Aliases for PKN2 Gene

Aliases for PKN2 Gene

  • Protein Kinase N2 2 3 5
  • Protein Kinase C-Like 2 2 3 4
  • Cardiolipin-Activated Protein Kinase Pak2 2 3
  • Serine/Threonine-Protein Kinase N2 3 4
  • Protein-Kinase C-Related Kinase 2 3 4
  • EC 2.7.11.13 4 54
  • PKN Gamma 3 4
  • PRKCL2 3 4
  • PRK2 3 4
  • EC 2.7.11 54
  • PRO2042 3
  • Pak-2 3
  • PAK2 3
  • STK7 3

External Ids for PKN2 Gene

Previous HGNC Symbols for PKN2 Gene

  • PRKCL2

Previous GeneCards Identifiers for PKN2 Gene

  • GC01P088618
  • GC01P088862
  • GC01P089149
  • GC01P087267

Summaries for PKN2 Gene

GeneCards Summary for PKN2 Gene

PKN2 (Protein Kinase N2) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is PKN1.

UniProtKB/Swiss-Prot Summary for PKN2 Gene

  • PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747).
  • (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.

Gene Wiki entry for PKN2 Gene

Additional gene information for PKN2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PKN2 Gene

Genomics for PKN2 Gene

GeneHancer (GH) Regulatory Elements for PKN2 Gene

Promoters and enhancers for PKN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J088682 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 788.4 +0.7 667 5.1 GTF3C2 ZNF785 SP1 ZBTB40 SIX5 LCORL FOXA1 SMARCE1 RBPJ POLR2A PKN2 PKN2-AS1 KYAT3 ELOCP19 GTF2B GBP2 GBP5 PTGES3P1 lnc-GTF2B-6
GH01J088647 Promoter/Enhancer 1.2 EPDnew FANTOM5 Ensembl 750.3 -35.5 -35492 3.4 ZNF24 NR2F6 CREB1 SP1 CEBPA RXRA POLR2A NR2C1 JUND USF1 PKN2 KYAT3 piR-57461-010 LOC105378838 PKN2-AS1
GH01J088832 Promoter 0.3 EPDnew 750.1 +148.6 148640 0.1 PKN2 ELOCP19 lnc-GBP6-5 piR-43107-014
GH01J088889 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 66.9 +207.5 207492 4.2 ZNF785 ZBTB40 SP1 FOXA1 RBPJ POLR2A CTBP1 USF2 ATF1 CREB1 GTF2B HSALNG0005035 lnc-GTF2B-2 PKN2 KYAT3 ELOCP19 ENSG00000235308 PTGES3P1 GBP3 GBP2
GH01J089523 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 44.2 +841.2 841235 4.3 ZNF785 ZNF24 RBPJ SMARCE1 POLR2A USF2 CTBP1 CREB1 MYC NFYC LRRC8B ENSG00000286548 PKN2 ELOCP19 GTF2B PTGES3P1 KYAT3 GBP3 GBP2 GBP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PKN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PKN2 gene promoter:
  • aMEF-2
  • AP-1
  • c-Fos
  • c-Jun
  • CREB
  • deltaCREB
  • FOXD3
  • MEF-2A
  • Nkx2-5
  • Olf-1

Genomic Locations for PKN2 Gene

Genomic Locations for PKN2 Gene
chr1:88,684,193-88,836,255
(GRCh38/hg38)
Size:
152,063 bases
Orientation:
Plus strand
chr1:89,149,905-89,301,938
(GRCh37/hg19)
Size:
152,034 bases
Orientation:
Plus strand

Genomic View for PKN2 Gene

Genes around PKN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKN2 Gene

Proteins for PKN2 Gene

  • Protein details for PKN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16513-PKN2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase N2
    Protein Accession:
    Q16513
    Secondary Accessions:
    • B4DQ21
    • B4DTP5
    • B4DVG1
    • D3DT24
    • Q08AF4
    • Q9H1W4

    Protein attributes for PKN2 Gene

    Size:
    984 amino acids
    Molecular mass:
    112035 Da
    Quaternary structure:
    • Interacts (via the REM repeats) with RHOA (GTP-bound form preferentially) and interacts (via the REM repeats) with RAC1 (GTP-bound form preferentially); the interactions induce its autophosphorylation (PubMed:9121475, PubMed:20974804). Interacts with RHOC (PubMed:20974804). Interacts with NCK1 and NCK2 (PubMed:10026169). Interacts with NCK1 (via SH3 domains) (By similarity). Interacts with CD44 (PubMed:15123640). Interacts (via C-terminal kinase domain) with PDPK1; the interaction stimulates PDPK1 kinase activity (PubMed:10226025, PubMed:10792047, PubMed:11781095, PubMed:18835241). Interacts with MAP3K2; the interaction activates PRK2 kinase activity in a MAP3K2-independent kinase activity (PubMed:10818102). Interacts (via C-terminal domain) with AKT1; the interaction occurs with the C-terminal cleavage product of PRK2 in apoptotic cells (PubMed:10926925). Interacts (via C-terminus) with PTPN13 (via PDZ 3 domain) (PubMed:11356191). Interacts with CDK10 (PubMed:27104747).
    • (Microbial infection) Interacts with HCV NS5B (via N-terminal finger domain).

    Three dimensional structures from OCA and Proteopedia for PKN2 Gene

    Alternative splice isoforms for PKN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PKN2 Gene

Selected DME Specific Peptides for PKN2 Gene

Q16513:
  • ELKVKQGAENM
  • ESSQKLDLL
  • ACVVLGLQ
  • LQDSKTKI
  • AVAEGAKNV
  • TSTFCGTPEF
  • EFTSEAP
  • RAVDWWGLGV
  • LEDFLDN
  • AVLGRGHFGKVLL
  • LGVLIYEM
  • PVIERRP
  • FAIKALKK
  • YRDLKLDN
  • EELRHHF
  • YSTLSKPA
  • DFGLCKE
  • SNGSSKD
  • RDLKLDN

Post-translational modifications for PKN2 Gene

  • Autophosphorylated. Phosphorylated during mitosis. Phosphorylated by CDK10 (PubMed:27104747).
  • Activated by limited proteolysis with trypsin (By similarity). Proteolytically cleaved by caspase-3 during the induction of apoptotic cell death.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PKN2 Gene

Gene Families for PKN2 Gene

Suggested Antigen Peptide Sequences for PKN2 Gene

GenScript: Design optimal peptide antigens:
  • Protein-kinase C-related kinase 2 (PKN2_HUMAN)
  • PKN2 protein (Q08AF4_HUMAN)
  • Protein kinase N2 (Q5TBX5_HUMAN)
  • Protein kinase N2 (Q5TBX8_HUMAN)
  • PKN2 protein (Q6P5W9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16513

UniProtKB/Swiss-Prot:

PKN2_HUMAN :
  • The N-terminal regioninterferes with the interaction between AKT1 and the C-terminal regionof PKN2.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Domain:
  • The N-terminal regioninterferes with the interaction between AKT1 and the C-terminal regionof PKN2.
  • The C1 domain does not bind the diacylglycerol (DAG).
  • The apoptotic C-terminal cleavage product inhibits EGF-induced kinase activity of AKT1 phosphorylation at 'Thr-308' and 'Ser-473' sites, PDPK1 autophosphorylation and kinases PRKCD and PRKCZ phosphorylations.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PKN2: view

Function for PKN2 Gene

Molecular function for PKN2 Gene

UniProtKB/Swiss-Prot Function:
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Kinase activity is activated upon binding to GTP-bound Rhoa/Rac1 GTPases. Activated by caspase-3 (CASP3) cleavage during apoptosis. Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids. Two specific sites, Thr-816 (activation loop of the kinase domain) and Thr-958 (turn motif), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=15.83 uM for HDAC5 {ECO:0000269 PubMed:20188095};
UniProtKB/Swiss-Prot Induction:
Up-regulated during keratinocyte differentiation.

Enzyme Numbers (IUBMB) for PKN2 Gene

Phenotypes From GWAS Catalog for PKN2 Gene

Gene Ontology (GO) - Molecular Function for PKN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0004672 protein kinase activity TAS 7851406
GO:0004674 protein serine/threonine kinase activity IBA,IDA 20188095
GO:0004697 protein kinase C activity IEA --
GO:0005515 protein binding IPI 10026169
genes like me logo Genes that share ontologies with PKN2: view
genes like me logo Genes that share phenotypes with PKN2: view

Animal Models for PKN2 Gene

MGI Knock Outs for PKN2:
  • Pkn2 Pkn2<tm1a(KOMP)Wtsi>
  • Pkn2 Pkn2<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for PKN2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PKN2 Gene

Localization for PKN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PKN2 Gene

Cytoplasm. Nucleus. Membrane. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Cell junction. Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm. {ECO:0000269 PubMed:11356191, ECO:0000269 PubMed:17332740}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PKN2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 4
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (3)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PKN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 11356191
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 17332740
GO:0005813 centrosome IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PKN2: view

Pathways & Interactions for PKN2 Gene

genes like me logo Genes that share pathways with PKN2: view

Pathways by source for PKN2 Gene

1 BioSystems pathway for PKN2 Gene
2 Cell Signaling Technology pathways for PKN2 Gene

SIGNOR curated interactions for PKN2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PKN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 17332740
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS 7851406
genes like me logo Genes that share ontologies with PKN2: view

Drugs & Compounds for PKN2 Gene

(6) Drugs for PKN2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Ingenol mebutate Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
[Ser25] Protein Kinase C (19-31) Pharma PKC substrate 0
sophoretin Pharma inhibitor Kinase Inhibitors 0

(1) Additional Compounds for PKN2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(1) ApexBio Compounds for PKN2 Gene

Compound Action Cas Number
[Ser25] Protein Kinase C (19-31) PKC substrate 136795-05-6
genes like me logo Genes that share compounds with PKN2: view

Drug Products

Transcripts for PKN2 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for PKN2

Alternative Splicing Database (ASD) splice patterns (SP) for PKN2 Gene

No ASD Table

Relevant External Links for PKN2 Gene

GeneLoc Exon Structure for
PKN2
ECgene alternative splicing isoforms for
PKN2

Expression for PKN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PKN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PKN2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (22.3) and Lung (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PKN2 Gene



Protein tissue co-expression partners for PKN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PKN2 Gene:

PKN2

SOURCE GeneReport for Unigene cluster for PKN2 Gene:

Hs.440833

mRNA Expression by UniProt/SwissProt for PKN2 Gene:

Q16513-PKN2_HUMAN
Tissue specificity: Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells.

Evidence on tissue expression from TISSUES for PKN2 Gene

  • Spleen(4.3)
  • Liver(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with PKN2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PKN2 Gene

Orthologs for PKN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PKN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PKN2 33 32
  • 99.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PKN2 33 32
  • 94.97 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PKN2 33 32
  • 94.8 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PKN2 33
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pkn2 32
  • 90.71 (n)
mouse
(Mus musculus)
Mammalia Pkn2 17 33 32
  • 90.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PKN2 33
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves PKN2 33 32
  • 84.37 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PKN2 33
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pkn2 32
  • 77.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21437 32
zebrafish
(Danio rerio)
Actinopterygii PKN2 (2 of 2) 33
  • 76 (a)
OneToMany
pkn2 33 32
  • 70.11 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007587 32
  • 56.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pkn 33 32
  • 56.21 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pkn-1 33 32
  • 49.44 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 33
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 44 (a)
OneToMany
Cin.7005 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7005 32
Species where no ortholog for PKN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PKN2 Gene

ENSEMBL:
Gene Tree for PKN2 (if available)
TreeFam:
Gene Tree for PKN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PKN2: view image

Paralogs for PKN2 Gene

genes like me logo Genes that share paralogs with PKN2: view

Variants for PKN2 Gene

Sequence variations from dbSNP and Humsavar for PKN2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000032077 -- 88,734,764(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000078927 -- 88,786,312(+) A/G intron_variant
rs1000132576 -- 88,794,902(+) C/T intron_variant
rs1000143057 -- 88,782,128(+) C/T intron_variant
rs1000153114 -- 88,825,152(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PKN2 Gene

Variant ID Type Subtype PubMed ID
dgv22n27 CNV gain 19166990
dgv359n54 CNV gain 21841781
dgv360n54 CNV gain 21841781
esv2665922 CNV deletion 23128226
esv3306396 CNV mobile element insertion 20981092
esv3307993 CNV mobile element insertion 20981092
esv3308381 CNV mobile element insertion 20981092
esv3340558 CNV insertion 20981092
esv3403767 CNV insertion 20981092
esv3428030 CNV insertion 20981092
esv3450284 CNV insertion 20981092
esv3586738 CNV loss 21293372
esv3586743 CNV loss 21293372
esv3586744 CNV loss 21293372
esv3586745 CNV gain 21293372
esv3586746 CNV loss 21293372
nsv1113147 CNV deletion 24896259
nsv1122376 CNV deletion 24896259
nsv462450 CNV gain 19166990
nsv546773 CNV loss 21841781
nsv546781 CNV gain 21841781
nsv830514 CNV loss 17160897
nsv830525 CNV loss 17160897
nsv830537 CNV gain 17160897
nsv946053 CNV duplication 23825009

Variation tolerance for PKN2 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PKN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PKN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKN2 Gene

Disorders for PKN2 Gene

Additional Disease Information for PKN2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PKN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PKN2 Gene

Publications for PKN2 Gene

  1. Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family. (PMID: 7851406) Palmer RH … Parker PJ (European journal of biochemistry 1995) 2 3 4 23 56
  2. Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases. (PMID: 20188095) Harrison BC … McKinsey TA (FEBS letters 2010) 3 4 23 56
  3. The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner. (PMID: 18835241) Lim WG … Duan W (Archives of biochemistry and biophysics 2008) 3 4 23 56
  4. Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck. (PMID: 10026169) Braverman LE … Quilliam LA (The Journal of biological chemistry 1999) 3 4 23 56
  5. Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy. (PMID: 9368003) Cryns VL … Yuan J (The Journal of biological chemistry 1997) 3 4 23 56

Products for PKN2 Gene

Sources for PKN2 Gene