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This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]
PKM (Pyruvate Kinase M1/2) is a Protein Coding gene. Diseases associated with PKM include Pyruvate Kinase Deficiency Of Red Cells and Pontocerebellar Hypoplasia, Type 10. Among its related pathways are Glucose metabolism and Photodynamic therapy-induced HIF-1 survival signaling. Gene Ontology (GO) annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is PKLR.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | IEA | -- |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0003824 | catalytic activity | IEA | -- |
GO:0004743 | pyruvate kinase activity | IEA,TAS | 2040271 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IEA,IDA | 17308100 |
GO:0005737 | cytoplasm | IBA,IDA | 18298799 |
GO:0005739 | mitochondrion | HDA | 20833797 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glucose metabolism |
Glycolysis and gluconeogenesis (short map)
.58
.52
|
.01
|
2 | Innate Immune System |
.61
|
|
3 | Glucose / Energy Metabolism | ||
4 | Carbon metabolism | ||
5 | Metabolism |
.40
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001666 | response to hypoxia | IEA | -- |
GO:0001889 | liver development | IEA | -- |
GO:0006006 | glucose metabolic process | IEA | -- |
GO:0006096 | glycolytic process | IEA,IBA | 21873635 |
GO:0006754 | ATP biosynthetic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Pyruvic acid | Approved, Investigational | Nutra | Target | 0 | ||
Acyclovir | Approved | Pharma | Enzyme, substrate | 117 | ||
Copper | Approved, Investigational | Pharma | Target | 249 | ||
Carbon dioxide | Approved, Investigational, Vet_approved | Pharma | 0 | |||
Magnesium | Approved, Experimental, Investigational | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 | |||
dADP |
|
2793-06-8 |
|
|||
dGDP |
|
3493-09-2 |
|
|||
IDP |
|
86-04-4 |
|
|||
inosine triphosphate |
|
132-06-9 |
|
Compound | Action | Cas Number |
---|---|---|
DASA-58 | activator of pyruvate kinase M2 (PKM2) | 1203494-49-8 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||
SP2: | - | - | - | ||||||||||
SP3: | - | - | |||||||||||
SP4: | |||||||||||||
SP5: | - | - | - | ||||||||||
SP6: | |||||||||||||
SP7: | |||||||||||||
SP8: | |||||||||||||
SP9: | |||||||||||||
SP10: | |||||||||||||
SP11: | |||||||||||||
SP12: | |||||||||||||
SP13: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PKM 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PKM 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PKM2 31 |
|
OneToOne | |
PKM 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
PKM 30 |
|
||||
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Pkm 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Pkm 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | PKM 31 |
|
OneToOne | |
PKM2 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | PKM 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pkm 30 |
|
||
Str.373 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | pkma 30 31 |
|
OneToMany | |
pkmb 31 |
|
OneToMany | |||
pkm2 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7227 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | PyK 30 31 |
|
ManyToMany | |
CG2964 31 |
|
ManyToMany | |||
CG7069 31 |
|
ManyToMany | |||
CG7362 31 |
|
ManyToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004596 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | pyk-1 30 31 |
|
ManyToMany | |
pyk-2 31 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC19 30 31 33 |
|
ManyToMany | |
PYK2 31 |
|
ManyToMany | |||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F23397g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADR368W 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G63680 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1458 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os04g0677500 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pyk1 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU06075 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4710 30 |
|
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
718586 | Benign: not provided | 72,209,809(-) | C/T | SYNONYMOUS_VARIANT | |
730512 | Benign: not provided | 72,208,731(-) | C/T | SYNONYMOUS_VARIANT | |
745689 | Likely Benign: not provided | 72,208,758(-) | G/A | SYNONYMOUS_VARIANT | |
745784 | Likely Benign: not provided | 72,209,857(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
788588 | Benign: not provided | 72,208,850(-) | A/G | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
pyruvate kinase deficiency of red cells |
|
|
pontocerebellar hypoplasia, type 10 |
|
|
kernicterus |
|
|
pigmentation disease |
|
|
anterior dislocation of lens |
|
|