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This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several b... See more...
Aliases for PLA2G1B Gene
Aliases for PLA2G1B Gene
External Ids for PLA2G1B Gene
- HGNC: 9030
- Entrez Gene: 5319
- Ensembl: ENSG00000170890
- OMIM: 172410
- UniProtKB: P04054
Previous HGNC Symbols for PLA2G1B Gene
- PLA2
- PPLA2
- PLA2A
Previous GeneCards Identifiers for PLA2G1B Gene
- GC12M119633
- GC12M120286
- GC12M120542
- GC12M119171
- GC12M119222
- GC12M119244
- GC12M120759
- GC12M117768
Summaries for PLA2G1B Gene
-
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
GeneCards Summary for PLA2G1B Gene
PLA2G1B (Phospholipase A2 Group IB) is a Protein Coding gene. Diseases associated with PLA2G1B include Blepharitis and Membranous Nephropathy. Among its related pathways are Sweet Taste Signaling and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2A.
UniProtKB/Swiss-Prot Summary for PLA2G1B Gene
-
Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:1420353, PubMed:10681567, PubMed:17603006). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:1420353, PubMed:10681567, PubMed:17603006). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (PubMed:7721806, PubMed:25335547). Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (PubMed:25335547). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).
-
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
Additional gene information for PLA2G1B Gene
- HGNC(9030)
- Entrez Gene(5319)
- Ensembl(ENSG00000170890)
- OMIM(172410)
- UniProtKB(P04054)
- Open Targets Platform(ENSG00000170890)
- Search for PLA2G1B at DataMed
- Search for PLA2G1B at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G1B Gene
Genomics for PLA2G1B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PLA2G1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PLA2G1B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G1B
- Top Transcription factor binding sites by QIAGEN in the PLA2G1B gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- NF-kappaB
- NF-kappaB1
- PPAR-gamma1
- PPAR-gamma2
- RelA
Genomic Locations for PLA2G1B Gene
Genomic Locations for PLA2G1B Gene
- chr12:120,322,115-120,327,779
- (GRCh38/hg38)
- Size:
- 5,665 bases
- Orientation:
- Minus strand
- chr12:120,759,914-120,765,592
- (GRCh37/hg19)
- Size:
- 5,679 bases
- Orientation:
- Minus strand
Genomic View for PLA2G1B Gene
Genes around PLA2G1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by HGNC
- 12q24.31 by Entrez Gene
- 12q24.31 by Ensembl
PLA2G1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLA2G1B Gene
Proteins for PLA2G1B Gene
-
Protein details for PLA2G1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04054-PA21B_HUMAN
- Recommended name:
- Phospholipase A2
- Protein Accession:
- P04054
- B2R4H5
- Q3KPI1
Protein attributes for PLA2G1B Gene
- Size:
- 148 amino acids
- Molecular mass:
- 16360 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
-
- The inactive pro-form is a homotrimer (PubMed:19297324). When anchored into the cell membrane, the inactive homotrimer is likely cleaved either by trypsin or by itself, producing an active trimer. The resulting conformational changes are thought to open up a center hole forming a channel for substrate entry (PubMed:19297324). Interacts with PLA2R1; this interaction mediates intracellular signaling as well as clearance of extracellular PLA2G1B via endocytotic pathway (PubMed:7721806).
Protein Expression for PLA2G1B Gene
Selected DME Specific Peptides for PLA2G1B Gene
- P04054:
-
- QTHDNCY
- GGSGTPVD
- AFICNCDR
- YGCYCGLGG
- HKNLDTKKYC
Post-translational modifications for PLA2G1B Gene
- Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.
Other Protein References for PLA2G1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PLA2G1B Antibody
- LifeSpan BioSciences PLA2G1B Antibody
-
Custom Antibody ServicesOriGene Antibodies for PLA2G1B
- Novus Biologicals Antibodies for PLA2G1B
-
Abcam antibodies for PLA2G1B
- Invitrogen Antibodies for PLA2G1B (AFLGC-PLA2G1B)
- Sino Biological Antibodies for PLA2G1B
Protein Products
- G Biosciences Human PLA2G1B/Phospholipase A2/PLA2/PLA2A/PPLA2, Liquid
- Search Origene for MassSpec and Protein Over-expression Lysates for PLA2G1B
- Origene Custom Protein Services for PLA2G1B
- Sino Biological Recombinant Proteins for PLA2G1B
- Sino Biological Cell Lysates for PLA2G1B
- ProSpec Recombinant Proteins for PLA2G1B
-
ProSci Proteins for PLA2G1B
-
Abcam proteins for PLA2G1B
Domains & Families for PLA2G1B Gene
Gene Families for PLA2G1B Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Candidate cardiovascular disease genes
- Enzymes
- FDA approved drug targets
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for PLA2G1B Gene
- InterPro:
- Blocks:
-
- Phospholipase A2
- ProtoNet:
Suggested Antigen Peptide Sequences for PLA2G1B Gene
- GenScript: Design optimal peptide antigens:
-
- Phosphatidylcholine 2-acylhydrolase 1B (PA21B_HUMAN)
- Mutant synovial phospholipase A2 (Q96RW8_HUMAN)
- Mutant synovial phospholipase A2 (Q96RW9_HUMAN)
- Mutant synovial phospholipase A2 (Q9C011_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P04054- Family:
-
- Belongs to the phospholipase A2 family.
Function for PLA2G1B Gene
Molecular function for PLA2G1B Gene
- UniProtKB/Swiss-Prot Function:
- Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:1420353, PubMed:10681567, PubMed:17603006). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:1420353, PubMed:10681567, PubMed:17603006). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (PubMed:7721806, PubMed:25335547). Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (PubMed:25335547). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000255|PROSITE-ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036, ECO:0000269|PubMed:10681567, ECO:0000269|PubMed:17603006};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate; Xref=Rhea:RHEA:54456, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:45240, ChEBI:CHEBI:64489; Evidence={ECO:0000269|PubMed:17603006};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence={ECO:0000250|UniProtKB:P04055};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence={ECO:0000269|PubMed:10681567};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence={ECO:0000250|UniProtKB:P04055};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+); Xref=Rhea:RHEA:40919, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72841, ChEBI:CHEBI:75158; Evidence={ECO:0000269|PubMed:1420353};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45424, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:78097, ChEBI:CHEBI:85217; Evidence={ECO:0000250|UniProtKB:P04055};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence={ECO:0000250|UniProtKB:P04055};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:56424, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:85334, ChEBI:CHEBI:85335; Evidence={ECO:0000250|UniProtKB:P04055};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Regulated by bile acid salts. Up-regulated by cholate and down-regulated by taurochenodeoxycholate. Cholate-activated rate of hydrolysis is lowered by hypolipidemic drug ezetimibe.
- GENATLAS Biochemistry:
- phospholipase A2,Ca2+ dependent,group 1B,pancreatic,secreted,cleaved by caspase 1 and caspase 8,for proteolysis and inactivation during apoptosis,inducing cell proliferation,smooth muscle contraction and lipid mediator release
Enzyme Numbers (IUBMB) for PLA2G1B Gene
Phenotypes From GWAS Catalog for PLA2G1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004623 | phospholipase A2 activity | IEA,IDA | 1918029 |
| GO:0005102 | signaling receptor binding | IEA,IPI | 7721806 |
| GO:0005509 | calcium ion binding | IEA,IDA | 7060561 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0032052 | bile acid binding | ISS | 7060561 |
Phenotypes for PLA2G1B Gene
- MGI mutant phenotypes for PLA2G1B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PLA2G1B:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- shRNA abundance <= 50%
- Increased IL-8 secretion
- Reduced mammosphere formation
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased interferon-beta reporter expression
- Decreased viability in esophageal squamous lineage; decreased viability in non-small-cell lung cancer (NSCLC) lineage
Animal Models for PLA2G1B Gene
- MGI Knock Outs for PLA2G1B:
-
- Pla2g1b Pla2g1b<tm1Dyh>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PLA2G1B - Select products 50% OFF >
- * PLA2G1B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PLA2G1B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G1B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G1B
- Browse OriGene Inhibitory RNA Products For PLA2G1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G1B
Clone Products
- Applied Biological Materials (abm): Clones for PLA2G1B - Select products 50% OFF >
- * PLA2G1B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PLA2G1B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G1B
Cell Line Products
-
Horizon Cell Lines for PLA2G1B
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLA2G1B Gene
Localization for PLA2G1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLA2G1B Gene
- Secreted. Note=Secreted from pancreatic acinar cells in its inactive form.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005615 | extracellular space | IDA | 7060561 |
| GO:0005623 | cell | IEA | -- |
| GO:0009986 | cell surface | IEA,IDA | 1918029 |
| GO:0030141 | secretory granule | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G1B Gene
Pathways & Interactions for PLA2G1B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Acyl chain remodelling of PE |
.30
|
|
| 2 | Glycerophospholipid biosynthesis | ||
| 3 | Linoleic acid metabolism | ||
| 4 | Metabolism |
.40
|
|
| 5 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
|
Endothelin-1 Signaling Pathway
.46
|
Pathways by source for PLA2G1B Gene
2 BioSystems pathways for PLA2G1B Gene
10 Reactome pathways for PLA2G1B Gene
10 KEGG pathways for PLA2G1B Gene
2 GeneGo (Thomson Reuters) pathways for PLA2G1B Gene
- Anandamide biosynthesis and metabolism
- Immune response CD16 signaling in NK cells
12 Qiagen pathways for PLA2G1B Gene
- Antioxidant Action of Vitamin-C
- Beta-Adrenergic Signaling
- cAMP Pathway
- Chemokine Signaling
- DHA Signaling
2 Cell Signaling Technology pathways for PLA2G1B Gene
Interacting Proteins for PLA2G1B Gene
GPS-Prot Interaction Network for PLA2G1B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | ISS | 15528384 |
| GO:0002227 | innate immune response in mucosa | IDA | 12860195 |
| GO:0002446 | neutrophil mediated immunity | ISS | 16005851 |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006633 | fatty acid biosynthetic process | IBA,IDA | 1918029 |
Drugs & Compounds for PLA2G1B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cholic acid | Approved | Pharma | Agonist, Full agonist, Target | 0 | ||
| Azelastine | Approved | Pharma | Target, inhibitor | 42 | ||
| Sulfasalazine | Approved | Pharma | Inhibitor, Inhibition, Target, antagonist | NF-κB activation inhibitor | 84 | |
| linoleic acid | Approved, Experimental | Pharma | Agonist, Full agonist, Activator, Pore Blocker, Channel blocker | 0 | ||
| Palmitic Acid | Approved | Pharma | Agonist, Full agonist | 27 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Arachidic acid |
|
506-30-9 |
|
|||
| Heptadecanoic acid |
|
506-12-7 |
|
|||
| Heptadecanoyl CoA |
|
3546-17-6 |
|
|||
| LysoPC(14:0/0:0) |
|
20559-16-4 |
|
|||
| LysoPC(14:1(9Z)) |
|
|
(5) Tocris Compounds for PLA2G1B Gene
| Compound | Action | Cas Number |
|---|---|---|
| AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
| Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
| m-3M3FBS | Phospholipase C activator | 200933-14-8 |
| o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
| U 73122 | Phospholipase C inhibitor | 112648-68-7 |
Drug Products
- G Biosciences Human PLA2G1B/Phospholipase A2/PLA2/PLA2A/PPLA2, Liquid
Transcripts for PLA2G1B Gene
mRNA/cDNA for PLA2G1B Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000308366 551 nts (view in UCSC)
- ENST00000423423 423 nts (view in UCSC)
- ENST00000549767 562 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PLA2G1B - Select products 50% OFF >
- * PLA2G1B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PLA2G1B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G1B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G1B
- Browse OriGene Inhibitory RNA Products For PLA2G1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G1B
Clone Products
- Applied Biological Materials (abm): Clones for PLA2G1B - Select products 50% OFF >
- * PLA2G1B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PLA2G1B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G1B
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | - |
Relevant External Links for PLA2G1B Gene
- GeneLoc Exon Structure for
- PLA2G1B
Expression for PLA2G1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
- Intraembryonic Epiblast Cells Epiblast
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Epithelial Cells
- Duct Cells Pancreatic Ducts
- Inner Cell Mass (Early Embryonic Tissues)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for PLA2G1B Gene
This gene is overexpressed in Pancreas (x52.8).
This gene is overexpressed in Pancreatic juice (67.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G1B Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G1B
SOURCE GeneReport for Unigene cluster for PLA2G1B Gene:
Hs.992mRNA Expression by UniProt/SwissProt for PLA2G1B Gene:
P04054-PA21B_HUMAN
Tissue specificity:
Selectively expressed in pancreas, lung, liver and kidney. Also detected at lower levels in ovary and testis.
Evidence on tissue expression from TISSUES for PLA2G1B Gene
- Pancreas(4.9)
- Lung(4.6)
- Heart(3)
- Blood(3)
- Muscle(2.9)
- Intestine(2.7)
- Nervous system(2.7)
- Kidney(2.6)
- Liver(2.4)
- Skin(2.3)
- Stomach(2.3)
- Urine(2.2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for PLA2G1B
-
OriGene qPCR primer pairs and template standards for PLA2G1B
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G1B Gene
Orthologs for PLA2G1B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PLA2G1B 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PLA2G1B 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pla2g1b 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Pla2g1b 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PLA2G1B 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PLA2G1B 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PLA2G1B 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PLA2G1B 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | PLA2G1B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pla2g1b 30 |
|
||
| Str.9482 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | pla2g1b 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9086 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | C07E3.9 31 |
|
OneToMany |
- Species where no ortholog for PLA2G1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PLA2G1B Gene
- ENSEMBL:
- Gene Tree for PLA2G1B (if available)
- TreeFam:
- Gene Tree for PLA2G1B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PLA2G1B: view image
Paralogs for PLA2G1B Gene
Paralogs for PLA2G1B Gene
(8) SIMAP similar genes for PLA2G1B Gene using alignment to 3 proteins:
- PA21B_HUMAN
- F8W062_HUMAN
- Q9BS22_HUMAN
Variants for PLA2G1B Gene
Residual Variation Intolerance Score:
38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.74;
15.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLA2G1B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PLA2G1B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G1B Gene
Disorders for PLA2G1B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| blepharitis |
|
|
| membranous nephropathy |
|
|
| myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency |
|
|
| acinar cell carcinoma |
|
|
| acute pancreatitis |
|
Search PLA2G1B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PLA2G1B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G1B Gene
Publications for PLA2G1B Gene
- The study of cytosolic phospholipase A2 gene polymorphism in schizophrenia using eye movement disturbances as an endophenotypic marker. (PMID: 12759552) Rybakowski JK … Hauser J (Neuropsychobiology 2003) 3 23 41
- sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor. (PMID: 25335547) Pan Y … Ding G (Scientific reports 2014) 3 4
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Structural insight into the activation mechanism of human pancreatic prophospholipase A2. (PMID: 19297324) Xu W … Liu J (The Journal of biological chemistry 2009) 3 4
- The effects of beta2 adrenergic receptor gene polymorphism in lipid profiles. (PMID: 18492292) Kao WT … Lung FW (Lipids in health and disease 2008) 3 41
ExternalLinks
Products for PLA2G1B Gene
- Custom Antibody ServicesOriGene Antibodies for PLA2G1B
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PLA2G1B
- Origene Custom Protein Services for PLA2G1B
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLA2G1B
- Browse OriGene Inhibitory RNA Products For PLA2G1B
- OriGene qPCR primer pairs for PLA2G1B
- OriGene qPCR primer pairs and template standards for PLA2G1B
- OriGene CRISPR knockouts for PLA2G1B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PLA2G1B
- Sino Biological Human cDNA Clone for PLA2G1B
- Sino Biological Recombinant Proteins for PLA2G1B
- Sino Biological Cell Lysates for PLA2G1B
- Sino Biological Antibodies for PLA2G1B
- Sino Biological Assays for PLA2G1B
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PLA2G1B
- Novus Biologicals proteins and lysates for PLA2G1B
- Novus Biologicals ELISA Kits for PLA2G1B
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PLA2G1B
- Abcam proteins for PLA2G1B
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for PLA2G1B (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PLA2G1B (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PLA2G1B (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PLA2G1B CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PLA2G1B
- antibodies-online: Show 426 available YWHAZ Antibodies ranked by validation data
- Compare Top YWHAZ Antibodies
- antibodies-online: Show 21 available YWHAZ Elisa Kits ranked by validation data
- Compare Top YWHAZ Elisa Kits
- antibodies-online: Show 37 available YWHAZ Proteins ranked by validation data
- Compare Top YWHAZ Proteins
- Horizon Cell Lines for PLA2G1B
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLA2G1B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLA2G1B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PLA2G1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G1B
Sources for PLA2G1B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB