This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this en... See more...

Aliases for PLA2G10 Gene

Aliases for PLA2G10 Gene

  • Phospholipase A2 Group X 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 10 3 4
  • Group 10 Secretory Phospholipase A2 3 4
  • Group X Secretory Phospholipase A2 3 4
  • SPLA2-X 3 4
  • GXPLA2 2 3
  • Phospholipase A2, Group X 2
  • EC 3.1.1.4 4
  • GX SPLA2 4
  • GXSPLA2 3
  • PLA2G10 5
  • SPLA2 3

External Ids for PLA2G10 Gene

Previous GeneCards Identifiers for PLA2G10 Gene

  • GC16M014715
  • GC16P017772
  • GC16M014732
  • GC16M014673
  • GC16M014767

Summaries for PLA2G10 Gene

Entrez Gene Summary for PLA2G10 Gene

  • This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]

GeneCards Summary for PLA2G10 Gene

PLA2G10 (Phospholipase A2 Group X) is a Protein Coding gene. Diseases associated with PLA2G10 include Acute Chest Syndrome and Sickle Cell Disease. Among its related pathways are Ras signaling pathway and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PLA2G2D.

UniProtKB/Swiss-Prot Summary for PLA2G10 Gene

  • Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:9188469, PubMed:12021277). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls (PubMed:12359733, PubMed:12021277). Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles (PubMed:12021277). Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (PubMed:12021277). Efficiently hydrolyzes and inactivates platelet activating factor (PAF), a potent lipid mediator present in oxidized LDL (PubMed:16962371). May act in an autocrine and paracrine manner. Secreted by lung epithelium, targets membrane phospholipids of infiltrating eosinophils, releasing arachidonate and boosting eicosanoid and cysteinyl leukotriene synthesis involved in airway inflammatory response (By similarity). Secreted by gut epithelium, hydrolyzes dietary and biliary phosphatidylcholines in the gastrointestinal lumen (By similarity). Plays a stem cell regulator role in colon epithelium. Within intracellular compartment, mediates Paneth-like cell differentiation and its stem cell supporting functions by inhibiting the Wnt signaling pathway in intestinal stem cell (ISC). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ISCs and tissue regeneration (By similarity). May participate in hair follicle morphogenesis by regulating phosphatidylethanolamines metabolism at the outermost epithelial layer and facilitating melanin synthesis (By similarity). By releasing lysophosphatidylcholines (LPCs) at sperm acrosome, controls sperm cell capacitation, acrosome reaction and overall fertility (By similarity). May promote neurite outgrowth in neuron fibers involved in nociception (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (PubMed:12359733). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). In pulmonary epithelium, may contribute to host defense response against adenoviral infection. Prevents adenovirus entry into host cells by hydrolyzing host cell plasma membrane, releasing C16:0 LPCs that inhibit virus-mediated membrane fusion and viral infection. Likely prevents adenoviral entry into the endosomes of host cells (PubMed:16146426). May play a role in maturation and activation of innate immune cells including macrophages, group 2 innate lymphoid cells and mast cells (By similarity).

Tocris Summary for PLA2G10 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G10 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLA2G10 Gene

Genomics for PLA2G10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLA2G10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J014694 Promoter 0.4 Ensembl 250.7 +0.7 662 2 CTCF PLA2G10 piR-37142-001 BFAR
GH16J013955 Enhancer 1.2 FANTOM5 ENCODE 5.8 +737.3 737275 3.8 NCOR1 IKZF1 SSRP1 JUND ZNF580 CEBPA ZNF10 NFIC ZIC2 BCL11A HSALNG0109712 ERCC4 PARN PKD1P3 BFAR NPIPA3 RPS26P52 NPIPA1 NPIPA2 PLA2G10
GH16J015481 Enhancer 1.3 Ensembl ENCODE dbSUPER 5.3 -788.9 -788939 4 ZNF600 IKZF1 JUND ZMYM3 CEBPA ATF3 CHD4 YY1 MXD4 CEBPB PARN NPIPA2 LOC100505915 ABCC1 ENSG00000183889 PKD1P3 BMERB1 PKD1P1 NPIPA3 ENSG00000261819
GH16J015607 Enhancer 1.1 Ensembl ENCODE 4.5 -914.1 -914130 4.8 ZNF600 SSRP1 ZMYM3 ATF2 KLF9 CEBPA ATF3 MXD4 CEBPB FOXA1 ENSG00000257769 lnc-MYH11-1 lnc-NDE1-4 ENSG00000183889 PKD1P3 PKD1P1 NPIPA3 ENSG00000261819 NPIPP1 NPIPA1
GH16J013993 Enhancer 1 FANTOM5 ENCODE 4.7 +700.0 699993 1.6 ZNF600 CEBPA YY1 FEZF1 HOMEZ FOXA2 SMAD4 RXRA RARA JUND ENSG00000261819 PLA2G10 RF00017-1763 LINC02185 HSALNG0109712 ERCC4 MRTFB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLA2G10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLA2G10

Top Transcription factor binding sites by QIAGEN in the PLA2G10 gene promoter:
  • AhR
  • AP-4
  • Arnt
  • CREB
  • ER-alpha
  • FOXO4
  • HNF-1
  • HNF-1A
  • p53
  • Sp1

Genomic Locations for PLA2G10 Gene

Latest Assembly
chr16:14,672,548-14,694,662
(GRCh38/hg38)
Size:
22,115 bases
Orientation:
Minus strand

Previous Assembly
chr16:14,766,405-14,788,430
(GRCh37/hg19 by Entrez Gene)
Size:
22,026 bases
Orientation:
Minus strand

chr16:14,766,405-14,788,526
(GRCh37/hg19 by Ensembl)
Size:
22,122 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr16(ALT_REF_LOCI_1):245,407-267,435 (-)

Genomic View for PLA2G10 Gene

Genes around PLA2G10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G10 Gene

Proteins for PLA2G10 Gene

  • Protein details for PLA2G10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15496-PA2GX_HUMAN
    Recommended name:
    Group 10 secretory phospholipase A2
    Protein Accession:
    O15496
    Secondary Accessions:
    • Q14DU3
    • Q6NT23

    Protein attributes for PLA2G10 Gene

    Size:
    165 amino acids
    Molecular mass:
    18153 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with PLA2R1; this interaction mediates PLA2G10 clearance and inactivation.

    Three dimensional structures from OCA and Proteopedia for PLA2G10 Gene

neXtProt entry for PLA2G10 Gene

Post-translational modifications for PLA2G10 Gene

  • Glycosylation at Asn113

Other Protein References for PLA2G10 Gene

Antibodies for research

No data available for DME Specific Peptides for PLA2G10 Gene

Domains & Families for PLA2G10 Gene

Gene Families for PLA2G10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for PLA2G10 Gene

Suggested Antigen Peptide Sequences for PLA2G10 Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidylcholine 2-acylhydrolase 10 (PA2GX_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15496

UniProtKB/Swiss-Prot:

PA2GX_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G10: view

Function for PLA2G10 Gene

Molecular function for PLA2G10 Gene

UniProtKB/Swiss-Prot Function:
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:9188469, PubMed:12021277). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls (PubMed:12359733, PubMed:12021277). Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles (PubMed:12021277). Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (PubMed:12021277). Efficiently hydrolyzes and inactivates platelet activating factor (PAF), a potent lipid mediator present in oxidized LDL (PubMed:16962371). May act in an autocrine and paracrine manner. Secreted by lung epithelium, targets membrane phospholipids of infiltrating eosinophils, releasing arachidonate and boosting eicosanoid and cysteinyl leukotriene synthesis involved in airway inflammatory response (By similarity). Secreted by gut epithelium, hydrolyzes dietary and biliary phosphatidylcholines in the gastrointestinal lumen (By similarity). Plays a stem cell regulator role in colon epithelium. Within intracellular compartment, mediates Paneth-like cell differentiation and its stem cell supporting functions by inhibiting the Wnt signaling pathway in intestinal stem cell (ISC). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ISCs and tissue regeneration (By similarity). May participate in hair follicle morphogenesis by regulating phosphatidylethanolamines metabolism at the outermost epithelial layer and facilitating melanin synthesis (By similarity). By releasing lysophosphatidylcholines (LPCs) at sperm acrosome, controls sperm cell capacitation, acrosome reaction and overall fertility (By similarity). May promote neurite outgrowth in neuron fibers involved in nociception (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (PubMed:12359733). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). In pulmonary epithelium, may contribute to host defense response against adenoviral infection. Prevents adenovirus entry into host cells by hydrolyzing host cell plasma membrane, releasing C16:0 LPCs that inhibit virus-mediated membrane fusion and viral infection. Likely prevents adenoviral entry into the endosomes of host cells (PubMed:16146426). May play a role in maturation and activation of innate immune cells including macrophages, group 2 innate lymphoid cells and mast cells (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000255|PROSITE-ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036, ECO:0000269|PubMed:12021277};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence={ECO:0000269|PubMed:12359733, ECO:0000269|PubMed:16962371};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40519, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:73858, ChEBI:CHEBI:74965; Evidence={ECO:0000269|PubMed:12359733};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence={ECO:0000269|PubMed:12359733};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+); Xref=Rhea:RHEA:44524, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:84472, ChEBI:CHEBI:84475; Evidence={ECO:0000269|PubMed:12359733};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate; Xref=Rhea:RHEA:45472, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72829, ChEBI:CHEBI:75158; Evidence={ECO:0000250|UniProtKB:Q9QXX3};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+); Xref=Rhea:RHEA:41752, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75020, ChEBI:CHEBI:75029; Evidence={ECO:0000269|PubMed:12359733};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence={ECO:0000269|PubMed:12359733};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+); Xref=Rhea:RHEA:63996, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57518, ChEBI:CHEBI:64839; Evidence={ECO:0000269|PubMed:12359733};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:40479, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:44811, ChEBI:CHEBI:64496; Evidence={ECO:0000269|PubMed:16962371};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.4. {ECO:0000269|PubMed:9188469};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by methyl indoxam.
GENATLAS Biochemistry:
phospholipase A2,group X,Ca2+ dependent,secreted,mainly expressed in spleen,thymus,peripheral blood lymphocytes (15kb transcript) pancreas,lung,colon (0.8kb),likely involved in the inflammatory process

Enzyme Numbers (IUBMB) for PLA2G10 Gene

Phenotypes From GWAS Catalog for PLA2G10 Gene

Gene Ontology (GO) - Molecular Function for PLA2G10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity IDA 16962371
GO:0004620 phospholipase activity ISS 20844270
GO:0004623 phospholipase A2 activity IEA,TAS 9188469
GO:0005509 calcium ion binding IEA,IBA 21873635
GO:0005515 protein binding IPI 28514442
genes like me logo Genes that share ontologies with PLA2G10: view
genes like me logo Genes that share phenotypes with PLA2G10: view

Animal Models for PLA2G10 Gene

MGI Knock Outs for PLA2G10:

Animal Models for research

  • Taconic Biosciences Mouse Models for PLA2G10

miRNA for PLA2G10 Gene

miRTarBase miRNAs that target PLA2G10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G10

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G10 Gene

Localization for PLA2G10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G10 Gene

Secreted. Lysosome. Cytoplasmic vesicle, secretory vesicle, acrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G10 gene
Compartment Confidence
extracellular 5
lysosome 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PLA2G10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 21805676
GO:0005764 lysosome IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with PLA2G10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G10 Gene

Pathways & Interactions for PLA2G10 Gene

genes like me logo Genes that share pathways with PLA2G10: view

Pathways by source for PLA2G10 Gene

2 GeneGo (Thomson Reuters) pathways for PLA2G10 Gene
  • Anandamide biosynthesis and metabolism
  • Immune response CD16 signaling in NK cells
7 Qiagen pathways for PLA2G10 Gene
  • Antioxidant Action of Vitamin-C
  • cAMP Pathway
  • Chemokine Signaling
  • DHA Signaling
  • Fc-EpsilonRI Pathway

Gene Ontology (GO) - Biological Process for PLA2G10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA,IBA 21873635
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006658 phosphatidylserine metabolic process IDA 12359733
GO:0007411 axon guidance IDA 15927955
genes like me logo Genes that share ontologies with PLA2G10: view

No data available for SIGNOR curated interactions for PLA2G10 Gene

Drugs & Compounds for PLA2G10 Gene

(22) Drugs for PLA2G10 Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
linoleic acid Approved, Experimental Pharma 0
Agkistrodon piscivorus antivenin Approved, Experimental Pharma Target, antagonist 0
Crotalus adamanteus antivenin Approved, Experimental Pharma Target, Enzyme, antagonist, inhibitor 0
Crotalus atrox antivenin Approved, Experimental Pharma Enzyme, inhibitor 0
Palmitic Acid Approved Pharma 27

(184) Additional Compounds for PLA2G10 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
506-30-9
Beta-Cortolone
  • 1-Palmityl-2-palmitoleoyl-sn-glycero-3-phosphocholine
  • Gpcho(16:0/16:1)
  • Gpcho(16:0/16:1n7)
  • Gpcho(16:0/16:1W7)
  • Gpcho(32:1)
CE(22:0)
  • 1-Tetradecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
  • GPCho(14:0/18:0)
  • Phosphatidylcholine(14:0/18:0)
  • 1-Myristoyl-2-stearoylphosphatidylcholine
  • 1m-2S-PC
61510-09-6
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
3546-17-6

(5) Tocris Compounds for PLA2G10 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G10: view

Transcripts for PLA2G10 Gene

mRNA/cDNA for PLA2G10 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLA2G10

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for PLA2G10 Gene

GeneLoc Exon Structure for
PLA2G10

Expression for PLA2G10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for PLA2G10 Gene

This gene is overexpressed in Colon - Transverse (x18.5), Stomach (x7.7), and Pancreas (x4.3).

Protein differential expression in normal tissues from HIPED for PLA2G10 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G10 Gene



Protein tissue co-expression partners for PLA2G10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLA2G10

SOURCE GeneReport for Unigene cluster for PLA2G10 Gene:

Hs.567366

mRNA Expression by UniProt/SwissProt for PLA2G10 Gene:

O15496-PA2GX_HUMAN
Tissue specificity: Found in spleen, thymus, peripheral blood leukocytes, pancreas, lung, and colon (PubMed:9188469). Expressed in neuronal fibers in dorsal root ganglia and in peripheral tissues including stomach, white adipose tissue and prostate (at protein level) (PubMed:21266581).

Evidence on tissue expression from TISSUES for PLA2G10 Gene

  • Lung(4.4)
  • Intestine(2.6)
  • Nervous system(2.6)
  • Heart(2.5)
  • Muscle(2.4)
  • Liver(2.4)
  • Kidney(2.3)
  • Pancreas(2.3)
  • Blood(2.2)
  • Stomach(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with PLA2G10: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G10 Gene

Orthologs for PLA2G10 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLA2G10 29 30
  • 98.28 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PLA2G10 29 30
  • 82.15 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pla2g10 29
  • 76.37 (n)
Cow
(Bos Taurus)
Mammalia PLA2G10 29 30
  • 76.33 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pla2g10 29 16 30
  • 76.12 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PLA2G10 30
  • 50 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 46 (a)
OneToMany
-- 30
  • 41 (a)
OneToMany
-- 30
  • 39 (a)
OneToMany
-- 30
  • 39 (a)
OneToMany
-- 30
  • 36 (a)
OneToMany
Chicken
(Gallus gallus)
Aves PLA2G10 29 30
  • 57.6 (n)
OneToMany
-- 30
  • 44 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia PLA2G10 30
  • 40 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100492785 29
  • 55.56 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:92162 29
  • 51.88 (n)
PLA2G10 30
  • 42 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea C07E3.9 30
  • 27 (a)
OneToMany
Species where no ortholog for PLA2G10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PLA2G10 Gene

ENSEMBL:
Gene Tree for PLA2G10 (if available)
TreeFam:
Gene Tree for PLA2G10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLA2G10: view image
Alliance of Genome Resources:
Additional Orthologs for PLA2G10

Paralogs for PLA2G10 Gene

(6) SIMAP similar genes for PLA2G10 Gene using alignment to 3 proteins:

  • PA2GX_HUMAN
  • H3BRW4_HUMAN
  • L8E7V2_HUMAN
genes like me logo Genes that share paralogs with PLA2G10: view

Variants for PLA2G10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLA2G10 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs149977312 Likely Benign: not provided 14,672,745(-) C/T
NM_003561.3(PLA2G10):c.360G>A (p.Pro120=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLA2G10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLA2G10 Gene

Variant ID Type Subtype PubMed ID
dgv2738n100 CNV gain 25217958
dgv2740n100 CNV loss 25217958
dgv4916n54 CNV loss 21841781
dgv4917n54 CNV loss 21841781
esv1008243 CNV gain 20482838
esv2758632 CNV gain+loss 17122850
esv28787 CNV gain+loss 19812545
esv3638012 CNV loss 21293372
nsv1143811 CNV deletion 24896259
nsv1160344 CNV deletion 26073780
nsv1740 CNV deletion 18451855
nsv571511 CNV loss 21841781
nsv821150 CNV deletion 20802225
nsv833144 CNV gain 17160897
nsv9353 CNV gain+loss 18304495
nsv952927 CNV deletion 24416366
nsv984262 CNV duplication 23825009

Variation tolerance for PLA2G10 Gene

Gene Damage Index Score: 0.04; 1.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLA2G10 Gene

Human Gene Mutation Database (HGMD)
PLA2G10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G10
Leiden Open Variation Database (LOVD)
PLA2G10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G10 Gene

Disorders for PLA2G10 Gene

MalaCards: The human disease database

(8) MalaCards diseases for PLA2G10 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
acute chest syndrome
  • acute chest syndrome in sickle cell disease
sickle cell disease
  • hbs disease
meconium aspiration syndrome
  • meconium aspiration
acute endometritis
gas gangrene
  • gas bacillus infection
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLA2G10

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PLA2G10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G10 Gene

Publications for PLA2G10 Gene

  1. Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2. (PMID: 9188469) Cupillard L … Lambeau G (The Journal of biological chemistry 1997) 2 3 4 22
  2. Group V and X secretory phospholipase A2 prevents adenoviral infection in mammalian cells. (PMID: 16146426) Mitsuishi M … Murakami M (The Biochemical journal 2006) 3 4 22
  3. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PMID: 19336475) Drenos F … Hingorani AD (Human molecular genetics 2009) 3 40
  4. Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s. (PMID: 18587072) Kuksis A … Pruzanski W (Journal of lipid research 2008) 3 22
  5. The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2. (PMID: 16962371) Gora S … Karabina SA (Biochimica et biophysica acta 2006) 3 4

Products for PLA2G10 Gene

Sources for PLA2G10 Gene