Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008... See more...

Aliases for PLA2G12A Gene

Aliases for PLA2G12A Gene

  • Phospholipase A2 Group XIIA 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 12A 3 4
  • Group XIIA Secretory Phospholipase A2 3 4
  • Phospholipase A2, Group XII 2 3
  • GXII SPLA2 3 4
  • SPLA2-XII 3 4
  • PLA2G12 3 4
  • Group XIIA Secreted Phospholipase A2 3
  • Group XII Secreted Phospholipase A2 3
  • Phospholipase A2, Group XIIA 2
  • EC 3.1.1.4 4
  • PLA2G12A 5
  • ROSSY 3
  • GXII 3

External Ids for PLA2G12A Gene

Previous HGNC Symbols for PLA2G12A Gene

  • PLA2G12

Previous GeneCards Identifiers for PLA2G12A Gene

  • GC04M111093
  • GC04M110992
  • GC04M110854
  • GC04M110631
  • GC04M106364

Summaries for PLA2G12A Gene

Entrez Gene Summary for PLA2G12A Gene

  • Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PLA2G12A Gene

PLA2G12A (Phospholipase A2 Group XIIA) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity. An important paralog of this gene is PLA2G12B.

UniProtKB/Swiss-Prot Summary for PLA2G12A Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.

Tocris Summary for PLA2G12A Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G12A Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G12A Gene

Genomics for PLA2G12A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLA2G12A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G12A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G12A

Top Transcription factor binding sites by QIAGEN in the PLA2G12A gene promoter:
  • ATF-2
  • C/EBPalpha
  • Evi-1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • POU2F1
  • POU2F1a
  • USF-1
  • USF1

Genomic Locations for PLA2G12A Gene

Latest Assembly
chr4:109,709,989-109,730,070
(GRCh38/hg38)
Size:
20,082 bases
Orientation:
Minus strand

Previous Assembly
chr4:110,631,145-110,651,226
(GRCh37/hg19 by Entrez Gene)
Size:
20,082 bases
Orientation:
Minus strand

chr4:110,631,145-110,651,233
(GRCh37/hg19 by Ensembl)
Size:
20,089 bases
Orientation:
Minus strand

Genomic View for PLA2G12A Gene

Genes around PLA2G12A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G12A Gene

Proteins for PLA2G12A Gene

  • Protein details for PLA2G12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM1-PG12A_HUMAN
    Recommended name:
    Group XIIA secretory phospholipase A2
    Protein Accession:
    Q9BZM1
    Secondary Accessions:
    • Q9BZ89

    Protein attributes for PLA2G12A Gene

    Size:
    189 amino acids
    Molecular mass:
    21067 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PLA2G12A Gene

Post-translational modifications for PLA2G12A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G12A Gene

No data available for DME Specific Peptides for PLA2G12A Gene

Domains & Families for PLA2G12A Gene

Gene Families for PLA2G12A Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for PLA2G12A Gene

InterPro:
Blocks:
  • Group XII secretory phospholipase A2

Suggested Antigen Peptide Sequences for PLA2G12A Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidylcholine 2-acylhydrolase 12A (PG12A_HUMAN)
  • cDNA, FLJ93563, Homo sapiens phospholipase A2, group XII (PLA2G12), mRNA (Q542Y6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BZM1

UniProtKB/Swiss-Prot:

PG12A_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G12A: view

Function for PLA2G12A Gene

Molecular function for PLA2G12A Gene

UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000255|PROSITE-ProRule:PRU10035};.

Enzyme Numbers (IUBMB) for PLA2G12A Gene

Phenotypes From GWAS Catalog for PLA2G12A Gene

Gene Ontology (GO) - Molecular Function for PLA2G12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IEA,IBA 21873635
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 32814053
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLA2G12A: view
genes like me logo Genes that share phenotypes with PLA2G12A: view

Animal Models for research

  • Taconic Biosciences Mouse Models for PLA2G12A

miRNA for PLA2G12A Gene

miRTarBase miRNAs that target PLA2G12A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G12A

Clone products for research

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G12A Gene

Localization for PLA2G12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G12A Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G12A gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PLA2G12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PLA2G12A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G12A Gene

Pathways & Interactions for PLA2G12A Gene

genes like me logo Genes that share pathways with PLA2G12A: view

Pathways by source for PLA2G12A Gene

1 GeneGo (Thomson Reuters) pathway for PLA2G12A Gene
  • Immune response CD16 signaling in NK cells
7 Qiagen pathways for PLA2G12A Gene
  • Antioxidant Action of Vitamin-C
  • cAMP Pathway
  • Chemokine Signaling
  • DHA Signaling
  • Fc-EpsilonRI Pathway

Gene Ontology (GO) - Biological Process for PLA2G12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008150 biological_process ND --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLA2G12A: view

No data available for SIGNOR curated interactions for PLA2G12A Gene

Drugs & Compounds for PLA2G12A Gene

(11) Drugs for PLA2G12A Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
linoleic acid Approved, Experimental Pharma 0
Palmitic Acid Approved Pharma 27
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
alpha-Linolenic acid Approved, Investigational Nutra 0

(16) Additional Compounds for PLA2G12A Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
506-30-9
Beta-Cortolone
  • 1-Palmityl-2-palmitoleoyl-sn-glycero-3-phosphocholine
  • Gpcho(16:0/16:1)
  • Gpcho(16:0/16:1n7)
  • Gpcho(16:0/16:1W7)
  • Gpcho(32:1)
CE(22:0)
  • 1-Tetradecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
  • GPCho(14:0/18:0)
  • Phosphatidylcholine(14:0/18:0)
  • 1-Myristoyl-2-stearoylphosphatidylcholine
  • 1m-2S-PC
61510-09-6
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
3546-17-6

(5) Tocris Compounds for PLA2G12A Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G12A: view

Transcripts for PLA2G12A Gene

mRNA/cDNA for PLA2G12A Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G12A

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G12A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6: - - -

Relevant External Links for PLA2G12A Gene

GeneLoc Exon Structure for
PLA2G12A

Expression for PLA2G12A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLA2G12A Gene

This gene is overexpressed in Liver (38.7), Peripheral blood mononuclear cells (12.6), and Testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLA2G12A Gene



Protein tissue co-expression partners for PLA2G12A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G12A

SOURCE GeneReport for Unigene cluster for PLA2G12A Gene:

Hs.389452

mRNA Expression by UniProt/SwissProt for PLA2G12A Gene:

Q9BZM1-PG12A_HUMAN
Tissue specificity: Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas.

Evidence on tissue expression from TISSUES for PLA2G12A Gene

  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with PLA2G12A: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G12A Gene

Orthologs for PLA2G12A Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G12A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLA2G12A 29 30
  • 99.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PLA2G12A 29
  • 93.65 (n)
Cow
(Bos Taurus)
Mammalia PLA2G12A 29 30
  • 90.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pla2g12a 29 16 30
  • 83.91 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PLA2G12A 30
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PLA2G12A 29 30
  • 77.19 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PLA2G12A 30
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pla2g12a 29
  • 73.96 (n)
Str.4030 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.31928 29
Zebrafish
(Danio rerio)
Actinopterygii pla2g12a 29 30
  • 65.46 (n)
OneToOne
Dr.20271 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10570 29
Fruit Fly
(Drosophila melanogaster)
Insecta GXIVsPLA2 30
  • 22 (a)
OneToMany
Species where no ortholog for PLA2G12A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PLA2G12A Gene

ENSEMBL:
Gene Tree for PLA2G12A (if available)
TreeFam:
Gene Tree for PLA2G12A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLA2G12A: view image
Alliance of Genome Resources:
Additional Orthologs for PLA2G12A

Paralogs for PLA2G12A Gene

Paralogs for PLA2G12A Gene

(1) SIMAP similar genes for PLA2G12A Gene using alignment to 3 proteins:

  • PG12A_HUMAN
  • D6RBP5_HUMAN
  • Q542Y6_HUMAN

Pseudogenes.org Pseudogenes for PLA2G12A Gene

genes like me logo Genes that share paralogs with PLA2G12A: view

Variants for PLA2G12A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLA2G12A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLA2G12A Gene

Variant ID Type Subtype PubMed ID
esv3569652 CNV loss 25503493
nsv4463 CNV deletion 18451855
nsv595142 CNV loss 21841781
nsv950375 CNV deletion 24416366

Variation tolerance for PLA2G12A Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G12A Gene

Human Gene Mutation Database (HGMD)
PLA2G12A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G12A
Leiden Open Variation Database (LOVD)
PLA2G12A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G12A Gene

Disorders for PLA2G12A Gene

Additional Disease Information for PLA2G12A

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for PLA2G12A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G12A Gene

Publications for PLA2G12A Gene

  1. Cloning and recombinant expression of a structurally novel human secreted phospholipase A2. (PMID: 11031251) Gelb MH … Lambeau G (The Journal of biological chemistry 2000) 2 3 4
  2. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. (PMID: 20385819) Chen W … Swaroop A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 40
  3. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 40
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 40

Products for PLA2G12A Gene

Sources for PLA2G12A Gene