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This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]
PKM (Pyruvate Kinase M1/2) is a Protein Coding gene. Diseases associated with PKM include Pyruvate Kinase Deficiency Of Red Cells and Acute Diarrhea. Among its related pathways are Pyruvate metabolism and G-protein signaling G-Protein alpha-i signaling cascades. Gene Ontology (GO) annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is PKLR.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000287 | magnesium ion binding | IEA | -- |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0003824 | catalytic activity | IEA | -- |
GO:0004743 | pyruvate kinase activity | TAS,IEA | 2040271 |
GO:0005515 | protein binding | IPI | 12620389 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IEA,IDA | 17308100 |
GO:0005737 | cytoplasm | IDA,IBA | 18298799 |
GO:0005739 | mitochondrion | HDA | 20833797 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glucose metabolism |
.52
|
.01
|
2 | Innate Immune System |
.61
|
|
3 | Glucose / Energy Metabolism | ||
4 | Carbon metabolism | ||
5 | Metabolism |
.40
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001666 | response to hypoxia | IEA | -- |
GO:0001889 | liver development | IEA | -- |
GO:0006006 | glucose metabolic process | IEA | -- |
GO:0006096 | glycolytic process | IBA,IEA | 21873635 |
GO:0006754 | ATP biosynthetic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Pyruvic acid | Approved, Investigational | Nutra | Target | 0 | ||
Acyclovir | Approved | Pharma | Enzyme, substrate | 113 | ||
Copper | Approved, Investigational | Pharma | Target | 227 | ||
Carbon dioxide | Approved, Investigational, Vet_approved | Pharma | 0 | |||
Magnesium | Approved, Experimental, Investigational | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 | |||
dADP |
|
2793-06-8 |
|
|||
dGDP |
|
3493-09-2 |
|
|||
IDP |
|
86-04-4 |
|
|||
inosine triphosphate |
|
132-06-9 |
|
Compound | Action | Cas Number |
---|---|---|
DASA-58 | activator of pyruvate kinase M2 (PKM2) | 1203494-49-8 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||
SP2: | - | - | - | ||||||||||
SP3: | - | - | |||||||||||
SP4: | |||||||||||||
SP5: | - | - | - | ||||||||||
SP6: | |||||||||||||
SP7: | |||||||||||||
SP8: | |||||||||||||
SP9: | |||||||||||||
SP10: | |||||||||||||
SP11: | |||||||||||||
SP12: | |||||||||||||
SP13: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PKM 33 32 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | PKM 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | PKM2 33 |
|
OneToOne | |
PKM 32 |
|
||||
dog (Canis familiaris) |
Mammalia | -- 33 |
|
OneToMany | |
PKM 32 |
|
||||
-- 33 |
|
OneToMany | |||
rat (Rattus norvegicus) |
Mammalia | Pkm 32 |
|
||
mouse (Mus musculus) |
Mammalia | Pkm 17 33 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
-- 33 |
|
OneToMany | |||
chicken (Gallus gallus) |
Aves | PKM 33 |
|
OneToOne | |
PKM2 32 |
|
||||
lizard (Anolis carolinensis) |
Reptilia | PKM 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | pkm 32 |
|
||
Str.373 32 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | pkma 33 32 |
|
OneToMany | |
pkmb 33 |
|
OneToMany | |||
pkm2 32 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7227 32 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | PyK 33 32 |
|
ManyToMany | |
CG2964 33 |
|
ManyToMany | |||
CG7069 33 |
|
ManyToMany | |||
CG7362 33 |
|
ManyToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004596 32 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | pyk-1 33 32 |
|
ManyToMany | |
pyk-2 33 |
|
ManyToMany | |||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC19 35 33 32 |
|
||
PYK2 33 |
|
ManyToMany | |||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F23397g 32 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADR368W 32 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G63680 32 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1458 32 |
|
||
rice (Oryza sativa) |
Liliopsida | Os04g0677500 32 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany | |
Cin.4710 32 |
|
||||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pyk1 32 |
|
||
bread mold (Neurospora crassa) |
Ascomycetes | NCU06075 32 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4710 32 |
|
SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11558368 | likely-benign, not specified | 72,202,513(-) | G/A | coding_sequence_variant, intron_variant, non_coding_transcript_variant, synonymous_variant | |
rs879255367 | uncertain-significance, not specified | 72,208,664(-) | T/C | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs10514 | benign, not specified | 72,209,800(-) | G/A | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
rs1000107033 | -- | 72,209,197(-) | T/C | intron_variant | |
rs1000246117 | -- | 72,200,374(-) | G/A | intron_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
pyruvate kinase deficiency of red cells |
|
|
acute diarrhea |
|
|
pigmentation disease |
|
|
autosomal dominant non-syndromic intellectual disability 2 |
|
|
kernicterus |
|
|