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This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, and the reference... See more...
Aliases for PKD1L2 Gene
Aliases for PKD1L2 Gene
External Ids for PKD1L2 Gene
- HGNC: 21715
- NCBI Entrez Gene: 114780
- Ensembl: ENSG00000166473
- OMIM®: 607894
- UniProtKB/Swiss-Prot: Q7Z442
Previous GeneCards Identifiers for PKD1L2 Gene
- GC16M080885
- GC16M080914
- GC16M079691
- GC16M081135
- GC16M066891
Summaries for PKD1L2 Gene
-
This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, and the reference genome encodes a non-functional allele. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2019]
GeneCards Summary for PKD1L2 Gene
PKD1L2 (Polycystin 1 Like 2 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with PKD1L2 include Polycystic Kidney Disease and Kidney Disease. Among its related pathways are Actin Dynamics Signaling Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and ion channel activity. An important paralog of this gene is PKD1.
UniProtKB/Swiss-Prot Summary for PKD1L2 Gene
-
May function as an ion-channel regulator. May function as a G-protein-coupled receptor.
Additional gene information for PKD1L2 Gene
- HGNC (21715)
- NCBI Entrez Gene (114780)
- Ensembl (ENSG00000166473)
- OMIM® (607894)
- UniProtKB/Swiss-Prot (Q7Z442)
- Open Targets Platform(ENSG00000166473)
- Monarch Initiative
- Search for PKD1L2 at DataMed
- Search for PKD1L2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PKD1L2 Gene
Genomics for PKD1L2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PKD1L2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PKD1L2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PKD1L2
- Top Transcription factor binding sites by QIAGEN in the PKD1L2 gene promoter:
-
- c-Myc
- GATA-6
- HTF
- LCR-F1
- Lhx3a
- LHX3b
- Max1
- MyoD
- S8
- Sox9
Genomic Locations for PKD1L2 Gene
Latest Assembly
- chr16:81,100,875-81,220,394
- (GRCh38/hg38)
- Size:
- 119,520 bases
- Orientation:
- Minus strand
Previous Assembly
- chr16:81,134,480-81,253,999
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 119,520 bases
- Orientation:
- Minus strand
- chr16:81,134,480-81,253,975
- (GRCh37/hg19 by Ensembl)
- Size:
- 119,496 bases
- Orientation:
- Minus strand
Genomic View for PKD1L2 Gene
Genes around PKD1L2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q23.2 by HGNC
- 16q23.2 by Entrez Gene
- 16q23.2 by Ensembl
PKD1L2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PKD1L2 Gene
Proteins for PKD1L2 Gene
-
Protein details for PKD1L2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z442-PK1L2_HUMAN
- Recommended name:
- Polycystic kidney disease protein 1-like 2
- Protein Accession:
- Q7Z442
- Q6UEE1
- Q6ZN46
- Q6ZSP2
- Q8N1H9
- Q96CL2
- Q96Q08
Protein attributes for PKD1L2 Gene
- Size:
- 2459 amino acids
- Molecular mass:
- 272514 Da
- Quaternary structure:
-
- May interact via its C-terminus with GNAS and GNAI1.
- SequenceCaution:
-
- Sequence=AAQ73173.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB67772.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAC05222.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAD18529.1; Type=Erroneous translation; Note=Wrong CDS prediction.; Evidence={ECO:0000305};
Protein Expression for PKD1L2 Gene
Post-translational modifications for PKD1L2 Gene
Other Protein References for PKD1L2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for PKD1L2
- Invitrogen Antibodies for PKD1L2 (AFLGC-Pkd1l2)
-
Biorbyt antibodies for PKD1L2
-
Custom Antibody ServicesProSci Antibodies for PKD1L2
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PKD1L2
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- antibodies-online: Show 5 available PKD1L2 Proteins ranked by validation data
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-
Quality Products:
-
Abcam proteins for PKD1L2
Assay products for research
No data available for DME Specific Peptides for PKD1L2 Gene
Domains & Families for PKD1L2 Gene
Gene Families for PKD1L2 Gene
Protein Domains for PKD1L2 Gene
- InterPro:
- Blocks:
-
- D-galactoside/L-rhamnose binding SUEL lectin domain
- ProtoNet:
Suggested Antigen Peptide Sequences for PKD1L2 Gene
- GenScript: Design optimal peptide antigens:
-
- Polycystic kidney disease 1-like 2, isoform CRA_a (D3DUL1_HUMAN)
- Polycystin-1L2 (PK1L2_HUMAN)
- PKD1L2 protein (Q96CM9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q7Z442- Family:
-
- Belongs to the polycystin family.
Function for PKD1L2 Gene
Molecular function for PKD1L2 Gene
- UniProtKB/Swiss-Prot Function:
- May function as an ion-channel regulator. May function as a G-protein-coupled receptor.
Phenotypes From GWAS Catalog for PKD1L2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005262 | calcium channel activity | IBA | 21873635 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0030246 | carbohydrate binding | IEA | -- |
Phenotypes for PKD1L2 Gene
- MGI mutant phenotypes for PKD1L2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PKD1L2:
Animal Models for PKD1L2 Gene
- MGI Knock Outs for PKD1L2:
-
- Pkd1l2 Pkd1l2<tm1b(KOMP)Mbp>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PKD1L2 - Starting at $85 >
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- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PKD1L2
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-
Santa Cruz Biotechnology (SCBT) CRISPR for PKD1L2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PKD1L2
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Clone products for research
- Applied Biological Materials (abm): Clones for PKD1L2 - Starting at $45 >
- * PKD1L2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
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Cell Lines for research
-
Horizon Cell Lines for PKD1L2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PKD1L2 Gene
Localization for PKD1L2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PKD1L2 Gene
- Membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IBA | 21873635 |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PKD1L2 Gene
Pathways & Interactions for PKD1L2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Actin Dynamics Signaling Pathway | ||
Pathways by source for PKD1L2 Gene
1 Sino Biological pathway for PKD1L2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0050982 | detection of mechanical stimulus | IBA | 21873635 |
| GO:0070588 | calcium ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for PKD1L2 Gene
Transcripts for PKD1L2 Gene
mRNA/cDNA for PKD1L2 Gene
- 5 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000534142 2012 nts (view in UCSC)
- ENST00000534447 5330 nts (view in UCSC)
- ENST00000299598 5818 nts (view in UCSC)
- ENST00000337114 3427 nts (view in UCSC)
- ENST00000525539 7379 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PKD1L2 - Starting at $85 >
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- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
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-
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miRNA products for research
Inhibitory RNAs for research
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Clone products for research
- Applied Biological Materials (abm): Clones for PKD1L2 - Starting at $45 >
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- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PKD1L2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PKD1L2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | ^ | 31a | · | 31b | ^ | 32 | ^ | 33a | · | 33b | ^ | 34a | · | 34b | ^ | 35 | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39 | ^ | 40 | ^ | 41a | · | 41b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - |
Relevant External Links for PKD1L2 Gene
- GeneLoc Exon Structure for
- PKD1L2
Expression for PKD1L2 Gene
This gene is overexpressed in Liver (33.8) and Serum (30.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PKD1L2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PKD1L2
SOURCE GeneReport for Unigene cluster for PKD1L2 Gene:
Hs.413525mRNA Expression by UniProt/SwissProt for PKD1L2 Gene:
Q7Z442-PK1L2_HUMAN
Tissue specificity:
Expressed in all tissues tested including brain, placenta, mammary gland, testis, lung and liver. Highest expression in skeletal muscle. Isoform 2 is expressed in heart and kidney.
Evidence on tissue expression from TISSUES for PKD1L2 Gene
- Nervous system(4.2)
- Kidney(4.2)
- Skin(4.2)
Primer products for research
-
OriGene qPCR primer pairs for PKD1L2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PKD1L2 Gene
Orthologs for PKD1L2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PKD1L2 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | PKD1L2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PKD1L2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pkd1l2 30 17 |
|
||
| Pkd1l3 31 |
|
OneToOne | |||
| Rat (Rattus norvegicus) |
Mammalia | LOC691069 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PKD1L2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PKD1L2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LOC100858437 30 |
|
||
| PKD1L2 31 |
|
OneToOne | |||
| Lizard (Anolis carolinensis) |
Reptilia | PKD1L2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pkd1l2 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.32680 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | im:7138475 30 |
|
||
| PKD1L2 (1 of 2) 31 |
|
OneToMany | |||
| PKD1L2 (2 of 2) 31 |
|
OneToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6839 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | lov-1 31 |
|
OneToOne |
- Species where no ortholog for PKD1L2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Paralogs for PKD1L2 Gene
Paralogs for PKD1L2 Gene
(3) SIMAP similar genes for PKD1L2 Gene using alignment to 5 proteins:
- PK1L2_HUMAN
- D3DUL1_HUMAN
- H0YEQ7_HUMAN
- L8EAM5_HUMAN
- Q96CM9_HUMAN
Variants for PKD1L2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PKD1L2 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1597273166 | Uncertain Significance: Marfanoid habitus and intellectual disability | 81,174,726(-) |
TCTGACGTCTATGCTC
NM_001076780.2(PKD1L2):c.2747_2771del (p.Gly916fs) |
FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT | |
| rs796052190 | Likely Benign: Long QT syndrome | 81,202,554(-) |
G/T NM_001076780.2(PKD1L2):c.1089C>A (p.Cys363Ter) |
NONSENSE,NON_CODING_TRANSCRIPT | |
| rs11150370 | - |
p.Pro301Ala |
|||
| rs12596941 | - |
p.Ala863Val |
|||
| rs12597040 | - |
p.Leu1036Pro |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
98.7% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PKD1L2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKD1L2 Gene
Disorders for PKD1L2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| polycystic kidney disease |
|
|
| kidney disease |
|
|
| macular degeneration, age-related, 10 |
|
|
| conduct disorder |
|
|
| neuromuscular disease |
|
|
Search PKD1L2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PKD1L2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PKD1L2 Gene
Publications for PKD1L2 Gene
- Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes. (PMID: 12782129) Li A … Somlo S (Genomics 2003) 2 3 4
- Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z … Genest J (European journal of human genetics : EJHG 2010) 3 41
- Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 41
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Polycystin-1L2 is a novel G-protein-binding protein. (PMID: 15203210) Yuasa T … Zhou J (Genomics 2004) 3 4
ExternalLinks
Products for PKD1L2 Gene
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- Biorbyt antibodies for PKD1L2
Sources for PKD1L2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB