Aliases for PKN1 Gene
Aliases for PKN1 Gene
External Ids for PKN1 Gene
- HGNC: 9405
- Entrez Gene: 5585
- Ensembl: ENSG00000123143
- OMIM: 601032
- UniProtKB: Q16512
Previous HGNC Symbols for PKN1 Gene
- PRKCL1
Previous GeneCards Identifiers for PKN1 Gene
- GC19P014400
- GC19P014544
- GC19P014121
Summaries for PKN1 Gene
-
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for PKN1 Gene
PKN1 (Protein Kinase N1) is a Protein Coding gene. Diseases associated with PKN1 include Paraneoplastic Cerebellar Degeneration. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and RhoA signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PKN2.
UniProtKB/Swiss-Prot for PKN1 Gene
-
PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates Ser-575, Ser-637 and Ser-669 of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of Thr-11 of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 Lys-9 (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates Thr-38 of PPP1R14A, Ser-159, Ser-163 and Ser-170 of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKN1 Gene
Genomics for PKN1 Gene
GeneHancer (GH) Regulatory Elements for PKN1 Gene
Promoters and enhancers for PKN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PKN1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PKN1 gene promoter:
Regulatory Element Products
Genomic Locations for PKN1 Gene
Genomic Locations for PKN1 Gene
- chr19:14,433,053-14,471,867
- (GRCh38/hg38)
- Size:
- 38,815 bases
- Orientation:
- Plus strand
- chr19:14,543,865-14,582,679
- (GRCh37/hg19)
Genomic View for PKN1 Gene
Genes around PKN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.12 by Ensembl
- 19p13.12 by Entrez Gene
- 19p13.12 by HGNC
PKN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PKN1 Gene
Proteins for PKN1 Gene
-
Protein details for PKN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16512-PKN1_HUMAN
- Recommended name:
- Serine/threonine-protein kinase N1
- Protein Accession:
- Q16512
- A8K7W5
- B2R9R4
- B3KVN3
- Q15143
- Q504U4
- Q8IUV5
- Q9UD44
Protein attributes for PKN1 Gene
- Size:
- 942 amino acids
- Molecular mass:
- 103932 Da
- Quaternary structure:
-
- Interacts with ZFAND6 (By similarity). Interacts with ANDR (PubMed:12514133). Interacts with PRKCB (PubMed:20228790). Interacts (via REM 1 and REM 2 repeats) with RAC1 (PubMed:14514689, PubMed:18006505). Interacts (via REM 1 repeat) with RHOA (PubMed:10619026, PubMed:8571126). Interacts with RHOB (PubMed:9478917). Interacts (via C-terminus) with PDPK1 (PubMed:10792047). Interacts with CCNT2; enhances MYOD1-dependent transcription (PubMed:16331689). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381).
- (Microbial infection) Interacts (via the second REM repeat) with S.typhimurium E3 ubiquitin-protein ligase SspH1 (via the leucine-rich repeat region) (PubMed:16611232, PubMed:24248594).
Three dimensional structures from OCA and Proteopedia for PKN1 Gene
Protein Expression for PKN1 Gene
Selected DME Specific Peptides for PKN1 Gene
- Q16512:
-
- ELKVKQGAENM
- ACVVLGLQ
- LQDSKTKI
- AVAEGAKNV
- TSTFCGTPEF
- RAVDWWGLGV
- LEDFLDN
- GVLLYEM
- AVLGRGHFGKVLL
- FAIKALKK
- YRDLKLDN
- LTDTSYT
- EELRHHF
- DFGLCKE
- LERARELE
- RDLKLDN
Post-translational modifications for PKN1 Gene
- (Microbial infection) In case of infection, polyubiquitinated by the bacterial E3 ubiquitin-protein ligase SspH1, leading to its proteasomal degradation.
- Activated by limited proteolysis with trypsin.
- Autophosphorylated; preferably on serine. Phosphorylated during mitosis.
- Ubiquitination at Lys263
- Modification sites at PhosphoSitePlus
Other Protein References for PKN1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PKN1 (PKN1)
-
Custom Antibody ServicesOriGene Antibodies for PKN1
- Novus Biologicals Antibodies for PKN1
-
Cloud-Clone Corp. Antibodies for PKN1
- Invitrogen Antibodies for PKN1
- Search GeneTex for Antibodies for PKN1
Protein Products
-
OriGene Purified Proteins for PKN1
- Search Origene for MassSpec and Protein Over-expression Lysates for PKN1
- Origene Custom Protein Services for PKN1
-
Cloud-Clone Corp. Proteins for PKN1
- Search GeneTex for Proteins for PKN1
-
Abcam proteins for PKN1
Assay Products
-
Cloud-Clone Corp. Assay Kits for PKN1
Domains & Families for PKN1 Gene
Gene Families for PKN1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PKN1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PKN1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q16512UniProtKB/Swiss-Prot:
PKN1_HUMAN :- The C1 domain does not bind the diacylglycerol (DAG).
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
- Domain:
-
- The C1 domain does not bind the diacylglycerol (DAG).
- Family:
-
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Function for PKN1 Gene
Molecular function for PKN1 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=20.6 uM for HDAC5 {ECO:0000269 PubMed:20188095};
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Kinase activity is activated upon binding to Rho proteins (RHOA, RHOB and RAC1). Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids. Activated by caspase-3 (CASP3) cleavage during apoptosis. Two specific sites, Thr-774 (activation loop of the kinase domain) and Ser-916 (turn motif), need to be phosphorylated for its full activation.
- UniProtKB/Swiss-Prot Function:
- PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates Ser-575, Ser-637 and Ser-669 of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of Thr-11 of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 Lys-9 (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates Thr-38 of PPP1R14A, Ser-159, Ser-163 and Ser-170 of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.
Enzyme Numbers (IUBMB) for PKN1 Gene
Phenotypes From GWAS Catalog for PKN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IDA | 18066052 |
| GO:0004672 | protein kinase activity | IEA,TAS | 8135837 |
| GO:0004674 | protein serine/threonine kinase activity | TAS,IEA | -- |
| GO:0004697 | protein kinase C activity | IEA | -- |
| GO:0005080 | protein kinase C binding | IPI | 20228790 |
Phenotypes for PKN1 Gene
- MGI mutant phenotypes for PKN1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PKN1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased shRNA abundance
- Increased cell death HMECs cells
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Decreased viability after gemcitabine stimulation
Animal Model Products
-
Taconic Biosciences Mouse Models for PKN1
- Cyagen custom Knockout/knockin (KOKI) mouse models for PKN1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PKN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PKN1 gene
- Search ViGene Biosciences for PKN1
CRISPR Products
-
OriGene CRISPR knockouts for PKN1
- genomics-online: gRNA clones - Search results for 102 available PKN1 gene related products
- Overview of 102 available PKN1 gene related products
- Applied Biological Materials CRISPR for PKN1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PKN1
- GenScript: Design CRISPR guide RNA sequences for PKN1
miRNA for PKN1 Gene
- miRTarBase miRNAs that target PKN1
miRNA Products
- Search ViGene Biosciences for PKN1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PKN1
- Browse OriGene Inhibitory RNA Products For PKN1
- genomics-online: shRNA clones - Search results for 102 available PKN1 gene related products
- Overview of 102 available PKN1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PKN1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PKN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PKN1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PKN1
- Applied Biological Materials Clones for PKN1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PKN1
-
ViGene Biosciences adenoviral particle packaged cDNA for PKN1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PKN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PKN1 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PKN1 Gene
Localization for PKN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PKN1 Gene
- Cytoplasm. Nucleus. Endosome. Cell membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. {ECO:0000250 UniProtKB:Q63433, ECO:0000269 PubMed:17332740}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| endosome | 5 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
- Cytosol (3)
- Nuclear bodies (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 12514133 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 12514133 |
| GO:0005768 | endosome | IDA,IEA | 9478917 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PKN1 Gene
Pathways by source for PKN1 Gene
1 GeneTex pathway for PKN1 Gene
5 BioSystems pathways for PKN1 Gene
5 Reactome pathways for PKN1 Gene
2 KEGG pathways for PKN1 Gene
4 GeneGo (Thomson Reuters) pathways for PKN1 Gene
2 Qiagen pathways for PKN1 Gene
1 Cell Signaling Technology pathway for PKN1 Gene
Interacting Proteins for PKN1 Gene
Selected Interacting proteins:
ENSP00000343325
Q16512-PKN1_HUMAN
for PKN1 Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for PKN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001782 | B cell homeostasis | IEA | -- |
| GO:0001783 | B cell apoptotic process | IEA | -- |
| GO:0001933 | negative regulation of protein phosphorylation | IEA | -- |
| GO:0002634 | regulation of germinal center formation | IEA | -- |
| GO:0002637 | regulation of immunoglobulin production | IEA | -- |
Drugs & Compounds for PKN1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(1) ApexBio Compounds for PKN1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| [Ser25] Protein Kinase C (19-31) | PKC substrate | 136795-05-6 |
Transcripts for PKN1 Gene
mRNA/cDNA for PKN1 Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (509) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PKN1
- genomics-online: gRNA clones - Search results for 102 available PKN1 gene related products
- Overview of 102 available PKN1 gene related products
- Applied Biological Materials CRISPR for PKN1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PKN1
- GenScript: Design CRISPR guide RNA sequences for PKN1
miRNA Products
- Search ViGene Biosciences for PKN1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PKN1
- Browse OriGene Inhibitory RNA Products For PKN1
- genomics-online: shRNA clones - Search results for 102 available PKN1 gene related products
- Overview of 102 available PKN1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PKN1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PKN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PKN1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PKN1
- Applied Biological Materials Clones for PKN1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | · | 23c | ^ | 24a | · | 24b | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||
| SP11: | - | ||||||||||||||||||||||||||||
| SP12: |
Expression for PKN1 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (14.9) and Lymph node (13.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PKN1 Gene
NURSA nuclear receptor signaling pathways regulating expression of PKN1 Gene:
PKN1SOURCE GeneReport for Unigene cluster for PKN1 Gene:
Hs.466044mRNA Expression by UniProt/SwissProt for PKN1 Gene:
Q16512-PKN1_HUMAN
Tissue specificity:
Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells.
Evidence on tissue expression from TISSUES for PKN1 Gene
- Nervous system(4.8)
- Kidney(4.5)
- Liver(4.3)
- Muscle(2.9)
- Lung(2.7)
- Heart(2.3)
- Eye(2.1)
Primer Products
-
OriGene qPCR primer pairs for PKN1
-
OriGene qPCR primer pairs and template standards for PKN1
- genomics-online: primer clones - Search results for 102 available PKN1 gene related products
- Overview of 102 available PKN1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PKN1 Gene
Orthologs for PKN1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PKN1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PKN1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PKN1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Pkn1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Pkn1 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PKN1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PKN1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PKN1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.15460 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pkn1 34 |
|
OneToMany | |
| LOC560840 33 |
|
||||
| PKN1 (2 of 2) 34 |
|
OneToMany | |||
| Dr.16985 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Pkn 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | pkn-1 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PKC1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for PKN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PKN1 Gene
Paralogs for PKN1 Gene
(128) SIMAP similar genes for PKN1 Gene using alignment to 7 proteins:
- EML2
- IDNK
- PACSIN2
- PLA2G6
- RNF217
- ZNF546
- WARS
- LINC00269
- CHID1
- TMEM44
- APOD
- ZNF738
- ZNF670
- ZNF564
- TMEM14B
- NF2
- FAM175A
- DCTN5
- ZNF737
- ZNF547
- ZNF283
- PLA2G15
- B3GALNT1
- ZNF28
- PKN2
- ZNF212
- PMS2P10
- LINC00596
- FP6651
- AURA2
- AGBL3
- MARK4
- SLC35E3
- DNMT1
- SPATS2L
- HECW1
- FAM3A
- TNFRSF17
- KIAA1651
- ZNF763
- USP10
- LYRM4
- CASP7
- ZNF83
- PRKCZ
- PHKG2
- AKT3
- ZNF468
- NSRP1
- HMGA2
- GOSR2
- UTY
- OK/SW-cl.41
- GVQW1
- AKT2
- AKT1
- PRKCH
- TSEN2
- DNAPTP3
- ARL13B
- PRKCE
- ZNF20
- SEPT2
- QRICH2
- GLT8D2
- RPS6KA2
- PKN3
- TCF4
- STK38L
- SHANK2
- RPS6KA1
- RPS6KA3
- TMEM135
- STK32A
- SGK3
- SGK2
- PRKCB
- PLEKHH2
- CTSS
- MARK2
- RPS6KB1
- RPS6KA5
- PRKCQ
- PRKCD
- PRKACG
- NRAMP1
- MAPK3
- LEPROTL1
- PRKCI
- C4orf22
- PRKACA
- ZNF74
- PRKX
- PRKD1
- POMZP3
- MED15
- CIT
- KIN27
- STK36
- SGK1
- RPS6KB2
- CDK4
- PRKACB
- PRKY
- SPAG11B
- SPAG11A
- PRKCG
- HUNK
- PRKAA1
- TMSB15B
- DKFZp564L2416
- APCDD1
- STK32B
- SNX31
- AURKC
- ZNF816
- STK25
- PDPK1
- NEK9
- CAMK1D
- BRSK2
- STK11
- FKBP3
- X-linked retinopathy protein
- MAP4K5
- CHEK1
- AURKB
- Plk-1 delta
Variants for PKN1 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs267605306 | A metastatic melanoma sample | 14,446,504(+) | C/G/T | coding_sequence_variant, missense_variant | |
| VAR_042344 | A breast infiltrating ductal carcinoma sample | p.Phe873Leu | |||
| VAR_042345 | A colorectal adenocarcinoma sample | p.Ala921Val | |||
| rs1000050050 | -- | 14,470,052(+) | G/A | intron_variant | |
| rs1000065077 | -- | 14,467,321(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1989e59 | CNV | duplication | 20981092 |
| nsv1136279 | CNV | deletion | 24896259 |
| nsv1144865 | CNV | deletion | 24896259 |
| nsv1160590 | CNV | deletion | 26073780 |
| nsv470127 | CNV | loss | 18288195 |
| nsv527867 | CNV | loss | 19592680 |
| nsv817814 | CNV | loss | 17921354 |
| nsv828456 | CNV | loss | 20364138 |
| nsv828457 | CNV | gain | 20364138 |
| nsv833764 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.62;
91.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PKN1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PKN1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKN1 Gene
Disorders for PKN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| paraneoplastic cerebellar degeneration |
|
|
Search PKN1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PKN1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PKN1 Gene
Publications for PKN1 Gene
- Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases. (PMID: 20188095) Harrison BC … McKinsey TA (FEBS letters 2010) 3 4 22 58
- The Rac1 polybasic region is required for interaction with its effector PRK1. (PMID: 18006505) Modha R … Mott HR (The Journal of biological chemistry 2008) 3 4 22 58
- A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer. (PMID: 12514133) Metzger E … Schüle R (The EMBO journal 2003) 3 4 22 58
- Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1). (PMID: 14514689) Owen D … Mott HR (The Journal of biological chemistry 2003) 3 4 22 58
- Biochemical and crystallographic characterization of a Rho effector domain of the protein serine/threonine kinase N in a complex with RhoA. (PMID: 10388627) Maesaki R … Hakoshima T (Journal of structural biology 1999) 3 4 22 58
Products for PKN1 Gene
- R&D Systems Antibodies for PKN1 (PKN1)
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- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PKN1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PKN1
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- Origene Custom Protein Services for PKN1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PKN1
- Browse OriGene Inhibitory RNA Products For PKN1
- OriGene qPCR primer pairs and template standards for PKN1
- OriGene qPCR primer pairs for PKN1
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- OriGene ORF clones in human for PKN1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Design CRISPR guide RNA sequences for PKN1
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- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for PKN1
- Novus Biologicals lysates and proteins for PKN1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for PKN1
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for PKN1
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- Browse Knockouts at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for PKN1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PKN1
- ApexBio compounds for PKN1
- Cyagen custom Knockout/knockin (KOKI) mouse models for PKN1
- VectorBuilder custom plasmid, inducible vectors for PKN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PKN1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PKN1
- antibodies-online: Search results for 37 available PKN1 Antibodies ranked by validation data
- Compare Top PKN1 Antibodies
- antibodies-online: Search results for 27 available PKN1 Elisa Kits ranked by validation data
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- antibodies-online: Search results for 11 available PKN1 Proteins ranked by validation data
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- Quality Products:
- Search GeneTex for Antibodies for PKN1
- Search GeneTex for Proteins for PKN1
- ViGene Biosciences adenoviral particle packaged cDNA for PKN1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PKN1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PKN1 gene
- Search ViGene Biosciences for PKN1
- Search Santa Cruz Biotechnology (SCBT) for PKN1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PKN1
- Horizon Cell Lines for PKN1
- genomics-online: cdna clones - Search results for 102 available PKN1 gene related products
- Overview of 102 available PKN1 gene related products
- orf clones - Search results for 102 available PKN1 gene related products
- Overview of 102 available PKN1 gene related products
- genomics-online: gRNA clones - Search results for 102 available PKN1 gene related products
- Overview of 102 available PKN1 gene related products
- genomics-online: primer clones - Search results for 102 available PKN1 gene related products
- Overview of 102 available PKN1 gene related products
- genomics-online: shRNA clones - Search results for 102 available PKN1 gene related products
- Overview of 102 available PKN1 gene related products
Sources for PKN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
