The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it function... See more...

Aliases for PLA2G12B Gene

Aliases for PLA2G12B Gene

  • Phospholipase A2 Group XIIB 2 3 5
  • Group XIIB Secretory Phospholipase A2-Like Protein 3 4
  • Phospholipase A2, Group XIII 2 3
  • SPLA2-GXIIB 3 4
  • PLA2G13 3 4
  • GXIIB 3 4
  • Group XIII Secretory Phospholipase A2-Like Protein 4
  • Group XIII Secreted Phospholipase A2 3
  • Phospholipase A2, Group XIIB 2
  • GXIII SPLA2-Like 4
  • GXIIIsPLA2 3
  • PLA2G12B 5
  • FKSG71 3

External Ids for PLA2G12B Gene

Previous HGNC Symbols for PLA2G12B Gene

  • PLA2G13

Previous GeneCards Identifiers for PLA2G12B Gene

  • GC10M074039
  • GC10M074364
  • GC10M074694
  • GC10M068688

Summaries for PLA2G12B Gene

Entrez Gene Summary for PLA2G12B Gene

  • The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for PLA2G12B Gene

PLA2G12B (Phospholipase A2 Group XIIB) is a Protein Coding gene. Diseases associated with PLA2G12B include Hepatitis C Virus and Tricuspid Atresia. Among its related pathways are Ras signaling pathway and Salivary secretion. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G12A.

UniProtKB/Swiss-Prot Summary for PLA2G12B Gene

Tocris Summary for PLA2G12B Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G12B Gene

Genomics for PLA2G12B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLA2G12B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J072951 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 250.7 +1.1 1122 4.2 ATF2 ATF3 NFIC YY1 FOXA2 KDM6A RXRA SAP130 DMAP1 TEAD3 PLA2G12B CFAP70 NUDT13 OIT3 ECD DNAJB12 DNAJC9-AS1 HSALNG0078807
GH10J073094 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.1 -140.8 -140797 4.5 BCLAF1 SP1 ZNF207 ZNF654 NCOR1 MYC IKZF1 ZNF592 POLR2A ZNF10 HSALNG0078818 P4HA1 DUSP8P5 GLUD1P3 ECD NUDT13 ENSG00000272140 DNAJB12 AGAP5 ZSWIM8
GH10J072934 Enhancer 0.7 Ensembl ENCODE 0.4 +19.7 19705 1.4 IKZF1 NFE2 PRDM10 PKNOX1 MEIS2 ATF3 ZNF24 RNF2 PBX2 RF00017-627 OIT3 DNAJB12 HSALNG0078807 PLA2G12B
GH10J072982 Enhancer 0.8 Ensembl 0.3 -27.1 -27057 0.2 MYC NCOR1 IKZF1 NFIC MNT ARNT TAL1 FOSL2 STAT5A SMARCA4 DNAJB12 GLUD1P3 ENSG00000272140 ECD DUSP8P5 SEC24C OIT3 NDST2 BMS1P4 ZSWIM8-AS1
GH10J072903 Enhancer 0.8 Ensembl 0.2 +50.5 50457 1.6 NCOR1 IKZF1 NFIC NONO HES1 ARNT NBN TAL1 SKIL ZNF318 NUDT13 ZSWIM8 piR-47132-001 OIT3 PLA2G12B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G12B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G12B

Top Transcription factor binding sites by QIAGEN in the PLA2G12B gene promoter:
  • ER-alpha
  • Lmo2
  • LUN-1
  • SEF-1 (1)
  • YY1

Genomic Locations for PLA2G12B Gene

Latest Assembly
chr10:72,934,762-72,955,044
(GRCh38/hg38)
Size:
20,283 bases
Orientation:
Minus strand

Previous Assembly
chr10:74,694,520-74,714,564
(GRCh37/hg19 by Entrez Gene)
Size:
20,045 bases
Orientation:
Minus strand

chr10:74,694,928-74,714,536
(GRCh37/hg19 by Ensembl)
Size:
19,609 bases
Orientation:
Minus strand

Genomic View for PLA2G12B Gene

Genes around PLA2G12B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G12B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G12B Gene

Proteins for PLA2G12B Gene

  • Protein details for PLA2G12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BX93-PG12B_HUMAN
    Recommended name:
    Group XIIB secretory phospholipase A2-like protein
    Protein Accession:
    Q9BX93
    Secondary Accessions:
    • B7ZL23
    • Q52LB2
    • Q96Q99

    Protein attributes for PLA2G12B Gene

    Size:
    195 amino acids
    Molecular mass:
    21659 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G12B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G12B Gene

Post-translational modifications for PLA2G12B Gene

No Post-translational modifications

Other Protein References for PLA2G12B Gene

No data available for DME Specific Peptides for PLA2G12B Gene

Domains & Families for PLA2G12B Gene

Gene Families for PLA2G12B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for PLA2G12B Gene

InterPro:
Blocks:
  • Group XII secretory phospholipase A2

Suggested Antigen Peptide Sequences for PLA2G12B Gene

GenScript: Design optimal peptide antigens:
  • Phospholipase A2, group XIIB, isoform CRA_c (B7ZL23_HUMAN)
  • sPLA2-GXIIB (PG12B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BX93

UniProtKB/Swiss-Prot:

PG12B_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G12B: view

Function for PLA2G12B Gene

Molecular function for PLA2G12B Gene

UniProtKB/Swiss-Prot Function:
Not known; does not seem to have catalytic activity.

Phenotypes From GWAS Catalog for PLA2G12B Gene

Gene Ontology (GO) - Molecular Function for PLA2G12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLA2G12B: view
genes like me logo Genes that share phenotypes with PLA2G12B: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G12B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLA2G12B Gene

Localization for PLA2G12B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G12B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G12B gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1
lysosome 0

Gene Ontology (GO) - Cellular Components for PLA2G12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLA2G12B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G12B Gene

Pathways & Interactions for PLA2G12B Gene

genes like me logo Genes that share pathways with PLA2G12B: view

Pathways by source for PLA2G12B Gene

1 GeneGo (Thomson Reuters) pathway for PLA2G12B Gene
  • Immune response CD16 signaling in NK cells
7 Qiagen pathways for PLA2G12B Gene
  • Antioxidant Action of Vitamin-C
  • cAMP Pathway
  • Chemokine Signaling
  • DHA Signaling
  • Fc-EpsilonRI Pathway

Gene Ontology (GO) - Biological Process for PLA2G12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0042632 cholesterol homeostasis IBA 21873635
GO:0050482 arachidonic acid secretion IEA --
GO:0070328 triglyceride homeostasis IBA 21873635
genes like me logo Genes that share ontologies with PLA2G12B: view

No data available for SIGNOR curated interactions for PLA2G12B Gene

Drugs & Compounds for PLA2G12B Gene

(8) Drugs for PLA2G12B Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
linoleic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
alpha-Linolenic acid Approved, Investigational Nutra 0
arachidonic acid Experimental Pharma 41
L-Dilinoleoyllecithin Experimental Pharma 0

(44) Additional Compounds for PLA2G12B Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CE(22:0)
  • 1-Tetradecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
  • GPCho(14:0/18:0)
  • Phosphatidylcholine(14:0/18:0)
  • 1-Myristoyl-2-stearoylphosphatidylcholine
  • 1m-2S-PC
61510-09-6
Hydroxyclomipramine
  • 1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
  • 1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-icosatetraenoyl)-sn-glycero-3-phosphoethanolamine zwitterion
  • 1-(1-Enyl-stearoyl)-2-arachidonoyl-sn-glycero-3-phosphoethanolamine
  • 1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
  • 1-Alkenyl-2-acyl-glycerophosphoethanolamine
97859-69-3
LysoPC(14:0/0:0)
  • 1-C14:0-Lysophosphatidylcholine betaine
  • 1-Myristoyl-glycero-3-phosphocholine
  • 1-Myristoyl-sn-glycero-3-phosphocholine betaine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine betaine
20559-16-4
LysoPC(14:1(9Z)/0:0)
  • 1-(9Z-Tetradecenoyl)-sn-glycero-3-phosphocholine
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC 14:1(9Z)/0:0
  • LPC(14:1(9Z)/0:0)
  • LysoPC 14:1(9Z)/0:0
LysoPC(15:0/0:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LysoPC(15:0/0:0)
  • Lysophosphatidylcholine (15:0)

(5) Tocris Compounds for PLA2G12B Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G12B: view

Transcripts for PLA2G12B Gene

mRNA/cDNA for PLA2G12B Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G12B

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G12B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:
SP2:
SP3: -

Relevant External Links for PLA2G12B Gene

GeneLoc Exon Structure for
PLA2G12B

Expression for PLA2G12B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G12B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G12B Gene

This gene is overexpressed in Liver (x33.7), Small Intestine - Terminal Ileum (x8.1), and Kidney - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for PLA2G12B Gene

This gene is overexpressed in Fetal Liver (52.0) and Fetal gut (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G12B Gene



Protein tissue co-expression partners for PLA2G12B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G12B

SOURCE GeneReport for Unigene cluster for PLA2G12B Gene:

Hs.333175

mRNA Expression by UniProt/SwissProt for PLA2G12B Gene:

Q9BX93-PG12B_HUMAN
Tissue specificity: Strong expression in liver, small intestine and kidney.

Evidence on tissue expression from TISSUES for PLA2G12B Gene

  • Liver(2.5)
genes like me logo Genes that share expression patterns with PLA2G12B: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G12B Gene

Orthologs for PLA2G12B Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G12B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLA2G12B 29 30
  • 99.83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PLA2G12B 29 30
  • 91.11 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PLA2G12B 29 30
  • 90.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pla2g12b 29
  • 87.01 (n)
Oppossum
(Monodelphis domestica)
Mammalia PLA2G12B 30
  • 87 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Pla2g12b 29 16 30
  • 86.5 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G12B 30
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PLA2G12B 29 30
  • 73.2 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PLA2G12B 30
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pla2g12b 29
  • 69.65 (n)
Str.8191 29
Zebrafish
(Danio rerio)
Actinopterygii pla2g12b 29 30
  • 69.11 (n)
OneToOne
wufb26d02 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2894 29
Fruit Fly
(Drosophila melanogaster)
Insecta GXIVsPLA2 30
  • 24 (a)
OneToMany
Species where no ortholog for PLA2G12B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PLA2G12B Gene

ENSEMBL:
Gene Tree for PLA2G12B (if available)
TreeFam:
Gene Tree for PLA2G12B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLA2G12B: view image
Alliance of Genome Resources:
Additional Orthologs for PLA2G12B

Paralogs for PLA2G12B Gene

Paralogs for PLA2G12B Gene

(1) SIMAP similar genes for PLA2G12B Gene using alignment to 2 proteins:

  • PG12B_HUMAN
  • B7ZL23_HUMAN
genes like me logo Genes that share paralogs with PLA2G12B: view

Variants for PLA2G12B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLA2G12B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLA2G12B Gene

Variant ID Type Subtype PubMed ID
esv2656992 CNV deletion 23128226
esv3623806 CNV loss 21293372
esv3623807 CNV loss 21293372
nsv528473 CNV gain 19592680

Variation tolerance for PLA2G12B Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G12B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G12B
Leiden Open Variation Database (LOVD)
PLA2G12B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G12B Gene

Disorders for PLA2G12B Gene

MalaCards: The human disease database

(2) MalaCards diseases for PLA2G12B Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitis c virus, susceptibility to
tricuspid atresia
  • congenital agenesis of the tricuspid valve
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLA2G12B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PLA2G12B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G12B Gene

Publications for PLA2G12B Gene

  1. Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients. (PMID: 19817957) Segat L … Crovella S (Journal of gastroenterology and hepatology 2009) 3 40
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4
  4. Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. (PMID: 14516201) Rouault M … Lambeau G (Biochemistry 2003) 3 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for PLA2G12B Gene

Sources for PLA2G12B Gene