Aliases for PKIA Gene
External Ids for PKIA Gene
Previous HGNC Symbols for PKIA Gene
Previous GeneCards Identifiers for PKIA Gene
The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PKIA Gene
PKIA (CAMP-Dependent Protein Kinase Inhibitor Alpha) is a Protein Coding gene. Diseases associated with PKIA include Myositis Fibrosa. Among its related pathways are Signal transduction_PKA signaling and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include protein kinase A catalytic subunit binding and cAMP-dependent protein kinase inhibitor activity. An important paralog of this gene is PKIB.
UniProtKB/Swiss-Prot Summary for PKIA Gene
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.