Aliases for PLA2G15 Gene
External Ids for PLA2G15 Gene
Previous HGNC Symbols for PLA2G15 Gene
Previous GeneCards Identifiers for PLA2G15 Gene
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
GeneCards Summary for PLA2G15 Gene
PLA2G15 (Phospholipase A2 Group XV) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis and Lysosome. Gene Ontology (GO) annotations related to this gene include phospholipid binding and O-acyltransferase activity. An important paralog of this gene is LCAT.
UniProtKB/Swiss-Prot for PLA2G15 Gene
Has transacylase and calcium-independent phospholipase A2 activity (PubMed:20410020, PubMed:23958596). Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (PubMed:11790796, PubMed:25727495). Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). May have weak lysophospholipase activity (PubMed:10092508).