expression patterns with PLA2G2C: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G2C Gene

Orthologs for PLA2G2C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLA2G2C 31
  • 84 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia PLA2G2C 30 31
  • 76.92 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pla2g2c 30 17 31
  • 75.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pla2g2c 30
  • 73.7 (n)
Dog
(Canis familiaris)
Mammalia PLA2G2C 31
  • 69 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PLA2G2C 31
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PLA2G2A 31
  • 33 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 39 (a)
OneToMany
Species where no ortholog for PLA2G2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PLA2G2C Gene

ENSEMBL:
Gene Tree for PLA2G2C (if available)
TreeFam:
Gene Tree for PLA2G2C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLA2G2C: view image

Paralogs for PLA2G2C Gene

(7) SIMAP similar genes for PLA2G2C Gene using alignment to 2 proteins:

  • PA2GC_HUMAN
  • J3KMZ3_HUMAN
genes like me logo Genes that share paralogs with PLA2G2C: view

Variants for PLA2G2C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G2C Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs6426616 - p.Gln139Arg

Additional dbSNP identifiers (rs#s) for PLA2G2C Gene

Structural Variations from Database of Genomic Variants (DGV) for PLA2G2C Gene

Variant ID Type Subtype PubMed ID
esv2380061 CNV deletion 18987734
esv2606339 CNV deletion 19546169
esv26309 CNV loss 19812545
esv26523 CNV loss 19812545
esv2674003 CNV deletion 23128226
esv2674305 CNV deletion 23128226
esv3553899 CNV deletion 23714750
esv3585415 CNV loss 21293372
esv3585416 CNV loss 21293372
esv3585417 CNV loss 21293372
nsv1122306 CNV deletion 24896259
nsv545731 CNV gain 21841781
nsv545731 CNV gain 21841781

Variation tolerance for PLA2G2C Gene

Gene Damage Index Score: 9.68; 89.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G2C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G2C Gene

Disorders for PLA2G2C Gene

No disorders were found for PLA2G2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G2C Gene

Publications for PLA2G2C Gene

  1. Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human. (PMID: 8838795) Tischfield JA … Lusis AJ (Genomics 1996) 2 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4
  4. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PMID: 12486725) Kurz M … Kramer W (Proteins 2003) 26
  5. Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. (PMID: 9745929) Schröder HC … Müller WE (Neurotoxicology 1998) 3

Products for PLA2G2C Gene

  • Biorbyt antibodies for PLA2G2C

Sources for PLA2G2C Gene