Aliases for PKDCC Gene
External Ids for PKDCC Gene
Previous GeneCards Identifiers for PKDCC Gene
GeneCards Summary for PKDCC Gene
PKDCC (Protein Kinase Domain Containing, Cytoplasmic) is a Protein Coding gene. Diseases associated with PKDCC include Rhizomelic Limb Shortening With Dysmorphic Features. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is MAP3K7.
UniProtKB/Swiss-Prot Summary for PKDCC Gene
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).