This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. [provi... See more...

Aliases for PKIG Gene

Aliases for PKIG Gene

  • CAMP-Dependent Protein Kinase Inhibitor Gamma 2 3 4 5
  • Protein Kinase (CAMP-Dependent, Catalytic) Inhibitor Gamma 2 3
  • PKI-Gamma 3 4
  • PKIG 5

External Ids for PKIG Gene

Previous GeneCards Identifiers for PKIG Gene

  • GC20P042889
  • GC20P043798
  • GC20P043845
  • GC20P042593
  • GC20P043160
  • GC20P039901

Summaries for PKIG Gene

Entrez Gene Summary for PKIG Gene

  • This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PKIG Gene

PKIG (CAMP-Dependent Protein Kinase Inhibitor Gamma) is a Protein Coding gene. Diseases associated with PKIG include Theileriasis. Among its related pathways are Signal transduction_PKA signaling and Myometrial Relaxation and Contraction Pathways. Gene Ontology (GO) annotations related to this gene include cAMP-dependent protein kinase inhibitor activity. An important paralog of this gene is PKIA.

UniProtKB/Swiss-Prot Summary for PKIG Gene

  • Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Gene Wiki entry for PKIG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PKIG Gene

Genomics for PKIG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PKIG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J044530 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 256.5 +0.1 105 2.6 ZNF207 MYC ZNF600 SSRP1 JUND ZNF580 ZNF592 ZMYM3 KLF9 POLR2A PKIG OSER1 PIGT IFT52 SYS1 TTPAL AB372643-009 ADA
GH20J044578 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 255.6 +51.7 51716 9.9 BCLAF1 ZNF600 ATF2 POLR2A BCL11A ZNF592 TRIM22 NR2C1 KLF9 SP2 PKIG HSALNG0130328 TTPAL OSER1 HSALNG0130327 ADA
GH20J044640 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 +115.4 115352 12.9 BCLAF1 SP1 ZNF654 ZNF600 IKZF1 ZNF580 ZMYM3 ZNF10 ZIC2 NFIC ADA GDAP1L1 KCNK15 PKIG CCN5 SYS1 ENSG00000132832 OSER1 STK4 lnc-PKIG-5
GH20J044552 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 17.7 +21.3 21316 4.6 NCOR1 ZNF600 JUND FEZF1 ZNF639 TAF9B SMAD4 TAL1 RARA STAT3 PKIG SERINC3 ADA TTPAL AB372643-009
GH20J044493 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 17.5 -35.8 -35830 4.8 JUND CEBPA ATF3 CEBPB EP300 RXRA IRF4 EBF1 BATF HNF4A piR-52343 PKIG TTPAL SERINC3 RPL37AP1 LINC01430 LINC01620 OSER1 ADA STK4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PKIG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PKIG

Top Transcription factor binding sites by QIAGEN in the PKIG gene promoter:
  • AREB6
  • E2F
  • E2F-1
  • Elk-1
  • Ik-1
  • LCR-F1
  • LUN-1
  • MZF-1
  • Pax-4a

Genomic Locations for PKIG Gene

Latest Assembly
chr20:44,531,785-44,624,247
(GRCh38/hg38)
Size:
92,463 bases
Orientation:
Plus strand

Previous Assembly
chr20:43,160,516-43,247,678
(GRCh37/hg19 by Entrez Gene)
Size:
87,163 bases
Orientation:
Plus strand

chr20:43,160,426-43,252,888
(GRCh37/hg19 by Ensembl)
Size:
92,463 bases
Orientation:
Plus strand

Genomic View for PKIG Gene

Genes around PKIG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKIG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKIG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKIG Gene

Proteins for PKIG Gene

  • Protein details for PKIG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2B9-IPKG_HUMAN
    Recommended name:
    cAMP-dependent protein kinase inhibitor gamma
    Protein Accession:
    Q9Y2B9

    Protein attributes for PKIG Gene

    Size:
    76 amino acids
    Molecular mass:
    7910 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PKIG Gene

Post-translational modifications for PKIG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PKIG Gene

Domains & Families for PKIG Gene

Gene Families for PKIG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PKIG Gene

InterPro:
Blocks:
  • cAMP-dependent protein kinase inhibitor

Suggested Antigen Peptide Sequences for PKIG Gene

GenScript: Design optimal peptide antigens:
  • cAMP-dependent protein kinase inhibitor gamma (IPKG_HUMAN)
  • cDNA, FLJ92327, Homo sapiens protein kinase (cAMP-dependent, catalytic) inhibitor gamma (PKIG), mRNA (Q549H9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2B9

UniProtKB/Swiss-Prot:

IPKG_HUMAN :
  • Belongs to the PKI family.
Family:
  • Belongs to the PKI family.
genes like me logo Genes that share domains with PKIG: view

Function for PKIG Gene

Molecular function for PKIG Gene

UniProtKB/Swiss-Prot Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
GENATLAS Biochemistry:
cAMP dependent,protein kinase,catalytic (C subunit),inhibitor gamma,widely expressed with highest levels in heart,skeletal muscle and testis (in mouse),may be tightly linked to ADA,tail to tail as in the mouse

Phenotypes From GWAS Catalog for PKIG Gene

Gene Ontology (GO) - Molecular Function for PKIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IEA --
GO:0004862 cAMP-dependent protein kinase inhibitor activity TAS,IBA 21873635
GO:0005515 protein binding IPI 32296183
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with PKIG: view
genes like me logo Genes that share phenotypes with PKIG: view

Animal Models for PKIG Gene

MGI Knock Outs for PKIG:
  • Pkig Pkig<tm1b(EUCOMM)Hmgu>

miRNA for PKIG Gene

miRTarBase miRNAs that target PKIG

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PKIG

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PKIG Gene

Localization for PKIG Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PKIG gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PKIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with PKIG: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PKIG Gene

Pathways & Interactions for PKIG Gene

PathCards logo

SuperPathways for PKIG Gene

genes like me logo Genes that share pathways with PKIG: view

Pathways by source for PKIG Gene

1 GeneGo (Thomson Reuters) pathway for PKIG Gene
  • Signal transduction_PKA signaling
1 Qiagen pathway for PKIG Gene
  • cAMP Pathway

Gene Ontology (GO) - Biological Process for PKIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0007165 signal transduction IEA --
GO:0016310 phosphorylation IEA --
GO:0042308 negative regulation of protein import into nucleus IEA --
genes like me logo Genes that share ontologies with PKIG: view

No data available for SIGNOR curated interactions for PKIG Gene

Drugs & Compounds for PKIG Gene

(1) Drugs for PKIG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with PKIG: view

Transcripts for PKIG Gene

mRNA/cDNA for PKIG Gene

5 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PKIG

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for PKIG Gene

No ASD Table

Relevant External Links for PKIG Gene

GeneLoc Exon Structure for
PKIG

Expression for PKIG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PKIG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PKIG Gene

This gene is overexpressed in Heart (24.5), Fetal Brain (17.0), Uterus (6.8), and Prostate (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PKIG Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PKIG

SOURCE GeneReport for Unigene cluster for PKIG Gene:

Hs.472831

mRNA Expression by UniProt/SwissProt for PKIG Gene:

Q9Y2B9-IPKG_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PKIG Gene

  • Thyroid gland(4.4)
  • Nervous system(3.4)
  • Muscle(2.6)
  • Heart(2.5)
genes like me logo Genes that share expression patterns with PKIG: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PKIG Gene

Orthologs for PKIG Gene

This gene was present in the common ancestor of chordates.

Orthologs for PKIG Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia PKIG 29 30
  • 90.35 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pkig 29
  • 89.47 (n)
Cow
(Bos Taurus)
Mammalia PKIG 29 30
  • 89.04 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pkig 29 16 30
  • 88.16 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PKIG 30
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PKIG 30
  • 76 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PKIG 30
  • 56 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii pkig 30
  • 44 (a)
OneToOne
Species where no ortholog for PKIG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PKIG Gene

ENSEMBL:
Gene Tree for PKIG (if available)
TreeFam:
Gene Tree for PKIG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PKIG: view image
Alliance of Genome Resources:
Additional Orthologs for PKIG

Paralogs for PKIG Gene

Paralogs for PKIG Gene

(1) SIMAP similar genes for PKIG Gene using alignment to 3 proteins:

  • IPKG_HUMAN
  • Q549H9_HUMAN
  • Q5H937_HUMAN
genes like me logo Genes that share paralogs with PKIG: view

Variants for PKIG Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PKIG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PKIG Gene

Variant ID Type Subtype PubMed ID
nsv1061719 CNV gain 25217958

Variation tolerance for PKIG Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PKIG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PKIG
Leiden Open Variation Database (LOVD)
PKIG

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PKIG Gene

Disorders for PKIG Gene

MalaCards: The human disease database

(1) MalaCards diseases for PKIG Gene - From: COP

Disorder Aliases PubMed IDs
theileriasis
  • infection by theileria
- elite association - COSMIC cancer census association via MalaCards
Search PKIG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PKIG

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PKIG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PKIG Gene

Publications for PKIG Gene

  1. Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA. (PMID: 10880337) Zheng L … Zhao S (The Biochemical journal 2000) 2 3 4 22
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  3. Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation. (PMID: 16870489) Zhao L … Zhu T (The international journal of biochemistry & cell biology 2006) 3 22
  4. Vascular endothelial cells express isoforms of protein kinase A inhibitor. (PMID: 11742798) Lum H … Uhler MD (American journal of physiology. Cell physiology 2002) 3 22
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4

Products for PKIG Gene

Sources for PKIG Gene