Aliases for PKN2 Gene
External Ids for PKN2 Gene
Previous HGNC Symbols for PKN2 Gene
Previous GeneCards Identifiers for PKN2 Gene
GeneCards Summary for PKN2 Gene
PKN2 (Protein Kinase N2) is a Protein Coding gene. Diseases associated with PKN2 include Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations and Posterior Pituitary Gland Neoplasm. Among its related pathways are Signaling by GPCR and RhoA signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is PKN1.
UniProtKB/Swiss-Prot Summary for PKN2 Gene
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747).
(Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.