Aliases for PLA2G12B Gene
External Ids for PLA2G12B Gene
Previous HGNC Symbols for PLA2G12B Gene
Previous GeneCards Identifiers for PLA2G12B Gene
The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for PLA2G12B Gene
PLA2G12B (Phospholipase A2 Group XIIB) is a Protein Coding gene. Diseases associated with PLA2G12B include Hepatitis C Virus and Tricuspid Atresia. Among its related pathways are Ras signaling pathway and Salivary secretion. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G12A.
UniProtKB/Swiss-Prot Summary for PLA2G12B Gene
Not known; does not seem to have catalytic activity.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.