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Aliases for PLA2G1B Gene

Aliases for PLA2G1B Gene

  • Phospholipase A2 Group IB 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 1B 3 4
  • Phospholipase A2, Group IB (Pancreas) 2 3
  • PLA2A 3 4
  • PPLA2 3 4
  • PLA2 3 4
  • Group IB Phospholipase A2 4
  • Phospholipase A2 3
  • EC 4

External Ids for PLA2G1B Gene

Previous HGNC Symbols for PLA2G1B Gene

  • PLA2
  • PPLA2
  • PLA2A

Previous GeneCards Identifiers for PLA2G1B Gene

  • GC12M119633
  • GC12M120286
  • GC12M120542
  • GC12M119171
  • GC12M119222
  • GC12M119244
  • GC12M120759
  • GC12M117768

Summaries for PLA2G1B Gene

Entrez Gene Summary for PLA2G1B Gene

  • This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

GeneCards Summary for PLA2G1B Gene

PLA2G1B (Phospholipase A2 Group IB) is a Protein Coding gene. Diseases associated with PLA2G1B include Distal Hereditary Motor Neuropathy, Type Ii and Neurodegeneration With Brain Iron Accumulation 2B. Among its related pathways are Immune response Fc epsilon RI pathway and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2A.

UniProtKB/Swiss-Prot for PLA2G1B Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.

Tocris Summary for PLA2G1B Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G1B Gene

Additional gene information for PLA2G1B Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G1B Gene

Genomics for PLA2G1B Gene

GeneHancer (GH) Regulatory Elements for PLA2G1B Gene

Promoters and enhancers for PLA2G1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J120327 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 650.7 -0.1 -147 1.5 ZNF768 FOXA2 TAL1 ZFP36 CBFA2T3 SMAD4 PLA2G1B MSI1
GH12J120301 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.8 +25.2 25227 1.8 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SIRT4 GCN1 PXN PLA2G1B RPLP0 RPL29P24 MSI1 RPS27P25 RAB35 RNU4-1
GH12J120239 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 +78.3 78259 19.3 PKNOX1 SMAD1 FOXA2 ARNT ZNF2 ZNF766 E2F8 FOS REST ZNF592 PXN SIRT4 RNU4-1 RNU4-2 RNU6-1088P PLA2G1B P2RX4 BICDL1 RNF10 RAB35
GH12J120580 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.8 -253.6 -253604 1.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 E2F8 POP5 COQ5 GATC HNF1A-AS1 MLEC UNC119B C12orf43 ACADS ENSG00000256569 OASL
GH12J120223 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +96.2 96204 16 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 PXN-AS1 PXN SIRT4 RAB35 RPLP0 RNU4-2 RNU4-1 RPL31P52 PLA2G1B GCN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLA2G1B gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • PPAR-gamma2
  • PPAR-gamma1
  • NF-kappaB
  • NF-kappaB1
  • RelA

Genomic Locations for PLA2G1B Gene

Genomic Locations for PLA2G1B Gene
5,679 bases
Minus strand
5,679 bases
Minus strand

Genomic View for PLA2G1B Gene

Genes around PLA2G1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G1B Gene

Proteins for PLA2G1B Gene

  • Protein details for PLA2G1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholipase A2
    Protein Accession:
    Secondary Accessions:
    • B2R4H5
    • Q3KPI1

    Protein attributes for PLA2G1B Gene

    148 amino acids
    Molecular mass:
    16360 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Monomer or homodimer (By similarity). The inactive pro-form is a homotrimer.

    Three dimensional structures from OCA and Proteopedia for PLA2G1B Gene

neXtProt entry for PLA2G1B Gene

Post-translational modifications for PLA2G1B Gene

  • Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.

Other Protein References for PLA2G1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G1B Gene

Domains & Families for PLA2G1B Gene

Gene Families for PLA2G1B Gene

Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PLA2G1B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phospholipase A2 family.
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G1B: view

Function for PLA2G1B Gene

Molecular function for PLA2G1B Gene

UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
GENATLAS Biochemistry:
phospholipase A2,Ca2+ dependent,group 1B,pancreatic,secreted,cleaved by caspase 1 and caspase 8,for proteolysis and inactivation during apoptosis,inducing cell proliferation,smooth muscle contraction and lipid mediator release

Enzyme Numbers (IUBMB) for PLA2G1B Gene

Gene Ontology (GO) - Molecular Function for PLA2G1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity TAS,IEA --
GO:0005102 signaling receptor binding IEA,IPI 7721806
GO:0005509 calcium ion binding IEA,IDA 7060561
GO:0016787 hydrolase activity IEA --
GO:0032052 bile acid binding ISS 7060561
genes like me logo Genes that share ontologies with PLA2G1B: view
genes like me logo Genes that share phenotypes with PLA2G1B: view

Animal Models for PLA2G1B Gene

MGI Knock Outs for PLA2G1B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G1B

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLA2G1B Gene

Localization for PLA2G1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G1B Gene

Secreted. Note=secreted from pancreatic acinar cells in its inactive form.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G1B gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
lysosome 2
peroxisome 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLA2G1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 7060561
GO:0005829 cytosol IDA --
GO:0009986 cell surface IEA,IDA 1918029
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with PLA2G1B: view

Pathways & Interactions for PLA2G1B Gene

genes like me logo Genes that share pathways with PLA2G1B: view

SIGNOR curated interactions for PLA2G1B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLA2G1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity ISS 15528384
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0002446 neutrophil mediated immunity ISS 16005851
GO:0006629 lipid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IDA 1918029
genes like me logo Genes that share ontologies with PLA2G1B: view

Drugs & Compounds for PLA2G1B Gene

(41) Drugs for PLA2G1B Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niflumic Acid Approved Pharma Channel blocker, Activator, Positive, inhibitor, Target Ca2+-activated Cl- channel blocker, Cyclooxygenase-2 (COX-2) inhibitor; GPR35 agonist 0
cholic acid Approved Pharma Full agonist, Agonist, Target 0
calcium Approved Nutra 0
cannabidiol Approved, Investigational Pharma Partial agonist, Agonist, Antagonist, Channel blocker, Activator, Enzyme 0
Nabiximols Approved, Investigational Pharma Enzyme 0

(77) Additional Compounds for PLA2G1B Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
  • Eicosanoic acid
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
  • 1-C14:0-Lysophosphatidylcholine betaine
  • 1-Myristoyl-glycero-3-phosphocholine
  • 1-Myristoyl-sn-glycero-3-phosphocholine betaine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine betaine
  • 1-(9Z-Tetradecenoyl)-sn-glycero-3-phosphocholine
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC 14:1(9Z)/0:0
  • LPC(14:1(9Z)/0:0)
  • LysoPC 14:1(9Z)/0:0

(5) Tocris Compounds for PLA2G1B Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G1B: view

Transcripts for PLA2G1B Gene

mRNA/cDNA for PLA2G1B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(74) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLA2G1B Gene

Phospholipase A2, group IB (pancreas):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G1B

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP2: -

Relevant External Links for PLA2G1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLA2G1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2G1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G1B Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for PLA2G1B Gene

This gene is overexpressed in Pancreatic juice (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G1B Gene

Protein tissue co-expression partners for PLA2G1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLA2G1B Gene:


SOURCE GeneReport for Unigene cluster for PLA2G1B Gene:


Evidence on tissue expression from TISSUES for PLA2G1B Gene

  • Pancreas(4.9)
  • Lung(4.5)
  • Blood(2.6)
  • Heart(2.4)
  • Muscle(2.4)
  • Intestine(2.2)
  • Kidney(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with PLA2G1B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G1B Gene

Orthologs for PLA2G1B Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLA2G1B 34 33
  • 98.87 (n)
(Canis familiaris)
Mammalia PLA2G1B 34 33
  • 84.47 (n)
(Rattus norvegicus)
Mammalia Pla2g1b 33
  • 81.25 (n)
(Mus musculus)
Mammalia Pla2g1b 16 34 33
  • 80.21 (n)
(Bos Taurus)
Mammalia PLA2G1B 34 33
  • 78.79 (n)
(Monodelphis domestica)
Mammalia PLA2G1B 34
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia PLA2G1B 34
  • 49 (a)
(Gallus gallus)
Aves PLA2G1B 34 33
  • 68.21 (n)
-- 34
  • 63 (a)
(Anolis carolinensis)
Reptilia PLA2G1B 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g1b 33
  • 65.36 (n)
Str.9482 33
(Danio rerio)
Actinopterygii pla2g1b 34 33
  • 60.93 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9086 33
(Caenorhabditis elegans)
Secernentea C07E3.9 34
  • 32 (a)
Species where no ortholog for PLA2G1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2G1B Gene

Gene Tree for PLA2G1B (if available)
Gene Tree for PLA2G1B (if available)
Evolutionary constrained regions (ECRs) for PLA2G1B: view image

Paralogs for PLA2G1B Gene

(8) SIMAP similar genes for PLA2G1B Gene using alignment to 3 proteins:

  • F8W062_HUMAN
  • Q9BS22_HUMAN
genes like me logo Genes that share paralogs with PLA2G1B: view

Variants for PLA2G1B Gene

Sequence variations from dbSNP and Humsavar for PLA2G1B Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000190054 -- 120,329,238(-) C/G upstream_transcript_variant
rs1000675828 -- 120,321,759(-) C/G/T downstream_transcript_variant
rs1000808358 -- 120,328,989(-) /A upstream_transcript_variant
rs1000831627 -- 120,327,928(-) T/A upstream_transcript_variant
rs1000963775 -- 120,327,411(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G1B Gene

Variant ID Type Subtype PubMed ID
nsv560435 CNV loss 21841781

Variation tolerance for PLA2G1B Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G1B Gene

Disorders for PLA2G1B Gene

MalaCards: The human disease database

(3) MalaCards diseases for PLA2G1B Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLA2G1B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PLA2G1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G1B Gene

Publications for PLA2G1B Gene

  1. The study of cytosolic phospholipase A2 gene polymorphism in schizophrenia using eye movement disturbances as an endophenotypic marker. (PMID: 12759552) Rybakowski JK … Hauser J (Neuropsychobiology 2003) 3 22 44 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Structural insight into the activation mechanism of human pancreatic prophospholipase A2. (PMID: 19297324) Xu W … Liu J (The Journal of biological chemistry 2009) 3 4 58
  4. The effects of beta2 adrenergic receptor gene polymorphism in lipid profiles. (PMID: 18492292) Kao WT … Lung FW (Lipids in health and disease 2008) 3 44 58
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 58

Products for PLA2G1B Gene

Sources for PLA2G1B Gene

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