This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several b... See more...

Aliases for PLA2G1B Gene

Aliases for PLA2G1B Gene

  • Phospholipase A2 Group IB 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 1B 3 4
  • Phospholipase A2, Group IB (Pancreas) 2 3
  • Phospholipase A2 3 4
  • EC 3.1.1.4 4 50
  • PLA2A 3 4
  • PPLA2 3 4
  • PLA2 3 4
  • Group IB Phospholipase A2 4
  • PLA2G1B 5

External Ids for PLA2G1B Gene

Previous HGNC Symbols for PLA2G1B Gene

  • PLA2
  • PPLA2
  • PLA2A

Previous GeneCards Identifiers for PLA2G1B Gene

  • GC12M119633
  • GC12M120286
  • GC12M120542
  • GC12M119171
  • GC12M119222
  • GC12M119244
  • GC12M120759
  • GC12M117768

Summaries for PLA2G1B Gene

Entrez Gene Summary for PLA2G1B Gene

  • This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

GeneCards Summary for PLA2G1B Gene

PLA2G1B (Phospholipase A2 Group IB) is a Protein Coding gene. Diseases associated with PLA2G1B include Membranous Nephropathy and Blepharitis. Among its related pathways are Ras signaling pathway and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2A.

UniProtKB/Swiss-Prot Summary for PLA2G1B Gene

  • Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:1420353, PubMed:10681567, PubMed:17603006). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:1420353, PubMed:10681567, PubMed:17603006). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (PubMed:7721806, PubMed:25335547). Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (PubMed:25335547). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).

Tocris Summary for PLA2G1B Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G1B Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G1B Gene

Genomics for PLA2G1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLA2G1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J120327 Promoter/Enhancer 1 EPDnew ENCODE dbSUPER 250.7 -0.2 -157 1.5 SMAD4 TAL1 ZNF384 ZNF768 GATA2 CBFA2T3 HSALNG0094515 RF00017-1186 PLA2G1B MSI1
GH12J120301 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.8 +25.2 25217 1.8 BCLAF1 SP1 ZNF654 ZNF207 NCOR1 IKZF1 ZNF600 SIX5 JUND ZNF580 SIRT4 FJ601666-020 HSALNG0094509 lnc-SIRT4-2 GCN1 PXN PLA2G1B RPL29P24 MSI1 RPS27P25
GH12J120223 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 +96.3 96273 15.9 BCLAF1 MYC NCOR1 ZNF654 IKZF1 ZNF600 SSRP1 JUND ZNF592 ZMYM3 PXN SIRT4 RPLP0 RNU4-1 RNU4-2 PXN-AS1 PLA2G1B GCN1 RAB35 MSI1
GH12J120244 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 +76.1 76062 14.1 IKZF1 ZNF600 JUND ZNF10 ZIC2 BCL11A CTCF CEBPB BHLHE40 KLF7 PXN piR-38580-070 SIRT4 RNU4-1 RNU4-2 RNU6-1088P PLA2G1B BICDL1 RNF10 RAB35
GH12J120580 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 9.8 -253.8 -253822 3.2 SP1 ZNF207 MYC ZNF600 JUND ZNF580 ATF2 POLR2A YY1 MXD4 POP5 lnc-COQ5-2 COQ5 GATC HNF1A-AS1 MLEC UNC119B C12orf43 ACADS ENSG00000256569
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G1B

Top Transcription factor binding sites by QIAGEN in the PLA2G1B gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • NF-kappaB
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2
  • RelA

Genomic Locations for PLA2G1B Gene

Latest Assembly
chr12:120,322,115-120,327,779
(GRCh38/hg38)
Size:
5,665 bases
Orientation:
Minus strand

Previous Assembly
chr12:120,759,918-120,765,582
(GRCh37/hg19 by Entrez Gene)
Size:
5,665 bases
Orientation:
Minus strand

chr12:120,759,914-120,765,592
(GRCh37/hg19 by Ensembl)
Size:
5,679 bases
Orientation:
Minus strand

Genomic View for PLA2G1B Gene

Genes around PLA2G1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G1B Gene

Proteins for PLA2G1B Gene

  • Protein details for PLA2G1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04054-PA21B_HUMAN
    Recommended name:
    Phospholipase A2
    Protein Accession:
    P04054
    Secondary Accessions:
    • B2R4H5
    • Q3KPI1

    Protein attributes for PLA2G1B Gene

    Size:
    148 amino acids
    Molecular mass:
    16360 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • The inactive pro-form is a homotrimer (PubMed:19297324). When anchored into the cell membrane, the inactive homotrimer is likely cleaved either by trypsin or by itself, producing an active trimer. The resulting conformational changes are thought to open up a center hole forming a channel for substrate entry (PubMed:19297324). Interacts with PLA2R1; this interaction mediates intracellular signaling as well as clearance of extracellular PLA2G1B via endocytotic pathway (PubMed:7721806).

    Three dimensional structures from OCA and Proteopedia for PLA2G1B Gene

neXtProt entry for PLA2G1B Gene

Selected DME Specific Peptides for PLA2G1B Gene

P04054:
  • QTHDNCY
  • GGSGTPVD
  • AFICNCDR
  • YGCYCGLGG
  • HKNLDTKKYC

Post-translational modifications for PLA2G1B Gene

  • Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.

Other Protein References for PLA2G1B Gene

Protein products for research

  • Abcam proteins for PLA2G1B

Domains & Families for PLA2G1B Gene

Gene Families for PLA2G1B Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PLA2G1B Gene

Suggested Antigen Peptide Sequences for PLA2G1B Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidylcholine 2-acylhydrolase 1B (PA21B_HUMAN)
  • Mutant synovial phospholipase A2 (Q96RW8_HUMAN)
  • Mutant synovial phospholipase A2 (Q96RW9_HUMAN)
  • Mutant synovial phospholipase A2 (Q9C011_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04054

UniProtKB/Swiss-Prot:

PA21B_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G1B: view

Function for PLA2G1B Gene

Molecular function for PLA2G1B Gene

UniProtKB/Swiss-Prot Function:
Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:1420353, PubMed:10681567, PubMed:17603006). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:1420353, PubMed:10681567, PubMed:17603006). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (PubMed:7721806, PubMed:25335547). Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (PubMed:25335547). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000255|PROSITE-ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036, ECO:0000269|PubMed:10681567, ECO:0000269|PubMed:17603006};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate; Xref=Rhea:RHEA:54456, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:45240, ChEBI:CHEBI:64489; Evidence={ECO:0000269|PubMed:17603006};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence={ECO:0000250|UniProtKB:P04055};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence={ECO:0000269|PubMed:10681567};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence={ECO:0000250|UniProtKB:P04055};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+); Xref=Rhea:RHEA:40919, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72841, ChEBI:CHEBI:75158; Evidence={ECO:0000269|PubMed:1420353};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45424, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:78097, ChEBI:CHEBI:85217; Evidence={ECO:0000250|UniProtKB:P04055};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence={ECO:0000250|UniProtKB:P04055};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:56424, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:85334, ChEBI:CHEBI:85335; Evidence={ECO:0000250|UniProtKB:P04055};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by bile acid salts. Up-regulated by cholate and down-regulated by taurochenodeoxycholate. Cholate-activated rate of hydrolysis is lowered by hypolipidemic drug ezetimibe.
GENATLAS Biochemistry:
phospholipase A2,Ca2+ dependent,group 1B,pancreatic,secreted,cleaved by caspase 1 and caspase 8,for proteolysis and inactivation during apoptosis,inducing cell proliferation,smooth muscle contraction and lipid mediator release

Enzyme Numbers (IUBMB) for PLA2G1B Gene

Phenotypes From GWAS Catalog for PLA2G1B Gene

Gene Ontology (GO) - Molecular Function for PLA2G1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IEA,IDA 1918029
GO:0005102 signaling receptor binding IEA,IPI 7721806
GO:0005509 calcium ion binding IEA,IDA 7060561
GO:0005515 protein binding IPI --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLA2G1B: view
genes like me logo Genes that share phenotypes with PLA2G1B: view

Animal Models for PLA2G1B Gene

MGI Knock Outs for PLA2G1B:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G1B

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLA2G1B Gene

Localization for PLA2G1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G1B Gene

Secreted. Note=Secreted from pancreatic acinar cells in its inactive form.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G1B gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for PLA2G1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 7060561
GO:0009986 cell surface IEA,IDA 1918029
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with PLA2G1B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G1B Gene

Pathways & Interactions for PLA2G1B Gene

genes like me logo Genes that share pathways with PLA2G1B: view

Pathways by source for PLA2G1B Gene

2 GeneGo (Thomson Reuters) pathways for PLA2G1B Gene
  • Anandamide biosynthesis and metabolism
  • Immune response CD16 signaling in NK cells
12 Qiagen pathways for PLA2G1B Gene
  • Antioxidant Action of Vitamin-C
  • Beta-Adrenergic Signaling
  • cAMP Pathway
  • Chemokine Signaling
  • DHA Signaling
2 Cell Signaling Technology pathways for PLA2G1B Gene

SIGNOR curated interactions for PLA2G1B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLA2G1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity ISS 15528384
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0002446 neutrophil mediated immunity ISS 16005851
GO:0006629 lipid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IBA,IDA 1918029
genes like me logo Genes that share ontologies with PLA2G1B: view

Drugs & Compounds for PLA2G1B Gene

(43) Drugs for PLA2G1B Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Target 0
Azelastine Approved Pharma Target, inhibitor 47
Sulfasalazine Approved Pharma Target, antagonist NF-κB activation inhibitor 89
linoleic acid Approved, Experimental Pharma 0
Palmitic Acid Approved Pharma 27

(82) Additional Compounds for PLA2G1B Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
506-30-9
Beta-Cortolone
  • 1-Palmityl-2-palmitoleoyl-sn-glycero-3-phosphocholine
  • Gpcho(16:0/16:1)
  • Gpcho(16:0/16:1n7)
  • Gpcho(16:0/16:1W7)
  • Gpcho(32:1)
CE(22:0)
  • 1-Tetradecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
  • GPCho(14:0/18:0)
  • Phosphatidylcholine(14:0/18:0)
  • 1-Myristoyl-2-stearoylphosphatidylcholine
  • 1m-2S-PC
61510-09-6
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
3546-17-6

(5) Tocris Compounds for PLA2G1B Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G1B: view

Transcripts for PLA2G1B Gene

mRNA/cDNA for PLA2G1B Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G1B

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for PLA2G1B Gene

GeneLoc Exon Structure for
PLA2G1B

Expression for PLA2G1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G1B Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for PLA2G1B Gene

This gene is overexpressed in Pancreatic juice (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G1B Gene



Protein tissue co-expression partners for PLA2G1B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G1B

SOURCE GeneReport for Unigene cluster for PLA2G1B Gene:

Hs.992

mRNA Expression by UniProt/SwissProt for PLA2G1B Gene:

P04054-PA21B_HUMAN
Tissue specificity: Selectively expressed in pancreas, lung, liver and kidney. Also detected at lower levels in ovary and testis.

Evidence on tissue expression from TISSUES for PLA2G1B Gene

  • Pancreas(4.9)
  • Lung(4.5)
  • Heart(2.7)
  • Muscle(2.7)
  • Blood(2.6)
  • Intestine(2.5)
  • Nervous system(2.4)
  • Kidney(2.3)
  • Skin(2.1)
  • Liver(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with PLA2G1B: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G1B Gene

Orthologs for PLA2G1B Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLA2G1B 29 30
  • 98.87 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PLA2G1B 29 30
  • 84.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pla2g1b 29
  • 81.25 (n)
Mouse
(Mus musculus)
Mammalia Pla2g1b 29 16 30
  • 80.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PLA2G1B 29 30
  • 78.79 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PLA2G1B 30
  • 65 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G1B 30
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PLA2G1B 29 30
  • 68.21 (n)
OneToMany
-- 30
  • 63 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia PLA2G1B 30
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pla2g1b 29
  • 65.36 (n)
Str.9482 29
Zebrafish
(Danio rerio)
Actinopterygii pla2g1b 29 30
  • 60.93 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9086 29
Worm
(Caenorhabditis elegans)
Secernentea C07E3.9 30
  • 32 (a)
OneToMany
Species where no ortholog for PLA2G1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PLA2G1B Gene

ENSEMBL:
Gene Tree for PLA2G1B (if available)
TreeFam:
Gene Tree for PLA2G1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLA2G1B: view image
Alliance of Genome Resources:
Additional Orthologs for PLA2G1B

Paralogs for PLA2G1B Gene

(8) SIMAP similar genes for PLA2G1B Gene using alignment to 3 proteins:

  • PA21B_HUMAN
  • F8W062_HUMAN
  • Q9BS22_HUMAN
genes like me logo Genes that share paralogs with PLA2G1B: view

Variants for PLA2G1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G1B Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs151139112 Benign: not provided 120,322,275(-) C/T
NM_000928.3(PLA2G1B):c.365G>A (p.Arg122His)
MISSENSE
rs189619430 Likely Benign: not provided 120,325,071(-) G/A
NM_000928.3(PLA2G1B):c.195-10C>T
INTRON
rs5632 -- p.Asp16Ala
rs5635 -- p.Asn89Thr
rs5636 -- p.Asn89Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLA2G1B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLA2G1B Gene

Variant ID Type Subtype PubMed ID
nsv560435 CNV loss 21841781

Variation tolerance for PLA2G1B Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G1B
Leiden Open Variation Database (LOVD)
PLA2G1B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G1B Gene

Disorders for PLA2G1B Gene

MalaCards: The human disease database

(17) MalaCards diseases for PLA2G1B Gene - From: COP and GCD

Disorder Aliases PubMed IDs
membranous nephropathy
  • membranous nephropathy, susceptibility to
blepharitis
acinar cell carcinoma
  • acinic cell carcinoma
acute pancreatitis
  • acute necrotizing pancreatitis
myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency
  • cms9
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLA2G1B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PLA2G1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G1B Gene

Publications for PLA2G1B Gene

  1. The study of cytosolic phospholipase A2 gene polymorphism in schizophrenia using eye movement disturbances as an endophenotypic marker. (PMID: 12759552) Rybakowski JK … Hauser J (Neuropsychobiology 2003) 3 22 40
  2. sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor. (PMID: 25335547) Pan Y … Ding G (Scientific reports 2014) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  4. Structural insight into the activation mechanism of human pancreatic prophospholipase A2. (PMID: 19297324) Xu W … Liu J (The Journal of biological chemistry 2009) 3 4
  5. The effects of beta2 adrenergic receptor gene polymorphism in lipid profiles. (PMID: 18492292) Kao WT … Lung FW (Lipids in health and disease 2008) 3 40

Products for PLA2G1B Gene

Sources for PLA2G1B Gene