Aliases for PKNOX2 Gene
External Ids for PKNOX2 Gene
Previous GeneCards Identifiers for PKNOX2 Gene
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
GeneCards Summary for PKNOX2 Gene
PKNOX2 (PBX/Knotted 1 Homeobox 2) is a Protein Coding gene. Diseases associated with PKNOX2 include Substance Dependence and Hydrolethalus Syndrome 1. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and actin monomer binding. An important paralog of this gene is PKNOX1.