The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] See more...

Aliases for PKIA Gene

Aliases for PKIA Gene

  • CAMP-Dependent Protein Kinase Inhibitor Alpha 2 3 4 5
  • CAMP-Dependent Protein Kinase Inhibitor, Muscle/Brain Isoform 3 4
  • Protein Kinase (CAMP-Dependent, Catalytic) Inhibitor Alpha 2 3
  • PKI-Alpha 3 4
  • PRKACN1 3 4
  • PKIA 5

External Ids for PKIA Gene

Previous HGNC Symbols for PKIA Gene

  • PRKACN1

Previous GeneCards Identifiers for PKIA Gene

  • GC08P079465
  • GC08P079152
  • GC08P079478
  • GC08P079590
  • GC08P074917

Summaries for PKIA Gene

Entrez Gene Summary for PKIA Gene

  • The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PKIA Gene

PKIA (CAMP-Dependent Protein Kinase Inhibitor Alpha) is a Protein Coding gene. Diseases associated with PKIA include Myositis Fibrosa. Among its related pathways are Signal transduction_PKA signaling and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include protein kinase A catalytic subunit binding and cAMP-dependent protein kinase inhibitor activity. An important paralog of this gene is PKIB.

UniProtKB/Swiss-Prot Summary for PKIA Gene

  • Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Gene Wiki entry for PKIA Gene

Additional gene information for PKIA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PKIA Gene

Genomics for PKIA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PKIA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J078515 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 606.5 +0.6 561 3.8 SP1 TEAD4 PRDM10 ZNF629 ZNF692 POLR2A BACH1 STAT3 LARP7 PRDM1 PKIA NONHSAG050570.2 ZC2HC1A ENSG00000260398 LOC105375911 PKIA-AS1
GH08J078591 Promoter 0.7 EPDnew Ensembl 610.5 +75.4 75351 1 PKIA ENSG00000260398 PKIA-AS1 ZC2HC1A LOC105375911 NONHSAG050570.2
GH08J078524 Enhancer 0.9 Ensembl ENCODE dbSUPER 57.7 +9.4 9361 3 FOXA1 RUNX3 GATA3 POLR2A JUNB JUND MAFK PRDM6 ATF2 JUN PKIA NONHSAG050570.2 ENSG00000260398 LOC105375911 PKIA-AS1 ZC2HC1A
GH08J078560 Enhancer 0.8 Ensembl ENCODE dbSUPER 56.2 +44.7 44661 2 JUND CEBPB RCOR1 MAFK GATA2 POLR2A PKIA NONHSAG050570.2 ENSG00000260398 LOC105375911 PKIA-AS1 ZC2HC1A
GH08J078535 Enhancer 0.7 Ensembl ENCODE dbSUPER 51.9 +19.1 19061 1.2 RUNX3 SPI1 PKIA NONHSAG050570.2 ENSG00000260398 LOC105375911 PKIA-AS1 ZC2HC1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PKIA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PKIA

Top Transcription factor binding sites by QIAGEN in the PKIA gene promoter:
  • FOXD3
  • FOXL1
  • GATA-1
  • GATA-2
  • GATA-3
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • Sox5

Genomic Locations for PKIA Gene

Genomic Locations for PKIA Gene
chr8:78,516,340-78,605,267
(GRCh38/hg38)
Size:
88,928 bases
Orientation:
Plus strand
chr8:79,428,336-79,517,502
(GRCh37/hg19)
Size:
89,167 bases
Orientation:
Plus strand

Genomic View for PKIA Gene

Genes around PKIA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKIA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKIA Gene

Proteins for PKIA Gene

  • Protein details for PKIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61925-IPKA_HUMAN
    Recommended name:
    cAMP-dependent protein kinase inhibitor alpha
    Protein Accession:
    P61925
    Secondary Accessions:
    • P04541
    • Q6IAV2

    Protein attributes for PKIA Gene

    Size:
    76 amino acids
    Molecular mass:
    7989 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and 'pseudosubstrate site' of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site.

    Three dimensional structures from OCA and Proteopedia for PKIA Gene

neXtProt entry for PKIA Gene

Post-translational modifications for PKIA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PKIA Gene

No data available for DME Specific Peptides for PKIA Gene

Domains & Families for PKIA Gene

Gene Families for PKIA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PKIA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PKIA Gene

GenScript: Design optimal peptide antigens:
  • cAMP-dependent protein kinase inhibitor, muscle/brain isoform (IPKA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61925

UniProtKB/Swiss-Prot:

IPKA_HUMAN :
  • Belongs to the PKI family.
Family:
  • Belongs to the PKI family.
genes like me logo Genes that share domains with PKIA: view

Function for PKIA Gene

Molecular function for PKIA Gene

UniProtKB/Swiss-Prot Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
GENATLAS Biochemistry:
protein kinase (CAMP-dependent,catalytic) inhibitor alpha,widely expressed,downregulated by CYP27B1

Phenotypes From GWAS Catalog for PKIA Gene

Gene Ontology (GO) - Molecular Function for PKIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IEA --
GO:0004862 cAMP-dependent protein kinase inhibitor activity IBA,TAS 1710219
GO:0005515 protein binding IPI 20485264
GO:0016301 kinase activity IEA --
GO:0034236 protein kinase A catalytic subunit binding IPI 21812984
genes like me logo Genes that share ontologies with PKIA: view
genes like me logo Genes that share phenotypes with PKIA: view

Animal Models for PKIA Gene

MGI Knock Outs for PKIA:
  • Pkia Pkia<tm1Idz>
  • Pkia Pkia<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for PKIA Gene

miRTarBase miRNAs that target PKIA

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PKIA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PKIA Gene

Localization for PKIA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PKIA gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PKIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with PKIA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PKIA Gene

Pathways & Interactions for PKIA Gene

genes like me logo Genes that share pathways with PKIA: view

Pathways by source for PKIA Gene

1 GeneGo (Thomson Reuters) pathway for PKIA Gene
  • Signal transduction_PKA signaling
1 Qiagen pathway for PKIA Gene
  • cAMP Pathway

SIGNOR curated interactions for PKIA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PKIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0010389 regulation of G2/M transition of mitotic cell cycle IEA --
GO:0016310 phosphorylation IEA --
GO:0042308 negative regulation of protein import into nucleus IEA --
genes like me logo Genes that share ontologies with PKIA: view

Drugs & Compounds for PKIA Gene

(31) Drugs for PKIA Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE Experimental Pharma Target 0
(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE Experimental Pharma Target 0
(2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine Experimental Pharma Target 0
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE Experimental Pharma Target 0
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PKIA: view

Transcripts for PKIA Gene

mRNA/cDNA for PKIA Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PKIA

Alternative Splicing Database (ASD) splice patterns (SP) for PKIA Gene

No ASD Table

Relevant External Links for PKIA Gene

GeneLoc Exon Structure for
PKIA

Expression for PKIA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PKIA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PKIA Gene

This gene is overexpressed in Muscle - Skeletal (x10.2), Brain - Nucleus accumbens (basal ganglia) (x4.2), and Heart - Left Ventricle (x4.0).

Protein differential expression in normal tissues from HIPED for PKIA Gene

This gene is overexpressed in Heart (48.3) and Fetal Brain (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PKIA Gene



Protein tissue co-expression partners for PKIA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PKIA

SOURCE GeneReport for Unigene cluster for PKIA Gene:

Hs.433700

Evidence on tissue expression from TISSUES for PKIA Gene

  • Muscle(4.6)
  • Nervous system(4.5)
  • Heart(3)
genes like me logo Genes that share expression patterns with PKIA: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PKIA Gene

Orthologs for PKIA Gene

This gene was present in the common ancestor of chordates.

Orthologs for PKIA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PKIA 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PKIA 30 31
  • 99.12 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PKIA 30 31
  • 97.37 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pkia 30
  • 94.3 (n)
Mouse
(Mus musculus)
Mammalia Pkia 30 17 31
  • 93.42 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PKIA 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PKIA 31
  • 25 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PKIA 30 31
  • 79.82 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PKIA 31
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pkia 30
  • 72.81 (n)
Species where no ortholog for PKIA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PKIA Gene

ENSEMBL:
Gene Tree for PKIA (if available)
TreeFam:
Gene Tree for PKIA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PKIA: view image

Paralogs for PKIA Gene

Paralogs for PKIA Gene

(2) SIMAP similar genes for PKIA Gene using alignment to 1 proteins:

  • IPKA_HUMAN
genes like me logo Genes that share paralogs with PKIA: view

Variants for PKIA Gene

Additional dbSNP identifiers (rs#s) for PKIA Gene

Structural Variations from Database of Genomic Variants (DGV) for PKIA Gene

Variant ID Type Subtype PubMed ID
esv1418655 CNV insertion 17803354
esv3617735 CNV loss 21293372
nsv1129809 CNV tandem duplication 24896259

Variation tolerance for PKIA Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PKIA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PKIA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PKIA Gene

Disorders for PKIA Gene

MalaCards: The human disease database

(1) MalaCards diseases for PKIA Gene - From: DISEASES

Disorder Aliases PubMed IDs
myositis fibrosa
  • interstitial myositis
- elite association - COSMIC cancer census association via MalaCards
Search PKIA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PKIA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PKIA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PKIA Gene

Publications for PKIA Gene

  1. Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor. (PMID: 1770951) Olsen SR … Uhler MD (Molecular endocrinology (Baltimore, Md.) 1991) 2 3 4
  2. A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample. (PMID: 20451256) Djurovic S … Andreassen OA (Journal of affective disorders 2010) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated. (PMID: 7836431) Wen W … Meinkoth JL (The Journal of biological chemistry 1995) 3 23
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for PKIA Gene

Sources for PKIA Gene