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Aliases for PLA2G15 Gene

Aliases for PLA2G15 Gene

  • Phospholipase A2 Group XV 2 3 5
  • Lysophospholipase 3 (Lysosomal Phospholipase A2) 2 3
  • LCAT-Like Lysophospholipase 3 4
  • Lysosomal Phospholipase A2 3 4
  • 1-O-Acylceramide Synthase 3 4
  • LYPLA3 3 4
  • LPLA2 3 4
  • LLPL 3 4
  • ACS 3 4
  • Phospholipase A2, Group XV 2
  • Group XV Phospholipase A2 3
  • Lysophospholipase 3 4
  • EC 2.3.1.43 56
  • EC 2.3.1.- 4
  • GXVPLA2 3

External Ids for PLA2G15 Gene

Previous HGNC Symbols for PLA2G15 Gene

  • LYPLA3

Previous GeneCards Identifiers for PLA2G15 Gene

  • GC16P066837
  • GC16P054152

Summaries for PLA2G15 Gene

Entrez Gene Summary for PLA2G15 Gene

  • Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLA2G15 Gene

PLA2G15 (Phospholipase A2 Group XV) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis and Lysosome. Gene Ontology (GO) annotations related to this gene include phospholipid binding and O-acyltransferase activity. An important paralog of this gene is LCAT.

UniProtKB/Swiss-Prot for PLA2G15 Gene

  • Has transacylase and calcium-independent phospholipase A2 activity (PubMed:20410020, PubMed:23958596). Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (PubMed:11790796, PubMed:25727495). Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). May have weak lysophospholipase activity (PubMed:10092508).

Gene Wiki entry for PLA2G15 Gene

Additional gene information for PLA2G15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G15 Gene

Genomics for PLA2G15 Gene

GeneHancer (GH) Regulatory Elements for PLA2G15 Gene

Promoters and enhancers for PLA2G15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I068244 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.6 638 3.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B YY1 E2F8 ZNF143 FOS PLA2G15 PRMT7 ENSG00000260441
GH16I068201 Enhancer 0.8 ENCODE dbSUPER 11.4 -43.3 -43349 1.4 SCRT1 CTCF ZBTB11 FEZF1 ZNF623 ZNF781 ZNF697 ZNF121 SCRT2 ENSG00000279621 ZFP90 ESRP2 PLA2G15 SLC7A6 PRMT7 SLC7A6OS RPS12P27 NFATC3
GH16I068200 Enhancer 0.7 dbSUPER 11.4 -44.6 -44574 0.6 PKNOX1 FOXA2 MZF1 EBF1 ZBTB40 FOSL1 ATF7 FOSL2 FOS IKZF2 ENSG00000262514 ENSG00000279621 ESRP2 PLA2G15 SLC7A6 PRMT7 SLC7A6OS NFATC3
GH16I068061 Enhancer 1.3 Ensembl ENCODE dbSUPER 5.6 -181.4 -181385 5.3 PKNOX1 ARNT ZNF143 FOS ATF7 REST KAT8 SSRP1 SMARCA4 CTCF PRMT7 EDC4 E2F4 ENSG00000263276 CTCF FBXL8 NFATC3 ENSG00000270165 THAP11 DDX28
GH16I068210 Enhancer 0.6 ENCODE dbSUPER 12 -34.0 -33995 1.7 JUNB ETV6 PRDM4 GC16P068209 RPS12P27 PRMT7 DUS2 ESRP2 PLA2G15 SLC7A6 NFATC3 SLC7A6OS EDC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLA2G15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLA2G15 gene promoter:

Genomic Locations for PLA2G15 Gene

Genomic Locations for PLA2G15 Gene
chr16:68,245,304-68,261,062
(GRCh38/hg38)
Size:
15,759 bases
Orientation:
Plus strand
chr16:68,279,207-68,294,961
(GRCh37/hg19)

Genomic View for PLA2G15 Gene

Genes around PLA2G15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G15 Gene

Proteins for PLA2G15 Gene

  • Protein details for PLA2G15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCC3-PAG15_HUMAN
    Recommended name:
    Group XV phospholipase A2
    Protein Accession:
    Q8NCC3
    Secondary Accessions:
    • B3KMF3
    • B4DUD1
    • Q53GZ1
    • Q9NPQ6
    • Q9UG04
    • Q9Y2B3

    Protein attributes for PLA2G15 Gene

    Size:
    412 amino acids
    Molecular mass:
    46658 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB53675.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLA2G15 Gene

    Alternative splice isoforms for PLA2G15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G15 Gene

Selected DME Specific Peptides for PLA2G15 Gene

Q8NCC3:
  • LEAKLDKP
  • SLGAPWGG

Post-translational modifications for PLA2G15 Gene

  • N-glycosylated (PubMed:11790796, PubMed:23958596). N-glycosylation is important for maturation of the enzyme and normal subcellular location (PubMed:23958596).
  • Glycosylation at isoforms=99, Asn273, isoforms=2289, and isoforms=2398

Domains & Families for PLA2G15 Gene

Gene Families for PLA2G15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for PLA2G15 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCC3

UniProtKB/Swiss-Prot:

PAG15_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PLA2G15: view

Function for PLA2G15 Gene

Molecular function for PLA2G15 Gene

UniProtKB/Swiss-Prot Function:
Has transacylase and calcium-independent phospholipase A2 activity (PubMed:20410020, PubMed:23958596). Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (PubMed:11790796, PubMed:25727495). Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). May have weak lysophospholipase activity (PubMed:10092508).

Enzyme Numbers (IUBMB) for PLA2G15 Gene

Phenotypes From GWAS Catalog for PLA2G15 Gene

Gene Ontology (GO) - Molecular Function for PLA2G15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity TAS 10092508
GO:0005543 phospholipid binding TAS 10092508
GO:0008374 O-acyltransferase activity IEA,ISS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with PLA2G15: view
genes like me logo Genes that share phenotypes with PLA2G15: view

Animal Models for PLA2G15 Gene

MGI Knock Outs for PLA2G15:

miRNA for PLA2G15 Gene

miRTarBase miRNAs that target PLA2G15

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G15 Gene

Localization for PLA2G15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G15 Gene

Lysosome. Secreted. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G15 gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 5
mitochondrion 2
endoplasmic reticulum 2
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLA2G15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IDA 20410020
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005764 lysosome NAS 11790796
genes like me logo Genes that share ontologies with PLA2G15: view

Pathways & Interactions for PLA2G15 Gene

genes like me logo Genes that share pathways with PLA2G15: view

Pathways by source for PLA2G15 Gene

2 KEGG pathways for PLA2G15 Gene

Gene Ontology (GO) - Biological Process for PLA2G15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0006650 glycerophospholipid metabolic process IDA,IEA 20410020
GO:0006672 ceramide metabolic process ISS,IEA --
genes like me logo Genes that share ontologies with PLA2G15: view

No data available for SIGNOR curated interactions for PLA2G15 Gene

Drugs & Compounds for PLA2G15 Gene

(5) Drugs for PLA2G15 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
calcium Approved Nutra 0
Choline alfoscerate Experimental, Investigational Pharma 0

(36) Additional Compounds for PLA2G15 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-Glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
LysoPC(16:0)
  • 1-Palmitoyl-glycero-3-phosphocholine
  • 1-Palmitoyl-lysophosphatidylcholine
  • LPC(16:0)
  • LPC(16:0/0:0)
  • LyPC(16:0)
genes like me logo Genes that share compounds with PLA2G15: view

Transcripts for PLA2G15 Gene

Unigene Clusters for PLA2G15 Gene

Phospholipase A2, group XV:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G15 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8:
SP9: -
SP10: - -
SP11:

Relevant External Links for PLA2G15 Gene

GeneLoc Exon Structure for
PLA2G15
ECgene alternative splicing isoforms for
PLA2G15

Expression for PLA2G15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2G15 Gene

mRNA differential expression in normal tissues according to GTEx for PLA2G15 Gene

This gene is overexpressed in Muscle - Skeletal (x4.8).

Protein differential expression in normal tissues from HIPED for PLA2G15 Gene

This gene is overexpressed in Liver (48.6) and Amniocyte (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLA2G15 Gene



NURSA nuclear receptor signaling pathways regulating expression of PLA2G15 Gene:

PLA2G15

SOURCE GeneReport for Unigene cluster for PLA2G15 Gene:

Hs.632199

mRNA Expression by UniProt/SwissProt for PLA2G15 Gene:

Q8NCC3-PAG15_HUMAN
Tissue specificity: Detected in blood plasma (at protein level) (PubMed:10092508, PubMed:20410020). Ubiquitous. Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes (PubMed:10092508).

Evidence on tissue expression from TISSUES for PLA2G15 Gene

  • Nervous system(4.8)
  • Kidney(4.5)
  • Heart(4.2)
  • Intestine(4.2)
  • Liver(4.2)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with PLA2G15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G15 Gene

Orthologs for PLA2G15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLA2G15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G15 33 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia PLA2G15 33 34
  • 89.83 (n)
rat
(Rattus norvegicus)
Mammalia Pla2g15 33
  • 87.65 (n)
mouse
(Mus musculus)
Mammalia Pla2g15 33 16 34
  • 86.84 (n)
cow
(Bos Taurus)
Mammalia PLA2G15 33 34
  • 85.63 (n)
oppossum
(Monodelphis domestica)
Mammalia PLA2G15 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G15 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G15 33 34
  • 72.15 (n)
lizard
(Anolis carolinensis)
Reptilia PLA2G15 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g15 33
  • 68.89 (n)
zebrafish
(Danio rerio)
Actinopterygii pla2g15 33 34
  • 66.93 (n)
wufa11g04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9525 33
fruit fly
(Drosophila melanogaster)
Insecta CG31683 33 34
  • 50.13 (n)
CG18858 34
  • 36 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008990 33
  • 49.77 (n)
worm
(Caenorhabditis elegans)
Secernentea M05B5.4 33 34
  • 47.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G27480 33
  • 46.08 (n)
rice
(Oryza sativa)
Liliopsida Os03g0730000 33
  • 48.25 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9541 34
  • 37 (a)
OneToMany
Species where no ortholog for PLA2G15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2G15 Gene

ENSEMBL:
Gene Tree for PLA2G15 (if available)
TreeFam:
Gene Tree for PLA2G15 (if available)

Paralogs for PLA2G15 Gene

Paralogs for PLA2G15 Gene

genes like me logo Genes that share paralogs with PLA2G15: view

Variants for PLA2G15 Gene

Sequence variations from dbSNP and Humsavar for PLA2G15 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000104782 -- 68,257,125(+) G/A intron_variant
rs1000196353 -- 68,256,895(+) G/T intron_variant
rs1000289923 -- 68,256,361(+) A/G intron_variant
rs1000556318 -- 68,261,290(+) G/A downstream_transcript_variant
rs1000662083 -- 68,254,522(+) T/C intron_variant

Variation tolerance for PLA2G15 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLA2G15 Gene

Disorders for PLA2G15 Gene

Additional Disease Information for PLA2G15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLA2G15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G15 Gene

Publications for PLA2G15 Gene

  1. Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase. (PMID: 10092508) Taniyama Y … Fujino M (Biochemical and biophysical research communications 1999) 2 3 4 22 58
  2. Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase. (PMID: 11790796) Hiraoka M … Shayman JA (The Journal of biological chemistry 2002) 3 4 22 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. The measurement of lysosomal phospholipase A2 activity in plasma. (PMID: 20410020) Abe A … Shayman JA (Journal of lipid research 2010) 3 4 58

Products for PLA2G15 Gene

Sources for PLA2G15 Gene

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