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Aliases for PKN2 Gene
Aliases for PKN2 Gene
External Ids for PKN2 Gene
- HGNC: 9406
- NCBI Entrez Gene: 5586
- Ensembl: ENSG00000065243
- OMIM®: 602549
- UniProtKB/Swiss-Prot: Q16513
Previous HGNC Symbols for PKN2 Gene
- PRKCL2
Previous GeneCards Identifiers for PKN2 Gene
- GC01P088618
- GC01P088862
- GC01P089149
- GC01P087267
Summaries for PKN2 Gene
GeneCards Summary for PKN2 Gene
PKN2 (Protein Kinase N2) is a Protein Coding gene. Diseases associated with PKN2 include Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations and Posterior Pituitary Gland Neoplasm. Among its related pathways are Signaling by GPCR and Yersinia infection. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is PKN1.
UniProtKB/Swiss-Prot Summary for PKN2 Gene
-
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747).
-
(Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.
Additional gene information for PKN2 Gene
- HGNC (9406)
- NCBI Entrez Gene (5586)
- Ensembl (ENSG00000065243)
- OMIM® (602549)
- UniProtKB/Swiss-Prot (Q16513)
- Open Targets Platform(ENSG00000065243)
- Search for PKN2 at DataMed
- Search for PKN2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PKN2 Gene
Genomics for PKN2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PKN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PKN2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PKN2
- Top Transcription factor binding sites by QIAGEN in the PKN2 gene promoter:
-
- aMEF-2
- AP-1
- c-Fos
- c-Jun
- CREB
- deltaCREB
- FOXD3
- MEF-2A
- Nkx2-5
- Olf-1
Genomic Locations for PKN2 Gene
Latest Assembly
- chr1:88,684,222-88,836,255
- (GRCh38/hg38)
- Size:
- 152,034 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:89,149,956-89,301,938
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 151,983 bases
- Orientation:
- Plus strand
- chr1:89,149,905-89,301,938
- (GRCh37/hg19 by Ensembl)
- Size:
- 152,034 bases
- Orientation:
- Plus strand
Genomic View for PKN2 Gene
Genes around PKN2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.2 by HGNC
- 1p22.2 by Entrez Gene
- 1p22.2 by Ensembl
PKN2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PKN2 Gene
Proteins for PKN2 Gene
-
Protein details for PKN2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16513-PKN2_HUMAN
- Recommended name:
- Serine/threonine-protein kinase N2
- Protein Accession:
- Q16513
- B4DQ21
- B4DTP5
- B4DVG1
- D3DT24
- Q08AF4
- Q9H1W4
Protein attributes for PKN2 Gene
- Size:
- 984 amino acids
- Molecular mass:
- 112035 Da
- Quaternary structure:
-
- Interacts (via the REM repeats) with RHOA (GTP-bound form preferentially) and interacts (via the REM repeats) with RAC1 (GTP-bound form preferentially); the interactions induce its autophosphorylation (PubMed:9121475, PubMed:20974804). Interacts with RHOC (PubMed:20974804). Interacts with NCK1 and NCK2 (PubMed:10026169). Interacts with NCK1 (via SH3 domains) (By similarity). Interacts with CD44 (PubMed:15123640). Interacts (via C-terminal kinase domain) with PDPK1; the interaction stimulates PDPK1 kinase activity (PubMed:10226025, PubMed:10792047, PubMed:11781095, PubMed:18835241). Interacts with MAP3K2; the interaction activates PRK2 kinase activity in a MAP3K2-independent kinase activity (PubMed:10818102). Interacts (via C-terminal domain) with AKT1; the interaction occurs with the C-terminal cleavage product of PRK2 in apoptotic cells (PubMed:10926925). Interacts (via C-terminus) with PTPN13 (via PDZ 3 domain) (PubMed:11356191). Interacts with CDK10 (PubMed:27104747).
- (Microbial infection) Interacts with HCV NS5B (via N-terminal finger domain).
Three dimensional structures from OCA and Proteopedia for PKN2 Gene
Protein Expression for PKN2 Gene
Selected DME Specific Peptides for PKN2 Gene
- Q16513:
-
- ELKVKQGAENM
- ESSQKLDLL
- ACVVLGLQ
- LQDSKTKI
- AVAEGAKNV
- TSTFCGTPEF
- EFTSEAP
- RAVDWWGLGV
- LEDFLDN
- AVLGRGHFGKVLL
- LGVLIYEM
- PVIERRP
- FAIKALKK
- YRDLKLDN
- EELRHHF
- YSTLSKPA
- DFGLCKE
- SNGSSKD
- RDLKLDN
Post-translational modifications for PKN2 Gene
- Autophosphorylated. Phosphorylated during mitosis. Phosphorylated by CDK10 (PubMed:27104747).
- Activated by limited proteolysis with trypsin (By similarity). Proteolytically cleaved by caspase-3 during the induction of apoptotic cell death.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PKN2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PKN2 Antibody
- GeneTex Anti-PKN2 antibody [N1N3] and Anti-PKN2 antibody
-
Custom Antibody ServicesOriGene Antibodies for PKN2
- Novus Biologicals Antibodies for PKN2
-
Abcam antibodies for PKN2
- Invitrogen Antibodies for PKN2 (AFLGC-PKN2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PKN2
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PKN2
- Origene Custom Protein Services for PKN2
-
Abcam proteins for PKN2
Assay products for research
- antibodies-online: Search results for available PKN2 related products ranked by validation data
Domains & Families for PKN2 Gene
Gene Families for PKN2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for PKN2 Gene
- InterPro:
- Blocks:
-
- C2 domain
- Protein kinase C-terminal domain
- Protein kinase PKN/PRK1, effector
- PKN/rhophilin/rhotekin rho-binding repeat
- ProtoNet:
Suggested Antigen Peptide Sequences for PKN2 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein-kinase C-related kinase 2 (PKN2_HUMAN)
- PKN2 protein (Q08AF4_HUMAN)
- Protein kinase N2 (Q5TBX5_HUMAN)
- Protein kinase N2 (Q5TBX8_HUMAN)
- PKN2 protein (Q6P5W9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16513UniProtKB/Swiss-Prot:
PKN2_HUMAN :- The N-terminal regioninterferes with the interaction between AKT1 and the C-terminal regionof PKN2.
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
- Domain:
-
- The N-terminal regioninterferes with the interaction between AKT1 and the C-terminal regionof PKN2.
- The C1 domain does not bind the diacylglycerol (DAG).
- The apoptotic C-terminal cleavage product inhibits EGF-induced kinase activity of AKT1 phosphorylation at 'Thr-308' and 'Ser-473' sites, PDPK1 autophosphorylation and kinases PRKCD and PRKCZ phosphorylations.
- Family:
-
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Function for PKN2 Gene
Molecular function for PKN2 Gene
- UniProtKB/Swiss-Prot Function:
- PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13;.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated during keratinocyte differentiation.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=15.83 uM for HDAC5 {ECO:0000269|PubMed:20188095};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Kinase activity is activated upon binding to GTP-bound Rhoa/Rac1 GTPases. Activated by caspase-3 (CASP3) cleavage during apoptosis. Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids. Two specific sites, Thr-816 (activation loop of the kinase domain) and Thr-958 (turn motif), need to be phosphorylated for its full activation.
Enzyme Numbers (IUBMB) for PKN2 Gene
Phenotypes From GWAS Catalog for PKN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0004672 | protein kinase activity | TAS | 7851406 |
| GO:0004674 | protein serine/threonine kinase activity | IBA,IDA | 20188095 |
| GO:0004697 | protein kinase C activity | IEA | -- |
Phenotypes for PKN2 Gene
- MGI mutant phenotypes for PKN2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PKN2:
-
- no effect
- Decreased viability
- shRNA abundance <= 50%
- Reduced mammosphere formation
- Decreased substrate adherent cell growth
- Decreased transferrin (TF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased cell migration
- Decreased homologous recombination repair frequency
- Increased viability with tamoxifen
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
- Increased Nanog expression
- Decreased melanin production
- Increased cell death in HCC-1954 cells
- Increased cell transformation
- Synthetic lethal with gemcitabine
Animal Models for PKN2 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PKN2 - Starting at $85 >
- * PKN2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PKN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PKN2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PKN2
miRNA for PKN2 Gene
- miRTarBase miRNAs that target PKN2
-
- hsa-miR-155-5p (MIRT001524)
- hsa-miR-573 (MIRT080893)
- hsa-miR-3616-5p (MIRT080896)
- hsa-miR-4795-5p (MIRT080898)
- hsa-miR-5692a (MIRT080899)
- hsa-miR-4672 (MIRT149009)
- hsa-let-7c-3p (MIRT555571)
- hsa-miR-7109-3p (MIRT555572)
- mmu-miR-3067-5p (MIRT594297)
- hsa-miR-202-5p (MIRT655041)
- hsa-miR-337-3p (MIRT655042)
- hsa-miR-4789-5p (MIRT655043)
- hsa-miR-4264 (MIRT655044)
- hsa-miR-4797-3p (MIRT655045)
- hsa-miR-26a-2-3p (MIRT655046)
- hsa-miR-26a-1-3p (MIRT655047)
- hsa-miR-1284 (MIRT655048)
- hsa-miR-16-1-3p (MIRT655049)
- hsa-miR-6768-5p (MIRT655050)
- hsa-miR-5582-3p (MIRT655051)
- hsa-miR-548x-3p (MIRT655052)
- hsa-miR-548j-3p (MIRT655053)
- hsa-miR-548aq-3p (MIRT655054)
- hsa-miR-548am-3p (MIRT655055)
- hsa-miR-548aj-3p (MIRT655056)
- hsa-miR-548ah-3p (MIRT655057)
- hsa-miR-548ae-3p (MIRT655058)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PKN2
- Browse OriGene Inhibitory RNA Products For PKN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PKN2
Clone products for research
- Applied Biological Materials (abm): Clones for PKN2 - Starting at $45 >
- * PKN2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PKN2
- Addgene plasmids for PKN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PKN2
Cell Lines for research
-
Horizon Cell Lines for PKN2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PKN2 Gene
Localization for PKN2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PKN2 Gene
- Cytoplasm. Nucleus. Membrane. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Cell junction. Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm. {ECO:0000269 PubMed:11356191, ECO:0000269 PubMed:17332740}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Intermediate filaments (4)
- Nucleoplasm (4)
- Centrosome (2)
- Cytosol (2)
- Nuclear bodies (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 11356191 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 17332740 |
| GO:0005813 | centrosome | IDA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PKN2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by Rho GTPases | ||
| 2 | Ca, cAMP and Lipid Signaling | ||
| 3 | Cytoskeletal Signaling | ||
| 4 | NOD-like receptor signaling pathway | ||
| 5 | PI3K-Akt signaling pathway | ||
Pathways by source for PKN2 Gene
1 BioSystems pathway for PKN2 Gene
4 Reactome pathways for PKN2 Gene
3 KEGG pathways for PKN2 Gene
2 Cell Signaling Technology pathways for PKN2 Gene
Interacting Proteins for PKN2 Gene
Selected Interacting proteins:
Q16513-PKN2_HUMAN
ENSP00000359552
for PKN2 Gene via
MINT
STRING
UniProtKB
IID
GPS-Prot Interaction Network for PKN2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IDA | 17332740 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007165 | signal transduction | TAS | 7851406 |
Drugs & Compounds for PKN2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Ingenol mebutate | Approved | Pharma | 0 | |||
| ATP | Investigational | Nutra | 0 | |||
| [Ser25] Protein Kinase C (19-31) | Pharma | PKC substrate | 0 | |||
| sophoretin | Pharma | inhibitor | Kinase Inhibitors | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
58-64-0 |
|
(1) ApexBio Compounds for PKN2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| [Ser25] Protein Kinase C (19-31) | PKC substrate | 136795-05-6 |
Transcripts for PKN2 Gene
mRNA/cDNA for PKN2 Gene
- 4 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000316005 2632 nts (view in UCSC)
- ENST00000370513 2890 nts (view in UCSC)
- ENST00000370521 6070 nts (view in UCSC)
- ENST00000436111 632 nts (view in UCSC)
- ENST00000449189 342 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PKN2 - Starting at $85 >
- * PKN2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PKN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PKN2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PKN2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PKN2
- Browse OriGene Inhibitory RNA Products For PKN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PKN2
Clone products for research
- Applied Biological Materials (abm): Clones for PKN2 - Starting at $45 >
- * PKN2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PKN2
- Addgene plasmids for PKN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PKN2
Relevant External Links for PKN2 Gene
- GeneLoc Exon Structure for
- PKN2
Expression for PKN2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Hematopoietic Bone Marrow
This gene is overexpressed in Bone marrow mesenchymal stem cell (22.3) and Lung (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PKN2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PKN2
SOURCE GeneReport for Unigene cluster for PKN2 Gene:
Hs.440833mRNA Expression by UniProt/SwissProt for PKN2 Gene:
Q16513-PKN2_HUMAN
Tissue specificity:
Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells.
Evidence on tissue expression from TISSUES for PKN2 Gene
- Spleen(4.4)
- Liver(4.4)
- Nervous system(3.1)
- Skin(2.2)
- Kidney(2.2)
- Muscle(2.1)
- Heart(2.1)
- Lung(2)
Primer products for research
-
OriGene qPCR primer pairs for PKN2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PKN2 Gene
Orthologs for PKN2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PKN2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PKN2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PKN2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PKN2 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pkn2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Pkn2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PKN2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PKN2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PKN2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pkn2 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.21437 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | PKN2 (2 of 2) 31 |
|
OneToMany | |
| pkn2 30 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007587 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Pkn 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | pkn-1 30 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PKC1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.7005 30 |
|
- Species where no ortholog for PKN2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PKN2 Gene
- ENSEMBL:
- Gene Tree for PKN2 (if available)
- TreeFam:
- Gene Tree for PKN2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PKN2: view image
Paralogs for PKN2 Gene
Paralogs for PKN2 Gene
(67) SIMAP similar genes for PKN2 Gene using alignment to 6 proteins:
- PKN2_HUMAN
- B1AL79_HUMAN
- H0Y429_HUMAN
- H0Y5V5_HUMAN
- Q6P5W9_HUMAN
- Q8N2Y1_HUMAN
- RPS6KA3
- PRKCZ
- PKN1
- PRKACA
- RPS6KA2
- PRKCG
- AKT2
- SGK2
- SGK1
- SGK494
- AKT1
- PRKCD
- MAP3K11
- RPS6KA1
- RPS6KB1
- IKBKB
- PRKCH
- MARK2
- AURKC
- PKN3
- PRKX
- PRKCI
- PRKY
- PRKACG
- ULK1
- PLK4
- NEK4
- MARK4
- WNK4
- TRIB1
- PAK1
- NEK9
- PRKD1
- PRKD2
- PRKCQ
- PAK4
- MAP3K9
- GRK6
- FGFR1
- AKT3
- PRKAA1
- RPS6KA4
- CDK4
- PRKCA
- NEK8
- CHEK1
- CAMK2D
- PHKG2
- AURKB
- SIK3
- MAP3K6
- GRK5
- CDKL3
- TAOK3
- MAST4
- CDC42BPA
- BRSK2
- STK32B
- CAMKV
- CAMKK2
- MAP3K3
- MAP3K15
- RPS6KA5
- CAMK1D
- STK38L
- TYK2
- MAP2K1
Variants for PKN2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PKN2 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs12039846 | - |
p.Glu94Asp |
|||
| rs12085658 | - |
p.Gln655Arg |
|||
| rs35207128 | - |
p.Ala197Glu |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv22n27 | CNV | gain | 19166990 |
| dgv359n54 | CNV | gain | 21841781 |
| dgv360n54 | CNV | gain | 21841781 |
| esv2665922 | CNV | deletion | 23128226 |
| esv3306396 | CNV | mobile element insertion | 20981092 |
| esv3307993 | CNV | mobile element insertion | 20981092 |
| esv3308381 | CNV | mobile element insertion | 20981092 |
| esv3340558 | CNV | insertion | 20981092 |
| esv3403767 | CNV | insertion | 20981092 |
| esv3428030 | CNV | insertion | 20981092 |
| esv3450284 | CNV | insertion | 20981092 |
| esv3586738 | CNV | loss | 21293372 |
| esv3586743 | CNV | loss | 21293372 |
| esv3586744 | CNV | loss | 21293372 |
| esv3586745 | CNV | gain | 21293372 |
| esv3586746 | CNV | loss | 21293372 |
| nsv1113147 | CNV | deletion | 24896259 |
| nsv1122376 | CNV | deletion | 24896259 |
| nsv462450 | CNV | gain | 19166990 |
| nsv546773 | CNV | loss | 21841781 |
| nsv546781 | CNV | gain | 21841781 |
| nsv830514 | CNV | loss | 17160897 |
| nsv830525 | CNV | loss | 17160897 |
| nsv830537 | CNV | gain | 17160897 |
| nsv946053 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.64;
45.52% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PKN2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PKN2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKN2 Gene
Disorders for PKN2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| toe syndactyly, telecanthus, and anogenital and renal malformations |
|
|
| posterior pituitary gland neoplasm |
|
|
| myasthenic syndrome, congenital, 12 |
|
|
| bubonic plague |
|
|
| polycystic kidney disease 3 with or without polycystic liver disease |
|
|
Search PKN2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PKN2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PKN2 Gene
Publications for PKN2 Gene
- Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family. (PMID: 7851406) Palmer RH … Parker PJ (European journal of biochemistry 1995) 2 3 4 23
- Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases. (PMID: 20188095) Harrison BC … McKinsey TA (FEBS letters 2010) 3 4 23
- The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner. (PMID: 18835241) Lim WG … Duan W (Archives of biochemistry and biophysics 2008) 3 4 23
- Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck. (PMID: 10026169) Braverman LE … Quilliam LA (The Journal of biological chemistry 1999) 3 4 23
- Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy. (PMID: 9368003) Cryns VL … Yuan J (The Journal of biological chemistry 1997) 3 4 23
ExternalLinks
Products for PKN2 Gene
- Custom Antibody ServicesOriGene Antibodies for PKN2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PKN2
- Origene Custom Protein Services for PKN2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PKN2
- Browse OriGene Inhibitory RNA Products For PKN2
- OriGene qPCR primer pairs for PKN2
- OriGene CRISPR knockouts for PKN2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PKN2
- Sino Biological Human cDNA Clone for PKN2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PKN2
- Novus Biologicals proteins and lysates for PKN2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PKN2
- Abcam proteins for PKN2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for PKN2 (AFLGC-PKN2)
- ApexBio compounds for PKN2
- VectorBuilder Custom and pre-made DNA vectors for PKN2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PKN2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PKN2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PKN2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PKN2
- Addgene plasmids for PKN2
- antibodies-online: Show 27 available PKN2 Antibodies ranked by validation data
- Compare Top PKN2 Antibodies
- antibodies-online: Search results for available PKN2 related products ranked by validation data
- antibodies-online: Show 13 available PKN2 Proteins ranked by validation data
- Compare Top PKN2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PKN2
- Search Santa Cruz Biotechnology (SCBT) for PKN2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PKN2
- Horizon Cell Lines for PKN2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PKN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PKN2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PKN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PKN2
Sources for PKN2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB