Aliases for PLA2G1B Gene
External Ids for PLA2G1B Gene
Previous HGNC Symbols for PLA2G1B Gene
Previous GeneCards Identifiers for PLA2G1B Gene
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
GeneCards Summary for PLA2G1B Gene
PLA2G1B (Phospholipase A2 Group IB) is a Protein Coding gene. Diseases associated with PLA2G1B include Membranous Nephropathy and Neurodegeneration With Brain Iron Accumulation 2B. Among its related pathways are Oxytocin signaling pathway and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2E.
UniProtKB/Swiss-Prot Summary for PLA2G1B Gene
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.