PKN1 Gene (Protein Coding)

Protein Kinase N1

GC19P014433
GIFtS:
48
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may m... See more...

Aliases for PKN1 Gene

Aliases for PKN1 Gene

  • Protein Kinase N1 2 3 5
  • Protein Kinase C-Like 1 2 3 4
  • Serine/Threonine-Protein Kinase N1 3 4
  • Protease-Activated Kinase 1 3 4
  • Protein Kinase C-Like PKN 3 4
  • Protein Kinase PKN-Alpha 3 4
  • EC 2.7.11.13 4 52
  • PRKCL1 3 4
  • PAK-1 3 4
  • PAK1 3 4
  • PRK1 3 4
  • PKN 3 4
  • Protein Kinase C-Related Kinase 1 3
  • Serine/Threonine Protein Kinase N 3
  • Protein-Kinase C-Related Kinase 1 4
  • Serine-Threonine Protein Kinase N 4
  • Serine-Threonine Kinase N 3
  • PKN-ALPHA 3
  • EC 2.7.11 52
  • DBK 3

External Ids for PKN1 Gene

Previous HGNC Symbols for PKN1 Gene

  • PRKCL1

Previous GeneCards Identifiers for PKN1 Gene

  • GC19P014400
  • GC19P014406
  • GC19P014544
  • GC19P014121

Summaries for PKN1 Gene

Entrez Gene Summary for PKN1 Gene

  • The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for PKN1 Gene

PKN1 (Protein Kinase N1) is a Protein Coding gene. Diseases associated with PKN1 include Bubonic Plague. Among its related pathways are G-protein signaling_RhoA regulation pathway and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PKN2.

UniProtKB/Swiss-Prot Summary for PKN1 Gene

  • PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.

Gene Wiki entry for PKN1 Gene

Additional gene information for PKN1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PKN1 Gene

Genomics for PKN1 Gene

GeneHancer (GH) Regulatory Elements for PKN1 Gene

Promoters and enhancers for PKN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PKN1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PKN1

Top Transcription factor binding sites by QIAGEN in the PKN1 gene promoter:
  • c-Myc
  • NF-kappaB1
  • RelA

Genomic Locations for PKN1 Gene

Genomic Locations for PKN1 Gene
chr19:14,433,053-14,471,867
(GRCh38/hg38)
Size:
38,815 bases
Orientation:
Plus strand
chr19:14,543,865-14,582,679
(GRCh37/hg19)
Size:
38,815 bases
Orientation:
Plus strand

Genomic View for PKN1 Gene

Genes around PKN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKN1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PKN1 Gene

Proteins for PKN1 Gene

Products:

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  • Protein details for PKN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16512-PKN1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase N1
    Protein Accession:
    Q16512
    Secondary Accessions:
    • A8K7W5
    • B2R9R4
    • B3KVN3
    • Q15143
    • Q504U4
    • Q8IUV5
    • Q9UD44

    Protein attributes for PKN1 Gene

    Size:
    942 amino acids
    Molecular mass:
    103932 Da
    Quaternary structure:
    • Interacts with ZFAND6 (By similarity). Interacts with ANDR (PubMed:12514133). Interacts with PRKCB (PubMed:20228790). Interacts (via REM 1 and REM 2 repeats) with RAC1 (PubMed:14514689, PubMed:18006505). Interacts (via REM 1 repeat) with RHOA (PubMed:10619026, PubMed:8571126). Interacts with RHOB (PubMed:9478917). Interacts (via C-terminus) with PDPK1 (PubMed:10792047). Interacts with CCNT2; enhances MYOD1-dependent transcription (PubMed:16331689). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381).
    • (Microbial infection) Interacts (via the second REM repeat) with S.typhimurium E3 ubiquitin-protein ligase SspH1 (via the leucine-rich repeat region) (PubMed:16611232, PubMed:24248594).

    Three dimensional structures from OCA and Proteopedia for PKN1 Gene

    Alternative splice isoforms for PKN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PKN1 Gene

Protein Expression for PKN1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PKN1 Gene

Q16512:
  • ELKVKQGAENM
  • ACVVLGLQ
  • LQDSKTKI
  • AVAEGAKNV
  • TSTFCGTPEF
  • RAVDWWGLGV
  • LEDFLDN
  • GVLLYEM
  • AVLGRGHFGKVLL
  • FAIKALKK
  • YRDLKLDN
  • LTDTSYT
  • EELRHHF
  • DFGLCKE
  • LERARELE
  • RDLKLDN

Post-translational modifications for PKN1 Gene

  • Autophosphorylated; preferably on serine. Phosphorylated during mitosis.
  • Activated by limited proteolysis with trypsin.
  • (Microbial infection) In case of infection, polyubiquitinated by the bacterial E3 ubiquitin-protein ligase SspH1, leading to its proteasomal degradation.
  • Glycosylation at Asn154
  • Ubiquitination at Lys263
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for PKN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PKN1 Gene

Gene Families for PKN1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PKN1 Gene

Blocks:
  • C2 domain
  • Protein kinase C-terminal domain
  • Protein kinase PKN/PRK1, effector
  • PKN/rhophilin/rhotekin rho-binding repeat
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PKN1 Gene

GenScript: Design optimal peptide antigens:
  • Serine-threonine protein kinase N (PKN1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16512

UniProtKB/Swiss-Prot:

PKN1_HUMAN :
  • The C1 domain does not bind the diacylglycerol (DAG).
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Domain:
  • The C1 domain does not bind the diacylglycerol (DAG).
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PKN1: view

Function for PKN1 Gene

Products:

  1. Animal Model
  2. CRISPR
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  5. Clone
  6. Cell Line

Molecular function for PKN1 Gene

UniProtKB/Swiss-Prot Function:
PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Kinase activity is activated upon binding to Rho proteins (RHOA, RHOB and RAC1). Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids. Activated by caspase-3 (CASP3) cleavage during apoptosis. Two specific sites, Thr-774 (activation loop of the kinase domain) and Ser-916 (turn motif), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=20.6 uM for HDAC5 {ECO:0000269 PubMed:20188095};

Enzyme Numbers (IUBMB) for PKN1 Gene

Phenotypes From GWAS Catalog for PKN1 Gene

Gene Ontology (GO) - Molecular Function for PKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 18066052
GO:0004672 protein kinase activity IEA,TAS 8135837
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0004697 protein kinase C activity IEA --
GO:0005080 protein kinase C binding IPI 20228790
genes like me logo Genes that share ontologies with PKN1: view
genes like me logo Genes that share phenotypes with PKN1: view

Animal Models for PKN1 Gene

MGI Knock Outs for PKN1:
  • Pkn1 Pkn1<tm1Ajmc>
  • Pkn1 Pkn1<tm1b(KOMP)Wtsi>
  • Pkn1 Pkn1<tm1Kik>

Animal Model Products

  • Taconic Biosciences Mouse Models for PKN1

CRISPR Products

miRNA for PKN1 Gene

miRTarBase miRNAs that target PKN1

Clone Products

  • Addgene plasmids for PKN1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PKN1 Gene

Localization for PKN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PKN1 Gene

Cytoplasm. Nucleus. Endosome. Cell membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. {ECO:0000250 UniProtKB:Q63433, ECO:0000269 PubMed:17332740}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PKN1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
endosome 5
cytosol 5
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12514133
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 12514133
GO:0005768 endosome IDA,IEA 9478917
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PKN1: view

Pathways & Interactions for PKN1 Gene

genes like me logo Genes that share pathways with PKN1: view

Pathways by source for PKN1 Gene

4 GeneGo (Thomson Reuters) pathways for PKN1 Gene
  • G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
  • G-protein signaling_RhoA regulation pathway
  • G-protein signaling_RhoB regulation pathway
  • Translation Translation regulation by Alpha-1 adrenergic receptors
2 Qiagen pathways for PKN1 Gene
  • Rho Family GTPases
  • RhoA Pathway
1 Cell Signaling Technology pathway for PKN1 Gene
1 GeneTex pathway for PKN1 Gene

SIGNOR curated interactions for PKN1 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis IEA --
GO:0001783 B cell apoptotic process IEA --
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0002634 regulation of germinal center formation IEA --
GO:0002637 regulation of immunoglobulin production IEA --
genes like me logo Genes that share ontologies with PKN1: view

Drugs & Compounds for PKN1 Gene

Products:

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(14) Drugs for PKN1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Ingenol mebutate Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
[Ser25] Protein Kinase C (19-31) Pharma PKC substrate 0
sophoretin Pharma inhibitor Kinase Inhibitors 0

(8) Additional Compounds for PKN1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(1) ApexBio Compounds for PKN1 Gene

Compound Action Cas Number
[Ser25] Protein Kinase C (19-31) PKC substrate 136795-05-6
genes like me logo Genes that share compounds with PKN1: view

Drug Products

Transcripts for PKN1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PKN1 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for PKN1

Alternative Splicing Database (ASD) splice patterns (SP) for PKN1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - -
SP2: - -
SP3: - - - -
SP4:
SP5: - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - -
SP9:
SP10: - - -
SP11:
SP12:

ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:

Relevant External Links for PKN1 Gene

GeneLoc Exon Structure for
PKN1

Expression for PKN1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PKN1 Gene

mRNA expression in normal human tissues for PKN1 Gene
mRNA expression by BioGPS for PKN1 GenemRNA expression by GTEx for PKN1 Gene

Protein differential expression in normal tissues from HIPED for PKN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.9) and Lymph node (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PKN1 Gene



Protein tissue co-expression partners for PKN1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PKN1

SOURCE GeneReport for Unigene cluster for PKN1 Gene:

Hs.466044

mRNA Expression by UniProt/SwissProt for PKN1 Gene:

Q16512-PKN1_HUMAN
Tissue specificity: Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells.

Evidence on tissue expression from TISSUES for PKN1 Gene

  • Nervous system(4.8)
  • Kidney(4.5)
  • Liver(4.3)
  • Muscle(2.9)
  • Lung(2.7)
  • Heart(2.3)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with PKN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PKN1 Gene

Orthologs for PKN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PKN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PKN1 31 30
  • 98.41 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia PKN1 31 30
  • 90.2 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia PKN1 31 30
  • 89.77 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Pkn1 30
  • 85.58 (n)
mouse
(Mus musculus)
 Mammalia Pkn1 17 31 30
  • 85.48 (n)
oppossum
(Monodelphis domestica)
 Mammalia PKN1 31
  • 80 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia PKN1 31
  • 80 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia PKN1 31
  • 68 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia Str.15460 30
zebrafish
(Danio rerio)
 Actinopterygii pkn1 31
  • 66 (a)
 OneToMany
LOC560840 30
  • 65.79 (n)
PKN1 (2 of 2) 31
  • 62 (a)
 OneToMany
Dr.16985 30
fruit fly
(Drosophila melanogaster)
 Insecta Pkn 31
  • 34 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea pkn-1 31
  • 33 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PKC1 31
  • 23 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 39 (a)
 OneToMany
Species where no ortholog for PKN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PKN1 Gene

ENSEMBL:
Gene Tree for PKN1 (if available)
TreeFam:
Gene Tree for PKN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PKN1: view image

Paralogs for PKN1 Gene

Paralogs for PKN1 Gene

(128) SIMAP similar genes for PKN1 Gene using alignment to 7 proteins:

  • PKN1_HUMAN
  • K7EKY9_HUMAN
  • K7EL10_HUMAN
  • K7EM57_HUMAN
  • K7EN76_HUMAN
  • K7EPK3_HUMAN
  • K7ES10_HUMAN
genes like me logo Genes that share paralogs with PKN1: view

Variants for PKN1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PKN1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
718842 Benign: not provided 14,458,382(+) C/A INTRON_VARIANT
728835 Likely Benign: not provided 14,450,400(+) T/C SYNONYMOUS_VARIANT
770284 Likely Benign: not provided 14,450,910(+) A/. NO_SEQUENCE_ALTERATION
771514 Benign: not provided 14,464,085(+) C/A MISSENSE_VARIANT
774238 Benign: not provided 14,463,952(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PKN1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PKN1 Gene

Variant ID Type Subtype PubMed ID
dgv1989e59 CNV duplication 20981092
nsv1136279 CNV deletion 24896259
nsv1144865 CNV deletion 24896259
nsv1160590 CNV deletion 26073780
nsv470127 CNV loss 18288195
nsv527867 CNV loss 19592680
nsv817814 CNV loss 17921354
nsv828456 CNV loss 20364138
nsv828457 CNV gain 20364138
nsv833764 CNV loss 17160897

Variation tolerance for PKN1 Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.62; 91.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PKN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PKN1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKN1 Gene

Disorders for PKN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PKN1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bubonic plague
  • black death
- elite association - COSMIC cancer census association via MalaCards
Search PKN1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PKN1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PKN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PKN1 Gene

Publications for PKN1 Gene

  1. Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases. (PMID: 20188095) Harrison BC … McKinsey TA (FEBS letters 2010) 3 4 23 54
  2. The Rac1 polybasic region is required for interaction with its effector PRK1. (PMID: 18006505) Modha R … Mott HR (The Journal of biological chemistry 2008) 3 4 23 54
  3. A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer. (PMID: 12514133) Metzger E … Schüle R (The EMBO journal 2003) 3 4 23 54
  4. Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1). (PMID: 14514689) Owen D … Mott HR (The Journal of biological chemistry 2003) 3 4 23 54
  5. Biochemical and crystallographic characterization of a Rho effector domain of the protein serine/threonine kinase N in a complex with RhoA. (PMID: 10388627) Maesaki R … Hakoshima T (Journal of structural biology 1999) 3 4 23 54

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