Aliases for PKN3 Gene

Aliases for PKN3 Gene

  • Protein Kinase N3 2 3 5
  • Serine/Threonine-Protein Kinase N3 3 4
  • Protein-Kinase C-Related Kinase 3 3 4
  • Protein Kinase PKN-Beta 3 4
  • EC 2.7.11.13 4 52
  • EC 2.7.11 52
  • UTDP4-1 3
  • PKNBETA 4

External Ids for PKN3 Gene

Previous GeneCards Identifiers for PKN3 Gene

  • GC09P126841
  • GC09P128544
  • GC09P130504
  • GC09P131464
  • GC09P101074

Summaries for PKN3 Gene

GeneCards Summary for PKN3 Gene

PKN3 (Protein Kinase N3) is a Protein Coding gene. Diseases associated with PKN3 include Pachyonychia Congenita 1. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PKN1.

UniProtKB/Swiss-Prot Summary for PKN3 Gene

Gene Wiki entry for PKN3 Gene

Additional gene information for PKN3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PKN3 Gene

Genomics for PKN3 Gene

GeneHancer (GH) Regulatory Elements for PKN3 Gene

Promoters and enhancers for PKN3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PKN3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PKN3

Top Transcription factor binding sites by QIAGEN in the PKN3 gene promoter:
  • c-Ets-1
  • c-Myc
  • Elk-1
  • IRF-1
  • Max
  • Meis-1
  • Meis-1a
  • Meis-1b

Genomic Locations for PKN3 Gene

Genomic Locations for PKN3 Gene
chr9:128,702,499-128,720,920
(GRCh38/hg38)
Size:
18,422 bases
Orientation:
Plus strand
chr9:131,464,802-131,483,199
(GRCh37/hg19)
Size:
18,398 bases
Orientation:
Plus strand

Genomic View for PKN3 Gene

Genes around PKN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKN3 Gene

Proteins for PKN3 Gene

  • Protein details for PKN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P5Z2-PKN3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase N3
    Protein Accession:
    Q6P5Z2
    Secondary Accessions:
    • Q9UM03

    Protein attributes for PKN3 Gene

    Size:
    889 amino acids
    Molecular mass:
    99421 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PKN3 Gene

Selected DME Specific Peptides for PKN3 Gene

Q6P5Z2:
  • ELKVKQGAENM
  • ESSQKLDLL
  • ACVVLGLQ
  • AVAEGAKNV
  • TSTFCGTPEF
  • RAVDWWGLGV
  • LEDFLDN
  • GVLLYEM
  • AVLGRGHFGKVLL
  • PVIERRP
  • YRDLKLDN
  • DFGLCKE
  • LERARELE
  • RDLKLDN

Post-translational modifications for PKN3 Gene

Other Protein References for PKN3 Gene

Domains & Families for PKN3 Gene

Protein Domains for PKN3 Gene

Blocks:
  • C2 domain
  • Protein kinase C-terminal domain
  • Protein kinase PKN/PRK1, effector
  • PKN/rhophilin/rhotekin rho-binding repeat
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PKN3 Gene

GenScript: Design optimal peptide antigens:
  • Protein-kinase C-related kinase 3 (PKN3_HUMAN)
  • PKN3 protein (Q05BU1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P5Z2

UniProtKB/Swiss-Prot:

PKN3_HUMAN :
  • The C1 domain does not bind the diacylglycerol (DAG).
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Domain:
  • The C1 domain does not bind the diacylglycerol (DAG).
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PKN3: view

Function for PKN3 Gene

Molecular function for PKN3 Gene

UniProtKB/Swiss-Prot Function:
Contributes to invasiveness in malignant prostate cancer.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Two specific sites, Thr-718 (activation loop of the kinase domain) and Thr-860 (turn motif), need to be phosphorylated for its full activation.

Enzyme Numbers (IUBMB) for PKN3 Gene

Phenotypes From GWAS Catalog for PKN3 Gene

Gene Ontology (GO) - Molecular Function for PKN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10441506
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0004697 protein kinase C activity IEA --
GO:0005515 protein binding IPI 11432776
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PKN3: view
genes like me logo Genes that share phenotypes with PKN3: view

Animal Models for PKN3 Gene

MGI Knock Outs for PKN3:
  • Pkn3 Pkn3<tm1.1(KOMP)Vlcg>
  • Pkn3 Pkn3<tm1Ajmc>
  • Pkn3 Pkn3<tm1.2Mrl>

Animal Model Products

CRISPR Products

miRNA for PKN3 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PKN3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PKN3 Gene

Localization for PKN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PKN3 Gene

Nucleus. Cytoplasm, perinuclear region. Note=Nuclear and perinuclear Golgi region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PKN3 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PKN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus TAS 10441506
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with PKN3: view

Pathways & Interactions for PKN3 Gene

genes like me logo Genes that share pathways with PKN3: view

Pathways by source for PKN3 Gene

Gene Ontology (GO) - Biological Process for PKN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 10441506
GO:0007165 signal transduction TAS 10441506
GO:0010631 epithelial cell migration IDA 21754995
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
genes like me logo Genes that share ontologies with PKN3: view

No data available for SIGNOR curated interactions for PKN3 Gene

Drugs & Compounds for PKN3 Gene

(3) Drugs for PKN3 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
ATU027 Pharma 0
sophoretin Pharma inhibitor Kinase Inhibitors 0

(1) Additional Compounds for PKN3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with PKN3: view

Transcripts for PKN3 Gene

mRNA/cDNA for PKN3 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PKN3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PKN3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2: -
SP3:
SP4: -
SP5:

Relevant External Links for PKN3 Gene

GeneLoc Exon Structure for
PKN3

Expression for PKN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PKN3 Gene

Protein differential expression in normal tissues from HIPED for PKN3 Gene

This gene is overexpressed in Heart (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PKN3 Gene



Protein tissue co-expression partners for PKN3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PKN3

SOURCE GeneReport for Unigene cluster for PKN3 Gene:

Hs.300485

mRNA Expression by UniProt/SwissProt for PKN3 Gene:

Q6P5Z2-PKN3_HUMAN
Tissue specificity: Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues.
genes like me logo Genes that share expression patterns with PKN3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PKN3 Gene

Orthologs for PKN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PKN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PKN3 31 30
  • 99.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PKN3 31 30
  • 87.96 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PKN3 31 30
  • 86.8 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pkn3 17 31 30
  • 82.07 (n)
oppossum
(Monodelphis domestica)
Mammalia PKN3 31
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PKN3 31
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PKN3 31 30
  • 61.44 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145241 30
  • 62.27 (n)
zebrafish
(Danio rerio)
Actinopterygii pkn3 31
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pkn 31
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pkn-1 31
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 31
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
OneToMany
Species where no ortholog for PKN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PKN3 Gene

ENSEMBL:
Gene Tree for PKN3 (if available)
TreeFam:
Gene Tree for PKN3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PKN3: view image

Paralogs for PKN3 Gene

(35) SIMAP similar genes for PKN3 Gene using alignment to 2 proteins:

  • PKN3_HUMAN
  • Q05BU1_HUMAN
genes like me logo Genes that share paralogs with PKN3: view

Variants for PKN3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PKN3 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs12932 - p.Val404Leu
rs56251280 - p.Ala180Glu

Additional dbSNP identifiers (rs#s) for PKN3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PKN3 Gene

Variant ID Type Subtype PubMed ID
nsv416266 CNV deletion 16902084
nsv951776 CNV deletion 24416366
nsv951777 CNV deletion 24416366

Variation tolerance for PKN3 Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PKN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PKN3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKN3 Gene

Disorders for PKN3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PKN3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pachyonychia congenita 1
  • pc1
- elite association - COSMIC cancer census association via MalaCards
Search PKN3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PKN3

genes like me logo Genes that share disorders with PKN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PKN3 Gene

Publications for PKN3 Gene

  1. Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha. (PMID: 10441506) Oishi K … Ona Y (Biochemical and biophysical research communications 1999) 2 3 4 23 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 54
  4. PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase. (PMID: 15282551) Leenders F … Klippel A (The EMBO journal 2004) 3 4 54
  5. PKN regulates phospholipase D1 through direct interaction. (PMID: 11259428) Oishi K … Ono Y (The Journal of biological chemistry 2001) 3 23 54

Products for PKN3 Gene

Sources for PKN3 Gene