Aliases for PKMYT1 Gene
External Ids for PKMYT1 Gene
Previous GeneCards Identifiers for PKMYT1 Gene
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for PKMYT1 Gene
PKMYT1 (Protein Kinase, Membrane Associated Tyrosine/Threonine 1) is a Protein Coding gene. Among its related pathways are Oocyte meiosis and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is WEE1.
UniProtKB/Swiss-Prot Summary for PKMYT1 Gene
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.